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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈立言(Lee-Yan Sheen) | |
| dc.contributor.author | Min-Shiuan Tsai | en |
| dc.contributor.author | 蔡旻軒 | zh_TW |
| dc.date.accessioned | 2021-06-07T17:40:32Z | - |
| dc.date.copyright | 2020-07-28 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-07-27 | |
| dc.identifier.citation | Adler, B. B., Beuchat, L. R., 2002. Death of Salmonella, Escherichia coli O157:H7, and Listeria monocytogenes in garlic butter as affected by storage temperature. Journal of Food Protection 65, 1976–1980. Aggarwal, B. B., Shishodia, S., 2004. Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Annals of the New York Academy of Sciences 1030, 434–441. Ahmad, A., Rasheed, N., Banu, N., Palit, G., 2010. Alterations in monoamine levels and oxidative systems in frontal cortex, striatum, and hippocampus of the rat brain during chronic unpredictable stress. Stress 13, 355–364. Aizawa, E., Tsuji, H., Asahara, T., Takahashi, T., Teraishi, T., Yoshida, S., Ota, M., Koga, N., Hattori, K., Kunugi, H., 2016. Possible association of Bifidobacterium and Lactobacillus in the gut microbiota of patients with major depressive disorder. Journal of Affective Disorders 202, 254–257. Al-brakati A.Y., 2016. Protective effect of garlic against diabetic retinopathy in adult albino rats. Research Journal of Pharmaceutical, Biological and Chemical Sciences 7, 2748–2759. Andersen J. K., 2004. Oxidative stress in neurodegeneration: cause or consequence. Nature Medicine 10, S18–S25. Arnold, J. W., Roach, J., Azcarate-Peril, M. A., 2016. Emerging Technologies for Gut Microbiome Research. Trends in microbiology 24, 887–901. Bernier, N. J., Peter, R. E., 2001. Appetite-suppressing effects of urotensin I and corticotropin-releasing hormone in goldfish (Carassius auratus). Neuroendocrinology 73, 248–260. Björkqvist K., 2001. Social defeat as a stressor in humans. Physiology and Behavior 73, 435–442. Blaut, M., Collins, M. D., Welling, G. W., Doré, J., van Loo, J., de Vos, W., 2002. Molecular biological methods for studying the gut microbiota: the EU human gut flora project. The British Journal of Nutrition, 87 Suppl 2, S203–S211. Bunnik, E. M., Le Roch, K. G., 2013. An Introduction to Functional Genomics and Systems Biology. Advances in Wound Care 2, 490–498. Chai, J. X., Li, H. H., Wang, Y. Y., Chai, Q., He, W. X., Zhou, Y. M., Hu, X. D., Wang, Z. H., 2016. Journal of Southern Medical University 36, 1417–1422. Chan, J. Y., Yuen, A. C., Chan, R. Y., Chan, S. W., 2013. A review of the cardiovascular benefits and antioxidant properties of allicin. Phytotherapy Research 27, 637–646. Chang, H. P., Huang, S. Y., Chen, Y. H., 2005. Modulation of cytokine secretion by garlic oil derivatives is associated with suppressed nitric oxide production in stimulated macrophages. Journal of Agricultural And Food Chemistry 53, 2530–2534. Chelakkot, C., Ghim, J., Ryu, S. H., 2018. Mechanisms regulating intestinal barrier integrity and its pathological implications. Experimental and Molecular Medicine 50, 103. de Rivero Vaccari, J. P., Dietrich, W. D., Keane, R. W., 2014. Activation and regulation of cellular inflammasomes: gaps in our knowledge for central nervous system injury. Journal of Cerebral Blood Flow and Metabolism 34, 369–375. Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E. K., Lanctôt, K. L., 2010. A meta-analysis of cytokines in major depression. Biological Psychiatry 67, 446–457. Foyet, H. S., Tchinda Deffo, S., Koagne Yewo, P., Antioch, I., Zingue, S., Asongalem, E. A., Kamtchouing, P., Ciobica, A., 2017. Ficus sycomorus extract reversed behavioral impairment and brain oxidative stress induced by unpredictable chronic mild stress in rats. BMC Complementary and Alternative Medicine 17, 502. Gamaro, G. D., Manoli, L. P., Torres, I. L., Silveira, R., Dalmaz, C., 2003. Effects of chronic variate stress on feeding behavior and on monoamine levels in different rat brain structures. Neurochemistry International 42, 107–114. Glowa, J. R., Barrett, J. E., Russell, J., Gold, P. W., 1992. Effects of corticotropin releasing hormone on appetitive behaviors. Peptides 13, 609–621. Golden, S. A., Covington, H. E., Berton, O., Russo, S. J., 2015. Corrigendum: a standardized protocol for repeated social defeat stress in mice. Nature Protocols 10, 643. Gurung, P., Lukens, J. R., Kanneganti, T. D., 2015. Mitochondria: diversity in the regulation of the NLRP3 inflammasome. Trends in Molecular Medicine 21, 193–201. Hall, C. S., 1934. Drive and emotionality: factors associated with adjustment in the rat. Journal of Comparative Psychology 17, 89–108. Hall, C., Ballachey, E. L., 1932. A study of the rat's behavior in a field. A contribution to method in comparative psychology. Psychology 6, 1–12. Hiroto, D. S., Seligman, M. E., 1975. Generality of learned helplessness in man. Journal of Personality and Social Psychology 31, 311–327. Horstmann, S., Binder, E. B, 2009. Pharmacogenomics of antidepressant drugs. Pharmacology and Therapeutics 124, 57–73. Houshmand, B., Mahjour, F., Dianat, O., 2013. Antibacterial effect of different concentrations of garlic (Allium sativum) extract on dental plaque bacteria. Indian Journal of Dental Research 24, 71–75. Inserra, A., Rogers, G. B., Licinio, J., Wong, M. L., 2018. The Microbiota-Inflammasome Hypothesis of Major Depression. BioEssays 40, e1800027. Irwin, M. R., Cole, S. W., 2011. Reciprocal regulation of the neural and innate immune systems. Immunology 11, 625–632. Katz, R. J., Hersh, S., 1981. Amitriptyline and scopolamine in an animal model of depression. Neuroscience and Biobehavioral Reviews 5, 265–271. Kelly, J. R., Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G., Hyland, N. P., 2015. Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders. Frontiers in Cellular Neuroscience 9, 392. Kohler, O., Krogh, J., Mors, O., Benros, M. E., 2016. Inflammation in Depression and the Potential for Anti-Inflammatory Treatment. Current Neuropharmacology 14, 732–742. Kyo, E., Uda, N., Kasuga, S., Itakura, Y., 2001. Immunomodulatory effects of aged garlic extract. The Journal of Nutrition 131, 1075S–9S. Lee, B., Moon, K. M., Kim, C. Y., 2018. Tight Junction in the Intestinal Epithelium: Its Association with Diseases and Regulation by Phytochemicals. Journal of Immunology Research, 2645465. Lee, S. H., Liu, Y. T., Chen, K. M., Lii, C. K., Liu, C. T., 2012. Effect of garlic sulfur compounds on neutrophil infiltration and damage to the intestinal mucosa by endotoxin in rats. Food and Chemical Toxicology 50, 567–574. Li, N., Wang, Q., Wang, Y., Sun, A., Lin, Y., Jin, Y., Li, X., 2019. Fecal microbiota transplantation from chronic unpredictable mild stress mice donors affects anxiety-like and depression-like behavior in recipient mice via the gut microbiota-inflammation-brain axis. Stress 22, 592–602. Liu, M. Y., Yin, C. Y., Zhu, L. J., Zhu, X. H., Xu, C., Luo, C. X., Chen, H., Zhu, D. Y., Zhou, Q. G., 2018. Sucrose preference test for measurement of stress-induced anhedonia in mice. Nature Protocols, 13, 1686–1698. Lu, J., He, H., Huang, C., Chen, Z., 2019. Effect of diallyl disulfide on lipopolysaccharide-induced depression-like behavior in mice. Research Square, 10.21203/rs.2.19757/v1. Lu, Y., Ho, C. S., Liu, X., Chua, A. N., Wang, W., McIntyre, R. S., Ho, R. C., 2017. Chronic administration of fluoxetine and pro-inflammatory cytokine change in a rat model of depression. PloS one 12, e0186700. Madsen, K., Cornish, A., Soper, P., McKaigney, C., Jijon, H., Yachimec, C., Doyle, J., Jewell, L., De Simone, C., 2001. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121, 580–591. Maes, M., Song, C., Yirmiya, R., 2012. Targeting IL-1 in depression. Expert Opinion on Therapeutic Targets 16, 1097–1112. Markowitz, J. C., Weissman, M. M., 2004. Interpersonal psychotherapy: principles and applications. Journal of the World Psychiatric Association 3, 136–139. Martí, O., Martí, J., Armario, A., 1994. Effects of chronic stress on food intake in rats: influence of stressor intensity and duration of daily exposure. Physiology and Behavior 55, 747–753. Mazzon, E., Sturniolo, G. C., Puzzolo, D., Frisina, N., Fries, W., 2002. Effect of stress on the paracellular barrier in the rat ileum. Gut 51, 507–513. Mor, N., Haran, D., 2009. Cognitive-behavioral therapy for depression. The Israel journal of Psychiatry and Related Sciences 46, 269–273. Münchberg, U., Anwar, A., Mecklenburg, S., Jacob, C., 2007. Polysulfides as biologically active ingredients of garlic. Organic and Biomolecular Chemistry 5, 1505–1518. Najjar, S., Pearlman, D. M., Alper, K., Najjar, A., Devinsky, O., 2013. Neuroinflammation and psychiatric illness. Journal of Neuroinflammation 10, 43. O'Gara, E. A., Hill, D. J., Maslin, D. J., 2000. Activities of garlic oil, garlic powder, and their diallyl constituents against Helicobacter pylori. Applied and Environmental Microbiology 66, 2269–2273. Owens, M. J., Nemeroff, C. B., 1991. Physiology and pharmacology of corticotropin-releasing factor. Pharmacological Reviews 43, 425–473. Pan, Y., Chen, X. Y., Zhang, Q. Y., Kong, L. D., 2014. Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats. Brain, Behavior, and Immunity 41, 90–100. Pearson-Leary, J., Zhao, C., Bittinger, K., Eacret, D., Luz, S., Vigderman, A. S., Dayanim, G., Bhatnagar, S., 2020. The gut microbiome regulates the increases in depressive-type behaviors and in inflammatory processes in the ventral hippocampus of stress vulnerable rats. Molecular Psychiatry 25, 1068–1079. Philpott, M., Ferguson, L. R., 2004. Immunonutrition and cancer. Mutation Research 551, 29–42. Picardi, A., Gaetano, P., 2014. Psychotherapy of mood disorders. Clinical Practice and Epidemiology in Mental Health 10, 140–158. Rahman, K., Lowe, G. M., 2006. Garlic and cardiovascular disease: a critical review. The Journal of Nutrition 136, 736S–740S. Raison, C. L., Miller, A. H., 2011. Is depression an inflammatory disorder. Current Psychiatry Reports 13, 467–475. Rana, S. V., Pal, R., Vaiphei, K., Sharma, S. K., Ola, R. P., 2011. Garlic in health and disease. Nutrition Research Reviews 24, 60–71. Rashid, A., Khan, H. H., 1985. The mechanism of hypotensive effect of garlic extract. The Journal of the Pakistan Medical Association 35, 357–362. Rhodes, A. N., Urbance, J. W., Youga, H., Corlew-Newman, H., Reddy, C. A., Klug, M. J., Tiedje, J. M., Fisher, D. C., 1998. Identification of bacterial isolates obtained from intestinal contents associated with 12,000-year-old mastodon remains. Applied and Environmental Microbiology, 64, 651–658. Ross, Z. M., O'Gara, E. A., Hill, D. J., Sleightholme, H. V., Maslin, D. J., 2001. Antimicrobial properties of garlic oil against human enteric bacteria: evaluation of methodologies and comparisons with garlic oil sulfides and garlic powder. Applied and Environmental Microbiology 67, 475–480. Sanada, K., Nakajima, S., Kurokawa, S., Barceló-Soler, A., Ikuse, D., Hirata, A., Yoshizawa, A., Tomizawa, Y., Salas-Valero, M., Noda, Y., Mimura, M., Iwanami, A., Kishimoto, T., 2020. Gut microbiota and major depressive disorder: A systematic review and meta-analysis. Journal of Affective disorders 266, 1–13. Seligman, M. E., Maier, S. F., 1967. Failure to escape traumatic shock. Journal of Experimental Psychology 74, 1–9. Shin, I. S., Hong, J., Jeon, C. M., Shin, N. R., Kwon, O. K., Kim, H. S., Kim, J. C., Oh, S. R., Ahn, K. S., 2013. Diallyl-disulfide, an organosulfur compound of garlic, attenuates airway inflammation via activation of the Nrf-2/HO-1 pathway and NF-kappaB suppression. Food and Chemical Toxicology 62, 506–513. Silva-Islas, C. A., Chánez-Cárdenas, M. E., Barrera-Oviedo, D., Ortiz-Plata, A., Pedraza-Chaverri, J., Maldonado, P. D., 2019. Diallyl Trisulfide Protects Rat Brain Tissue against the Damage Induced by Ischemia-Reperfusion through the Nrf2 Pathway. Antioxidants 8, 410. Slavich, G. M., Irwin, M. R., 2014. From stress to inflammation and major depressive disorder: a social signal transduction theory of depression. Psychological Bulletin 140, 774–815. Söderholm, J. D., Perdue, M. H., 2001. Stress and gastrointestinal tract. II. Stress and intestinal barrier function. American journal of physiology. Gastrointestinal and Liver Physiology 280, G7–G13. Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X. N., Kubo, C., Koga, Y., 2004. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. The Journal of Physiology 558(Pt 1), 263–275. Walsh, J. G., Muruve, D. A., Power, C., 2014. Inflammasomes in the CNS. Nature Reviews. Neuroscience 15, 84–97. Wang, G., Liu, Q., Guo, L., Zeng, H., Ding, C., Zhang, W., Xu, D., Wang, X., Qiu, J., Dong, Q., Fan, Z., Zhang, Q., Pan, J., 2018. Gut Microbiota and Relevant Metabolites Analysis in Alcohol Dependent Mice. Frontiers in Microbiology 9, 1874. Wang, J., Zhang, X., Lan, H., Wang, W., 2017. Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials. Food and Nutrition Research 61, 1377571. Willner P., 2016. The chronic mild stress (CMS) model of depression: History, evaluation and usage. Neurobiology of Stress 6, 78–93. Willner, P., Muscat, R., Papp, M., 1992. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neuroscience and biobehavioral reviews 16, 525–534. Xiao, D., Pinto, J. T., Soh, J. W., Deguchi, A., Gundersen, G. G., Palazzo, A. F., Yoon, J. T., Shirin, H., Weinstein, I. B., 2003. Induction of apoptosis by the garlic-derived compound S-allylmercaptocysteine (SAMC) is associated with microtubule depolymerization and c-Jun NH(2)-terminal kinase 1 activation. Cancer Research 63, 6825–6837. Yang, R., Wang, P., Chen, Z., Hu, W., Gong, Y., Zhang, W., Huang, C., 2017. WY-14643, a selective agonist of peroxisome proliferator-activated receptor-α, ameliorates lipopolysaccharide-induced depressive-like behaviors by preventing neuroinflammation and oxido-nitrosative stress in mice. Pharmacology, Biochemistry, and Behavior 153, 97–104. Yang, Y., Yang, F., Huang, M., Wu, H., Yang, C., Zhang, X., Yang, L., Chen, G., Li, S., Wang, Q., Liu, S., Liu, Y., Lei, Y., Lei, Z., Guo, J., 2019. Fatty liver and alteration of the gut microbiome induced by diallyl disulfide. International journal of molecular medicine 44, 1908–1920. You, S., Nakanishi, E., Kuwata, H., Chen, J., Nakasone, Y., He, X., He, J., Liu, X., Zhang, S., Zhang, B., Hou, D. X., 2013. Inhibitory effects and molecular mechanisms of garlic organosulfur compounds on the production of inflammatory mediators. Molecular Nutrition and Food Research 57, 2049–2060. Zhang, W. Y., Guo, Y. J., Han, W. X., Yang, M. Q., Wen, L. P., Wang, K. Y., Jiang, P., 2019. Curcumin relieves depressive-like behaviors via inhibition of the NLRP3 inflammasome and kynurenine pathway in rats suffering from chronic unpredictable mild stress. International Immunopharmacology 67, 138–144. Zhang, Y. Q., Wang, X. B., Xue, R. R., Gao, X. X., Li, W., 2019. Ginsenoside Rg1 attenuates chronic unpredictable mild stress-induced depressive-like effect via regulating NF-κB/NLRP3 pathway in rats. Neuroreport 30, 893–900. Zou, W., Feng, R., Yang, Y., 2018. Changes in the serum levels of inflammatory cytokines in antidepressant drug-naïve patients with major depression. PloS one 13, e0197267. P. Willner., 2009. Animal models for psychiatric states. I.P. Stolerman (Ed.), Encyclopedia of Psychopharmacology, Springer, Heidelberg. https://www.uptodate.com/contents/unipolar-depression-in-adults-supportive-psychotherapy http://www.human-microbiome.org/ 行政院農委會-大蒜產銷現階段問題及因應輔導措施-1992年 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15426 | - |
| dc.description.abstract | 世界衛生組織統計全球約有3億人罹患憂鬱症，此疾病嚴重將造成患者自殺及帶來社會經濟上的重擔，現今研究已知壓力引起腦部中的發炎體蛋白3號 (NOD-, LRR- and pyrin domain-containing protein 3, NLRP3) 之活化，使得下游促發炎細胞激素 IL-1β 的累積，將導致慢性神經發炎；另外壓力造成腸道菌相組成及腸道屏障功能的改變使腸道菌產生之毒素如脂多醣可能得以進入血液循環系統中，造成周邊慢性發炎，此現象與部分憂鬱症患者血液檢測中，發現有較高發炎指標的濃度有相似性。目前臨床之抗憂鬱劑藥物常因副作用、作用發揮期過長和高復發率受到討論，故尋找其它具有類抗憂鬱之素材有其必要性。大蒜 (Allium sativum L.) 為多年生草本植物之地下鱗莖，除作為日常使用之辛香料外，草本綱目和文獻研究皆指出其具有解毒、消炎等功用，另外本實驗室先前於大鼠類憂鬱動物模式中，已發現大蒜精油介入後具有促進神經增生和調控單胺類物質代謝速率而具類抗憂鬱的效果。故本研究目的欲探討介入大蒜精油 (Garlic essential oil, GEO) 及其活性成分二烯丙基二硫化物 (Diallyl disulfide, DADS) 於大鼠不可預期慢性溫和壓力模式下是否透過上述途徑而能發揮類抗憂鬱功效，因而對其機制有更多面的了解。後續分析大鼠腦部神經傳導物質的代謝情形，探討腦部發炎體蛋白及腸通透道蛋白之表現量，並測定血清發炎指標之濃度及腸道菌相之變化情形。實驗以DADS 10 mg/kg bw及GEO 5、15、25 mg/kg bw分別介入，結果顯示大蒜精油能有效改善大鼠因壓力而減少對糖水偏好之程度 (p < 0.05)，且顯著降低腦部單胺類神經傳導物質升高的代謝速率 (p < 0.05)。分析腦部發炎體蛋白中NLRP3、ASC、Caspase-1與其下游IL-1β及腸道結構蛋白表現情形，結果發現在大蒜精油25 mg/kg bw介入後，可以顯著降低NLRP3發炎體蛋白及下游IL-1β之表現，在腸道通透蛋白則能回復其表現量及腸屏障功能，在血清中接受壓力之組別IL-1β及TNF-α濃度顯著增加，而在大蒜精油25 mg/kg bw介入的組別中能顯著減少其濃度 (p < 0.05)，顯示大蒜精油具有降低周邊系統發炎之效果，在腸道菌結果大蒜精油具有增加Ruminococcaceae的相對豐富度，此類菌群具有維持腸屏障的功能，此外也發現在壓力組別中Marvinbryantia菌屬數量的減少，與先前研究具有相似結果，綜合上述，大蒜精油藉由減緩大鼠腦部單胺類神經傳導物質的代謝速率、減少腦部NLRP3發炎體蛋白和下游IL-1β之表現，另外透過降低血清中發炎指標之濃度，增加腸道菌Ruminococcaceae豐富度回復腸屏障功能，達到類抗憂鬱之效果。 | zh_TW |
| dc.description.abstract | According to the statistics of the World Health Organization, about 300 million people worldwide suffer from depression. This disease will cause patients to commit suicide and bring social and economic burdens. Nowadays, it is known that stress causes the activation of NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) causes the accumulation of the downstream proinflammatory cytokine IL-1β, which will lead to chronic neuroinflammation; in addition, the pressure causes changes gut microbiota composition and intestinal barrier function to make toxins such as lipopolysaccharide may enter the blood circulation system, causing chronic inflammation in the periphery. This phenomenon is similar to the concentration of high inflammation indicators found in serum of some depression patients. At present, clinical antidepressant drugs are argued by side effects, long duration of action and high recurrence rate, so it is necessary to search new antidepressant-like compounds. Garlic (Allium sativum L.) is an underground bulb of a perennial herb. In addition to being a spice for daily use, literature studies have pointed out that it has detoxification and anti-inflammatory functions. In addition, our laboratory preliminary results showed that garlic essential oil was found to have anti-depressive effects by promoting nerve proliferation and regulating the turnover rate of monoamines in depressive-like animal model. Therefore, the purpose of this study is to investigate whether gavage of garlic essential oil (GEO) and its active compound diallyl disulfide (DADS) in rats can be expected through the above-mentioned mechanisms under unpredictable chronic mild stress model to learn more about its anti-depression effects. Analysis of the turnover rate of neurotransmitters in the brain of rat, to explore the expression of inflammasome protein in the brain and intestinal permeability protein, and to determine the concentration of serum inflammation indicators and changes gut microbiota composition. The experiment involved DADS 10 mg/kg bw and GEO 5, 15, 25 mg/kg bw, respectively. The results showed that GEO can effectively improve the reducing of the preference sucrose water in rats due to stress (p <0.05), and significantly reduce the brain increased turnover rate of monoamine neurotransmitters (p <0.05). Analysis of the expression of NLRP3, ASC, Caspase-1 and its downstream IL-1β and intestinal structural protein. In the inflammasome protein of the brain showed that after the intervention of GEO 25 mg/kg bw, it can significantly reduce the NLRP3 protein and downstream performance of IL-1β, the intestinal permeability protein can restore its expression level and intestinal barrier function, and the concentration of IL-1β and TNF-α in serum significantly increased in stress group, while in GEO 25 mg/kg bw group can significantly reduce its concentration (p <0.05), showing that GEO has the effect of reducing inflammation in the peripheral system. In the gut microbiota, GEO has increased the relative abundance of Ruminococcaceae. In addition, it is also found that the number of Marvinbryantia bacteria in the stress group is reduced, which has similar results to previous studies. Based on the above, GEO reduces the turnover rate of neurotransmitters in the brain, the performance of NLRP3 inflammasome protein and downstream IL-1β, in addition, by reducing the concentration of inflammation indicators in the serum, increasing the abundance of intestinal bacteria Ruminococcaceae to restore intestinal barrier function, to achieve anti-depressant effects. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-07T17:40:32Z (GMT). No. of bitstreams: 1 U0001-2407202002153300.pdf: 5585338 bytes, checksum: 49da36898990d68e7f90eb18d75d9ae3 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 目次 致謝 I 中文摘要 II Abstract III 目次 V 圖次 VII 表次 IX 縮寫表 X 第一章 前言 1 第二章 文獻回顧 2 第一節 憂鬱症 2 第二節 腸道菌 9 第三節 大蒜 16 第三章 研究假說與研究目的 19 第四章 實驗架構 21 第五章 材料與方法 22 第一節 實驗材料 22 第二節 實驗藥品與試劑 22 第三節 實驗儀器設備 24 第四節 實驗方法 26 第五節 實驗結果統計分析方法 31 第六章 實驗結果 32 第一節 大蒜精油成分分析 32 第二節 不可預期慢性溫和壓力 32 第三節 腦部單胺類神經傳導物質分析 33 第四節 NLRP3腦部發炎體蛋白與腸道通透蛋白表現量分析 33 第五節 血清發炎指標分析 34 第六節 腸道菌相分析 34 第七章 討論 52 第一節 大蒜精油之成分探討 52 第二節 不可預期慢性溫和壓力 53 第三節 腦部單胺類神經傳導物質探討 54 第四節 NLRP3腦部發炎體蛋白與腸道通透蛋白表現量探討 55 第五節 血清發炎指標探討 55 第六節 腸道菌相變化探討 56 第八章 結論 58 第九章 未來研究方向 59 第十章 參考文獻 60 第十一章 附錄 66 | |
| dc.language.iso | zh-TW | |
| dc.title | 大蒜精油及二烯丙基二硫之類抗憂鬱效果在大鼠不可預期慢性溫和壓力模式中透過調節腦部NLRP3發炎體途徑和對腸道屏障及腸道菌相之影響 | zh_TW |
| dc.title | Antidepressant-like Effects of Garlic Essential Oil and Diallyl Disulfide in Unpredictable Chronic Mild Stress Rat Model through Mediating Brain NLRP3 Inflammasome Pathway and Influencing of Gut Barrier and Gut Microbiota | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳碩菲(Shou-Fei Chen),莊曉莉(Hsiao-Li Chuang) | |
| dc.subject.keyword | 大蒜精油,二烯丙基二硫,憂鬱症,不可預期慢性溫和壓力,發炎,NLRP3發炎體,腸道通透性, | zh_TW |
| dc.subject.keyword | garlic essential oil,diallyl disulfide,depression,unpredictable chronic mild stress,inflammation,NLRP3 inflammasome,intestinal permeability, | en |
| dc.relation.page | 109 | |
| dc.identifier.doi | 10.6342/NTU202001808 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2020-07-28 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-2407202002153300.pdf 目前未授權公開取用 | 5.45 MB | Adobe PDF |
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