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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳嘉文 | zh_TW |
| dc.contributor.advisor | Kevin C.-W. Wu | en |
| dc.contributor.author | 黃芷欣 | zh_TW |
| dc.contributor.author | Zhu-Xin Ng | en |
| dc.date.accessioned | 2026-07-08T16:11:53Z | - |
| dc.date.available | 2026-07-09 | - |
| dc.date.copyright | 2026-07-08 | - |
| dc.date.issued | 2026 | - |
| dc.date.submitted | 2026-07-01 | - |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/102507 | - |
| dc.description.abstract | 經皮治療系統能有效避免肝臟的首過效應並提升患者的方便性，具有極大的優勢。然而，皮膚角質層的屏障作用大幅限制了其實際應用。為了克服此瓶頸，本研究應用以 Pluronic F127 表面穩定處理的 MIL-100(Fe) 奈米粒子，嵌入聚乙烯吡咯烷酮與羧甲基纖維素（PVP/CMC）的混合高分子基質中，開發出一款複合性溶解型微針貼片。實驗結果顯示，Pluronic F127 的表面修飾成功抑制了奈米粒子的聚集現象，並顯著提升其分散穩定性。XRD、FTIR、XPS、BET 及 TGA 等分析進一步證實了Pluronic F127表面修飾的成功。在微針製備上，含有 10 wt% PVP 與 5 wt% CMC 的高分子基質搭配針長 1000 µm 的微針幾何形狀設計，可提供微針貼片足夠的機械強度與良好的加工適性。體外豬皮測試證實該微針能有效於皮膚建立微通道。同時，體外釋放試驗也顯示微針基質能迅速溶解，並在 30 分鐘內達到約 96% 的累積藥物釋放率。總結而言，本研究成功驗證了將 Pluronic F127 包覆之 MIL-100(Fe) 結合至溶解型微針中的可行性，為奈米粒子輔助經皮治療平台提供一項具發展潛力的設計方向。 | zh_TW |
| dc.description.abstract | Transdermal drug delivery systems can bypass hepatic first-pass metabolism and improve patient compliance, but their applications remain limited by the stratum corneum barrier. To overcome this challenge, this study developed a composite dissolving microneedle patch by incorporating Pluronic F127-stabilized MIL-100(Fe) nanoparticles into a polyvinylpyrrolidone/carboxymethylcellulose (PVP/CMC) matrix. Pluronic F127 surface modification effectively reduced nanoparticle aggregation and enhanced dispersion stability, and this successful surface modification was supported by XRD, FTIR, XPS, BET, and TGA analyses. Microneedles prepared from 10 wt% PVP + 5 wt% CMC with a 1000 µm microneedle geometry exhibited sufficient mechanical strength and suitable processability. Ex vivo porcine skin tests confirmed effective microchannel formation, and in vitro assays revealed that the cumulative release of the model payload reached approximately 96% within 30 min. In summary, this study validates the integration of PF127-MIL-100(Fe) nanoparticles into dissolving microneedles as a promising strategy for nanoparticle-mediated transdermal drug delivery. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2026-07-08T16:11:53Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2026-07-08T16:11:53Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書 i
致謝 ii 摘要 iii Abstract iv Table of Contents v List of Figures ix List of Tables xii 1. Introduction 1 1.1. Transdermal drug delivery systems 1 1.2. Microneedle drug delivery systems 3 1.3. Microneedle material and geometry 6 1.4. Metal-organic frameworks (MOFs) 7 1.5. Limitations of MOF nanoparticles 10 1.6. Surface modification 11 2. Literature Review 13 2.1. Marketed and clinical-stage dissolving microneedles 13 2.1.1. Hyaluronic acid (HA) microneedles 14 2.1.2. Poly(lactic-co-glycolic) acid (PLGA) microneedles 15 2.2. Previous studies on PVP-CMC based microneedles 15 2.2.1. Blends of natural and synthetic polymers 16 2.2.2. Physical crosslinking of PVP-CMC 17 2.2.3. Previous studies on PVP/CMC-based microneedles 19 2.2.3.1 Preparation and properties of PVP/CMC soluble microneedles 19 2.2.3.2 Dissolvable PVP/CMC microneedle arrays for cutaneous leishmaniasis treatment 19 2.3. MOF-integrated microneedles 20 3. Objective 22 4. Experimental 24 4.1. Materials 24 4.2. Equipment 25 4.3. Synthesis of MIL-100(Fe) 27 4.4. Synthesis of PF127-MIL-100(Fe) 28 4.5. Material characterization 29 4.5.1. X-ray diffraction (XRD) 29 4.5.2. Fourier-transform infrared spectroscopy (FTIR) 30 4.5.3. X-ray photoelectron spectroscopy (XPS) 30 4.5.4. Specific surface area and pore size distribution 30 4.5.5. Thermogravimetric analysis (TGA) 31 4.5.6. Colloidal stability 31 4.5.6.1 Polydispersity index (PdI) 31 4.5.6.2 Visual observations 32 4.6. Microneedle patches 32 4.6.1. PDMS mold 32 4.6.2. Fabrication of microneedle patches 34 4.6.3. Microneedle morphology 35 4.6.4. Mechanical strength 35 4.6.5. Evaluation of the insertion capability 36 4.6.6. Ex vivo penetration test 38 4.6.7. In vitro drug release test 39 5. Results and Discussion 40 5.1. Characterization of MIL-100(Fe) and PF127-MIL-100(Fe) 40 5.1.1. Crystalline structures (XRD) 40 5.1.2. FTIR analysis 41 5.1.3. Surface elemental analysis (XPS) 43 5.1.4. Specific surface area and pore size distribution 45 5.1.5. Thermal stability (TGA) 47 5.1.6. Colloidal stability of nanoparticles 48 5.2. Characterization of microneedle patches 51 5.2.1. Morphology of microneedle patches 51 5.2.2. Mechanical strength and penetration efficiency 53 5.2.2.1 Effect of microneedle geometries 53 5.2.2.2 Optimization of the polymer matrix composition 55 5.2.3. Ex vivo skin penetration test 57 5.2.4. In vitro drug release profile 59 6. Conclusions 60 7. Future works 62 References 63 | - |
| dc.language.iso | en | - |
| dc.subject | 經皮治療系統 | - |
| dc.subject | 溶解型微針 | - |
| dc.subject | PVP/CMC | - |
| dc.subject | MIL-100(Fe) | - |
| dc.subject | Pluronic F127 | - |
| dc.subject | 表面修飾 | - |
| dc.subject | transdermal drug delivery | - |
| dc.subject | dissolving microneedle | - |
| dc.subject | PVP/CMC | - |
| dc.subject | MIL-100(Fe) | - |
| dc.subject | Pluronic F127 | - |
| dc.subject | surface modification | - |
| dc.title | Pluronic F127 表面穩定化 MOF 奈米粒結合可溶性微針以提升經皮治療系統應用潛力 | zh_TW |
| dc.title | Pluronic F127 Surface-Stabilized MOF Nanoparticles Integrated into Dissolving Microneedles for Improved Transdermal Drug Delivery Systems | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 114-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 游佳欣;莊爾元;李亦淇;高煌凱 | zh_TW |
| dc.contributor.oralexamcommittee | JiaShing Yu;Er-Yuan Chuang;I-Chi Lee;Huang-Kai Kao | en |
| dc.subject.keyword | 經皮治療系統; 溶解型微針; PVP/CMC; MIL-100(Fe); Pluronic F127; 表面修飾 | zh_TW |
| dc.subject.keyword | transdermal drug delivery; dissolving microneedle; PVP/CMC; MIL-100(Fe); Pluronic F127; surface modification | en |
| dc.relation.page | 77 | - |
| dc.identifier.doi | 10.6342/NTU202601522 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2026-07-02 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 化學工程學系 | - |
| dc.date.embargo-lift | 2026-07-09 | - |
| 顯示於系所單位： | 化學工程學系 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-114-2.pdf | 4.09 MB | Adobe PDF | 檢視/開啟 |
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