以濃度相轉換方式製備石蠟油O/W型奈米乳液

Abstract

本論文以濃度相轉換 (Phase Inversion Concentration， PIC ) 的方式，於固定30℃下將水緩慢加入油相製備成乳液，其中油相所包含的藥品為石蠟油及Span80/Tween80 兩種界面活性劑，且以改Span80 的含量、油與界面活性劑的比例及水的含量多寡作為操作變因，並以動態粒徑分析儀（Dynamic light scattering）Zetasizer Nano 及實驗設計軟體Design-Expert 7 進行分析並討論。 本研究所製成之石蠟油乳液為O/W型乳液，其pH 值介於5~6 之間，粒徑小於200nm。奈米乳液最佳配方為油與界面活性劑比例為1.5~2之間，水含量為70wt%，HLB 值為11.3。另透過實驗設計軟體分析得知本研究之顯著變因為A，B，AB，BC，ABC，其中 A 為Span80 的含量，B為油與界面活性劑的比例，C為水的含量多寡。

Emulsions of the paraffin oil were prepared from Tween 80/Span 80 and water at 30°C using the phase inversion concentration method. The influences of the key parameters on the nature of the emlsions prepared, in particular, its size distribution, are investigated. These include the amount of surfactant (%Span, A) and the corresponding HLB value, the oil/surfactant (O/S) ratio (B), the amount of water (C), and the pH of the bulk liquid phase. Paraffin oil emulsions with droplet size below 200 nm were O/W type emulsion and pH value 5~6. The best formed of the makeup nano-emulsions were 70wt% of the distilled water with oil/surfactant between 1.5 and 2 as well as the HLB value 11.3. The main and interactive effects of the process parameters have been studied by using analysis of variance (ANOVA) method. In this case, A, B, AB, BC, ABC are significant model terms. The three process control parameters (%Span, Oil/Surfactant (O/S) and water) termed as A, B, and C.