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標題: | 圓周徑向掃描譜域式光學同調斷層內視鏡之設計開發 Design and Development of Circular Scanning Endoscopic Spectral Domain Optical Coherence Tomography |
作者: | 莊璿湰 Hsuan-Lung Chuang |
指導教授: | 黃光裕 Kuang-Yuh Huang |
共同指導教授: | 駱遠 Yuan Luo |
關鍵字: | 譜域式光學同調斷層掃描術,內視鏡,梯度折射率透鏡,超穎透鏡,圓周掃描, Spectral domain optical coherence tomography,Endoscope,GRIN lens,Metalens,Circular scanning, |
出版年 : | 2023 |
學位: | 碩士 |
摘要: | 光學同調斷層掃描術(Optical Coherence Tomography; OCT)是一種非侵入性的影像技術,可高分辨率地成像生物組織,已成為眼科領域中非常重要的影像診斷工具。結合內視鏡成像技術更適合進入人體腔道內進行檢查,可以幫助醫師觀察並診斷病變,並且搭配內視鏡手術。探測深度1 mm到3 mm、深度解析度1 μm到10μm的影像很適合用於偵測腫瘤,目前OCT內視鏡已應用於胃腸道、泌尿生殖系統、呼吸系統等器官的疾病檢查中,例如胃癌、膀胱癌、支氣管肺癌等。本論文提出一種圓周掃描譜域式光學同調斷層內視鏡,透過光源臂中的濾鏡、偵測臂的繞射光柵和聚焦透鏡之搭配測試分析,選出最適合的系統架構。採用880 nm±70 nm的光源,以達成高解析度和探測深度的合併特性,以推廣至生醫及工業的探測領域上。致動則採用微型馬達圓周掃描,穩定且快速地建構三維圓周影像,其掃描速率可達94 fps。同樣也可將樣本置於電控平台上,以獲取建構三維立體影像。為了使內視鏡微小化,設計開發三種內視鏡分別加入梯度折射率透鏡(GRIN lens)、NA=0.5和NA=0.8的超穎透鏡(Metalens),內視鏡的直徑為6 mm,使其尺寸微小化的同時又有優良成像效能。經過實驗性能測試與驗證,深度解析度分別為12.6 μm、9.7 μm和5 μm,空氣中的探測深度分別可達到1 mm、1.8 mm及1.2 mm,對透明樣本皆可達到探測深度1 mm,並能探測隱形眼鏡的厚度。 Optical Coherence Tomography (OCT) is a non-invasive imaging technique allowing high-resolution biological tissue imaging. It has become a vital imaging diagnostic tool in the field of ophthalmology. Combined with endoscopic imaging technology, it is more suitable for inspection in the human cavity. It helps physicians observe and diagnose lesions, and can be used in endoscopic surgeries. Imagery with a detection depth of 1 mm to 3 mm and a depth resolution of 1 μm to 10 μm is ideal for tumor detection. Currently, OCT endoscopes are widely used in the examination of organs such as the gastrointestinal tract, urinary reproductive system, and respiratory system, for diseases such as gastric cancer, bladder cancer, and bronchial lung cancer. This paper proposes a circular scanning spectral domain OCT endoscope. The optimal system architecture is determined through the combination and testing analysis of the filters of the light source, diffractive gratings and focusing lens in the detection arm. A light source of 880 nm±70 nm is used to achieve the combined characteristics of high resolution and detection depth. It can be applied to biomedical inspection and industrial detection and inspection work. The actuator adopts a miniature motor for circumferential scanning, which enables stable and rapid construction of three-dimensional images, with a scanning rate of up to 94 fps. Additionally, if the sample is placed on an electrically controlled platform, it can also be scanned and reconstructed into a three-dimensional image. To miniaturize the endoscope, three types of endoscopes are designed and developed, incorporating Gradient Index lens (GRIN lens), NA=0.5 metalens and NA=0.8 metalens, respectively. They make the size miniaturized while having excellent imaging performance. After experimental performance testing and verification, the diameter of the endoscope is 6 mm, with axial resolutions of 12.6 μm, 9.7 μm and 5 μm and detection depths of 1 mm, 1.8 mm and 1.2 mm in air, respectively. It achieves a detection depth of 1 mm for transparent samples and can detect the thickness of contact lenses. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/88247 |
DOI: | 10.6342/NTU202301862 |
全文授權: | 未授權 |
顯示於系所單位: | 機械工程學系 |
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