具有多個[2]交環烷分枝之內鎖分子的合成研究

Abstract

本實驗室在先前的研究中發展出以鈉離子為模板，使含有二乙二醇鏈的二胺分子兩兩正交排列，並與二醛分子反應生成[2]交環烷的辨識系統。本研究主要希望利用導入二乙二醇鏈的合適互補基到大環結構中，製作出可以有效組裝異[2]交環烷的辨識系統。利用此一系統，我們可以簡單而有效率地(31%)合成出同時具有三個[2]交環烷分枝的高階異交環烷。

Previously, we reported that Na+ ions can template the orthogonal alignment of two di(ethylene glycol)-containing diamines, which can then react with two units of dialdehyde to generate homo-[2]catenanes. In this study, we applied this strategy to the synthesis of hetero-[2]catenanes. By introducing a proper complementary unit for di(ethylene glycol) chain to the structures of the macrocycles, we are able to selectively assemble the desire hetero-[2]catenanes in solution. A stable [2]catenane trimer was synthesized directly from a simple hexa-aldehyde in 31% yield.