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標題: | 遺傳相關研究中的基因劑量分析:潛在的偏差及其校正方法 Gene-Dose Analysis in Genetic Association Studies:A Potential Bias and its Correction |
作者: | Hsiao-Yuan Huang 黃筱元 |
指導教授: | 李文宗 |
關鍵字: | 基因劑量分析,排列校正方法,流行病學方法學,遺傳流行病學, gene-dose analysis,permutation correction method,epidemiologic methods,genetic epidemiology, |
出版年 : | 2005 |
學位: | 碩士 |
摘要: | 探討基因與疾病相關性的病例對照研究中,許多研究進行基因劑量分析。作者發現其中約有三分之一的研究,其定義高危險基因型(高危險基因)的方式是依資料本身該基因型頻率(基因頻率)病例組大於對照組而定。作者進行蒙地卡羅模擬,發現此種定義方式下即使各基因座與疾病無相關,亦會呈現偽陽性的基因劑量關係。作者提出排列校正方法,可以成功地校正各偏差。本研究所提方法執行容易且校正效果良好,可望成為基因劑量效應研究之標準程序。 Many case-control association studies performed the “gene-dose analysis” to investigate the association between multiple loci and the disease. The authors found that the researchers in about one-third of these studies defined the high-risk genotypes (high-risk alleles) as those that have higher genotype frequencies (allele frequencies) in the case group than in the control in the study. The authors performed Monte-Carlo simulation and found that even though there is no association between each locus and the disease, this kind of definition will show false-positive gene-dose relationships. The authors proposed a permutation correction method which is easy to perform and can correct the biases very effectively. The permutation correction method may become a standard procedure for a valid gene-dose analysis in the days to come. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/35467 |
全文授權: | 有償授權 |
顯示於系所單位: | 流行病學與預防醫學研究所 |
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