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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99933完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 郭育良 | zh_TW |
| dc.contributor.advisor | Yue-Leon Guo | en |
| dc.contributor.author | 陳奕安 | zh_TW |
| dc.contributor.author | I-An Chen | en |
| dc.date.accessioned | 2025-09-19T16:20:27Z | - |
| dc.date.available | 2025-09-20 | - |
| dc.date.copyright | 2025-09-19 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-08-06 | - |
| dc.identifier.citation | Balieva, F., Finlay, A., Kupfer, J., Aragones, L. T., Lien, L., Gieler, U., Poot, F., Jemec, G. B., Misery, L., & Kemeny, L. (2018). The role of therapy in impairing quality of life in dermatological patients: a multinational study. Acta dermato-venereologica, 98(6), 563-569.
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Dusunen Adam Journal of Psychiatry and Neurological Sciences, 29(2), 139. Song, J., Gao, Y., Wang, Y., Dai, H., Jia, X., Xiang, Q., Zhang, H., Zheng, R., & Zhang, W. (2023). Assessment of Anxiety, Depression, and Sleep Quality in Mothers of Children with Atopic Dermatitis: A Qualitative Questionnaire Study. Journal of Asthma and Allergy, 879-887. Suárez-Varela, M. M., Alvarez, L. G., Kogan, M. D., Ferreira, J. C., Martínez Gimeno, A., Aguinaga Ontoso, I., González Díaz, C., Arnedo Pena, A., Domínguez Aurrecoechea, B., Busquets Monge, R. M., Blanco Quiros, A., Batlles Garrido, J., García de Andoain, N., Varela, A. L., García Merino, A., Gimeno Clemente, N., & Llopis González, A. (2010). Diet and prevalence of atopic eczema in 6 to 7-year-old schoolchildren in Spain: ISAAC phase III. J Investig Allergol Clin Immunol, 20(6), 469-475. Wang, I., Guo, Y., Weng, H., Hsieh, W., Chuang, Y., Lin, S.-J., & Chen, P. (2007). Environmental risk factors for early infantile atopic dermatitis. Pediatric Allergy and Immunology, 18(5), 441-447. Wang, I., Hsieh, W., Guo, Y., Jee, S., Hsieh, C., Hwang, Y., & Chen, P. (2008). Neuro‐mediators as predictors of paediatric atopic dermatitis. Clinical & Experimental Allergy, 38(8), 1302-1308. Wang, I., Wen, H., Chiang, T., Lin, S., Chen, P., & Guo, Y. (2013). Maternal employment and atopic dermatitis in children: a prospective cohort study. British Journal of Dermatology, 168(4), 794-801. Wang, I., Wen, H., Chiang, T., Lin, S., & Guo, Y. (2016). Maternal psychologic problems increased the risk of childhood atopic dermatitis. Pediatric Allergy and Immunology, 27(2), 169-176. Wen, H.-J., Wang, S.-L., Chuang, Y.-C., Chen, P.-C., & Guo, Y. L. (2019). Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children. Chemosphere, 231, 25-31. Wen, H. J., Chen, P. C., Chiang, T. L., Lin, S. J., Chuang, Y. L., & Guo, Y. L. (2009). Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. British Journal of Dermatology, 161(5), 1166-1172. Wen, H. J., Wang, Y. J., Lin, Y. C., Chang, C. C., Shieh, C. C., Lung, F. W., & Guo, Y. L. (2011). Prediction of atopic dermatitis in 2‐yr‐old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy. Pediatric Allergy and Immunology, 22(7), 695-703. Wollenberg, A., Barbarot, S., Bieber, T., Christen‐Zaech, S., Deleuran, M., Fink‐Wagner, A., Gieler, U., Girolomoni, G., Lau, S., & Muraro, A. (2018). Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II. Journal of the European Academy of Dermatology and Venereology, 32(6), 850-878. 曾旭民, 盧瑞芬, & 蔡益堅. (2003). 國人生活品質評量(Ⅱ)：SF-36台灣版的常模與效度檢測 [Assessment of Health-related Quality of Life in Taiwan (Ⅱ): Norming and Validation of SF-36 Taiwan Version]. 台灣公共衛生雜誌, 22(6), 512-518. https://doi.org/10.6288/tjph2003-22-06-10 盧瑞芬, 曾旭民, & 蔡益堅. (2003). 國人生活品質評量(Ⅰ)：SF-36台灣版的發展及心理計量特質分析 [Assessment of Health-related Quality of Life in Taiwan (I): Development and Psychometric Testing of SF-36 Taiwan Version]. 台灣公共衛生雜誌, 22(6), 501-511. https://doi.org/10.6288/tjph2003-22-06-09 | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99933 | - |
| dc.description.abstract | 背景與目的：
異位性皮膚炎（Atopic Dermatitis, AD）在幼兒族群中相當常見，主要照顧責任多由母親承擔，可能對其身心健康造成影響。本研究旨在探討照顧AD兒童對母親健康相關生活品質（Health-related Quality of Life, HRQoL）之影響，涵蓋身體與心理層面。 方法： 本研究資料來自台灣出生世代研究（Taiwan Birth Cohort Study, TBCS），為一具全國代表性之母嬰世代資料庫。研究樣本來自2005年全台89個鄉鎮，採多階段分層系統抽樣獲得。以SF-36量表評估母親之生活品質，並將得分落於第25百分位以下者定義為低生活品質。使用邏輯斯迴歸模型分析AD兒童對母親低生活品質的影響，並調整母親年齡、教育程度、慢性病史及家庭月收入等潛在混雜因子。 結果： 與無AD兒童之母親相比，照顧AD兒童之母親有顯著較高風險呈現低生活品質，無論在身體層面（調整後勝算比[aOR]=1.42，95%信賴區間[CI]：1.25–1.61）或心理層面（aOR=1.25，95% CI：1.10–1.43）皆為顯著。 結論： 本研究利用全國性出生世代資料發現，AD兒童對母親之健康相關生活品質具有負面影響，顯示此族群照顧者之身心健康需求值得重視，應納入公共衛生與照護政策考量。 | zh_TW |
| dc.description.abstract | Purpose：
Atopic Dermatitis (AD) is prevalent in young children. The primary caregivers, predominantly the mothers, have the burden of taking care of the AD children. This study aimed to evaluate the physical and mental quality of life (QoL) impact on mothers of children with AD. Method： We surveyed a represented mother-infant cohort in Taiwan, the Taiwan Birth Cohort Study (TBCS) cohort, which involved newborns and their mothers selected through a multistage stratified systematic sampling method across 89 towns in Taiwan in 2005. The SF-36 questionnaire was employed to assess mothers’ QoL, focusing on both physical and mental aspects. For this study, we defined low QoL as a score of the SF-36 that fell into the lowest quartile. Logistic regression was used to determine the adjusted odds ratio (aOR) of having low QoL, considering potential confounders. Result： Mothers with AD children had a higher risk of having lower QoL than those with non-AD children on both physical (aOR: 1.42, 95 % confidence interval (CI): 1.25-1.61) and mental (aOR: 1.25, CI: 1.10-1.43) aspects, adjusting for mothers’ age, education level, chronic disease, and family monthly income. Conclusion： In a nationally representative child cohort study, we found poorer QoL among mothers of AD children in both physical and mental components. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-09-19T16:20:27Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-09-19T16:20:27Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 致謝 i
中文摘要 ii 英文摘要 iv 目次 v 圖次 vii 表次 viii Chapter 1. Introduction 1 1.1 Introduction to Atopic Dermatitis (AD) 1 1.2 Impact of AD on Children and Caregivers 1 1.3 Clinical Manifestations and Vicious Cycle 1 1.4 Family Burden and Emotional Impact 2 1.5 Measuring the Impact of AD on Quality of Life 2 1.5.1 Dermatology-specific vs. generic questionnaires 3 1.6 Limitations of Existing Studies and Study Purpose 3 1.7 Objective of the study 4 Chapter 2. Literature Review 5 2.1 Atopic Dermatitis (AD) 5 2.2 Risk Factors of Atopic Dermatitis 5 2.2.1 Hereditary and Genetic Factors 5 2.2.2 Parental and maternal factors 6 2.2.3 Indoor environmental factors 7 2.2.4 Outdoor environmental factors and air pollution 8 2.2.5 Child-specific factors 9 2.3 Quality of Life (QoL) 10 2.4 The impact of AD on QoL 10 2.5 The concept development—the Greater Patient 11 2.6 QoL instrument of AD 12 2.7 Parent’s impact of AD 12 2.8 Impact on the mother 13 2.9 Mother’s role in the family 13 Chapter 3. Methods 14 3.1 Study Design and Data Source 14 3.2 Exclusion Criteria 14 3.3 Exposure Variable 15 3.3.1 Diagnosis of Atopic Dermatitis 15 3.4 Primary Outcome 16 3.4.1 Calculation of SF-36 17 3.5 Binary Classification of PCS and MCS 18 3.6 Covariates and Regression Models 18 3.7 Category of multivariate logistic regression model 19 3.8 Statistical Analysis 19 Chapter 4. Results 21 4.1 Demographic Characteristics 21 4.1.1 Distribution of maternal quality of life groups 22 4.2 Multivariate Regression Model—baseline results 23 4.2.1 Overall quality of life 23 4.2.2 Physical and mental aspects of quality of life 23 4.3 Multivariate Regression Model—18-month results 23 4.3.1 Overall quality of life 24 4.3.2 Physical and mental aspects of quality of life 24 4.4 Multivariate Regression Model—36-month results 24 4.4.1 Overall quality of life 24 4.4.2 Physical and mental aspects of quality of life 25 Chapter 5. Discussion and Conclusion 26 5.1 Main findings 26 5.1.1 Consistent findings in the literature 27 5.1.2 Points of divergence from other studies 29 5.1.3 Underlying mechanisms 30 5.2 Limitations 33 5.3 Conclusion 33 5.4 Perspectives 34 參考文獻 48 附錄 52 | - |
| dc.language.iso | en | - |
| dc.subject | 異位性皮膚炎 | zh_TW |
| dc.subject | 出生世代研究 | zh_TW |
| dc.subject | 健康相關生活品質 | zh_TW |
| dc.subject | SF-36 | zh_TW |
| dc.subject | 母親健康 | zh_TW |
| dc.subject | Birth cohort | en |
| dc.subject | Health-related quality of life | en |
| dc.subject | Atopic dermatitis | en |
| dc.subject | SF-36 | en |
| dc.title | 異位性皮膚炎兒童母親生活品質之探討: 以族群為基礎之世代追蹤研究 | zh_TW |
| dc.title | Investigating the Quality of Life of Mothers of Children with Atopic Dermatitis: A Population-based Cohort Study | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 江東亮;朱家瑜 | zh_TW |
| dc.contributor.oralexamcommittee | Tung-Liang Chiang;Chia-Yu Chu | en |
| dc.subject.keyword | 異位性皮膚炎,出生世代研究,健康相關生活品質,SF-36,母親健康, | zh_TW |
| dc.subject.keyword | Atopic dermatitis,Birth cohort,Health-related quality of life,SF-36, | en |
| dc.relation.page | 61 | - |
| dc.identifier.doi | 10.6342/NTU202503455 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2025-08-07 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | - |
| dc.date.embargo-lift | N/A | - |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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