請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99913完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中 | zh_TW |
| dc.contributor.advisor | Pau-Chung Chen | en |
| dc.contributor.author | 蘇一宇 | zh_TW |
| dc.contributor.author | Yi-Yu Su | en |
| dc.date.accessioned | 2025-09-19T16:16:49Z | - |
| dc.date.available | 2025-09-20 | - |
| dc.date.copyright | 2025-09-19 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-07-16 | - |
| dc.identifier.citation | Chapter 1
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Baldassarre, M.E., et al., Premature Birth is an Independent Risk Factor for Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years. Nutrients, 2020. 12(12). 29. Lim, J., S.J. Yoon, and S.M. Lee, Growth patterns of preterm infants in Korea. Clin Exp Pediatr, 2022. 65(1): p. 1-9. 30. Okada, T., et al., Early postnatal alteration of body composition in preterm and small-for-gestational-age infants: implications of catch-up fat. Pediatr Res, 2015. 77(1-2): p. 136-42. 31. Casirati, A., et al., Preterm birth and metabolic implications on later life: A narrative review focused on body composition. Frontiers in Nutrition, 2022. 9. 32. Li, P., et al., Early-life weight gain patterns of term small-for-gestational-age infants and the predictive ability for later childhood overweight/obesity: A prospective cohort study. Front Endocrinol (Lausanne), 2022. 13: p. 1030216. 33. Zheng, M., et al., Rapid weight gain during infancy and subsequent adiposity: a systematic review and meta-analysis of evidence. Obes Rev, 2018. 19(3): p. 321-332. 34. Mericq, V., et al., Long-term metabolic risk among children born premature or small for gestational age. Nat Rev Endocrinol, 2017. 13(1): p. 50-62. 35. Yan, S., et al., Association of gestational hypertension and preeclampsia with offspring adiposity: A systematic review and meta-analysis. Front Endocrinol (Lausanne), 2022. 13: p. 906781. 36. Kuciene, R. and V. Dulskiene, Associations of maternal gestational hypertension with high blood pressure and overweight/obesity in their adolescent offspring: a retrospective cohort study. Scientific Reports, 2022. 12(1). 37. Tong, V.T., et al., Risks of Preterm Delivery and Small for Gestational Age Infants: Effects of Nondaily and Low-Intensity Daily Smoking During Pregnancy. Paediatr Perinat Epidemiol, 2017. 31(2): p. 144-148. 38. Sbrana, M., et al., Alcohol consumption during pregnancy and perinatal results: a cohort study. Sao Paulo Med J, 2016. 134(2): p. 146-52. 39. Liu, X., et al., Factors affecting the catch-up growth of preterm infants after discharge in China: a multicenter study based on the health belief model. Ital J Pediatr, 2019. 45(1): p. 87. 40. Chien, L.Y., et al., National prevalence of breastfeeding in Taiwan. J Hum Lact, 2005. 21(3): p. 338-44. 41. Neves, P.A.R., et al., Rates and time trends in the consumption of breastmilk, formula, and animal milk by children younger than 2 years from 2000 to 2019: analysis of 113 countries. Lancet Child & Adolescent Health, 2021. 5(9): p. 619-630. 42. Li, W.Q., et al., The association between breastfeeding and childhood obesity/underweight: a population-based birth cohort study with repeated measured data. International Breastfeeding Journal, 2022. 17(1). Chapter 3 1. Thomsen SF. Epidemiology and natural history of atopic diseases. Eur Clin Respir J. 2015;2:24642. 2. Pierau M, Arra A, Brunner-Weinzierl MC. Preventing atopic diseases during childhood—early exposure matters. Front Immunol. 2021;12:617731. 3. Alkotob SS, Cannedy C, Harter K, Movassagh H, Paudel B, Prunicki M, et al. Advances and novel developments in environmental influences on the development of atopic diseases. Allergy. 2020;75(12):3077–86. 4. Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol. 2010;105(2):99–106; quiz 107–9, 117. 5. Tsuge M, Ikeda M, Matsumoto N, Yorifuji T, Tsukahara H. Current insights into atopic march. Children (Basel). 2021;8(11):1004. 6. Nobile S, Di Sipio Morgia C, Vento G. Perinatal origins of adult disease and opportunities for health promotion: a narrative review. J Pers Med. 2022;12(2):193. 7. Pagano F, Conti MG, Boscarino G, Pannucci C, Dito L, Regoli D, et al. Atopic manifestations in children born preterm: a long-term observational study. Children (Basel). 2021;8(10):894. 8. Kim K, Lee JY, Kim YM, Kim G, Kim EH, Lee BK, et al. Prevalence of asthma in preterm and associated risk factors based on prescription data from the Korean National Health Insurance database. Sci Rep. 2023;13(1):4484. 9. Goedicke-Fritz S, Hartel C, Krasteva-Christ G, Kopp MV, Meyer S, Zemlin M. Preterm birth affects the risk of developing immune-mediated diseases. Front Immunol. 2017;8:1266. 10. Liu X, Olsen J, Agerbo E, Yuan W, Cnattingius S, Gissler M, et al. Birth weight, gestational age, fetal growth, and childhood asthma hospitalization. Allergy Asthma Clin Immunol. 2014;10(1):13. 11. Wang JJ, Zhang ZY, Chen OU. What is the impact of birth weight corrected for gestational age on later onset asthma: a meta-analysis. Allergy Asthma Clin Immunol. 2022;18(1):15. 12. Hsieh CY, Su CC, Shao SC, Sung SF, Lin SJ, Kao Yang YH, et al. Taiwan's National Health Insurance Research Database: past and future. Clin Epidemiol. 2019;11:349–58. 13. Li ZY, Chen LH, Qiu MJ, Liang FW, Lu ZX. 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Preterm birth is associated with higher prevalence of wheeze and asthma in a selected population of Japanese children aged three years. Allergol Immunopathol (Madr). 2019;47(5):425–30. 19. Kowalik A, Cichocka-Jarosz E, Kwinta P. Atopic dermatitis and gestational age—Is there an association between them? A review of the literature and an analysis of pathology. Postepy Dermatol Alergol. 2023;40(3):341–9. 20. Caffarelli C, Gracci S, Gianni G, Bernardini R. Are babies born preterm high-risk asthma candidates? J Clin Med. 2023;12(16):5250. 21. Crump C, Sundquist K, Sundquist J, Winkleby MA. Gestational age at birth and risk of allergic rhinitis in young adulthood. J Allergy Clin Immunol. 2011;127(5):1173–9. 22. Mitselou N, Hallberg J, Stephansson O, Almqvist C, Melén E, Ludvigsson JF. Adverse pregnancy outcomes and risk of later allergic rhinitis—Nationwide Swedish cohort study. Pediatr Allergy Immunol. 2020;31(5):471–9. 23. Egan M, Bunyavanich S. Allergic rhinitis: the "Ghost Diagnosis" in patients with asthma. Asthma Res Pract. 2015;1:8. 24. Giavina-Bianchi P, Aun MV, Takejima P, Kalil J, Agondi RC. United airway disease: current perspectives. J Asthma Allergy. 2016;9:93–100. 25. El-Heis S, Crozier SR, Healy E, Robinson SM, Harvey NC, Cooper C, et al. Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study. Clin Epidemiol. 2018;10:1851–64. 26. Miyake Y, Tanaka K. Lack of relationship between birth conditions and allergic disorders in Japanese children aged 3 years. J Asthma. 2013;50(6):555–9. 27. Morken NH, Källén K, Jacobsson B. Fetal growth and onset of delivery: a nationwide population-based study of preterm infants. Am J Obstet Gynecol. 2006;195(1):154–61. 28. Srinivas SK, Edlow AG, Neff PM, Sammel MD, Andrela CM, Elovitz MA. Rethinking IUGR in preeclampsia: dependent or independent of maternal hypertension? J Perinatol. 2009;29(10):680–4. 29. Villar J, Carroli G, Wojdyla D, Abalos E, Giordano D, Ba'aqeel H, et al. Preeclampsia, gestational hypertension and intrauterine growth restriction, related or independent conditions? Am J Obstet Gynecol. 2006;194(4):921–31. 30. Henderson I, Quenby S. Gestational hypertension and childhood atopy: a Millennium Cohort Study analysis. Eur J Pediatr. 2021;180(8):2419–27. 31. Stokholm J, Sevelsted A, Anderson UD, Bisgaard H. Preeclampsia associates with asthma, allergy, and eczema in childhood. Am J Respir Crit Care Med. 2017;195(5):614–21. 32. Saito M, Yamamoto-Hanada K, Pak K, Ayabe T, Mezawa H, Ishitsuka K, et al. Having small-for-gestational-age infants was associated with maternal allergic features in the JECS birth cohort. Allergy. 2018;73(9):1908–11. Chapter 4 Fertility GBD, Forecasting C. Global fertility in 204 countries and territories, 1950-2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. 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Wu H, Zhao M, Liang Y, Liu F, Xi B. Maternal age at birth and neonatal mortality: Associations from 67 low-income and middle-income countries. Paediatr Perinat Epidemiol. 2021;35(3):318-27. 16. Farrant BM, Stanley FJ, Hardelid P, Shepherd CC. Stillbirth and neonatal death rates across time: the influence of pregnancy terminations and birth defects in a Western Australian population-based cohort study. BMC Pregnancy Childbirth. 2016;16:112. 17. Tamir TT. Neonatal mortality rate and determinants among births of mothers at extreme ages of reproductive life in low and middle income countries. Scientific Reports. 2024;14(1):12596. 18. Bhusal MK, Khanal SP. A Systematic Review of Factors Associated with Under-Five Child Mortality. Biomed Res Int. 2022;2022:1181409. 19. Barclay K, Myrskylä M. Advanced Maternal Age and Offspring Outcomes: Reproductive Aging and Counterbalancing Period Trends. Popul Dev Rev. 2016;42(1):69-94. 20. Myrskylä M, Fenelon A. Maternal age and offspring adult health: evidence from the health and retirement study. Demography. 2012;49(4):1231-57. 21. Chang HY, Hwu WL, Chen CH, Hou CY, Cheng W. Children Conceived by Assisted Reproductive Technology Prone to Low Birth Weight, Preterm Birth, and Birth Defects: A Cohort Review of More Than 50,000 Live Births During 2011-2017 in Taiwan. Front Pediatr. 2020;8:87. 22. Matsumoto N, Mitsui T, Kadowaki T, Mitsuhashi T, Hirota T, Masuyama H, et al. In vitro fertilization and long-term child health and development: nationwide birth cohort study in Japan. Eur J Pediatr. 2024;184(1):24. 23. Esposito G, Mauri PA, Cipriani S, Franchi M, Corrao G, Parazzini F. The role of maternal age on the risk of preterm birth among singletons and multiples: a retrospective cohort study in Lombardy, Northern Italy. BMC Pregnancy and Childbirth. 2022;22(1):234. 24. Ferré C, Callaghan W, Olson C, Sharma A, Barfield W. Effects of Maternal Age and Age-Specific Preterm Birth Rates on Overall Preterm Birth Rates - United States, 2007 and 2014. Mmwr-Morbid Mortal W. 2016;65(43):1181-4. 25. Martin JA, Osterman MJK. Shifts in the Distribution of Births by Gestational Age: United States, 2014-2022. Natl Vital Stat Rep. 2024;73(1):1-11. 26. Aradhya S, Tegunimataka A, Kravdal O, Martikainen P, Myrskyla M, Barclay K, et al. Maternal age and the risk of low birthweight and pre-term delivery: a pan-Nordic comparison. Int J Epidemiol. 2023;52(1):156-64. 27. Oh Y, Bae J. Impact of Changes in Maternal Age and Parity Distribution on the Increasing Trends in the Low Birth Weight and Very Low Birth Weight Rates in South Korea, 2005-2015. J Prev Med Public Health. 2019;52(2):123-30. 28. Fall CHD, Sachdev HS, Osmond C, Restrepo-Mendez MC, Victora C, Martorell R, et al. Association between maternal age at childbirth and child and adult outcomes in the offspring: a prospective study in five low-income and middle-income countries (COHORTS collaboration). The Lancet Global Health. 2015;3(7):e366-e77. 29. Kozuki N, Lee ACC, Silveira MF, Sania A, Vogel JP, Adair L, et al. The associations of parity and maternal age with small-for-gestational-age, preterm, and neonatal and infant mortality: a meta-analysis. BMC Public Health. 2013;13(3):S2. 30. McLennan AS, Gyamfi-Bannerman C, Ananth CV, Wright JD, Siddiq Z, D'Alton ME, et al. The role of maternal age in twin pregnancy outcomes. Am J Obstet Gynecol. 2017;217(1):80.e1-.e8. 31. Goetzinger KR, Shanks AL, Odibo AO, Macones GA, Cahill AG. Advanced Maternal Age and the Risk of Major Congenital Anomalies. Am J Perinatol. 2017;34(3):217-22. 32. You SJ, Kang D, Sung JH, Park H, Cho J, Choi SJ, et al. The influence of advanced maternal age on congenital malformations, short- and long-term outcomes in offspring of nulligravida: a Korean National Cohort Study over 15 years. Obstet Gynecol Sci. 2024. 33. Hvolgaard Mikkelsen S, Olsen J, Bech BH, Obel C. Parental age and attention-deficit/hyperactivity disorder (ADHD). International Journal of Epidemiology. 2017;46(2):409-20. 34. Lyall K, Song L, Botteron K, Croen LA, Dager SR, Fallin MD, et al. The Association Between Parental Age and Autism-Related Outcomes in Children at High Familial Risk for Autism. Autism Res. 2020;13(6):998-1010. 35. Ni G, Amare AT, Zhou X, Mills N, Gratten J, Lee SH. The genetic relationship between female reproductive traits and six psychiatric disorders. Scientific Reports. 2019;9(1):12041. 36. Cui H, Mu Z. Prenatal Maternal Risk Factors Contributing to Atopic Dermatitis: A Systematic Review and Meta-Analysis of Cohort Studies. Ann Dermatol. 2023;35(1):11-22. Chapter 5 1. Tollanes MC, Wilcox AJ, Stoltenberg C, et al. Neurodevelopmental disorders or early death in siblings of children with cerebral palsy. Pediatrics. 2016;138(2):e20160269. doi:10.1542/peds.2016-0269 2. Reimelt C, Wolff N, Holling H, et al. Siblings and birth order—are they important for the occurrence of ADHD? J Atten Disord. 2021;25(1):81-90. doi:10.1177/1087054718770020 3. Alvares GA, Licari MK, Stevenson PG, et al. Investigating associations between birth order and autism diagnostic phenotypes. J Child Psychol Psychiatry. 2021;62(8):961-970. doi:10.1111/jcpp.13349 4. Bhattacharjee NV, Schumacher AE, Aali A, et al. Global fertility in 204 countries and territories, 1950–2021, with forecasts to 2100: a comprehensive demographic analysis for the Global Burden of Disease Study 2021. Lancet. 2024;403(10440):2057-2099. doi:10.1016/S0140-6736(24)00550-6 5. Faraone SV, Larsson H. Genetics of attention deficit hyperactivity disorder. 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Aoyama S, Haruna M, Yonezawa K, Tahara-Sasagawa E, Usui Y, Ohori R, et al. Factors associated with inadequate gestational weight gain: a prospective multicenter cohort study. Nurs Health Sci. 2025;27(1):e70047. 34. Richardson BS, Ruttinger S, Brown HK, Regnault TRH, de Vrijer B. Maternal body mass index impacts fetal-placental size at birth and umbilical cord oxygen values with implications for regulatory mechanisms. Early Hum Dev. 2017;112:42–47. 35. Xu H, Hutcheon JA, Liu X, Stephansson O, Cnattingius S, Arkema EV, et al. Risk of gestational diabetes mellitus in relation to early pregnancy and gestational weight gain before diagnosis: a population-based cohort study. Acta Obstet Gynecol Scand. 2022;101(11):1253–1261. 36. Lourenço J, Guedes-Martins L. Pathophysiology of maternal obesity and hypertension in pregnancy. J Cardiovasc Dev Dis. 2025;12(3):91. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99913 | - |
| dc.description.abstract | 背景
懷孕與出生後初期是決定兒童長期健康結果的關鍵時期。母體與胎兒的風險因子，例如高齡產婦、早產、小於胎齡兒、妊娠期體重增加及出生序等，皆可能深刻影響兒童的發育、疾病風險與死亡率。雖然相關議題在部分高收入國家已有廣泛探討，但在東亞族群中，這些因子累積性的影響與具體機制仍有待釐清。 方法 本論文整合五項以台灣全國性人口資料庫為基礎的世代研究，研究主題涵蓋：(1) 早產與小於胎齡兒的成長軌跡與幼年肥胖風險；(2) 早產與小於胎齡兒對異位性疾病（氣喘、異位性皮膚炎、過敏性鼻炎）風險的影響；(3) 母親年齡對出生預後、兒童死亡率、神經發展遲緩與過敏疾病的影響；(4) 兄弟姊妹的存在與出生序對注意力不足過動症與自閉症風險的影響；以及 (5) 妊娠期體重增加對新生兒不良預後的關聯性，並探討母親身體質量指數是否調節此關聯。我們運用多元邏輯斯迴歸與Cox比例風險模型，調整社經地位、都市化程度與妊娠相關因子進行分析。 結果 早產與小於胎齡兒在學齡前呈現出異於常態的生長曲線，並具有較高的肥胖風險。早產與氣喘及過敏性鼻炎風險上升相關，卻與異位性皮膚炎風險下降有關；小於胎齡兒則在足月兒中與異位性疾病風險無明顯關聯。母親年齡過低或過高皆與不良出生結果、兒童死亡率與神經發展異常風險上升有關。兄弟姊妹的存在與較低的注意力不足過動症與自閉症風險相關，但獨生子女與長子女的神經發展風險較高。過低或過高的妊娠期體重增加會增加新生兒不良預後風險，尤其在身體質量指數偏高或偏低的母親中影響更顯著。 結論 本論文結果強調孕期與新生兒期風險因子對兒童健康的長期影響，凸顯早期辨識與個別化照護的重要性。本研究有助於發展具地區適應性的公共衛生政策、妊娠與育兒指引，並可用以促進兒童健康平等與預防長期疾病負擔。 | zh_TW |
| dc.description.abstract | Background
The prenatal and early postnatal periods represent critical windows during which maternal and fetal risk factors can shape lifelong health trajectories. Factors such as advanced maternal age, preterm birth, small-for-gestational-age (SGA) status, gestational weight gain (GWG), and birth order are increasingly recognized for their influence on child development, morbidity, and mortality. Despite growing global attention to these risks, their cumulative effects and population-specific implications remain underexplored in East Asian contexts. Methods This dissertation integrates findings from five nationwide, population-based cohort studies. We examined: (1) the longitudinal growth trajectories and early childhood obesity risk among preterm and SGA infants; (2) associations between prematurity/SGA and pediatric atopic diseases; (3) the effects of maternal age on birth outcomes, child mortality, neurodevelopmental delay, and allergic diseases; (4) the influence of sibling presence and birth order on the risk of neurodevelopmental disorders; and (5) the relationship between maternal gestational weight gain and neonatal outcomes stratified by maternal body mass index (BMI). Statistical analyses included multivariate logistic regression and Cox proportional hazards modeling, with adjustment for socioeconomic, urbanization, and obstetric confounders. Results Preterm and SGA infants showed distinct growth patterns and elevated obesity risk by early childhood. Prematurity was associated with higher risks of asthma and allergic rhinitis but a lower risk of atopic dermatitis. Both younger and advanced maternal age were linked to adverse birth outcomes and increased risks of mortality, developmental delay, and allergic diseases in children. Sibling presence was protective against attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD), while only children and firstborns exhibited elevated neurodevelopmental risks. Inadequate or excessive gestational weight gain was associated with increased risks of adverse neonatal outcomes, particularly among mothers at the extremes of the BMI spectrum. Conclusion These findings underscore the long-term health implications of maternal, fetal, and familial factors during pregnancy and early infancy. The evidence highlights the importance of precision-based prenatal care, informed reproductive counseling, and targeted pediatric surveillance. Results may inform clinical guidelines and public health strategies aimed at reducing disparities in child health rooted in early life exposures. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-09-19T16:16:49Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-09-19T16:16:49Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 1
誌謝 2 中文摘要 3 ABSTRACT 5 CONTENTS 7 LIST OF FIGURES 8 LIST OF TABLES 9 Chapter 1 Introduction 10 References 12 Chapter 2 Long-term Effects on Growth in Preterm and SGA Infants 14 References 32 Chapter 3 Atopic Diseases Related to Prematurity and Fetal Growth 39 References 55 Chapter 4 Maternal Age and Pediatric Outcomes 60 References 80 Chapter 5 Birth Order and Neurodevelopmental Disorders 85 References 102 Chapter 6 Gestational Weight Gain and Perinatal Outcomes 107 References 123 Chapter 7 Conclusion 128 | - |
| dc.language.iso | en | - |
| dc.subject | 胎兒生長遲滯 | zh_TW |
| dc.subject | 神經發展障礙 | zh_TW |
| dc.subject | 異位性疾病 | zh_TW |
| dc.subject | 妊娠期體重增加 | zh_TW |
| dc.subject | 兒童世代研究 | zh_TW |
| dc.subject | 出生胎序 | zh_TW |
| dc.subject | 高齡產婦 | zh_TW |
| dc.subject | 早產 | zh_TW |
| dc.subject | pediatric cohort study | en |
| dc.subject | birth order | en |
| dc.subject | atopic diseases | en |
| dc.subject | neurodevelopmental disorders | en |
| dc.subject | gestational weight gain | en |
| dc.subject | small for gestational age | en |
| dc.subject | prematurity | en |
| dc.subject | maternal age | en |
| dc.title | 從孕期到童年：母胎風險因子對兒童健康的長期影響探討 | zh_TW |
| dc.title | From Womb to Childhood: Evaluating the Longitudinal Effects of Maternal and Fetal Risk Factors on Pediatric Health | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 博士 | - |
| dc.contributor.oralexamcommittee | 邱弘毅;郭育良;謝武勳;陳中明;曹伯年 | zh_TW |
| dc.contributor.oralexamcommittee | Hung-Yi Chiou;Yue-Leon Guo;Wu-Shiun Hsieh;Chung-Ming Chen;Po-Nien Tsao | en |
| dc.subject.keyword | 高齡產婦,早產,胎兒生長遲滯,妊娠期體重增加,神經發展障礙,異位性疾病,出生胎序,兒童世代研究, | zh_TW |
| dc.subject.keyword | maternal age,prematurity,small for gestational age,gestational weight gain,neurodevelopmental disorders,atopic diseases,birth order,pediatric cohort study, | en |
| dc.relation.page | 133 | - |
| dc.identifier.doi | 10.6342/NTU202501827 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2025-07-17 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | - |
| dc.date.embargo-lift | 2025-09-20 | - |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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