路易斯酸異構化生質物葡萄糖

Abstract

隨著全球對化石能源依賴的加劇及其資源日益枯竭，發展替代性再生能源已成為當前國際間的重要課題。台灣每年生成大量富含木質纖維素的農林剩餘資材，可進一步異構化為果糖，並成為5-HMF等關鍵生質化合物的重要中間產物。為提升異構化效率與整合反應系統，研究中以AlCl₃為主要催化劑，以120°C下進行3小時異構化反應，可獲得較好的26.09%果糖收率。並且葡萄糖於鹼性環境（pH 10-11）下，有利於異構化反應進行。為提升催化劑可重複使用性，進一步合成Mg-Al水滑石催化劑。其中Mg-Al-3經一次回收後仍可保有約87%新鮮催化劑的果糖收率，而二次回收使用時，可保留68%的果糖收率，顯示其具備低毒、可回收與可重複使用等綠色催化潛力。最後，將纖維素酶水解與AlCl₃催化異構化整合於一鍋反應中，在0.5% 酸進行蒸氣爆碎的柳杉木漿中，果糖收率可到達40.30%。此一整合式操作策略除可簡化製程、減少操作步驟外，亦符合綠色化學與資源循環利用理念，展現其於未來生質物高值化與永續製程開發上的應用潛力。

With the increasing global reliance on fossil fuels and the progressive depletion of these resources, the development of alternative renewable energy sources has emerged as a critical international issue. Taiwan annually generates large quantities of lignocellulose-rich agricultural and forestry residues, which can be isomerized into fructose and further converted into key bio-based platform chemicals such as 5-hydroxymethylfurfural (5-HMF). To enhance isomerization efficiency and integrate the reaction system, AlCl₃ was employed as the primary catalyst in this study, achieving a favorable fructose yield of 26.09% after a 3-hour reaction at 120°C. The isomerization of glucose was further promoted under alkaline conditions (pH 10.0-11.0). To improve catalyst reusability, Mg-Al hydrotalcite catalysts were synthesized. Among them, Mg-Al-3 retained approximately 87% of its initial fructose yield after one cycle of reuse, and 68% after a second reuse, demonstrating its potential as a low- oxicity, recyclable, and reusable green catalyst. Finally, the integration of enzymatic hydrolysis and AlCl₃-catalyzed isomerization into a one-pot process using 0.5% acid steam-exploded Japanese cedar pulp yielded a fructose yield of up to 40.30%. This integrated strategy not only simplifies the process and reduces operational steps but also aligns with the principles of green chemistry and circular resource utilization, highlighting its potential for future applications in biomass valorization and sustainable process development.