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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 鄭光成 | zh_TW |
| dc.contributor.advisor | Kuan-Chen Cheng | en |
| dc.contributor.author | 顧子嵐 | zh_TW |
| dc.contributor.author | Tzu-Lan Ku | en |
| dc.date.accessioned | 2024-09-16T16:21:43Z | - |
| dc.date.available | 2024-09-17 | - |
| dc.date.copyright | 2024-09-16 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-07-24 | - |
| dc.identifier.citation | 曾天倪 (2016)。評估聚乙烯醇/右旋醣酐/甲殼素水凝膠在傷口敷料之應用。國立臺灣大學生物資源暨農學院農業化學研究所學位論文，臺北市。
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Research progress on chemical modification of alginate: A review. Carbohydrate Polymers, 84(1), 33-39. Yang, L., Chen, C., Hu, Y., Wei, F., Cui, J., Zhao, Y., ... & Sun, D. (2020). Three-dimensional bacterial cellulose/polydopamine/TiO2 nanocomposite membrane with enhanced adsorption and photocatalytic degradation for dyes under ultraviolet-visible irradiation. Journal of Colloid and Interface Science, 562, 21-28. Yang, X. J., Fane, A. G., & MacNaughton, S. (2001). Removal and recovery of heavy metals from wastewaters by supported liquid membranes. Water Science and Technology, 43(2), 341-348. Yoshino, T., Asakura, T., & Toda, K. (1996). Cellulose production by Acetobacter pasteurianus on silicone membrane. Journal of Fermentation and Bioengineering, 81(1), 32-36. Zohuriaan, M. J., & Shokrolahi, F. J. P. T. (2004). Thermal studies on natural and modified gums. Polymer Testing, 23(5), 575-579. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/95773 | - |
| dc.description.abstract | 隨著工業化的迅速發展和人類生活方式的改變，生產和消費活動導致大量污染物排放，這些污染物主要來自各種行業的工業廢水，包括電池製造、殺蟲劑生產、皮革加工、紡織業、石化產品製造和造紙等行業，其中，重金屬是工業廢水中最主要的污染物，對生態環境和人體健康造成嚴重的負面影響。在本研究中，透過共培養Komagataeibacter xylinus ATCC 700178和基因工程改造的Escherichia coli (E. coli)，將多孔狀細菌性纖維 (foaming bacterial cellulose，FBC)與黑色素 (melanin)結合，開發一款環境友善的納米複合材料，用於去除水溶液中的重金屬。本研究利用各項分析方法，包括掃描式電子顯微鏡分析、傅里葉紅外線光譜分析、X光繞射分析、熱重分析和介面電位分析，以了解FBC/melanin複合材料的物理化學特性。此外，通過批次實驗研究了重金屬在FBC/melanin複合材料上的吸附情況。FBC/melanin複合材料在pH值6時表現出對於Cu(II)的最佳吸附性能，其吸附在前20分鐘內快速上升，隨後緩慢上升並逐漸達到平衡。FBC/melanin複合材料對Cu(II)的最大吸附容量為293.59 mg/g，此結果高於其他改性細菌性纖維及其他類型的吸附劑。能量色散X射線光譜分析、傅里葉紅外線光譜分析和X射線光電子能譜分析證實了Cu(II)與FBC/melanin複合材料表面的結合，並且探討了其對Cu(II)的吸附機制。基於以上結果，FBC/melanin複合材料具有作為去除水溶液中Cu(II)的高效吸附劑的潛力。此外，本研究所提出的創新策略，即透過基因工程E. coli合成melanin並將其與多孔狀細菌性纖維透過共培養結合，這種方法不僅簡化了細菌性纖維基複合材料的製造過程並降低了成本，還成功開發出一款具有重金屬吸附能力的新型吸附劑。 | zh_TW |
| dc.description.abstract | The rapid advancement of industrialization and evolving human lifestyles have led to significant emissions of pollutants, predominantly originating from industrial wastewater across various sectors like battery manufacturing, pesticide production, leather processing, textiles, petrochemicals, and papermaking. Among these, heavy metals emerge as the primary pollutants in industrial wastewater, causing severe adverse effects on both ecological environments and human health. In this study, foaming bacterial cellulose (FBC) was combined with bacterial pigment, melanin nanocrystals by co-culturing Komagataeibacter xylinus ATCC 700178 with genetically engineered Escherichia coli (E. coli) to develop an environmentally friendly nanocomposite, which can effectively serve as an adsorbent for removing heavy metals from aqueous solutions. Various characterization methods, including scanning electron microscope, fourier transform infrared spectroscopy, X-ray diffraction analysis, thermogravimetric analysis and zeta potential analysis were used to analyze the material properties of FBC/melanin composite. Batch experiments were conducted to investigate the adsorption of heavy metals. The FBC/melanin composite exhibited excellent adsorption performance at an optimized pH of 6, with rapid adsorption in the first 20 minutes followed by a gradual increase until equilibrium was reached. The maximum adsorption capacity of the FBC/melanin composite for Cu(II) was found to be 293.59 mg/g, which is higher than that of other modified BC and other types of adsorbents. The binding of heavy metals to the FBC/melanin composite surface was confirmed by energy-dispersive X-ray spectroscopy, fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy, and the mechanism of Cu(II) adsorption by the FBC/melanin composite was investigated. Considering these results, the FBC/melanin composite shows potential as an efficient adsorbent for the removal of Cu(II) ions from aqueous solutions. Additionally, this study provides an innovative strategy by using genetic engineered E. coli to synthesize melanin and integrating it with foaming bacterial cellulose through co-culture. This approach not only simplifies the fabrication process and reduces costs of producing BC-based composites but also produces a new bioadsorbent with heavy metal adsorption capacity. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-09-16T16:21:43Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-09-16T16:21:43Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書 i
謝辭 ii 中文摘要 iii 英文摘要 iv 目次 v 圖次 xi 表次 xiv List of Figures xvi List of Tables xix 壹、 前言 1 貳、 文獻回顧 3 2.1 重金屬簡介 3 2.1.1 重金屬汙染問題 3 2.1.2 相關法規 7 2.1.3 水中重金屬汙染處理技術 8 2.1.3.1 化學沉澱 8 2.1.3.2 化學混凝和絮凝 9 2.1.3.3 電化學方法 10 2.1.3.4 膜過濾 10 2.1.3.5 離子交換 11 2.1.3.6 光催化 11 2.1.3.7 吸附 12 2.2 生物材料 14 2.2.1 動物及植物來源之生物材料 14 2.2.2 微生物來源之生物材料 15 2.3 細菌性纖維 (Bacterial cellulose) 24 2.3.1 細菌性纖維結構及特性 24 2.3.2 細菌性纖維來源及其生合成 25 2.3.3 細菌性纖維之應用 29 2.3.3.1 生物醫學應用 29 2.3.3.2 食品應用 30 2.3.3.3 環境應用 30 2.4 細菌性纖維修飾方法 31 2.4.1 原位修飾 (In-situ modifications) 31 2.4.2 異位修飾 (Ex-situ modifications) 33 2.4.3 微生物共培養 (Co-culture fermentation) 34 2.5 黑色素 (Melanin) 37 2.5.1 黑色素之簡介 37 2.5.2 黑色素生合成路徑 39 2.5.3 黑色素之生理活性與應用 40 2.5.3.1 光保護 40 2.5.3.2 熱調節 41 2.5.3.3 抗輻射 41 2.5.3.4 抗氧化 42 2.5.3.5 抗菌 42 2.5.3.6 金屬離子螯合 43 2.6 基因工程 45 2.6.1 重組DNA技術之簡介 45 2.6.2 以質體為基礎的重組蛋白生產 46 2.6.3 重組蛋白生產之宿主 48 2.6.4 大腸桿菌生產黑色素之代謝工程 50 參、 研究目的與架構 57 3.1 研究目的 57 3.2 研究架構 57 肆、 材料與方法 59 4.1 實驗材料 59 4.1.1 實驗菌種 59 4.1.2 質體 60 4.1.3 引子 60 4.1.4 實驗藥品 61 4.2 儀器設備 61 4.3 實驗方法 62 4.3.1 質體建構與轉型作用 62 4.3.1.1 B. megaterium培養及其genomic DNA抽取 62 4.3.1.2 目標基因片段PCR擴增及尺寸確認 62 4.3.1.3 目標基因片段接合 63 4.3.1.4 E.coli轉型作用與酪胺酸酶表達 63 4.3.2 K. xylinus凍管製作 63 4.3.3 利用共培養合成BC/melanin複合膜 64 4.3.4 利用共培養合成FBC/melanin複合膜 65 4.3.5 色差儀檢測FBC/melanin複合膜之外觀顏色 66 4.3.6 FBC/melanin複合膜之melanin萃取與定量 66 4.3.7 材料特性分析 66 4.3.7.1 水含量分析 (Water content analysis) 66 4.3.7.2 掃描式電子顯微鏡分析 (Scanning electron microscopy) 66 4.3.7.3 傅立葉紅外線光譜分析 (Fourier transfer infrared spectroscopy) 67 4.3.7.4 X光繞射分析 (X-ray diffraction) 67 4.3.7.5 熱重分析 (Thermogravimetric analysis) 67 4.3.7.6 介面電位分析 (Zeta potential) 67 4.3.8 細胞毒性分析 67 4.3.9 重金屬離子批次吸附實驗 68 4.3.9.1 FBC/melanin複合膜之複合重金屬吸附能力 68 4.3.9.2 FBC/melanin複合膜吸附Cu(II)之最適條件探討 69 4.3.9.2.1 FBC/melanin複合膜在不同pH值下的Cu(II)吸附能力評估 69 4.3.9.2.2 FBC/melanin複合膜在不同接觸時間下的Cu(II)吸附能力評估 69 4.3.9.2.3 FBC/melanin複合膜之最大Cu(II)承載量 70 4.3.10 FBC/melanin複合膜吸附Cu(II)之機制 70 4.3.10.1 能量色散X射線光譜分析 (Energy-dispersive X-ray spectroscopy) 70 4.3.10.2 傅立葉紅外線光譜分析 (Fourier transfer infrared spectroscopy) 70 4.3.10.3 X射線光電子能譜分析 (X-ray photoelectron spectroscopy) 71 4.3.11 統計分析 71 伍、 結果與討論 72 5.1 pBBR1-melC質體之建構與轉型作用 72 5.2 重組大腸桿菌之melanin生產 75 5.3 FBC/melanin複合膜之外觀顏色 76 5.4 FBC/melanin複合膜之melanin萃取與定量 79 5.5 材料特性分析 80 5.5.1 水含量分析 80 5.5.2 傅立葉紅外線光譜分析 82 5.5.3 掃描式電子顯微鏡分析 84 5.5.4 熱重分析 86 5.5.5 X射線繞射分析 88 5.5.6 介面電位分析 90 5.6 細胞毒性分析 93 5.7 重金屬離子批次吸附實驗 95 5.7.1 複合金屬溶液中FBC/melanin複合膜之重金屬吸附 95 5.7.2 FBC/melanin複合模吸附Cu(II)之最適條件探討 97 5.7.2.1 FBC/melanin複合膜在不同pH值下的Cu(II)吸附能力評估 97 5.7.2.2 FBC/melanin複合膜在不同接觸時間下的Cu(II)吸附能力評估 99 5.7.2.3 FBC/melanin複合膜之最大Cu(II)承載量 102 5.8 FBC/melanin複合膜吸附Cu(II)之機制 104 5.8.1 能量色散X-射線光譜分析 104 5.8.2 傅立葉紅外線光譜分析 106 5.8.3 X射線光電子能譜分析 108 陸、 結論 112 柒、 未來展望 113 捌、 參考文獻 114 玖、 附錄 xxi 9.1 學位論文原創性比對檢核 xxi 9.2 個人簡歷 xxii 9.3 pBBR1-MelC之melC基因與B. megaterium之melC基因比對結果 xxiii 9.4 不同K. xylinus和E. coli共培養比例下製備的FBC/melanin複合膜之外觀 xxiv 9.5 FBC的O 1s高分辨率掃描光譜 xxiv 9.6 小論文 xxv | - |
| dc.language.iso | zh_TW | - |
| dc.title | 利用共培養木質醋酸菌和基因工程大腸桿菌製備多孔性細菌性纖維/黑色素複合膜及其重金屬離子吸附功能之研究 | zh_TW |
| dc.title | Foaming bacterial cellulose/biosynthetic melanin production through co-culturing Komagataeibacter xylinus and genetically modified Escherichia coli for heavy metal adsorption application | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.coadvisor | 林欣平 | zh_TW |
| dc.contributor.coadvisor | Shin-Ping Lin | en |
| dc.contributor.oralexamcommittee | 林詠凱;李俊霖;徐國強 | zh_TW |
| dc.contributor.oralexamcommittee | Yung-Kai Lin;Chun-Lin Lee;Kuo-Chiang Hsu | en |
| dc.subject.keyword | 細菌性纖維,多孔狀細菌性纖維,生物合成,黑色素,重金屬吸附,共培養, | zh_TW |
| dc.subject.keyword | Bacterial cellulose,Foaming bacterial cellulose,Biosynthesis,Melanin,Heavy metal adsorption,Co-culture, | en |
| dc.relation.page | 156 | - |
| dc.identifier.doi | 10.6342/NTU202402194 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2024-07-26 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 生物科技研究所 | - |
| 顯示於系所單位： | 生物科技研究所 | |
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