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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94885完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳立涵 | zh_TW |
| dc.contributor.advisor | Li-Han Chen | en |
| dc.contributor.author | 陳益鴻 | zh_TW |
| dc.contributor.author | I-Hung Chen | en |
| dc.date.accessioned | 2024-08-21T16:09:44Z | - |
| dc.date.available | 2024-08-22 | - |
| dc.date.copyright | 2024-08-21 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-08-07 | - |
| dc.identifier.citation | 張致銜.黃建智.賴繼昌.黃星翰.翁進興(2019).台灣沿近海烏魚漁業資源變動現況. 水產試驗所海洋漁業組,沿近海資源研究中心, 科技研究73
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Aquaculture 287(3-4): 349-353. 板野公一, et al. (2006). "Comparison of sensitivity between yellowtail Seriola quinqueradiata and red sea bream Pagrus major to Nocardia seriolae." 魚病研究 41(4): 135-139. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94885 | - |
| dc.description.abstract | 烏魚 (Mugil cephalus) 是台灣重要的養殖魚類。近年烏魚許多嚴重疾病如: 奴卡氏菌症造成嚴重損失。目前在烏魚養殖上仍沒有有效的奴卡氏菌症的防治方式，加上由於益生菌已被證實能幫助魚類增加抗病能力，因此本研究旨以添加多株益生菌的方式，來對抗奴卡氏菌的感染。研究中以不同組合的Lactobacillus rhamnosus、Lactobacillus reuteri和Bacillus subtilis natto三株益生菌以1*109CFU/g添加於飼料，投餵35天後始使用奴卡氏菌進行攻毒。結果顯示，餵食L. reuteri和B. subtilis natto的混菌組別中在增重率、特殊成長率以及飼料轉換率都有所提升；免疫基因表現結果顯示，添加三株益生菌的飼料提升了促發炎因子IL-8和IL-1β，此外抗奴卡相關基因 TNFRSF25、PANX1表現也有顯著上升。攻毒後，也以混合L. rhamnosus，L. reuteri和B. subtilis natto的組別活存率最高，達到86%，顯著高於控制組。在菌相組成方面，Alpha diversity沒有顯著的差異，但在Beta diversity中，有添加益生菌的組別其菌相組成與控制組相比具有明顯的分群，從LefSE分析中，在控制組中，大多與病原菌有關，例如:Cytophagales、Erysipelothrix、Pseudomonas fragi、Streptococcus、Staphylococcus及Nocardioides，在有添加益生菌組別中大多發現有益菌的存在，Lre+Bsn組發現Bacillus；Lrh+Bsn組發現Sphingobacteriales、Dysgonomonadaceae；Lre+Lrh+Bsn組發現Lysinibacillus豐度的提高，綜合上述結果，在經過35天的多株益生菌投餵後，這三株菌益生菌可以藉由改變腸道中的微生物相來降低腸道中病原菌的數量，從而提升烏魚的免疫能力以及生長性能。因此未來可以針對這三株益生菌的使用作為烏魚養殖抗奴卡氏菌症的防治策略之方法，提升經濟效益。 | zh_TW |
| dc.description.abstract | Grey mullet (Mugil cephalus) is an important aquaculture species in Taiwan. In recent years, serious diseases such as infections caused by Nocardia seriolae have resulted in significant losses. Currently, there is no effective method to prevent and control N. seriolae infection in grey mullet aquaculture. Given that probiotics have been proven to enhance disease resistance in fish, this study aims to protect against N. seriolae infection by treating fish with multiple probiotic strains. In the study, different combinations of three probiotic strains Lactobacillus rhamnosus, Lactobacillus reuteri, and Bacillus subtilis natto were added to the feed at a concentration of 1*109 CFU/g. After 35 days of feeding, the growth rate, immunity, and gut microbiota were analyzed followed by a challenge test using N. seriolae. The results showed that the group fed with the combination of L. reuteri and B. subtilis natto exhibited improvements in weight gain rate, specific growth rate, and feed conversion ratio. The results of immune gene expression revealed that feeding with diet containing the three probiotic strains enhanced the expression of pro-inflammatory factors IL-8 and IL-1β. Additionally, the expression of anti-N. seriolae related genes TNFRSF25 and PANX1 also significantly increased. After the challenge, the group supplemented with a combination of the three probiotics also showed the highest survival rate at 86%, which was significantly higher than that of the control group. In microbial composition, there was no significant difference observed in alpha diversity. However, in beta diversity, the group supplemented with probiotics showed distinct clustering compared to the control group, indicating notable differences in microbial composition. From LefSE analysis, most of enriched taxa in the control group were associated with pathogens such as Cytophagales, Erysipelothrix, Pseudomonas fragi, Streptococcus, Staphylococcus, and Nocardioides. In contrast, in groups supplemented with probiotics, beneficial bacteria were predominantly found: the Lre+Bsn group showed Bacillus; the Lrh+Bsn group showed Sphingobacteriales and Dysgonomonadaceae; and the Lre+Lrh+Bsn group showed increased abundance of Lysinibacillus. Combining the above results, after 35 days of feeding with a multi-strain probiotic, these three probiotic strains can reduce the abundance of pathogens in the intestine by altering the gut microbiota. This process enhances the immune response and growth performance of grey mullet. Therefore, in the future, utilizing these three probiotic strains could serve as a strategy to combat N. seriolae infections in grey mullet aquaculture, potentially enhancing economic benefits. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-21T16:09:44Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-21T16:09:44Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 致謝 I
中文摘要 II Abstract III 目次 V 表次 VIII 圖次 IX 第一章 前言 1 1.1 烏魚 1 1.2 奴卡氏菌症 2 1.3 益生菌 3 1.4 水產益生菌 4 1.41 革蘭氏陽性菌 5 1.42 革蘭氏陰性菌 5 1.5 多株益生菌在水產養殖的應用 5 1.6 芽孢桿菌的介紹 6 1.7 乳酸菌的介紹 7 1.8 Bacillus subtilis natto 8 1.9 Lactobacillus rhamnosus 8 1.10 Lactobacillus reuteri 9 1.11 多株益生菌的篩選 10 1.12 微生物相的介紹 10 1.13 魚類腸胃道微生物相 11 第二章 研究目的 13 第三章 材料與方法 14 3.1 烏魚 14 3.2 細菌鑑定 14 3.3 病原菌和益生菌培養 14 3.4 生長曲線 15 3.5 低pH值耐受力 15 3.6 膽鹽耐受力 15 3.7 溶血性測試 15 3.8 澱粉酶測試 16 3.9 蛋白酶測試 16 3.10 脂肪酶測試 16 3.11 纖維酶測試 16 3.12 體外抑菌測試 17 3.13 製備複合益生菌飼料 17 3.14 動物投餵實驗 17 3.15 樣本收集及成長表現計算 18 3.16 腸道細菌DNA萃取和次世代定序分析 18 3.17 攻毒實驗 19 3.18 抽取 RNA 19 3.19 反轉錄cDNA 19 3.20 Real-time PCR 19 3.21 菌株來源 20 3.22 宏基因體學(Metagenomics)定序資料分析 20 3.22.1 上傳序列檔案與品質控制 (Quality control) 20 3.22.2 稀釋曲線圖 (Rarefaction curve)和Alpha diversity 21 3.22.3 Beta diversity 21 3.22.4 微生物相的功能性預測 (Microbiome function prediction) 21 3.22.5 LEfSe (Linear discriminant analysis (LDA) Effect Size) 21 3.23 統計分析 21 第四章 實驗結果 22 4.1 溶血性測試 22 4.2 體外產消化酶測試 22 4.3 pH耐受性 23 4.4 膽鹽耐受性 23 4.5 體外抑菌實驗 24 4.6 投餵試驗後成長表現 24 4.8 添加多株益生菌對烏魚抗奴卡氏菌免疫基因表現量 25 4.9 攻毒實驗結果 25 4.11 比較有投餵多株益生菌組別和沒投餵益生菌組別在門的分類階層差異 26 4.12 α多樣性（Alpha diversity） 27 4.13 β多樣性（Beta diversity） 28 4.14 LEfSe (Linear discriminant analysis (LDA) Effect Size) 28 第五章 討論 30 5.1 益生菌的安全性試驗 30 5.2 益生菌耐酸性以及耐膽鹽試驗 31 5.3 益生菌產生消化酶活性與烏魚的成長表現 33 5.4 益生菌對抗病原菌的能力 34 5.5 發炎因子與抗奴卡免疫基因表現量 35 5.6 餵食多株益生菌後烏魚抗N. seriolae的能力 38 5.7 比較有添加多株益生菌和沒有添加多株益生菌烏魚腸道微生物多樣性 39 5.8 比較添加多株益生菌和沒有添加多株益生菌烏魚腸道微生物的關鍵菌種 40 5.9 有添加多株益生菌和沒有添加益生菌在代謝途徑上的功能性分析 48 5.10 比較多株菌益生菌組別添加的細菌濃度對烏魚的影響 51 第六章 結論 53 參考文獻 54 結果圖/表 74 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 奴卡氏菌 | zh_TW |
| dc.subject | 腸道菌相 | zh_TW |
| dc.subject | 益生菌 | zh_TW |
| dc.subject | 乳酸菌 | zh_TW |
| dc.subject | 芽孢桿菌 | zh_TW |
| dc.subject | 成長表現 | zh_TW |
| dc.subject | 免疫基因 | zh_TW |
| dc.subject | 烏魚 | zh_TW |
| dc.subject | Nocardia seriolae | en |
| dc.subject | Mugil cephalus | en |
| dc.subject | Probiotics | en |
| dc.subject | Lactobacillus | en |
| dc.subject | Bacillus subtilis | en |
| dc.subject | Growth performance | en |
| dc.subject | Immune genes | en |
| dc.subject | Gut microbiota | en |
| dc.title | 使用多株益生菌透過調節烏魚免疫反應及腸道微生物群提升生長性能和抗奴卡氏菌(Nocardia seriolae)能力 | zh_TW |
| dc.title | Multi-strain probiotics improved the growth performance and resistance against Nocardia seriolae via regulating immunity and gut microbiota in grey mullet (Mugil cephalus) | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 賴亮全;韓玉山;吳育騏;蓋玉軒 | zh_TW |
| dc.contributor.oralexamcommittee | Liang-Quan Lai;Yu-San Han;Yu-Chi Wu;Yu-Hsuan Kai | en |
| dc.subject.keyword | 烏魚,奴卡氏菌,益生菌,乳酸菌,芽孢桿菌,成長表現,免疫基因,腸道菌相, | zh_TW |
| dc.subject.keyword | Mugil cephalus,Nocardia seriolae,Probiotics,Lactobacillus,Bacillus subtilis,Growth performance,Immune genes,Gut microbiota, | en |
| dc.relation.page | 101 | - |
| dc.identifier.doi | 10.6342/NTU202403325 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2024-08-11 | - |
| dc.contributor.author-college | 生命科學院 | - |
| dc.contributor.author-dept | 漁業科學研究所 | - |
| dc.date.embargo-lift | 2029-08-07 | - |
| 顯示於系所單位： | 漁業科學研究所 | |
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