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  1. NTU Theses and Dissertations Repository
  2. 進修推廣部
  3. 生物科技管理碩士在職學位學程
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94437
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dc.contributor.advisor劉震鐘zh_TW
dc.contributor.advisorChen-Chung Liuen
dc.contributor.author連解瑗zh_TW
dc.contributor.authorHsieh-Yuan Lienen
dc.date.accessioned2024-08-15T17:29:33Z-
dc.date.available2024-08-16-
dc.date.copyright2024-08-15-
dc.date.issued2024-
dc.date.submitted2024-07-02-
dc.identifier.citation1. Albert, N., & Weibell, M. A. (2019). The Outcome of Early Intervention in First Episode Psychosis. International Review of Psychiatry, 31(5–6), 1136–1158. https://doi.org/https://doi.org/10.1080/09540261.2019.1643703
2. Andrea murrua, & Bernardo carpiniellob. (2016, October 4). Duration of Untreated Illness as a Key to Early Intervention in Schizophrenia : A Review. Science Direct. https://doi.org/10.1016/j.neulet.2016.10.003
3. Bellani, M., & Brambilla, P. (2008). The use and meaning of the continuous performance test in schizophrenia. Epidemiologia e Psichiatria Sociale, 17(3), 188–191. doi:10.1017/S1121189X00001275
4. Blyler, C. R., Gold, J. M., Iannone, V. N., & Buchannan, R. W. (2000). Short Form of the WAIS-III for Use with Patients with Schizophrenia. Schizophrenia Research, 46(2–3), 209–215. https://doi.org/https://doi.org/10.1016/S0920-9964(00)00017-7
5. Bozikas, V. p, Kosmidis, M. h, Kiosseoglou, G., & Karavatos, A. (2006). Neuropsychological Profile of Cognitively Impaired Patients with Schizophrenia. Comprehensive Psychiatry, 47, 136–143. https://doi.org/10.1016/j.comppsych.2005.05.002
6. Brady, jr., R. o., Gonsalvez, I., Lee, I., Öngür, D., Seidman, L. j., Schmahmann, J. d., Eack, S. m., Keshavan, M. s., Pascual-leone, A., & Mark a., M. a. (2019). Cerebellar-Prefrontal Network Connectivity and Negative Symptoms in Schizophrenia. The American Journal of Psychiatry, 176(7), 512–520. https://doi.org/https://doi.org/10.1176/appi.ajp.2018.18040429
7. Brebion, G., Amador, X., Smith, M. J., & Gorman, J. M. (1998). Memory impairment and schizophrenia: the role of processing speed. Schizophrenia Research, 30, 31–39. https://doi.org/https://doi.org/10.1016/S0920-9964(97)00123-0
8. Bryson, G., Bell, M., & Lysaker, P. (1997). Affect Recognition in Schizophrenia: A Function of Global Impairment or a Specific Cognitive Deficit. Psychiatry Research, 71, 105–113. https://doi.org/https://doi.org/10.1016/S0165-1781(97)00050-4
9. Chong, H. Y., Siew, S. L., Wu, D. B., Kotirum, S., Chiou, C.- fang, & Nathorn, N. (2016). Global Economic Burden of Schizophrenia: A Systematic Review. Neuropsychiatric Disease and Treatment, 12, 357–373. https://doi.org/https://doi.org/10.2147/NDT.S96649
10. Correll, C. u, & Schooler, N. r. (2020). Negative Symptoms in Schizophrenia: A Review and Clinical Guide for Recognition, Assessment, and Treatment. Neuropsychiatric Disease and Treatment, 16, 519–534. https://doi.org/https://doi.org/10.2147/NDT.S225643
11. Crespo-facorro, B., Pedro, P., Anna-greta, A., Jessica, J., Resemann, H. k., Worthington, E., O’connor, M., Drane, E., Steeves, S., & Newton, R. (2022). The Burden of Disease in Early Schizophrenia – a Systematic Literature Review. Current Medical Research and Opinion, 37(1), 109–121. https://doi.org/https://www.tandfonline.com/action/showCitFormats?doi=10.1080/03007995.2020.1841618
12. Emsley, R., Rabinowitz, J., & Torreman, M. (2003). The Factor Structure for the Positive and Negative Syndrome Scale (PANSS) in Recent-Onset Psychosis. Schizophrenia Research, 61, 47–57. https://doi.org/https://doi.org/10.1016/S0920-9964(02)00302-X
13. Fountoulakis, K. N., Dragioti, E., Theofilidis, A. T., Wikilund, T., Atmatzidis, X., Nimatoudis, I., Thys, E., Wampers, M., Hranov, L., Hristova, T., & Aptalidis, D. (2019). Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study. International Journal of Neuropsychopharmacology, 22(11), 681–697. https://doi.org/https://doi.org/10.1093/ijnp/pyz053
14. Grace, A. a., & Gomes, F. v. (2019). The Circuitry of Dopamine System Regulation and Its Disruption in Schizophrenia: Insights Into Treatment and Prevention. Schizophrenia Bulletin, 45, 148–157. https://doi.org/10.1093/schbul/sbx199
15. Greve, K. W., Stickle, T. R., Love, J. M., Bianchini, K. J., & Standford, M. S. (2005). Latent Structure of the Wisconsin Card Sorting Test: A Confirmatory Factor Analytic Study. Archives of Clinical Neuropsychology, 20, 355–354. https://doi.org/https://doi.org/10.1016/j.acn.2004.09.004
16. Guo, J., Ragland, J., & Carter, C. (2018). Memory and Cognition in Schizophrenia. Mol Psychiatry, 24(5), 633–642. https://doi.org/10.1038/s41380-018-0231-1
17. I Ishigaki, T., & Tanno, Y. (1999). The Signal Detection Ability of Patients with Auditory Hallucination:Analysis Using the Continuous Performance Test. Psychiatry and Clinical Neurosciences, 531, 471–476. https://doi.org/10.1046/j.1440-1819.1999.00586.x
18. James, E., Lavoie, K., Gagnon, J., & Gosselin, N. (2001). Performance of Patients with Schizophrenia on the Wisconsin Card Sorting Test (WCST). Journal of Psychiatry & Neuroscience, 26(2), 123–130. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1407748/
19. Kane, J. m., Robinson, D. g., Schooler, N. r., Mueser, K. t., Penn, D. l., Rosenheck, R. a., Addington, J., Brunette, M. f., Correll, C. u., Sue e, S. e., Glynn, S. m., Lynde, D. w., Pipes, L., Kurian, B. t., Miller, A. l., Azrin, S. t., Goldstein, A. b., Severe, J. b., Lin, H., … Heinssen, R. k. (2016). Comprehensive Versus Usual Community Care for First-Episode Psychosis: 2-Year Outcomes From the NIMH RAISE Early Treatment Program. The American Journal of Psychiatry, 173(4), 362–372. https://doi.org/10.1176/appi.ajp.2015.15050632
20. Leucht, S., Kane, J. M., Kissling, W., Hamann, J., Etschel, E., & Engel, R. R. (2005). What Does the PANSS Mean? Schizophrenia Research, 79(2–13), 231–238. https://doi.org/https://doi.org/10.1016/j.schres.2005.04.008
21. Levine, S. Z., & Rabinowitz, J. (2009). A Population-Based Examination of the Role of Years of Education, Age of Onset, and Sex on the Course of Schizophrenia. Psychiatry Research, 168, 11–17. https://doi.org/doi.org/10.1016/j.psychres.2008.05.005
22. Li, C. ray. (2004). Do Schizophrenia Patients Make More Perseverative than Non-Perseverative Errors on the Wisconsin Card Sorting Test? A Meta-Analytic Study. Psychiatry Research, 192(2), 179–190. https://doi.org/https://doi.org/10.1016/j.psychres.2004.06.016
23. Li, T., Wang, Q., Zhang, J., Öngür, D., Rolls, E. t., Yang, W., Palaniyappan, L., Zhang, L., Cheng, W., Liu, Z., Luo, Q., Tang, Y., Crow, T. j., Broome, M. r., Xu, K., Li, C., Wang, J., Liu, Z., Lu, G., … Feng, J. (2017). Brain-Wide Analysis of Functional Connectivity in First-Episode and Chronic Stages of Schizophrenia . Schizophrenia Bulletin, 43(2), 436–448. https://doi.org/https://doi.org/10.1093/schbul/sbw099
24. Lin, S., Liu, C., Hwang, T., Hsieh, M. H., Hsiao, P., Faraone, S. V., Tsuang, M. T., Hwu, H., & Chen, W. J. (2011). Performance on the Wisconsin Card Sorting Test in Families of Schizophrenia Patients with Different Familial Loadings. Schizophrenia Bulletin. Schizophrenia Bulletin, 39(3), 537–546. https://doi.org/10.1093/schbul/sbs141
25. Lysaker, P., & Bell, M. (1994). Insight and Cognitive Impairment in Schizophrenia. The Journal of Nervous and Mental Disease, 182(11), 656–660.
26. Mallash, E., & Patrick, R. T. (2019). The Case for Case Management in Schizophrenia. Professional Case Management, 24(5), 273–276. https://doi.org/10.1097/NCM.0000000000000385
27. Mcgorry, P. D. (2015). Early Intervention in Psychosis. The Journal of Nervous and Mental Disease, 203, 310–318. https://doi.org/10.1097/NMD.0000000000000284
28. Mokhtari, M., & Rajarethinam, R. (2013). Early Intervention and the Treatment of Prodrome in Schizophrenia A Review of Recent Developments. Journal of Psychiatric Practice, 19(5), 375–385. https://doi.org/10.1097/01.pra.0000435036.83426.94
29. Naheed, M., Akter, K. A., Tabassum, F., & Mawla, R. (2012). Factors Contributing the Outcome of Schizophrenia in Developing and Developed Countries: A Brief Review. International Current Pharmaceutical Journal, 1(4), 81–85. https://doi.org/10.3329/icpj.v1i4.10063
30. Novick, D., Haro, J. M., Hong, J., Brugnoli, R., Lepine, J. P., Bertsch, J., Karagianis, J., Dossenbach, M., & Alvarez, E. (2012). Regional Differences in Treatment Response and Three Year Course of Schizophrenia across the World. Journal of Psychiatric Research, 46(7), 856–864. https://doi.org/10.1016/j.jpsychires.2012.03.017
31. Orellana, G., & Slachevsky, A. (2013). Executive Functioning in Schizophrenia. Frontiers in Psychiatry, 4(35), 1–15. https://doi.org/10.3389/fpsyt.2013.00035
32. Palmer, C. D., Heiby, E., Fujii, D., & Kameoka, V. (2008). Executive Functioning in Schizophrenia: The Contributions of Attention, Working Memory, Processing Speed. Graduate Student Journal of Psychology, 10, 38–51. https://doi.org/10.52214/gsjp.v10i.10832
33. Polgar, P., Rethelyi, J. m, Balint, S., Komlosi, S., Czobor, P., & Bitter, I. (2010). Executive Function in Deficit Schizophrenia: What Do the Dimensions of the Wisconsin Card Sorting Test Tell Us? Schizophrenia Research, 122(1–3), 85–93. https://doi.org/https://doi.org/10.1016/j.schres.2010.06.007
34. Rajji, T. k., Isamil, Z., & Mulsant, B. h. (2009). Age at Onset and Cognition in Schizophrenia: Meta-Analysis. The British Journal of Psychiatry, 195(4), 286–293. https://doi.org/10.1192/bjp.bp.108.060723
35. Reichenberg, A. (avi). (2010). The Assessment of Neuropsychological Functioning in Schizophrenia. Dialogues in Clinical Neuroscience, 12(3), 383–392. https://doi.org/10.31887/DCNS.2010.12.3/areichenberg
36. Scott, J. E., & Dixon, L. B. (1995). Assertive Community Treatment and Case Management for Schizophrenia. Schizophrenia Bulletin, 21(4), 657–668. https://doi.org/https://doi.org/10.1093/schbul/21.4.657
37. Snyder, M. a., & Gao, W. (2020). NMDA Receptor Hypofunction for Schizophrenia Revisited: Perspectives from Epigenetic Mechanisms. Schizophrenia Research, 217, 60–70. https://doi.org/https://doi.org/10.1016/j.schres.2019.03.010
38. Srihari, V. h, Ferrara, M., Li, F., Kline, E., gülöksüz , S., Pollard, J. m, Cahill , J. d, Mathis , W. s, Sykes, L. Y., Walsh , B. c, Mcdermott, G., Seidman , L. j, Gueorguieva, R., Woods , S. w, Tek , C., & Keshavan , M. s. (2022, January 4). Reducing the Duration of Untreated Psychosis (DUP) in a US Community: A Quasi-Experimental Trial. Schizophrenia Bulletin Open. https://doi.org/10.1016/j.neulet.2016.10.003
39. Walker, E., Kestler, L., Bollini, A., & Hochman, K. M. (2004). SCHIZOPHRENIA: Etiology and Course. Annual Review of Psychology, 55(4), 401–430. https://doi.org/10.1146/annurev.psych.55.090902.141950
40. Wander, C. (2020). Schizophrenia: Opportunitites to Improve Outcomes and Reduce Economic Burden through Managed Care. The American Journal of Managed Care, 26(3), 62–68. http://ajmc.s3.amazonaws.com/_media/_pdf/AJMC_ACE0162_Schizophrenia Final%20Part%203_413.pdf
41. Wolf G, Singh S, Blakolmer K, Lerer L, Lifschytz T, Heresco-Levy U, Lotan A, Lerer B. Could psychedelic drugs have a role in the treatment of schizophrenia? Rationale and strategy for safe implementation. Mol Psychiatry. 2023 Jan;28(1):44-58. https:// 10.1038/s41380-022-01832-z. Epub 2022 Oct 24. PMID: 36280752.
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dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/94437-
dc.description.abstract背景介紹:思覺失調症為世界上各國不管在經濟,或是社會上財政支出與醫療負擔沉重的疾病之一,且目前尚無一個治癒的方式的重大精神疾病,病人會經歷認知功能缺損,深受正性、負性症狀之苦,進而影響社交、學業、工作功能,成為家庭與社會負擔。本研究目的在檢視藉由早期介入與個案管理,是否能有效改善病人的認知功能與症狀。

研究方法:本研究招募151位受試者,取了124位的資料,進行認知功能、電腦測驗、威斯康辛卡片分類測驗、魏氏記憶量表、活性與負性症狀的評估。

結果與結論:在電腦測驗的表現上,在試驗的第二年,受試者展現更積極回應刺激;在心智測驗中,第二年有早期介入處置與個案管理,其表現也較第一年進步:在正性與負性狀評估當中,其分數在第二年也大幅下降,顯示受試者降低了受症狀干擾之苦。
zh_TW
dc.description.abstractIntroduction: Previous research into patients with schizophrenia shows that they suffer from cognitive impairments which lead to social, academic and vocational dysfunction. As a result, they require long-term treatment which can cause an economic burden. In this thesis we will examine whether it is beneficial to provide early intervention and case management for patients with schizophrenia.

Method: We recruited 151 subjects but only retrieved data from 124 of them. We assessed cognitive function through CPT, WCST, and memory tests. We also assessed positive and negative symptoms using the PANSS assessment tool.

Result and Conclusion: We found that the subjects became more proactive by answering stimuli in the CPT and that scores for cognitive function and positive and negative symptoms improved in the second year. As a result, we believe that providing early intervention and case management can bring positive influences on Schizophrenia patients.
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dc.description.tableofcontents摘要 II
ABSTRACT III
CHAPTER 1 PAPER REVIEW 1
SECTION 1 1
Incidence and key features of Schizophrenia 1
Introduction of Schizophrenia 1
Early intervention in first-episode Schizophrenia by case management 2
SECTION 2 6
Etiology in Schizophrenia 6
The association between prenatal and postnatal Schizophrenia 6
Neuroimaging in brain structure 6
Cognitive deficit 7
Attention, Executive function and working memory 7
Memory and Processing Speed 8
CHAPTER 2: METHODOLOGY AND STATICAL ANALYSIS 10
Subject information 10
Assessment tool 12
Statical method 14
CHAPTER 3: RESULT 15
Demographic 15
Analysis results for CPT, WCST, and NPT 16
Analysis results for PANSS 18
CHAPTER 4: DISCUSSION AND LIMITATIONS 19
General Discussion and Clinical Implications 19
Limitation and Suggestion 23
TABLES 25
Table 1 (CPT and WCST Descriptive Statistics for year 1 and 2) 25
Table 2 (CPT and WCST Paired Samples Statistics for year 1 and 2) 29
Table 3 (NPT Descriptive Statistics for year 1 and 2) 32
Table 4 (NPT Paired Samples Statistics for year 1 and 2) 43
Table 5 (PANSS Descriptive Statistics for year 1 and 2) 50
Table 6 (PANSS Paired Samples Statistics for year 1 and 2) 52
REFERENCE 53
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dc.language.isoen-
dc.subject思覺失調症zh_TW
dc.subject個案管理zh_TW
dc.subject早期介入處置zh_TW
dc.subject心智功能zh_TW
dc.subject認知功能zh_TW
dc.subject電腦測驗zh_TW
dc.subject威斯康辛卡片分類測驗zh_TW
dc.subject魏氏記憶量表zh_TW
dc.subject活性與負性症狀量表zh_TW
dc.subjectWMS-IIIen
dc.subjectSchizophreniaen
dc.subjectWisconsin Card Sorting Test (WCST)en
dc.subjectCase Managementen
dc.subjectEarly interventionen
dc.subjectCognitive Functionen
dc.subjectComputerized Cognitive Testingen
dc.subjectPANSSen
dc.subjectWAIS-IIIen
dc.title早期介入與個案管理對思覺失調症患者之潛在益處zh_TW
dc.titleThe potential benefits of early intervention and case management in patients with Schizophreniaen
dc.typeThesis-
dc.date.schoolyear112-2-
dc.description.degree碩士-
dc.contributor.oralexamcommittee劉智民;胡凱焜zh_TW
dc.contributor.oralexamcommitteeChih-Ming Liu;Kae-Kuen Huen
dc.subject.keyword思覺失調症,個案管理,早期介入處置,心智功能,認知功能,電腦測驗,威斯康辛卡片分類測驗,魏氏記憶量表,活性與負性症狀量表,zh_TW
dc.subject.keywordSchizophrenia,Case Management,Early intervention,Cognitive Function,Computerized Cognitive Testing,Wisconsin Card Sorting Test (WCST),WMS-III,WAIS-III,PANSS,en
dc.relation.page59-
dc.identifier.doi10.6342/NTU202401417-
dc.rights.note未授權-
dc.date.accepted2024-07-03-
dc.contributor.author-college進修推廣學院-
dc.contributor.author-dept生物科技管理碩士在職學位學程-
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