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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李翔傑 | zh_TW |
dc.contributor.advisor | Hsiang-Chieh Lee | en |
dc.contributor.author | 施昶安 | zh_TW |
dc.contributor.author | Chang-An Shih | en |
dc.date.accessioned | 2023-10-03T17:23:15Z | - |
dc.date.available | 2023-11-09 | - |
dc.date.copyright | 2023-10-03 | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-03 | - |
dc.identifier.citation | Alam, S., et al., Clinical application of rapid serial Fourier-domain optical coherence tomography for macular imaging. Ophthalmology, 2006. 113(8): p. 1425-1431.
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Swanson, The development, commercialization, and impact of optical coherence tomography. Investigative ophthalmology & visual science, 2016. 57(9): p. OCT1-OCT13. Monroy, G.L., et al., Clinical translation of handheld optical coherence tomography: practical considerations and recent advancements. Journal of biomedical optics, 2017. 22(12): p. 121715-121715. Kim, S., et al., Design and implementation of a low-cost, portable OCT system. Biomedical optics express, 2018. 9(3): p. 1232-1243. Cho, H., et al., Development of raspberry Pi single-board computer architecture based ultra-compact optical coherence tomography. Optics and Lasers in Engineering, 2022. 148: p. 106754. Dsouza, R., et al., Economical and compact briefcase spectral-domain optical coherence tomography system for primary care and point-of-care applications. Journal of biomedical optics, 2018. 23(9): p. 096003-096003. Song, G., et al., A review of low-cost and portable optical coherence tomography. Progress in Biomedical Engineering, 2021. 3(3): p. 032002. Arduino vs Raspberry Pi: What’s the difference? . https://www.mygreatlearning.com/blog/arduino-vs-raspberry-pi/, 2022, September 20. "Arduino Uno Rev3" https://store-usa.arduino.cc/products/arduino-uno-rev3. "Raspberry Pi 3 Model B+" https://www.raspberrypi.com/products/raspberry-pi-3-model-b-plus/. Boutros, A. and V. Betz, FPGA architecture: Principles and progression. IEEE Circuits and Systems Magazine, 2021. 21(2): p. 4-29. Jin, K.-C., K.-S. Lee, and G.-H. Kim. High-speed FPGA-GPU processing for 3D-OCT imaging. in 2017 3rd IEEE International Conference on Computer and Communications (ICCC). 2017. IEEE. Li, J., M.V. Sarunic, and L. Shannon. Scalable, high performance Fourier domain optical coherence tomography: Why FPGAs and not GPGPUs. in 2011 ieee 19th annual international symposium on field-programmable custom computing machines. 2011. IEEE. Meemon, P., Y. Lenaphet, and J. Widjaja, Spectral fusing Gabor domain optical coherence microscopy based on FPGA processing. Applied Optics, 2021. 60(7): p. 2069-2076. "Zynq UltraScale+ MPSoC ZCU104 Evaluation Kit" https://www.xilinx.com/products/boards-and-kits/zcu104.html. Huang, D., et al., Optical coherence tomography. science, 1991. 254(5035): p. 1178-1181. Izatt, J.A. and M.A. Choma, Theory of optical coherence tomography, in Optical Coherence Tomography: Technology and Applications. 2008, Springer. p. 47-72. De Boer, J.F., et al., Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography. Optics letters, 2003. 28(21): p. 2067-2069. Leitgeb, R., C. Hitzenberger, and A.F. Fercher, Performance of fourier domain vs. time domain optical coherence tomography. Optics express, 2003. 11(8): p. 889-894. Choma, M.A., et al., Sensitivity advantage of swept source and Fourier domain optical coherence tomography. Optics express, 2003. 11(18): p. 2183-2189. Potsaid, B., et al., Ultrahigh speed 1050nm swept source/Fourier domain OCT retinal and anterior segment imaging at 100,000 to 400,000 axial scans per second. Optics express, 2010. 18(19): p. 20029-20048. Wojtkowski, M., et al., Ultrahigh-resolution, high-speed, Fourier domain optical coherence tomography and methods for dispersion compensation. Optics express, 2004. 12(11): p. 2404-2422. Introduction to FPGA Design with Vivado High-Level Synthesis https://docs.xilinx.co/v/u/en-US/ug998-vivado-intro-fpga-design-hls, January 22, 2019. 7 Series FPGAs Configurable Logic Block https://docs.xilinx.com/v/u/en-US/ug474_7Series_CLB, September 27, 2016. UltraScale Architecture Configurable Logic Block https://docs.xilinx.com/v/u/en-US/ug574-ultrascale-clb, February 28, 2017. Spartan-6 FPGA Configurable Logic Block https://docs.xilinx.com/v/u/en-US/ug384, February 23, 2010. Vivado System-Level Design Flows Overview https://docs.xilinx.com/r/en-US/ug892-vivado-design-flows-overview/Working-with-Tcl, April 20, 2022. "3D SKIN VIEWER" https://opxiontech.com/#/MainPlatform/home. Ng, C.Y., et al., In Vivo Identification of Skin Photodamage Induced by Fractional CO2 and Picosecond Nd: YAG Lasers with Optical Coherence Tomography. Diagnostics, 2022. 12(4): p. 822. "CYUSB3KIT-003" https://www.infineon.com/cms/en/product/evaluation-boards/cyusb3kit-003/. Getting Started with EZ-USB® FX3™. https://www.infineon.com/dgdl/Infineon-AN75705_Getting_Started_with_EZ-USB_FX3-ApplicationNotes-v11_00-EN.pdf?fileId=8ac78c8c7cdc391c017d073989df5e15. Gorecki, C. and S. Bargiel. MEMS scanning mirrors for optical coherence tomography. in Photonics. 2020. MDPI. Integrated MEMS Mirrors https://www.mirrorcletech.com/wp/products/mems-mirrors/. Mirrorcle MEMS Drivers 5.x User Guide https://www.mirrorcletech.com/pdf/Mirrorcle_MEMS_Drivers_5.x_-_User_Guide.pdf, Jul. 2021. "F1M16.2" Device Parameters Summary https://mirrorcletech.com/pdf/DSI/MirrorcleTech_Datasheet_F1M16.2-1600AL.pdf. "AD5664" DAC Datasheet https://www.analog.com/media/en/technical-documentation/data-sheets/AD5624R_5644R_5664R.pdf. Serial Peripheral Interface https://en.wikipedia.org/wiki/Serial_Peripheral_Interface. | - |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90734 | - |
dc.description.abstract | 可攜式光學同調斷層掃描(Portable optical coherence tomography, portable OCT)系統通過在頻域式光學同調斷層掃描術(Spectral-domain OCT, SD-OCT)上整合微型化且低成本的運算平台,克服了傳統OCT系統體積龐大且造價昂貴的缺點,並繼承了傳統OCT系統所具備的高解析度、非侵入式的優勢,使其不再受限於大型醫療院所內的使用。然而,當使用單板電腦和小型電腦代替傳統個人電腦時,受限於運算平台有限的運算效能,無法快速地運算OCT重建所需的影像處理函式,導致可攜式OCT系統無法提供快速的成像以及高品質的三維立體影像。
在本論文中,我們將使用現場可程式化邏輯閘陣列(Field programmable gate array, FPGA)開發訊號控制模組,以實現電腦通過通用序列匯流排(Universal serial bus, USB) 3.0介面傳輸指令,使FPGA控制微機電系統(Microelectromechanical systems, MEMS)反射鏡以及同步擷取裝置的目標。訊號控制模組由兩個子模組所組成,分別為USB模組和MEMS模組。USB模組負責與USB控制器溝通,並將接收到的封包解碼成對應的指令,從而實現電腦與FPGA之間以USB 3.0傳輸的功能。MEMS模組則進一步將USB模組傳輸的指令分解為掃描範圍、軌跡等,並通過序列周邊介面(Serial peripheral interface, SPI)對數位微機電系統驅動電路板(Digital MEMS driver)輸出訊號以控制MEMS反射鏡,並將同步訊號輸出至擷取裝置,以實現系統掃描和擷取的同步。 在本論文中,我們首先獨立以USB模組測試FPGA與電腦之間傳輸資料的效能和正確度,接著使用共軛焦顯微術(Reflectance confocal microscopy)架構整合訊號控制模組對resolution target、grid target以及位置感測模組(Position sensing module, PSM)進行掃描,並以掃描結果驗證訊號控制模組的可行性。最後我們將訊號控制模組與芯聖科技(OPXION Technology, Inc.)開發的手持式光學同調斷層掃描儀整合,並將電腦通過USB 3.0控制FPGA的C++程式與台大光電所先進生醫光電影像實驗室(Advanced biomedical optical imaging laboratory (ABOIL), National Taiwan University (NTU))先前開發的圖形使用者介面(Graphical user interface, GUI)整合。達成以訊號控制模組控制和同步週邊裝置的同時,通過簡單的介面操作提供即時的二維成像、enface影像和高品質的三維立體影像,實現了以FPGA為基礎的可攜式OCT系統。我們相信本論文所得到的研究成果能為日後可攜式OCT的研究奠定良好的基礎,並促使可攜式OCT應用於更多偏鄉醫療檢測設施,為初級醫療(Primary care)展現更多的應用價值。 | zh_TW |
dc.description.abstract | Portable optical coherence tomography (Portable OCT) systems, by integrating miniaturized and low-cost computing platforms on spectral-domain OCT (SD-OCT) overcome the limitation of traditional OCT systems, such as being bulky and expensive, and also retain the high-resolution and non-invasive advantages of traditional OCT systems, allowing them from being utilized beyond large medical institutions. However, when using a single-board computer or a mini PC instead of a personal computer, the limited computational power of these platforms limits the speed of essential image processing functions for OCT reconstruction. This limitation restricts portable OCT systems from providing fast imaging and high-quality three-dimensional OCT images.
In this thesis, we propose the development of a signal control module by using a field programmable gate array (FPGA) to achieve the goal of controlling and synchronizing peripheral devices with FPGA. The system control module consists of two main submodules, the universal serial bus (USB) module and the microelectromechanical systems (MEMS) module. The USB module is designed to communicate with the USB controller and also decode the received packets into corresponding instructions, enabling the USB 3.0 communication between the computer and FPGA. The MEMS module decomposes the instructions received from the USB module to MEMS scanning range, MEMS scanning pattern, etc., and then transfers signals to the digital MEMS driver by serial peripheral interface (SPI), which controls the MEMS mirror. It outputs synchronization signals to the detector simultaneously in order to synchronize MEMS mirror and detector. In this thesis, we conducted tests using the USB module to evaluate the performance and accuracy of the USB 3.0 communication between the FPGA and the computer. Subsequently, we integrated the signal control module into a reflectance confocal microscopy framework in order to validate the feasibility of the signal control module by the results of scanning resolution targets, grid targets and position sensing module. Furthermore, we integrated the system control module with a handheld 3D skin viewer system developed by OPXION Technology, Inc. We also integrated the C++ program which controls the FPGA through USB 3.0 into a graphical user interface (GUI) developed by our laboratory. By successfully controlling and synchronizing peripheral devices using the signal control module, we also provide real-time 2D imaging, enface images, and high-quality 3D images through a user-friendly interface, representing that we implemented a portable OCT system based on FPGA. We believe the accomplishment of this thesis will establish a solid foundation for future studies on portable OCT, encourage the application of portable OCT in a wider range of healthcare facilities in rural areas, and shows the potential value of portable OCT being utilized in primary care. | en |
dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-10-03T17:23:15Z No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2023-10-03T17:23:15Z (GMT). No. of bitstreams: 0 | en |
dc.description.tableofcontents | 論文口試委員審定書 i
誌謝 ii 中文摘要 iii ABSTRACT v 目錄 vii 表目錄 x 圖目錄 xi Chapter 1 緒論 1 1.1 可攜式光學同調斷層掃描系統之發展 1 1.2 運算平台介紹 3 1.2.1 單晶片處理器介紹 3 1.2.2 現場可程式化邏輯閘陣列(Field programmable gate array, FPGA)介紹 5 1.3 研究動機 7 1.4 論文範疇 8 Chapter 2 光學同調斷層掃描術(Optical coherence tomography, OCT) 9 2.1 光學同調斷層掃描術介紹 9 2.2 光學同調斷層掃描術之基本原理與其特性 9 2.2.1 低同調干涉儀 9 2.2.2 軸向解析度 13 2.2.3 橫向解析度 14 2.3 光學同調斷層掃描術之發展 14 2.3.1 時域式光學同調斷層掃描術(Time-domain OCT, TD-OCT) 14 2.3.2 掃頻式光學同調斷層掃描術(Swept-source OCT, SS-OCT) 15 2.3.3 頻域式光學同調斷層掃描術(Spectral-domain OCT, SD-OCT) 16 Chapter 3 FPGA基本原理 17 3.1 FPGA架構組成 17 3.1.1 可程式化邏輯區塊(Programmable logic block) 17 3.1.1.1 查找表(Look-up table, LUT) 19 3.1.1.2 數據多工器(Multiplexer, MUX) 20 3.1.1.3 加法器(CARRY4) 21 3.1.1.4 正反器(Flip-flop, FF)/閂鎖(Latch) 22 3.1.2 可程式化繞線(Programmable routing) 23 3.1.3 可程式化輸入/輸入(Programmable Input/Output) 23 3.2 測試環境(Testbench)與模擬(Simulation) 24 3.3 合成(Synthesis)與實作(Implementation) 25 Chapter 4 實驗架構與模擬 26 4.1 光電整合架構 26 4.1.1 共軛焦顯微術(Reflectance confocal microscopy)架構 26 4.1.2 手持式光學同調斷層皮膚掃描儀架構 27 4.2 訊號控制模組架構 29 4.3 EZ-USB FX3介面設計 30 4.4 微機電系統(Microelectromechanical systems, MEMS)&MEMS驅動電路板(Driver)設計 34 4.4.1 MEMS基本介紹 34 4.4.2 MEMS driver基本介紹以及控制方法 36 4.4.3 MEMS反射鏡掃描之實作方法 39 4.4.4 系統同步設計 45 Chapter 5 實驗結果與討論 47 5.1 EZ-USB FX3傳輸結果 47 5.2 Digital/Analog MEMS driver電壓輸出比較 49 5.3 基於共軛焦顯微術架構掃描影像和位置感測模組(Position sensing module, PSM)量測結果比較 51 5.4 皮膚儀OCT影像 56 Chapter 6 結論與未來展望 59 6.1 結論 59 6.2 未來展望 60 參考文獻 61 | - |
dc.language.iso | zh_TW | - |
dc.title | 現場可程式化邏輯閘陣列應用於光學同調斷層掃描系統之訊號控制模組 | zh_TW |
dc.title | Development of Signal Control Module with Field Programmable Gate Array for Optical Coherence Tomography Application | en |
dc.type | Thesis | - |
dc.date.schoolyear | 111-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 楊家驤;蔡睿哲;孫家偉 | zh_TW |
dc.contributor.oralexamcommittee | Chia-Hsiang Yang;Jui-Che Tsai;Chia-Wei Sun | en |
dc.subject.keyword | 光學同調斷層掃描術,現場可程式化邏輯閘陣列,可攜式OCT,偏鄉醫療,初級醫療,手持式探頭, | zh_TW |
dc.subject.keyword | optical coherence tomography,field programmable gate array,portable OCT,primary care,handheld scanner, | en |
dc.relation.page | 64 | - |
dc.identifier.doi | 10.6342/NTU202302516 | - |
dc.rights.note | 同意授權(限校園內公開) | - |
dc.date.accepted | 2023-08-07 | - |
dc.contributor.author-college | 電機資訊學院 | - |
dc.contributor.author-dept | 光電工程學研究所 | - |
顯示於系所單位: | 光電工程學研究所 |
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