請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90254
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 黃耀輝 | zh_TW |
dc.contributor.advisor | Yaw-Huei Huang | en |
dc.contributor.author | 卓芸郁 | zh_TW |
dc.contributor.author | Yun-Yu Cho | en |
dc.date.accessioned | 2023-09-25T16:07:11Z | - |
dc.date.available | 2023-11-10 | - |
dc.date.copyright | 2023-09-25 | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-07 | - |
dc.identifier.citation | Aps, J. K., & Martens, L. C. (2005). Review: the physiology of saliva and transfer of drugs into saliva. Forensic Science International, 150(2-3), 119–131. https://doi.org/10.1016/j.forsciint.2004.10.026
ATSDR (2007). Toxicological profile for arsenic. Atlanta, GA: U.S. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services, Public Health Service. ATSDR (2012a). Toxicological profile for chromium. Atlanta, GA: U.S. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services, Public Health Service. ATSDR (2012b). Toxicological profile for cadmium. Atlanta, GA: U.S. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services, Public Health Service. ATSDR (2020). Toxicological profile for lead. Atlanta, GA: U.S. Agency for Toxic Substances and Disease Registry. Department of Health and Human Services, Public Health Service. Balali-Mood, M., Naseri, K., Tahergorabi, Z., Khazdair, M. R., & Sadeghi, M. (2021). Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic. Frontiers in Pharmacology, 12, 643972. https://doi.org/10.3389/ fphar.2021.643972 Bales, C. W., Freeland-Graves, J. H., Askey, S., Behmardi, F., Pobocik, R. S., Fickel, J. J., & Greenlee, P. (1990). Zinc, magnesium, copper, and protein concentrations in human saliva: age- and sex-related differences. The American Journal of Clinical Nutrition, 51(3), 462–469. https://doi.org/10.1093/ajcn/51.3.462 Banerjee, S., Levitz, M., & Rosenberg, C. R. (1985). On the stability of salivary progesterone under various conditions of storage. Steroids, 46(6), 967-974. https://doi.org/10.1016/S0039-128X(85)80004-0 Baranowska-Wójcik, E., Szwajgier, D., Oleszczuk, P., & Winiarska-Mieczan, A. (2020). Effects of titanium dioxide nanoparticles exposure on human health- a review. Biological Trace Element Research, 193(1), 118–129. https://doi.org/ 10.1007/ s12011-019-01706-6 Barbosa, F., Jr, Tanus-Santos, J. E., Gerlach, R. F., & Parsons, P. J. (2005). A critical review of biomarkers used for monitoring human exposure to lead: advantages, limitations, and future needs. Environmental Health Perspectives, 113(12), 1669–1674. https://doi.org/10.1289/ehp.7917 Bellagambi, F. G., Lomonaco, T., Salvo, P., Vivaldi, F., Hangouët, M., Ghimenti, S., Biagini, D., Francesco, D.B., Fuoco, R., Errachid, A. (2020). Saliva sampling: methods and devices. An overview. TrAC Trends in Analytical Chemistry, 124, 115781. https://doi.org/10.1016/j.trac.2019.115781 Bel'skaya, L. V., Kosenok, V. K., & Sarf, E. A. (2017). Chronophysiological features of the normal mineral composition of human saliva. Archives of Oral Biology, 82, 286–292. https://doi.org/10.1016/j.archoralbio.2017.06.024 Berglund, M., & Wieser, M. E. (2011). Isotopic compositions of the elements 2009 (IUPAC Technical Report). Pure and Applied Chemistry, 83(2), 397-410. https://doi.org/10.1351/PAC-REP-10-06-02 Bhowmick, S., Halder, D., Kundu, A. K., Saha, D., Iglesias, M., Nriagu, J., Guha Mazumder, D. N., Roman-Ross, G., & Chatterjee, D. (2013). Is saliva a potential biomarker of arsenic exposure? A case-control study in West Bengal, India. Environmental Science & Technology, 47(7), 3326–3332. https://doi.org/ 10.1021/es303756s Borella, P., Fantuzzi, G., & Aggazzotti, G. (1994). Trace elements in saliva and dental caries in young adults. The Science of the Total Environment, 153(3), 219–224. https://doi.org/10.1016/0048-9697(94)90201-1 Buchet, J. P., Lauwerys, R., & Roels, H. (1981). Comparison of the urinary excretion of arsenic metabolites after a single oral dose of sodium arsenite, monomethylarsonate, or dimethylarsinate in man. International Archives of Occupational and Environmental Health, 48(1), 71–79. https://doi.org/ 10.1007/BF00405933 Buettner, K. M., & Valentine, A. M. (2012). Bioinorganic chemistry of titanium. Chemical Reviews, 112(3), 1863–1881. https://doi.org/10.1021/ cr1002886 Butler, L., Gennings, C., Peli, M., Borgese, L., Placidi, D., Zimmerman, N., Hsu, H. L., Coull, B. A., Wright, R. O., Smith, D. R., Lucchini, R. G., & Claus Henn, B. (2019). Assessing the contributions of metals in environmental media to exposure biomarkers in a region of ferroalloy industry. Journal of Exposure Science & Environmental Epidemiology, 29(5), 674–687. https://doi.org/ 10.1038/s41370-018-0081-6 Caporossi, L., Santoro, A., & Papaleo, B. (2010). Saliva as an analytical matrix: state of the art and application for biomonitoring. Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals, 15(6), 475–487. https://doi.org/10.3109/1354750X.2010.481364 Carlson, A. J., & Crittenden, A. L. (1910). The relation of ptyalin concentration to the diet and to the rate of secretion of the saliva. American Journal of Physiology-Legacy Content, 26(1), 169-177. Chojnowska, S., Baran, T., Wilińska, I., Sienicka, P., Cabaj-Wiater, I., & Knaś, M. (2018). Human saliva as a diagnostic material. Advances in Medical Sciences, 63(1), 185–191. https://doi.org/10.1016/j.advms.2017.11.002 Cohen, S. M., Arnold, L. L., Eldan, M., Lewis, A. S., & Beck, B. D. (2006). Methylated arsenicals: the implications of metabolism and carcinogenicity studies in rodents to human risk assessment. Critical Reviews in Toxicology, 36(2), 99–133. https://doi.org/10.1080/10408440500534230 Costa de Almeida, G. R., de Freitas Tavares, C. F., de Souza, A. M., Sampaio de Sousa, T., Rodrigues Funayama, C. A., Barbosa, F., Jr, Tanus-Santos, J. E., & Gerlach, R. F. (2010). Whole blood, serum, and saliva lead concentrations in 6- to 8-year-old children. The Science of the Total Environment, 408(7), 1551–1556. https://doi.org/10.1016/j.scitotenv.2009.12.034 Crouch D. J. (2005). Oral fluid collection: the neglected variable in oral fluid testing. Forensic Science International, 150(2-3), 165–173. https://doi.org/10.1016/ j.forsciint.2005.02.028 Czégény, Z. S., Chicharro, J. L., Fernández, P., Gutiérrez, A., & Cámara, C. (2001). Homogeneity and stability studies on sodium, calcium, magnesium, and manganese in human saliva. Biological Trace Element Research, 79(2), 131–137. https://doi.org/10.1385/BTER:79:2:131 d'Amone, L., Matzeu, G., & Omenetto, F. G. (2021). Stabilization of salivary biomarkers. ACS Biomaterials Science & Engineering, 7(12), 5451–5473. https://doi.org/10.1021/acsbiomaterials.1c01138 Daniel, F. I., Lima, L., & Santos, C. R. D. (2016). Salivary calcium and phosphate stability in different time and temperature storage. Brazilian Journal of Pharmaceutical Sciences, 52, 679-684. https://doi.org/10.1590/S1984-82502016000400011 Dawes, C., & Kubieniec, K. (2004). The effects of prolonged gum chewing on salivary flow rate and composition. Archives of Oral Biology, 49(8), 665–669. https://doi.org/10.1016/j.archoralbio.2004.02.007 Diaz-Arnold, A. M., & Marek, C. A. (2002). The impact of saliva on patient care: a literature review. The Journal of Prosthetic Dentistry, 88(3), 337–343. https://doi.org/10.1067/mpr.2002.128176 Eliasson, L., & Carlén, A. (2010). An update on minor salivary gland secretions. European Journal of Oral Sciences, 118(5), 435–442. https://doi.org/ 10.1111/j.1600-0722.2010.00766.x Fage, S. W., Muris, J., Jakobsen, S. S., & Thyssen, J. P. (2016). Titanium: a review on exposure, release, penetration, allergy, epidemiology, and clinical reactivity. Contact Dermatitis, 74(6), 323–345. https://doi.org/10.1111/ cod.12565 Fenoll-Palomares, C., Muñoz Montagud, J. V., Sanchiz, V., Herreros, B., Hernández, V., Mínguez, M., & Benages, A. (2004). Unstimulated salivary flow rate, pH and buffer capacity of saliva in healthy volunteers. Revista Espanola De Enfermedades Digestivas, 96(11), 773–783. https://doi.org/10.4321/s1130-01082004001100005 Ferguson, D. B., & Botchway, C. A. (1979). Circadian variations in the flow rate and composition of whole saliva stimulated by mastication. Archives of Oral Biology, 24(12), 877–881. https://doi.org/10.1016/0003-9969(79)90212-7 Franco-Martínez, L., Cerón, J. J., Martínez-Subiela, S., & Tvarijonaviciute, A. (2023). Effects of filtration and alpha-amylase depletion on salivary biochemical composition measurements. PloS One, 18(5), e0286092. https://doi.org/ 10.1371/journal.pone.0286092 Garelick, H., Jones, H., Dybowska, A., & Valsami-Jones, E. (2008). Arsenic pollution sources. Reviews of Environmental Contamination and Toxicology, 197, 17–60. https://doi.org/10.1007/978-0-387-79284-2_2 Genchi, G., Sinicropi, M. S., Lauria, G., Carocci, A., & Catalano, A. (2020). The effects of cadmium toxicity. International Journal of Environmental Research and Public Health, 17(11), 3782. https://doi.org/10.3390/ijerph17113782 Gidlow D. A. (2015). Lead toxicity. Occupational Medicine (Oxford, England), 65(5), 348–356. https://doi.org/10.1093/occmed/kqv018 Gil, F., Hernández, A. F., Márquez, C., Femia, P., Olmedo, P., López-Guarnido, O., & Pla, A. (2011). Biomonitorization of cadmium, chromium, manganese, nickel and lead in whole blood, urine, axillary hair and saliva in an occupationally exposed population. The Science of the Total Environment, 409(6), 1172–1180. https://doi.org/10.1016/j.scitotenv.2010.11.033 Godt, J., Scheidig, F., Grosse-Siestrup, C., Esche, V., Brandenburg, P., Reich, A., & Groneberg, D. A. (2006). The toxicity of cadmium and resulting hazards for human health. Journal of Occupational Medicine and Toxicology (London, England), 1, 22. https://doi.org/10.1186/1745-6673-1-22 Golasik, M., Herman, M., & Piekoszewski, W. (2016). Toxicological aspects of soluble titanium- a review of in vitro and in vivo studies. Metallomics: Integrated Biometal Science, 8(12), 1227–1242. https://doi.org/10.1039/c6mt00110f Granger, D. A., Shirtcliff, E. A., Booth, A., Kivlighan, K. T., & Schwartz, E. B. (2004). The "trouble" with salivary testosterone. Psychoneuroendocrinology, 29(10), 1229–1240. https://doi.org/10.1016/j.psyneuen.2004.02.005 Guo, W., Dong, S., Jin, Y., Pan, Z., Pearce, E. N., Wu, W., Zhang, Y., Chen, W., & Zhang, W. (2021). Evaluation of variation of saliva iodine and recommendations for sample size and sampling time: Implications for assessing iodine nutritional status. Clinical Nutrition (Edinburgh, Scotland), 40(5), 3559–3566. https://doi.org/10.1016/j.clnu.2020.12.010 Gürbüz-Urvasızoğlu, G., Ataol, M., & Özgeriş, F. B. (2022). Trace elements released from dental implants with periimplantitis: a cohort study. Irish Journal of Medical Science, 191(5), 2305–2310. https://doi.org/10.1007/s11845-022-03020-y Haeckel R. (1993). Factors influencing the saliva/plasma ratio of drugs. Annals of the New York Academy of Sciences, 694, 128–142. https://doi.org/10.1111/j.1749-6632.1993.tb18347.x Hamadamin S. I. (2022). In vivo kinetic release of five metal ions (iron, titanium, nickel, copper, and chromium) from fixed orthodontic alloys in Erbil city- Kurdistan region/Iraq. Environmental Science and Pollution Research International, 29(8), 11730–11735. https://doi.org/10.1007/s11356-021-16479-6 Hinhumpatch, P., Navasumrit, P., Chaisatra, K., Promvijit, J., Mahidol, C., & Ruchirawat, M. (2013). Oxidative DNA damage and repair in children exposed to low levels of arsenic in utero and during early childhood: application of salivary and urinary biomarkers. Toxicology and Applied Pharmacology, 273(3), 569–579. https://doi.org/10.1016/j.taap.2013.10.002 Hornung, R. W., & Reed, L. D. (1990). Estimation of average concentration in the presence of nondetectable values. Applied Occupational and Environmental Hygiene, 5(1), 46-51. https://doi.org/10.1080/1047322X.1990.10389587 Hossini, H., Shafie, B., Niri, A. D., Nazari, M., Esfahlan, A. J., Ahmadpour, M., Nazmara, Z., Ahmadimanesh, M., Makhdoumi, P., Mirzaei, N., & Hoseinzadeh, E. (2022). A comprehensive review on human health effects of chromium: insights on induced toxicity. Environmental Science and Pollution Research International, 29(47), 70686–70705. https://doi.org/10.1007/s11356-022-22705-6 Humphrey, S. P., & Williamson, R. T. (2001). A review of saliva: normal composition, flow, and function. The Journal of Prosthetic Dentistry, 85(2), 162–169. https://doi.org/10.1067/mpr.2001.113778 IARC (2012a). Chromium (VI) compounds. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 49 Suppl. 7, 100C, 147-167. IARC (2012b). Cadmium and cadmium compounds. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, 58, 100C, 147-167. Jan, A. T., Azam, M., Siddiqui, K., Ali, A., Choi, I., & Haq, Q. M. (2015). Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants. International Journal of Molecular Sciences, 16(12), 29592–29630. https://doi.org/10.3390/ijms161226183 Järup L. (2003). Hazards of heavy metal contamination. British Medical Bulletin, 68, 167–182. https://doi.org/10.1093/bmb/ldg032 Järup, L., & Akesson, A. (2009). Current status of cadmium as an environmental health problem. Toxicology and Applied Pharmacology, 238(3), 201–208. https:// doi.org/10.1016/j.taap.2009.04.020 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C. J., & Valko, M. (2011). Arsenic: toxicity, oxidative stress and human disease. Journal of Applied Toxicology: JAT, 31(2), 95–107. https://doi.org/ 10.1002/jat.1649 Junaid, M., Hashmi, M. Z., & Malik, R. N. (2016). Evaluating levels and health risk of heavy metals in exposed workers from surgical instrument manufacturing industries of Sialkot, Pakistan. Environmental Science and Pollution Research International, 23(18), 18010–18026. https://doi.org/10.1007/s11356-016-6849-0 Kim, Y. J., Kim, Y. K., & Kho, H. S. (2010). Effects of smoking on trace metal levels in saliva. Oral Diseases, 16(8), 823–830. https://doi.org/10.1111/j.1601-0825.2010.01698.x Koh, D., Ng, V., Chua, L. H., Yang, Y., Ong, H. Y., & Chia, S. E. (2003). Can salivary lead be used for biological monitoring of lead exposed individuals? Occupational and environmental medicine, 60(9), 696–698. https://doi.org/10.1136/oem.60.9. 696 Konieczka, P. (2007). The role of and the place of method validation in the quality assurance and quality control (QA/QC) system. Critical Reviews in Analytical Chemistry, 37(3), 173–190. https://doi.org/10.1080/10408340701244649 Langård, S., & Costa, M. (2015). Chapter 33: Chromium. In Nordberg, G.F., Fowler, B.A., Nordberg, M. (Ed.), Handbook on the toxicology of metals. 4th ed. (pp. 717-742). San Diego: Academic Press. https://doi.org/10.1016/B978-0-444-59453-2.00033-0 Lew, K., Acker, J. P., Gabos, S., & Le, X. C. (2010). Biomonitoring of arsenic in urine and saliva of children playing on playgrounds constructed from chromated copper arsenate-treated wood. Environmental Science & Technology, 44(10), 3986–3991. https://doi.org/10.1021/es100128n Mannino, D. M., Holguin, F., Greves, H. M., Savage-Brown, A., Stock, A. L., & Jones, R. L. (2004). Urinary cadmium levels predict lower lung function in current and former smokers: data from the Third National Health and Nutrition Examination Survey. Thorax, 59(3), 194–198. https://doi.org/10.1136/thorax.2003.012054 Marín Martínez, L., Molino Pagán, D., & López Jornet, P. (2018). Trace elements in saliva as markers of type 2 diabetes mellitus. Biological Trace Element Research, 186(2), 354–360. https://doi.org/10.1007/s12011-018-1326-x Marín-Martínez, L., Molino-Pagán, D., & López-Jornet, P. (2019). Trace elements in saliva and plasma of patients with type 2 diabetes: association to metabolic control and complications. Diabetes Research and Clinical Practice, 157, 107871. https://doi.org/10.1016/j.diabres.2019.107871 Mese, H., & Matsuo, R. (2007). Salivary secretion, taste and hyposalivation. Journal of Oral Rehabilitation, 34(10), 711–723. https://doi.org/10.1111/j.1365-2842.2007.01794.x Michalke, B., Rossbach, B., Göen, T., Schäferhenrich, A., & Scherer, G. (2015). Saliva as a matrix for human biomonitoring in occupational and environmental medicine. International Archives of Occupational and Environmental Health, 88(1), 1–44. https://doi.org/10.1007/s00420-014-0938-5 Mitra, P., Sharma, S., Purohit, P., & Sharma, P. (2017). Clinical and molecular aspects of lead toxicity: An update. Critical Reviews in Clinical Laboratory Sciences, 54(7-8), 506–528. https://doi.org/10.1080/10408363.2017.1408562 Mombelli, A., Hashim, D., & Cionca, N. (2018). What is the impact of titanium particles and biocorrosion on implant survival and complications? A critical review. Clinical Oral Implants Research, 29 Suppl 18, 37–53. https:// doi.org/10.1111/clr.13305 Nagler, R. M., & Hershkovich, O. (2005). Relationships between age, drugs, oral sensorial complaints and salivary profile. Archives of Oral Biology, 50(1), 7–16. https://doi.org/10.1016/j.archoralbio.2004.07.012 Nagler, R. M., Hershkovich, O., Lischinsky, S., Diamond, E., & Reznick, A. Z. (2002). Saliva analysis in the clinical setting: revisiting an underused diagnostic tool. Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research, 50(3), 214–225. https://doi.org/ 10.2310/6650.2002.33436 Navazesh, M., Kumar, S. K., & University of Southern California School of Dentistry (2008). Measuring salivary flow: challenges and opportunities. Journal of the American Dental Association (1939), 139 Suppl, 35S–40S. https:// doi.org/10.14219/jada.archive.2008.0353 Nriagu, J., Burt, B., Linder, A., Ismail, A., & Sohn, W. (2006). Lead levels in blood and saliva in a low-income population of Detroit, Michigan. International Journal of Hygiene and Environmental Health, 209(2), 109–121. https://doi.org/ 10.1016/ j.ijheh.2005.11.005 Ogami, K., Sakurai, K., & Ando, T. (2004). A method of measuring salivary flow rate in the lower labial mucosal region. Journal of oral rehabilitation, 31(9), 861–865. https://doi.org/10.1111/j.1365-2842.2004.01319.x Pavesi, T., & Moreira, J. C. (2020). Mechanisms and individuality in chromium toxicity in humans. Journal of Applied Toxicology: JAT, 40(9), 1183–1197. https://doi.org/10.1002/jat.3965 Peana, M., Pelucelli, A., Chasapis, C. T., Perlepes, S. P., Bekiari, V., Medici, S., & Zoroddu, M. A. (2022). Biological effects of human exposure to environmental cadmium. Biomolecules, 13(1), 36. https://doi.org/10.3390/biom13010036 Priya, K. Y., & Prathibha, K. M. (2017). Methods of collection of saliva-a review. International Journal of Oral Health Dentistry, 3(3), 149-153. https://doi.org/10.18231/2395-499X.2017.0032 Quadras, D. D., Nayak, U. S. K., Kumari, N. S., Priyadarshini, H. R., Gowda, S., & Fernandes, B. (2019). In vivo study on the release of nickel, chromium, and zinc in saliva and serum from patients treated with fixed orthodontic appliances. Dental Research Journal, 16(4), 209–215. Racovita A. D. (2022). Titanium dioxide: structure, impact, and toxicity. International Journal of Environmental Research and Public Health, 19(9), 5681. https://doi.org/10.3390/ijerph19095681 Rad, M., Kakoie, S., Niliye Brojeni, F., & Pourdamghan, N. (2010). Effect of Long-term Smoking on Whole-mouth Salivary Flow Rate and Oral Health. Journal of Dental Research, Dental Clinics, Dental Prospects, 4(4), 110–114. https://doi.org/10.5681/joddd.2010.028 Rafati Rahimzadeh, M., Rafati Rahimzadeh, M., Kazemi, S., & Moghadamnia, A. A. (2017). Cadmium toxicity and treatment: an update. Caspian Journal of Internal Medicine, 8(3), 135–145. https://doi.org/10.22088/cjim.8.3.135 Rehman, K., Fatima, F., Waheed, I., & Akash, M. S. H. (2018). Prevalence of exposure of heavy metals and their impact on health consequences. Journal of Cellular Biochemistry, 119(1), 157–184. https://doi.org/10.1002/jcb.26234 Renu, K., Chakraborty, R., Myakala, H., Koti, R., Famurewa, A. C., Madhyastha, H., Vellingiri, B., George, A., & Valsala Gopalakrishnan, A. (2021). Molecular mechanism of heavy metals (lead, chromium, arsenic, mercury, nickel and aadmium)– induced hepatotoxicity– a review. Chemosphere, 271, 129735. https://doi.org/10.1016/j.chemosphere.2021.129735 Repić, A., Bulat, P., Antonijević, B., Antunović, M., Džudović, J., Buha, A., & Bulat, Z. (2020). The influence of smoking habits on cadmium and lead blood levels in the Serbian adult people. Environmental Science and Pollution Research International, 27(1), 751–760. https://doi.org/10.1007/s11356-019-06840-1 Romano, F., Castiblanco, A., Spadotto, F., Di Scipio, F., Malandrino, M., Berta, G. N., & Aimetti, M. (2020). ICP-mass-spectrometry ionic profile of whole saliva in patients with untreated and treated periodontitis. Biomedicines, 8(9), 354. https://doi.org/10.3390/biomedicines8090354 Schipper, R. G., Silletti, E., & Vingerhoeds, M. H. (2007). Saliva as research material: biochemical, physicochemical and practical aspects. Archives of Oral Biology, 52(12), 1114–1135. https://doi.org/10.1016/j.archoralbio.2007.06.009 Schrøder, S. A., Homøe, P., Wagner, N., & Bardow, A. (2017). Does saliva composition affect the formation of sialolithiasis? The Journal of Laryngology and Otology, 131(2), 162–167. https://doi.org/10.1017/S002221511600966X Shi, H., Magaye, R., Castranova, V., & Zhao, J. (2013). Titanium dioxide nanoparticles: a review of current toxicological data. Particle and Fibre Toxicology, 10, 15. https://doi.org/10.1186/1743-8977-10-15 Skerfving, S., Bergdahl, I.A. (2015). Chapter 43: Lead. In Nordberg, G.F., Fowler, B.A., Nordberg, M. (Ed.), Handbook on the toxicology of metals. 4th ed. (pp. 911-967). San Diego: Academic Press. https://doi.org/10.1016/B978-0-444-59453-2.00043-3 Slomiany, B. L., Murty, V. L., & Slomiany, A. (1985). Salivary lipids in health and disease. Progress in Lipid Research, 24(4), 311–324. https://doi.org/ 10.1016/0163-7827(85)90009-8 Soto-Alvaredo, J., Blanco, E., Bettmer, J., Hevia, D., Sainz, R. M., López Cháves, C., Sánchez, C., Llopis, J., Sanz-Medel, A., & Montes-Bayón, M. (2014). Evaluation of the biological effect of Ti generated debris from metal implants: ions and nanoparticles. Metallomics: Integrated Biometal Science, 6(9), 1702–1708. https://doi.org/10.1039/c4mt00133h Staff, J. F., Harding, A. H., Morton, J., Jones, K., Guice, E. A., & McCormick, T. (2014). Investigation of saliva as an alternative matrix to blood for the biological monitoring of inorganic lead. Toxicology Letters, 231(2), 270–276. https:// doi.org/10.1016/j.toxlet.2014.09.018 Stahr, S., Chiang, T. C., Bauer, M. A., Runnells, G. A., Rogers, L. J., Vi Do, H., Kadlubar, S. A., & Joseph Su, L. (2021). Low level environmental heavy metals are associated with obesity among postmenopausal women in a southern state. Exposure and Health, 13(2), 269–280. https://doi.org/10.1007/s12403-020-00381-6 Strawn, D. G., & Hettiarachchi, G. M. (2021). Fifty years of articles in JEQ on trace elements in the environment and future outlook. Journal of Environmental Quality, 50(6), 1266–1281. https://doi.org/10.1002/jeq2.20296 Swiatkowska, I., Martin, N., & Hart, A. J. (2019). Blood titanium level as a biomarker of orthopaedic implant wear. Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS), 53, 120–128. https://doi.org/10.1016/j.jtemb.2019.02.013 Talio, M. C., Luconi, M. O., Masi, A. N., & Fernández, L. P. (2010). Cadmium monitoring in saliva and urine as indicator of smoking addiction. The Science of the Total Environment, 408(16), 3125–3132. https://doi.org/10.1016/ j.scitotenv.2010.03.052 Tchounwou, P. B., Yedjou, C. G., Patlolla, A. K., & Sutton, D. J. (2012). Heavy metal toxicity and the environment. Experientia Supplementum (2012), 101, 133–164. https://doi.org/10.1007/978-3-7643-8340-4_6 Thanakun, S., Watanabe, H., Thaweboon, S., & Izumi, Y. (2013). An effective technique for the processing of saliva for the analysis of leptin and adiponectin. Peptides, 47, 60–65. https://doi.org/10.1016/j.peptides.2013. 06.010 Thomas, R. G., & Archuleta, R. F. (1980). Titanium retention in mice. Toxicology Letters, 6(2), 115–118. https://doi.org/10.1016/0378-4274(80)90177-0 Toone, R. J., Peacock, O. J., Smith, A. A., Thompson, D., Drawer, S., Cook, C., & Stokes, K. A. (2013). Measurement of steroid hormones in saliva: Effects of sample storage condition. Scandinavian Journal of Clinical and Laboratory Investigation, 73(8), 615-621. https://doi.org/10.3109/00365513.2013.835862 Wang, D., Du, X., & Zheng, W. (2008). Alteration of saliva and serum concentrations of manganese, copper, zinc, cadmium and lead among career welders. Toxicology Letters, 176(1), 40–47. https://doi.org/10.1016/j.toxlet. 2007.10.003 Wang, D., Shimoda, Y., Wang, S., Wang, Z., Liu, J., Liu, X., Jin, H., Gao, F., Tong, J., Yamanaka, K., Zhang, J., & An, Y. (2017). Total arsenic and speciation analysis of saliva and urine samples from individuals living in a chronic arsenicosis area in China. Environmental Health and Preventive Medicine, 22(1), 45. https://doi.org/10.1186/s12199-017-0652-5 Wang, M., Chen, Z., Song, W., Hong, D., Huang, L., & Li, Y. (2021). A review on cadmium exposure in the population and intervention strategies against cadmium toxicity. Bulletin of Environmental Contamination and Toxicology, 106(1), 65–74. https://doi.org/10.1007/s00128-020-03088-1 Watanabe, K., Tanaka, T., Shigemi, T., Hayashida, Y., & Maki, K. (2009). Mn and Cu concentrations in mixed saliva of elementary school children in relation to sex, age, and dental caries. Journal of Trace Elements in Medicine and Biology: Organ of the Society for Minerals and Trace Elements (GMS), 23(2), 93–99. https://doi.org/10.1016/j.jtemb.2009.01.003 Wilschefski, S. C., & Baxter, M. R. (2019). Inductively coupled plasma mass spectrometry: introduction to analytical aspects. The Clinical Biochemist. Reviews, 40(3), 115–133. https://doi.org/10.33176/AACB-19-00024 Wolff, A., Begleiter, A., & Moskona, D. (1997). A novel system of human submandibular/sublingual saliva collection. Journal of Dental Research, 76(11), 1782-1786. Zoroddu, M. A., Aaseth, J., Crisponi, G., Medici, S., Peana, M., & Nurchi, V. M. (2019). The essential metals for humans: a brief overview. Journal of Inorganic Biochemistry, 195, 120–129. https://doi.org/10.1016/j.jinorgbio.2019.03.013 | - |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90254 | - |
dc.description.abstract | 生物偵測可反映個人在採樣當下的身體內金屬暴露負擔。而唾液樣本採樣簡單、便宜且侵入性低,具有作為生物偵測工具的潛在價值,但採樣方法、樣品前處理和分析儀器皆可能影響唾液樣本的分析結果。先前研究使用的唾液分析方法並不一致,且較少探討使用唾液樣本進行人體內金屬暴露生物偵測的效能。
本研究的目的分為兩部分。第一,開發並驗證一種使用感應耦合電漿質譜儀(inductively coupled plasma mass spectrometry)檢測人體唾液中鈦、鉻、砷、鎘和鉛的方法,並評估不同的樣本前處理方式對金屬濃度分析結果的影響,以優化分析方法。第二,招募20名健康成年志願者為受試者,並使用上述新開發的方法來測定人類唾液中的金屬濃度,同時利用問卷調查受測者的人口學、生活習慣、飲食頻率及口腔衛生相關的資料。 分析唾液樣本金屬濃度的前處理方法,首先使用人工唾液作為檢測唾液中金屬濃度的檢量線基質。唾液樣本以3500 rpm(≅1000 xg)離心10分鐘,取上清液後保存於4℃冰箱,並於5天內分析完。分析前,每個唾液上清液樣本以1%硝酸稀釋5倍,充分混合及過濾後進行金屬測定。該方法在測定鈦、鉻、砷、鎘和鉛的準確度分別為84.0%、102.7%、107.8%、116.3%、117.8%;且重複性及再現性皆小於8%。根據上述新開發方法所測定的受測者唾液中鈦、鉻、砷、鎘和鉛的平均濃度分別為140.2 ± 34.1 µg/L、0.21 ± 0.14 µg/L、0.16 ± 0.06 µg/L、0.03 ± 0.03 µg/L、0.85 ± 1.14 µg/L。此外,在兩小時內採樣五次的樣本分析結果發現,唾液中金屬平均濃度非常相近,顯示不同時點採樣的唾液中金屬濃度穩定。 本研究開發的方法僅需要簡單的樣品前處理,可準確地測量唾液中金屬濃度,並期許可作為人體暴露於金屬後之健康風險評估的重要工具之一。 | zh_TW |
dc.description.abstract | Biomonitoring could reflect individual's current body burden of metal exposure. Saliva sampling is simple, inexpensive and non-invasive, leading it a valuable medium for the assessment of human exposure. Unfortunately, the methods for saliva sampling, preparations, and analysis varied across previous studies, which might affect the analytical results. However, limited research was conducted to study the efficacy of using saliva samples to monitor human exposure to metals.
The purposes of this study were two aspects. The first was to develop and validate an analytical method for the determination of titanium, chromium, arsenic, cadmium, and lead in human saliva using inductively coupled plasma mass spectrometry (ICP-MS). Tests were performed to evaluate the effects of sample preparation procedures on the measurement results of salivary metal concentrations to optimize the analytical method. Second, 20 healthy adult subjects were recruited for saliva collection, and the newly developed method mentioned above was applied to determine the concentrations of metals in the saliva samples. Meanwhile, a structured questionnaire was administered to survey the study subjects' demographic information, lifestyle, food consumption frequency, and oral hygiene. The concluded preparation procedures for the analysis of the study metals in saliva samples are as follows. Artificial saliva was applied for matrix control to establish the calibration curves. The saliva samples were first centrifuged at 3500 rpm (≅1000 xg) for 10 minutes, and then the supernatant of saliva was stored in a 4°C refrigerator and analyzed within 5 days after sampling. Each saliva supernatant sample was diluted 5 times in volume with 1% nitric acid, vortexed, and filtered prior to metal measurements. The measurement accuracy of this method for titanium, chromium, arsenic, cadmium, and lead was 84.0%, 102.7%, 107.8%, 116.3%, and 117.8%, respectively. And the precision and reproducibility were both less than 8%. With the newly developed method mentioned above, the average concentrations of salivary titanium, chromium, arsenic, cadmium, and lead in the saliva of the study subjects were determined as 140.2 µg/L, 0.21 µg/L, 0.16 µg/L, 0.03 µg/L, and 0.85 µg/L, respectively. In addition, the analysis results show that the average concentrations of these study metals in the 5 saliva samples collected in sequence within a two-hour period were very close. The method developed in this study requires only simple and reliable sample preparation procedures to accurately determine metal concentrations in saliva. This newly developed method is expected to be used as part of risk assessment tools for human exposure to metals. | en |
dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-09-25T16:07:11Z No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2023-09-25T16:07:11Z (GMT). No. of bitstreams: 0 | en |
dc.description.tableofcontents | 中文摘要 i
Abstract ii Contents iv List of Figures vii List of Tables viii Chapter 1 Introduction 1 1.1 Background 1 1.2 Study aims 3 1.3 Study framework 4 Chapter 2 Literature Review 6 2.1 Metal exposures and the health effects 6 2.1.1 Titanium 6 2.1.2 Chromium 7 2.1.3 Arsenic 9 2.1.4 Cadmium 10 2.1.5 Lead 12 2.2 Potential factors affecting metal concentrations in saliva 13 2.2.1 Saliva composition 13 2.2.2 Individual factors 16 2.2.3 Sample collection method 17 2.2.4 Sample preparation and analysis 20 2.3 Saliva as a biomonitoring media 23 2.3.1 Metal concentrations in saliva 23 2.3.2 The correlations between metal exposure and metal levels in saliva and other biological media 33 Chapter 3 Materials and Methods 38 3.1 Method validation 38 3.1.1 Saliva sample collection 38 3.1.2 Evaluation on the effect of sample preparation 39 3.2 Field study 45 3.2.1 Study subjects 45 3.2.2 Questionnaire 45 3.2.3 Study subject’s saliva sample collection 46 3.2.4 Preparation of calibration curves 48 3.2.5 Saliva sample preparation 48 3.3 Chemicals and reagents 49 3.4 Instrument analysis 49 3.5 Quality assessment and quality control 51 3.6 Statistical analysis 53 Chapter 4 Results 55 4.1 Sample preparation 55 4.1.1 Calibration curve and filtration 55 4.1.2 Centrifugation 58 4.1.3 Dilution 61 4.1.4 Storage 68 4.2 Study subjects’ characteristics 70 4.2.1 Socio-demographics 70 4.2.2 Lifestyle 71 4.2.3 Frequency of food consumption 73 4.2.4 Oral hygiene 75 4.3 The distribution of salivary metal concentrations 77 4.3.1 Metal concentrations in saliva samples 77 4.3.2 Metal concentration distributions of saliva samples collected at different sampling times 78 Chapter 5 Discussions 84 5.1 Effects of different sample preparation conditions on the determination of metal concentrations in saliva 84 5.2 The distribution of salivary metal concentrations of the study subjects 93 5.2.1 Comparison of metal concentration distributions among saliva samples between different studies 93 5.2.2 Distributions of metal concentrations in saliva samples collected in a short-time period of sampling 99 Chapter 6 Conclusions 103 References 105 Appendix 1 116 | - |
dc.language.iso | en | - |
dc.title | 檢測人體唾液鈦、鉻、砷、鎘、鉛之最佳化分析方法探討 | zh_TW |
dc.title | Optimization of an Analytical Method for the Determination of Titanium, Chromium, Arsenic, Cadmium and Lead in Saliva | en |
dc.type | Thesis | - |
dc.date.schoolyear | 111-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 蔡詩偉;簡伶朱 | zh_TW |
dc.contributor.oralexamcommittee | Shih-Wei Tsai;Ling-Chu Chien | en |
dc.subject.keyword | 鈦,鉻,砷,鎘,鉛,唾液,感應耦合電漿質譜儀, | zh_TW |
dc.subject.keyword | titanium,chromium,arsenic,cadmium,lead,saliva,inductively coupled plasma mass spectrometry, | en |
dc.relation.page | 120 | - |
dc.identifier.doi | 10.6342/NTU202302889 | - |
dc.rights.note | 同意授權(限校園內公開) | - |
dc.date.accepted | 2023-08-08 | - |
dc.contributor.author-college | 公共衛生學院 | - |
dc.contributor.author-dept | 環境與職業健康科學研究所 | - |
顯示於系所單位: | 環境與職業健康科學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-111-2.pdf 目前未授權公開取用 | 2.05 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。