請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9003完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 閔明源(MIN-YUAN MIN) | |
| dc.contributor.author | Hui Chen | en |
| dc.contributor.author | 陳慧 | zh_TW |
| dc.date.accessioned | 2021-05-20T20:06:17Z | - |
| dc.date.available | 2011-08-22 | |
| dc.date.available | 2021-05-20T20:06:17Z | - |
| dc.date.copyright | 2011-08-22 | |
| dc.date.issued | 2011 | |
| dc.date.submitted | 2011-08-15 | |
| dc.identifier.citation | Accili EA, Proenza C, Baruscotti M, DiFrancesco D (2002) From funny current to HCN channels: 20 years of excitation. News Physiol. Sci. 17: 32–37.
Akins PT and McCleskey EW (1996) Characterization of potassium currents in adult rat sensory neurons and modulation by opioids and cyclic AMP. Neuroscience 56: 759-769. Augustine JR (1996) Circuitry and functional aspects of the insular lobe in primates including humans. Brain Res Rev 22: 229–44. Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B. (1998) PIP2 and PIP as determi-nants for ATP inhibition of KATP channels. Science 282: 1141–1144. Beaumont V, Zhong N, Froemke RC, Ball RW, Zucker RS (2002) Temporal synaptic tagging by I(h) activation and actin: involvement in long-term facilitation and cAMP-induced synaptic enhancement. Neuron 33: 601–613. Beaumont V, Zucker RS (2000) Enhancement of synaptic transmission by cyclic AMP modulation of presynaptic Ih channels. Nat. Neurosci. 3: 133–141. Berger T, Larkum ME, Luscher HR (2001) High I(h) channel density in the distal apical dendrite of layer V pyramidal cells increases bidirectional attenuation of EPSPs. J. Neurophysiol. 85: 855–868. Bhave G, Zhu W, Wang H, et al (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35: 721-731. Biel M, Wahl-Schott C, Michalakis S, Zong X (2009) Hyperpolarization-activated cation channels: from genes to function. Physiol Rev 89: 847-885. Bird GC, Lash LL, Han JS, Zou X, Willis WD, Neugebauer V (2005) Protein kinase A-dependent enhanced NMDA receptor function in pain-related synaptic plasticity in rat amygdala neurones. J Physiol 564: 907-921. Brown H, DiFrancesco D (1980) Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrialnode. J. Physiol. (Lond) 308: 331–351. Capogna M, McKinney RA, O’Connor V, Ga‥hwiler BH, Thompson SM (1997) Ca2+ or Sr 2+ partially rescues synaptic transmission in hippocampal cultures treated with botulinum toxin A and C, but not tetanus toxin. J Neurosci 17: 7190 –7202. Carlson JD, Heinricher M (2007) Sensitization of Pain-Modulating Neurons in the Rostral Ventromedial Medulla Following Peripheral Nerve Injury. J. Neurosci 27: 13222-13231. Carrasquillo Y, Gereau RW (2007) Activation of the extracellular signal regulated kinase in the amygdala modulates pain perception. J Neurosci. 27: 1543–1551. Cerbai E, Pino R, Sartiani L, Mugelli A (1999) Influence of postnataldevelopmenton I(f) occurrence and properties in neonatal rat ventricular myocytes. Cardiovasc Res 42: 416–423. Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Velumian AA, Butler MP, Brown SM, Dubin AE (2003) Neuronal hyperpolarizationactivated pacemaker channels drive neuropathic pain, J. Neurosci. 23: 1169–1178. Cheng SJ,Chen CC, Yang HW, Chang YT, Bai SW, Chen CC, Yen CT and Min MY (2011) Role of Extracellular Signal-Regulated Kinase in Synaptic Transmission and Plasticity of a Nociceptive Input on Capsular Central Amygdaloid Neurons in Normal and Acid-Induced Muscle Pain Mice. J Neurosci. 31(6): 2258 –2270 Ciocchi S, Herry C, Grenier F, Wolff SB, Letzkus JJ, Vlachos I, Ehrlich I, Sprengel R, Deisseroth K, Stadler MB, Muller C, Luthi A (2010) Encoding of conditioned fear in central amygdala circuits. Nature 468: 277–282 dimension of pain. Science 288:1769–72. Everill B, Rizzo MA, and Kocsis JD (1998) Morphologically identified cutaneous afferent DRG neurons express three different potassium currents in varying proportions. J Neurophysiol 79: 1814-1824. Fogle KJ, Lyashchenko AK, Turbendian HK, Tibbs GR (2007) HCN pacemaker channel activation is controlled by acidic lipids downstream of diacylglycerol kinase and phospholipase A2. J Neurosci 27: 2802–2814. Francis HW, Scott JC, Manis PB (2002) Protein kinase C mediates potentiation of synaptic transmission by phorbol ester at parallel fibers in the dorsal cochlear nucleus. Brain Res 951: 9 –22. Gauriau C, Bernard J-F (2002) Pain pathways and parabrachial circuits in the rat. Exp Physiol 87:251–258. Gold MS, Shuster MJ, and Levine JD (1996) Characterization of six voltage-gated K+ currents in adult rat sensory neurons. J Neurophysiol 75: 2629-2646 Herbert JM, Augereau JM, Gieye J, Maffrand JP (1990) Chelerythrine is a potent and specific inhibitor of protein kinase C. Biochem Biophys Res Commun. 172: 993-999. Hori T, Takai Y, Takahashi T (1999) Presynaptic mechanism for phorbol ester-induced synaptic potentiation. J Neurosci 19: 7262–7267. Hu HJ, Alter BJ, Carrasquillo Y, Qiu CS, Gereau RW (2007) Metabotropic glutamate receptor 5 modulates nociceptive plasticity via extracellular signal-regulated kinase-Kv4.2 signaling in spinal cord dorsal horn neurons. Journal of Neuroscience 27(48): 13181-91. Hu HJ, Carrasquillo Y, Karim F, Jung WE, Nerbonne JM, Schwarz TL, and Gereau RW. The Kv4.2 potassium channel subunit is required for pain plasticity. Neuron 2006 50: 89-100. Hu HJ, Gereau RW (2003b) Integrates PKA and PKC signaling in superficial dorsal horn neurons. II. Modulation of neuronal excitability. J Neurophysiol 90:1680–8. Hu HJ, Glauner KS and Gereau RW(2003a) ERK integrates PKA and PKC signaling in superficial dorsal dorn neurons. I. Modulation of A-type K+ currents, J. Neurophysiol. 90: 1671–1679 Huang CL, Feng S, Hilgemann DW (1998) Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by G. Nature 391: 803–806. Ikeda H, Heinke B, Ruscheweyh R, Sandkuhler J (2003) Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Science 299:1237-1240. Ikeda R, Takahashi Y, Inoue K, Kato F (2007) NMDA receptor-independent synaptic plasticity in the central amygdala in the rat model of neuropathic pain. Pain 127:161-172. Ji G, Fu Y, Ruppert KA, Neugebauer V (2007) Pain-related anxiety-like behavior in the hippocampus by phorbol esters. Nature 321:175–177. Ji G, Neugebauer V (2007) Differential effects of CRF1 and CRF2 receptor antagonists on pain-related sensitization of neurons in the central nucleus Ji RR, Strichartz G (2004) Cell Signaling and the Genesis of Neuropathic Pain. Sci. STKE: re14. Kolber BJ, Montana MC, Carrasquillo Y, Zhu J, Heinemann SF, Muglia L, and Gereau RW (2003) Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. Journal of Neuroscience 30: 8203-13. Latremoliere A, Woolf CJ (2010) Synaptic plasticity and central sensitization: author reply. J Pain11:801–3. Li W, Neugebauer V (2004) Block of NMDA and non-NMDA receptor activation results in reduced background and evoked activity of central amygdala neurons in a model of arthritic pain. Pain 2004;110:112–122. Li Z, Ji G, Neugebauer V: Mitochondrial reactive oxygen species are activated by mGluR5 through IP3 and activate ERK and PKA to increase excitability of amygdala neurons and pain behavior. J Neurosci 2011, 31: 1114-1127. Lou X, Korogod N, Brose N, Schneggenburger R (2008) Phorbol esters modulate spontaneous and Ca2_-evoked transmitter release via acting on both Munc13 and protein kinase C. J Neurosci 28:8257– 8267. Ludwig A, Zong X, Jeglitsch M, Hofmann F, Biel M (1998) A family of hyperpolarization-activated mammalian cation channels. Nature 393: 587–591. Lupica CR, Bell JA, HoffmanAF, Watson PL (2001) Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. J. Neurophysiol. 86: 261–268. Luthi A, McCormick DA (1998) Neuron. H-current: properties of a neuronal and network pacemaker. Vol. 21: 9-12. Magee JC (1998) Dendritic hypepolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. J. Neurosci. 18: 7613–7624. Malenka RC, Madison DV, Nicoll RA (1986) Potentiation of synaptic transmission requires CRF1 receptors in the amygdala. Mol Pain 3: 13–17. Malmberg AB, Chen C, Tonegawa S, Basbaum AI (1997) Preserved acute pain and reduced neuropathic pain in mice lacking PKCgamma. Science 278:279-283. Manning BH (1998) A lateralized deficit in morphine antinociception after unilateral inactivation of the central amygdala. J Neurosci 18:9453-9470. Manning BH, Mayer DJ (1995a) The central nucleus of the amygdala contributes to the production of morphine antinociception in the rat tail-flick test. J Neurosci 15: 8199-8213. Manning BH, Mayer DJ (1995b) The central nucleus of the amygdala contributes to the production of morphine antinociception in the formalin test. Pain 63:141-152. Manning BH, Merin NM, Meng ID, Amaral DG (2001) Reduction in opioid- and cannabinoid-induced antinociception in rhesus monkeys after bilateral lesions of the amygdaloid complex. J Neurosci 21:8238-8246. Mantyh PW ,Hunt SP(2004) Setting the tone: superficial dorsal horn projection neurons regulate pain sensitivity. Trends Neurosc 27:582–584. McFarlane S and Cooper E (1991) Kinetics and voltage dependence of A-type currents on neonatal rat sensory neurons. J Neurophysiol 66: 1380-1391, 1991. Montana MC, Cavallone LF, Stubbert KK, Stefanescu AD, Kharasch ED, and Gereau RW. (2003) The mGlu5 antagonist fenobam is analgesic and has improved in vivo selectivity as compared to the prototypical antagonist MPEP. Journal of Pharmacology and Experimental Therapeutics 330(3): 834-43 Neugebauer V (2006) Subcortical processing of nociceptive information: basal ganglia and amygdala. Clin Neurol 81: 141–158. Neugebauer V (2007) The amygdala: different pains, different mechanisms. Pain 127:1-2. Neugebauer V, Li W (2002) Processing of nociceptive mechanical and thermal information in central amygdala neurons with knee-joint input. J Neurophysiol 87:103-112. Neugebauer V, Li W, Bird GC, Bhave G, Gereau RW (2003) Synaptic plasticity in the amygdala in a model of arthritic pain: differential roles of metabotropic glutamate receptors 1 and 5. J Neurosci 23:52-63. Neugebauer V, Li W, Bird GC, Han JS (2004) The amygdala and persistent pain. Neuroscientist 10:221-234. Noma A, Irisawa H (1976) Membrane currents in the rabbit sinoatrialnode cell as studied by the double microelectrode method. Pflu‥ gers Arch 364: 45–52. Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B (2004) Functional conversion between A-type and delayed rectifier Kchannels by membrane lipids. Science 304: 265–270. Pape HC (1996) Queer current and pacemaker: the hyperpolarizationactivated cation current in neurons. Annu. Rev. Physiol. 58: 299–327. Parfitt KD, Madison DV (1993) Phorbol esters enhance synaptic transmission by a presynaptic, calcium-dependent mechanism in rat hippocampus. J Physiol 471:245–268. Poolos NP, Migliore M, Johnston D (2002) Pharmacological upregulation of h-channels reduces the excitability of pyramidal neuron dendrites. Nat. Neurosci. 5: 767–774. Price DD (2000) Psychological and neural mechanisms of the affective Qu J, Barbuti A, Protas L, Santoro B, Cohen IS, Robinson RB (2001) HCN2 overexpression in newborn and adult ventricular myocytes: distinct effects on gating and excitability. Circ Res 89: E8–14. Robinson RB, Siegelbaum SA (2003) Hyperpolarization-activated cation currents: from molecules to physiological function. Annu. Rev. Physiol. 65: 453–480. Robinson RB, Yu H, Chang F, Cohen IS (1997) Developmental change in the voltage-dependence of the pacemaker current, if, in rat ventricle cells. Pflu‥ gers Arch 433: 533–535. Santoro B, Liu DT, Yao H, Bartsch D, Kandel ER, Siegelbaum SA, Tibbs GR (1998) Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell 93: 717–729. Schrader LA, Birnbaum SG, Nadin BM, Ren Y, Bui D, Anderson AE, Sweatt JD (2006) ERK/MAPK regulates the Kv4.2 potassium channel by direct phosphorylation of the pore-forming subunit. Am J Physiol Cell Physiol 290:C852–C861. Shah MM, Anderson AE, Leung V, Lin X, Johnston D (2004) Seizureinduced plasticity of h channels in entorhinal cortical layer III pyramidal neurons. Neuron 44: 495–508. Shapira R, Silberberg SD, Ginsburg S, Rahamimoff R (1987) Activation of protein kinase Caugments evoked transmitter release. Nature 325:58–60. Shyng SL, Nichols CG (1998) Membrane phospholipid control of nucleotide sensitivity of KATP channels. Science 282: 1138–1141. Stefanacci L, Amaral DG (2000) Topographic organization of cortical inputs to the lateral nucleus of the macaque monkey amygdala: a retrograde tracing study. J Comp Neurol 421:52–79. Walker JM and Huang SM (2002) Cannabinoid analgesia, Pharmacol Ther 95: 127–135 Welie I, Hooft JA, Wadman WJ (2004) Homeostatic scaling of neuronal excitability by synaptic modulation of somatic hyperpolarization- activated Ih channels. Proc. Natl. Acad. Sci. 101: 5123–5128. Willis WD (2001) Role of Neurotransmitters in Sensitization of Pain Responses. Annals of the New York Academy of Sciences 933: 142–156. Womble MD, Moises HC (1993) Hyperpolarization-activated currents in neurons of the rat basolateral amygdale. J. Neurophysiol. 70: 2056–2065. Woolf CJ (1983) Evidence for a central component of post-injury pain hypersensitivity. Nature 306:686-688. Xu GY, Winston JH, Shenoy M (2006) Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol 291:G424–31. Yashpal K, Fisher K, Chabot JG, Coderre TJ (2001) Differential effects of NMDA and group I mGluR antagonists on both nociception and spinal cord protein kinase C translocation in the formalin test and a model of neuropathic pain in rats. Pain 94:17-29. Yashpal K, Pitcher GM, Parent A, Quirion R, Coderre TJ (1995) Noxious thermal and chemical stimulation induce increases in 3H-phorbol 12,13-dibutyrate binding in spinal cord dorsal horn as well as persistent pain and hyperalgesia, which is reduced by inhibition of protein kinase C. J Neurosci 15:3263-3272. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/9003 | - |
| dc.description.abstract | 杏仁體中央被核(CeAC)可接收經由杏仁體-旁臂核(PBA)路徑傳遞，來自腦幹及脊髓的痛覺訊息，同時也接收直接由脊髓投射上來的痛覺訊息，此核區被稱為「痛覺杏仁核」已將近十年，先前研究指出佛波醇12,13-乙酸酯(PDA)可顯著促進旁臂核到CeAC的神經傳導作用，且與細胞內部的胞外訊息傳遞激脢(ERK)有關，本研究使用全細胞紀錄電生理紀錄以及藥理方式探討ERK在調節CeAC神經細胞興奮性上所扮演的角色，給予短期PDA(蛋白激脢C之活化劑)可提高動作電位發生的頻率，然而給予長期PDA卻會降低其頻率；另外短期PDA也會增加Ih-current，但長期PDA則減緩其強度，此外，給予長期PDA也會延遲動作電位發生的時間，在給予蛋白激脢C(PKC)抑制劑－Chelerythrine與GF109203X之後，短期與長期的PDA反應都不復出現，給予U0126不會影響短期PDA帶來的反應，卻逆轉了長期PDA先前的反應情形，實驗結果顯示：(1)給予PDA會經由PKC—ERK路徑作用，在不同的時間條件下，調節CeAC的神經興奮性；(2)活化ERK加劇動作電位延遲發生的情形(A型鉀離子通道)。 | zh_TW |
| dc.description.abstract | The capsular central amygdaloid (CeAC) nucleus acquires nociceptive specific information from the brainstem and spinal cord via the parabrachio-amygdaloid (PBA) pain pathway as well as via direct projections from the spinal cord. It has been termed as “nociceptive amygdala” for almost a decade. Previous study indicated that application of phorbol 12,13-diacetate (PDA) caused marked enhancement of synaptic transmission of parabrachial input onto CeAC nucleus and the elevation of intracellular ERK was involved. In the present study, using patch-clamp technique and pharmacological methods, the role of ERK in regulating neuronal excitability of CeAC was examined. Short-term application of the PKC activator, PDA increased the number of action potentials whereas the long-term application decreased the spike number. Beside, short-term PDA enhanced the size of Ih current but long-term PDA downsized it. In the meanwhile, long-term application of PDA also increased the first spike latency. Protein Kinase C (PKC) inhibitors, Chelerythrine and GF109203X abolished the effect of PDA in both time-scales. Application of U0126 had no effect on short-term PDA however it reversed the effect caused by long term PDA application. The result suggested that (1) PKC—ERK pathway induced by PDA regulated input-output function of neuronal excitability of CeAC in different time-scales; (2) ERK activation enhanced the delay onset of action potential (stongly related to A-type potassium channel). | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T20:06:17Z (GMT). No. of bitstreams: 1 ntu-100-R97b41036-1.pdf: 2389564 bytes, checksum: 65f03bb48742ce75335329308807f19b (MD5) Previous issue date: 2011 | en |
| dc.description.tableofcontents | Contents
致謝……………………………………………………………………………………I 摘要………………………………………………….………………………………III ABSTRACT……...…………………………………………………………………..IV INTRDUCTION Capsular central amygdaloid nucleus and Nociception………………………………1 Central sensitization…………………………………………………………………...3 Objectives……………………………………………………………………………...6 MATERIALS AND METHODS Preparation of amygdala slices……………………………………………….……….8 Whole-cell Patch clamp recording…………………………………………………….9 Drug application……………………………………………………………………..10 Data and statistical analyses…………………………………………………………10 RESULTS Identification of Capsular Central amygdaloid neuron………...……………………12 PDA modulates input-output function of neuronal excitability in different time scales…………………………………………………………………………………13 Effect of Chelerythrine –PDA on capsular central amygdaloid neuron……………..16 Effect of GF109203X –PDA on capsular central amygdaloid neuron……………….18 Effect of U0126–PDA on capsular central amygdaloid neuron……………………...19 DISCUSSION PKC activation by PDA regulates the neuronal excitability in different time scale....21 ERK activation by PDA decreases neuronal excitability…………………………….23 REFERENCES……………………………………………………………………….27 FIGURES…………………………………………………………………………….35 | |
| dc.language.iso | en | |
| dc.title | ERK在杏仁體中央被核神經元細胞興奮性角色探討 | zh_TW |
| dc.title | Role of extracellular signal-regulated kinase in neuronal excitability of capsular central amygdaloid neurons | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 99-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 楊琇雯(XIU-WEN YANG),陳瑞芬(RUI-FEN CHEN) | |
| dc.subject.keyword | 中樞神經敏感化,神經興奮性,杏仁體,杏仁體中央被核,胞外訊息調節激脢,鉀離子通道,佛波酯,蛋白激脢C, | zh_TW |
| dc.subject.keyword | central sensitization,neuronal excitability,amygdale,ERK,potassium channel,PDA,PKC, | en |
| dc.relation.page | 64 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2011-08-16 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 動物學研究所 | zh_TW |
| 顯示於系所單位： | 動物學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-100-1.pdf | 2.33 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。