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標題: | 醫院廢水中三高用藥調查及以UV/Chlorine程序移除之研究 Detections of Three-Hypers Series Medicine in Hospital Wastewater and Their Removals with UV/Chlorine Processes |
作者: | 余姿蓉 Zih-Rong Yu |
指導教授: | 王根樹 Gen-Shuh Wang |
關鍵字: | 醫院廢水,高級氧化,UV/Chlorine,藥物及個人防護產品,三高用藥, hospital wastewater,advanced oxidation processes (AOPs),pharmaceuticals and personal care products (PPCPs),three-hyper series medicine,UV/Chlorine, |
出版年 : | 2023 |
學位: | 碩士 |
摘要: | 水是生活中不可或缺的資源,但在現今,水資源的獲取變得越來越困難。由於台灣地形狹長且人口密集等原因,水資源的獲得及保存變得困難,而單一個人可使用的水資源亦相對匱乏。此外,使用過的廢污水經處理後再次排放到環境水體中,其中的污染物可能對環境生態造成影響。
水處理的過程可分為自來水處理和廢水處理,這些處理程序的主要目標是確保水質的安全性。除了常規的水質監測外,隨著檢測技術和儀器的進步,新興的污染物也開始在不同的水體中被檢測到。藥物及個人防護產品(PPCPs)是新興污染物的一環,其流佈與人為活動有關。台灣目前已邁入高齡化社會,隨之而來是逐漸盛行的慢性病問題。高血壓、高血脂、高血糖則是台灣最廣為認知的三大慢性病,三者俗稱為「三高」,一直是大眾所關注的議題。而治療三高所需的三高用藥也在台灣被廣泛使用,根據健保署藥物使用資料,這些藥物近年被大量使用,並可能在水體中被檢測出來。這些藥物包含治療高血壓的beta-blockers類藥物(atenolol, metoprolol, propranolol)、治療高血脂的fibrates類藥物(bezafibrate, gemfibrozil, fenofibrate)以及治療高血糖的gliclazide。 傳統的廢水處理方法對於移除民生廢水或醫院廢水中PPCPs的效率並不一致。本研究的目的在調查醫院廢水中三高用藥的濃度,使用UV/Chlorine處理方式了解高級氧化處理的去除效率,並比較傳統處理與高級氧化處理(UV/Chlorine)對三高用藥的移除效率。 此研究調查了三間醫院沸水中的三高用藥。研究結果顯示,醫院廢水處理廠原廢水、二級處理水和放流水中,原廢水中的藥物濃度最高,並可在原廢水中測出Atenolol、Metoprolol、Propranolol、Bezafibrate、Gemfibrozil、Fenofibrate和Gliclazide這七種藥物。透過一級和二級處理後,大多數的三高用藥皆有降解,而降解百分比根據原廢水及二級處理水中濃度介於至-900%至100%,但大多數藥物在二次處理水仍可以被檢出。而在二級處理水與加氯消毒後放流水的濃度比較中,兩者濃度並無太大差異。將二級處理水進行高級氧化處理,降解污染物,可觀察到加氯的濃度以及照UV光的反應時間會影響三高用藥的降解效率。並且在此研究的實驗中,氯在UV/Chlorine處理的反應終點幾乎耗盡。在消毒副產物的生成上,發現THMs、HAAs、HANs等消毒副產物濃度有少量增加,但與單純加氯相較並無太大差異。 隨著加氯的濃度增加以及反應時間增加,PPCPs移除的效率也隨之增加。在醫院廢水中,經過UV/Chlorine處理的三高用藥與未處理前比較下,降解率介於14%至99%之間。這其中beta-blockers類和gliclazide降解效率較好,fibrates類之降解效率相對較低。不同間醫院廢水間,因為有機污染物濃度以及起始pH值不同,其降解效率也有很大的差異。 Water is an essential resource, but access to water is becoming increasingly difficult. Because of Taiwan's long and narrow terrain and dense population, it is challenging to preserve water resources, and the water resources that a single person can use are relatively scarce. Moreover, the used wastewater will be discharged into the receiving environmental water after treatment, and the contaminants in the effluent may affect the environmental ecology and human health. Water treatment can be divided into drinking water treatment and wastewater treatment. In addition to general water quality monitoring, emerging contaminants have begun to be detected in different water bodies with the improvements of analytical technologies and instruments. Among the pharmaceutical and personal care products (PPCPs), hypertension, hyperlipidemia, and diabetes are common chronic diseases in the elderly in Taiwan, and the corresponding amount of therapeutic drugs used are also considerable when compared with other medicines prescribed. In this study, seven commonly used medicines for these diseases, including beta-blockers (atenolol, metoprolol, propranolol), fibrates (bezafibrate, gemfibrozil, fenofibrate), and gliclazide were assessed for their presences and removals in hospital wastewater; these medicines have been used in high amounts in Taiwan and may cause potential health hazards when presented in environmental waters, such as bezafibrate may induce the proliferation of peroxisomes in rodent livers. To effectively remove PPCPs, advanced oxidation processes (AOPs) are classified as available treatment technology for PPCPs. AOPs have been shown effective for degrading refractory organic contaminants, reducing disinfection by-product formation, rapid reaction rates, and promoting water reuses. This study determined the concentrations of three-hypers series medicine in three hospital wastewater, the PPCPs removal efficiencies after conventional wastewater treatments were assessed, and UV/chlorine process was adopted to assess its ability to remove PPCPs from hospital wastewater. The results of the study showed that, among the three investigated hospital wastewater samples (raw wastewater, secondary treatment water, and effluents), the PPCP concentration in the raw wastewater was the highest, and atenolol, metoprolol, propranolol, bezafibrate, gemfibrozil, fenofibrate, and gliclazide could be detected in the raw wastewater. After primary and secondary treatment, most of the three-hypers series medicine are degraded, and the percentage degradation was -900% to 100% according to the PPCP concentrations of the raw wastewater and the post secondary treatment water. However, most of the PPCPs were still left in the post secondary treatment water. In comparing the concentration of the secondary treated water and the effluents after chlorination, there was not apparent difference between their concentrations. The post secondary treatment water was subjected to an advanced oxidation treatment to degrade contaminants. It can be observed that the concentration of chlorine and the reaction time of UV irradiation will affect the degradation efficiency of the three high drugs. Moreover, in this study, the chlorine was almost consumed at the end of the reaction. In terms of the generation of disinfection by-products (DBPs), it was found that THMs, HAAs, and HANs increased slightly, but there was no significant difference when compared to the DBPs after simple chlorination. As the concentration of chlorine added and the reaction time increased, the removal efficiency also increased. In hospital wastewater, the degradation rate of the UV/Chlorine-treated three-high drug was between 14 % and 100 % when compared with that before treatment. Most of the beta-blockers and gliclazide can be thoroughly degraded, and the degradation efficiency for fibrates were relatively low in. The degradation efficiency of wastewater from different hospitals varies significantly due to the different concentrations of organic pollutants and initial pH. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/89821 |
DOI: | 10.6342/NTU202303773 |
全文授權: | 同意授權(限校園內公開) |
顯示於系所單位: | 環境與職業健康科學研究所 |
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