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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉扶東 | zh_TW |
| dc.contributor.advisor | Fu-Tong Liu | en |
| dc.contributor.author | 林峰任 | zh_TW |
| dc.contributor.author | Feng-Jen Lin | en |
| dc.date.accessioned | 2023-09-22T16:12:56Z | - |
| dc.date.available | 2023-11-09 | - |
| dc.date.copyright | 2023-09-22 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-08-04 | - |
| dc.identifier.citation | Alestas, T., Ganceviciene, R., Fimmel, S., Muller-Decker, K., & Zouboulis, C. C. (2006). Enzymes involved in the biosynthesis of leukotriene B4 and prostaglandin E2 are active in sebaceous glands. J Mol Med (Berl), 84(1), 75-87. https://doi.org/10.1007/s00109-005-0715-8
Amerio, P., Frezzolini, A., Feliciani, C., Verdolini, R., Teofoli, P., De Pita, O., & Puddu, P. (2003). Eotaxins and CCR3 receptor in inflammatory and allergic skin diseases: therapeutical implications. Curr Drug Targets Inflamm Allergy, 2(1), 81-94. https://doi.org/10.2174/1568010033344480 Arensdorf, A. M., & Rutkowski, D. T. (2013). Endoplasmic reticulum stress impairs IL-4/IL-13 signaling through C/EBPbeta-mediated transcriptional suppression. J Cell Sci, 126(Pt 17), 4026-4036. https://doi.org/10.1242/jcs.130757 Banfer, S., Schneider, D., Dewes, J., Strauss, M. T., Freibert, S. A., Heimerl, T., Maier, U. G., Elsasser, H. P., Jungmann, R., & Jacob, R. (2018). Molecular mechanism to recruit galectin-3 into multivesicular bodies for polarized exosomal secretion. Proc Natl Acad Sci U S A, 115(19), E4396-E4405. https://doi.org/10.1073/pnas.1718921115 Blauer, M., Vaalasti, A., Pauli, S. L., Ylikomi, T., Joensuu, T., & Tuohimaa, P. (1991). Location of androgen receptor in human skin. J Invest Dermatol, 97(2), 264-268. https://doi.org/10.1111/1523-1747.ep12480373 Blume-Peytavi, U., Chen, W., Djemadji, N., Zouboulis, C. C., & Goerdt, S. (1997). Eosinophilic pustular folliculitis (Ofuji's disease). J Am Acad Dermatol, 37(2 Pt 1), 259-262. https://doi.org/10.1016/s0190-9622(97)80135-1 Bolger, A. M., Lohse, M., & Usadel, B. (2014). Trimmomatic: a flexible trimmer for Illumina sequence data. Bioinformatics, 30(15), 2114-2120. https://doi.org/10.1093/bioinformatics/btu170 Bu, J., Wu, Y., Cai, X., Jiang, N., Jeyalatha, M. V., Yu, J., He, X., He, H., Guo, Y., Zhang, M., Quantock, A. J., Liu, Z., & Li, W. (2019). Hyperlipidemia induces meibomian gland dysfunction. Ocul Surf, 17(4), 777-786. https://doi.org/10.1016/j.jtos.2019.06.002 Chang, H., Wang, Y., Wu, H., & Nathans, J. (2014). Flat mount imaging of mouse skin and its application to the analysis of hair follicle patterning and sensory axon morphology. J Vis Exp(88), e51749. https://doi.org/10.3791/51749 Chen, H. L., Chiang, P. C., Lo, C. H., Lo, Y. H., Hsu, D. K., Chen, H. Y., & Liu, F. T. (2016). Galectin-7 Regulates Keratinocyte Proliferation and Differentiation through JNK-miR-203-p63 Signaling. J Invest Dermatol, 136(1), 182-191. https://doi.org/10.1038/JID.2015.366 Chen, H. L., Lo, C. H., Huang, C. C., Lu, M. P., Hu, P. Y., Chen, C. S., Chueh, D. Y., Chen, P., Lin, T. N., Lo, Y. H., Hsiao, Y. P., Hsu, D. K., & Liu, F. T. (2021). Galectin-7 downregulation in lesional keratinocytes contributes to enhanced IL-17A signaling and skin pathology in psoriasis. J Clin Invest, 131(1). https://doi.org/10.1172/JCI130740 Chen, L., Zhang, J., Zou, Y., Wang, F., Li, J., Sun, F., Luo, X., Zhang, M., Guo, Y., Yu, Q., Yang, P., Zhou, Q., Chen, Z., Zhang, H., Gong, Q., Zhao, J., Eizirik, D. L., Zhou, Z., Xiong, F., . . . Wang, C. Y. (2021). Kdm2a deficiency in macrophages enhances thermogenesis to protect mice against HFD-induced obesity by enhancing H3K36me2 at the Pparg locus. Cell Death Differ, 28(6), 1880-1899. https://doi.org/10.1038/s41418-020-00714-7 Chen, W., Yang, C. C., Sheu, H. M., Seltmann, H., & Zouboulis, C. C. (2003). Expression of peroxisome proliferator-activated receptor and CCAAT/enhancer binding protein transcription factors in cultured human sebocytes. J Invest Dermatol, 121(3), 441-447. https://doi.org/10.1046/j.1523-1747.2003.12411.x Chitraju, C., Mejhert, N., Haas, J. T., Diaz-Ramirez, L. G., Grueter, C. A., Imbriglio, J. E., Pinto, S., Koliwad, S. K., Walther, T. C., & Farese, R. V., Jr. (2017). Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis. Cell Metab, 26(2), 407-418 e403. https://doi.org/10.1016/j.cmet.2017.07.012 Choi, J. J., Park, M. Y., Lee, H. J., Yoon, D. Y., Lim, Y., Hyun, J. W., Zouboulis, C. C., & Jin, M. (2012). TNF-alpha increases lipogenesis via JNK and PI3K/Akt pathways in SZ95 human sebocytes. J Dermatol Sci, 65(3), 179-188. https://doi.org/10.1016/j.jdermsci.2011.11.005 Coelho, A. L., Hogaboam, C. M., & Kunkel, S. L. (2005). Chemokines provide the sustained inflammatory bridge between innate and acquired immunity. Cytokine Growth Factor Rev, 16(6), 553-560. https://doi.org/10.1016/j.cytogfr.2005.03.004 Cruikshank, W. W., Kornfeld, H., & Center, D. M. (2000). Interleukin-16. J Leukoc Biol, 67(6), 757-766. https://doi.org/10.1002/jlb.67.6.757 Cummings, R. D., Liu, F. T., Rabinovich, G. A., Stowell, S. R., & Vasta, G. R. (2022). Galectins. In th, A. Varki, R. D. Cummings, J. D. Esko, P. Stanley, G. W. Hart, M. Aebi, D. Mohnen, T. Kinoshita, N. H. Packer, J. H. Prestegard, R. L. Schnaar, & P. H. Seeberger (Eds.), Essentials of Glycobiology (pp. 491-504). https://doi.org/10.1101/glycobiology.4e.36 Daniel, B., Nagy, G., Czimmerer, Z., Horvath, A., Hammers, D. W., Cuaranta-Monroy, I., Poliska, S., Tzerpos, P., Kolostyak, Z., Hays, T. T., Patsalos, A., Houtman, R., Sauer, S., Francois-Deleuze, J., Rastinejad, F., Balint, B. L., Sweeney, H. L., & Nagy, L. (2018). The Nuclear Receptor PPARgamma Controls Progressive Macrophage Polarization as a Ligand-Insensitive Epigenomic Ratchet of Transcriptional Memory. Immunity, 49(4), 615-626 e616. https://doi.org/10.1016/j.immuni.2018.09.005 Daugherty, B. L., Siciliano, S. J., DeMartino, J. A., Malkowitz, L., Sirotina, A., & Springer, M. S. (1996). Cloning, expression, and characterization of the human eosinophil eotaxin receptor. J Exp Med, 183(5), 2349-2354. https://doi.org/10.1084/jem.183.5.2349 de Vries, J. E., & Zurawski, G. (1995). Immunoregulatory properties of IL-13: its potential role in atopic disease. Int Arch Allergy Immunol, 106(3), 175-179. https://doi.org/10.1159/000236842 Di Nardo, A., Wertz, P., Giannetti, A., & Seidenari, S. (1998). Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol, 78(1), 27-30. https://doi.org/10.1080/00015559850135788 Downie, M. M., Sanders, D. A., Maier, L. M., Stock, D. M., & Kealey, T. (2004). Peroxisome proliferator-activated receptor and farnesoid X receptor ligands differentially regulate sebaceous differentiation in human sebaceous gland organ cultures in vitro. Br J Dermatol, 151(4), 766-775. https://doi.org/10.1111/j.1365-2133.2004.06171.x Dozsa, A., Dezso, B., Toth, B. I., Bacsi, A., Poliska, S., Camera, E., Picardo, M., Zouboulis, C. C., Biro, T., Schmitz, G., Liebisch, G., Ruhl, R., Remenyik, E., & Nagy, L. (2014). PPARgamma-mediated and arachidonic acid-dependent signaling is involved in differentiation and lipid production of human sebocytes. J Invest Dermatol, 134(4), 910-920. https://doi.org/10.1038/jid.2013.413 Fischer, H., Fumicz, J., Rossiter, H., Napirei, M., Buchberger, M., Tschachler, E., & Eckhart, L. (2017). Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death. J Invest Dermatol, 137(3), 587-594. https://doi.org/10.1016/j.jid.2016.10.017 Fluhr, J. W., Mao-Qiang, M., Brown, B. E., Wertz, P. W., Crumrine, D., Sundberg, J. P., Feingold, K. R., & Elias, P. M. (2003). Glycerol regulates stratum corneum hydration in sebaceous gland deficient (asebia) mice. J Invest Dermatol, 120(5), 728-737. https://doi.org/10.1046/j.1523-1747.2003.12134.x Fonseca, S. G., Fukuma, M., Lipson, K. L., Nguyen, L. X., Allen, J. R., Oka, Y., & Urano, F. (2005). WFS1 is a novel component of the unfolded protein response and maintains homeostasis of the endoplasmic reticulum in pancreatic beta-cells. J Biol Chem, 280(47), 39609-39615. https://doi.org/10.1074/jbc.M507426200 Galli, S. J., Grimbaldeston, M., & Tsai, M. (2008). Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol, 8(6), 478-486. https://doi.org/10.1038/nri2327 Garrigue, J. L., Nicolas, J. F., Fraginals, R., Benezra, C., Bour, H., & Schmitt, D. (1994). Optimization of the mouse ear swelling test for in vivo and in vitro studies of weak contact sensitizers. Contact Dermatitis, 30(4), 231-237. https://doi.org/10.1111/j.1600-0536.1994.tb00650.x Graber, P., Gretener, D., Herren, S., Aubry, J. P., Elson, G., Poudrier, J., Lecoanet-Henchoz, S., Alouani, S., Losberger, C., Bonnefoy, J. Y., Kosco-Vilbois, M. H., & Gauchat, J. F. (1998). The distribution of IL-13 receptor alpha1 expression on B cells, T cells and monocytes and its regulation by IL-13 and IL-4. Eur J Immunol, 28(12), 4286-4298. https://doi.org/10.1002/(SICI)1521-4141(199812)28:12<4286::AID-IMMU4286>3.0.CO;2-H Grunig, G., Warnock, M., Wakil, A. E., Venkayya, R., Brombacher, F., Rennick, D. M., Sheppard, D., Mohrs, M., Donaldson, D. D., Locksley, R. M., & Corry, D. B. (1998). Requirement for IL-13 independently of IL-4 in experimental asthma. Science, 282(5397), 2261-2263. https://doi.org/10.1126/science.282.5397.2261 Guo, Q., Hu, H., Liu, X., Yang, D., Yin, Y., Zhang, B., He, H., Oh, Y., Wu, Q., Liu, C., & Gu, N. (2019). C/EBPbeta mediates palmitate-induced musclin expression via the regulation of PERK/ATF4 pathways in myotubes. Am J Physiol Endocrinol Metab, 316(6), E1081-E1092. https://doi.org/10.1152/ajpendo.00478.2018 Halbleib, K., Pesek, K., Covino, R., Hofbauer, H. F., Wunnicke, D., Hanelt, I., Hummer, G., & Ernst, R. (2017). Activation of the Unfolded Protein Response by Lipid Bilayer Stress. Mol Cell, 67(4), 673-684 e678. https://doi.org/10.1016/j.molcel.2017.06.012 Harrison, W. J., Bull, J. J., Seltmann, H., Zouboulis, C. C., & Philpott, M. P. (2007). Expression of lipogenic factors galectin-12, resistin, SREBP-1, and SCD in human sebaceous glands and cultured sebocytes. J Invest Dermatol, 127(6), 1309-1317. https://doi.org/10.1038/sj.jid.5700743 Heymann, W. R. (2006). Toll-like receptors in acne vulgaris. J Am Acad Dermatol, 55(4), 691-692. https://doi.org/10.1016/j.jaad.2006.05.049 Hinde, E., Haslam, I. S., Schneider, M. R., Langan, E. A., Kloepper, J. E., Schramm, C., Zouboulis, C. C., & Paus, R. (2013). A practical guide for the study of human and murine sebaceous glands in situ. Exp Dermatol, 22(10), 631-637. https://doi.org/10.1111/exd.12207 Hong, M. H., Weng, I. C., Li, F. Y., Lin, W. H., & Liu, F. T. (2021). Intracellular galectins sense cytosolically exposed glycans as danger and mediate cellular responses. J Biomed Sci, 28(1), 16. https://doi.org/10.1186/s12929-021-00713-x Ikeda, J., Ichiki, T., Takahara, Y., Kojima, H., Sankoda, C., Kitamoto, S., Tokunou, T., & Sunagawa, K. (2015). PPARgamma Agonists Attenuate Palmitate-Induced ER Stress through Up-Regulation of SCD-1 in Macrophages. PLoS One, 10(6), e0128546. https://doi.org/10.1371/journal.pone.0128546 Indra, A. K., Warot, X., Brocard, J., Bornert, J. M., Xiao, J. H., Chambon, P., & Metzger, D. (1999). Temporally-controlled site-specific mutagenesis in the basal layer of the epidermis: comparison of the recombinase activity of the tamoxifen-inducible Cre-ER(T) and Cre-ER(T2) recombinases. Nucleic Acids Res, 27(22), 4324-4327. https://doi.org/10.1093/nar/27.22.4324 Jensen, K. B., Collins, C. A., Nascimento, E., Tan, D. W., Frye, M., Itami, S., & Watt, F. M. (2009). Lrig1 expression defines a distinct multipotent stem cell population in mammalian epidermis. Cell Stem Cell, 4(5), 427-439. https://doi.org/10.1016/j.stem.2009.04.014 Jin, H., He, R., Oyoshi, M., & Geha, R. S. (2009). Animal models of atopic dermatitis. J Invest Dermatol, 129(1), 31-40. https://doi.org/10.1038/jid.2008.106 Johnson, Z., Proudfoot, A. E., & Handel, T. M. (2005). Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine Growth Factor Rev, 16(6), 625-636. https://doi.org/10.1016/j.cytogfr.2005.04.006 Jun, I., Kim, B. R., Park, S. Y., Lee, H., Kim, J., Kim, E. K., Seo, K. Y., & Kim, T. I. (2020). Interleukin-4 stimulates lipogenesis in meibocytes by activating the STAT6/PPARgamma signaling pathway. Ocul Surf, 18(4), 575-582. https://doi.org/10.1016/j.jtos.2020.04.015 Jung, Y. R., Lee, J. H., Sohn, K. C., Lee, Y., Seo, Y. J., Zouboulis, C. C., Kim, C. D., Lee, J. H., Hong, S. P., Seo, S. J., Kim, S. J., & Im, M. (2017). Correction: Adiponectin Signaling Regulates Lipid Production in Human Sebocytes. PLoS One, 12(9), e0185081. https://doi.org/10.1371/journal.pone.0185081 Kanda, N., Hoashi, T., & Saeki, H. (2019). The Roles of Sex Hormones in the Course of Atopic Dermatitis. Int J Mol Sci, 20(19). https://doi.org/10.3390/ijms20194660 Kaplan, M. H., Schindler, U., Smiley, S. T., & Grusby, M. J. (1996). Stat6 is required for mediating responses to IL-4 and for development of Th2 cells. Immunity, 4(3), 313-319. https://doi.org/10.1016/s1074-7613(00)80439-2 Kaser, A., Dunzendorfer, S., Offner, F. A., Ludwiczek, O., Enrich, B., Koch, R. O., Cruikshank, W. W., Wiedermann, C. J., & Tilg, H. (2000). B lymphocyte-derived IL-16 attracts dendritic cells and Th cells. J Immunol, 165(5), 2474-2480. https://doi.org/10.4049/jimmunol.165.5.2474 Kim, J. E., Jung, K., Kim, J. A., Kim, S. H., Park, H. S., & Kim, Y. S. (2019). Engineering of anti-human interleukin-4 receptor alpha antibodies with potent antagonistic activity. Sci Rep, 9(1), 7772. https://doi.org/10.1038/s41598-019-44253-9 Kobayashi, T., Voisin, B., Kim, D. Y., Kennedy, E. A., Jo, J. H., Shih, H. Y., Truong, A., Doebel, T., Sakamoto, K., Cui, C. Y., Schlessinger, D., Moro, K., Nakae, S., Horiuchi, K., Zhu, J., Leonard, W. J., Kong, H. H., & Nagao, K. (2019). Homeostatic Control of Sebaceous Glands by Innate Lymphoid Cells Regulates Commensal Bacteria Equilibrium. Cell, 176(5), 982-997 e916. https://doi.org/10.1016/j.cell.2018.12.031 Kovacs, D., Lovaszi, M., Poliska, S., Olah, A., Biro, T., Veres, I., Zouboulis, C. C., Stahle, M., Ruhl, R., Remenyik, E., & Torocsik, D. (2016). Sebocytes differentially express and secrete adipokines. Exp Dermatol, 25(3), 194-199. https://doi.org/10.1111/exd.12879 Kumar, N., Leonzino, M., Hancock-Cerutti, W., Horenkamp, F. A., Li, P., Lees, J. A., Wheeler, H., Reinisch, K. M., & De Camilli, P. (2018). VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites. J Cell Biol, 217(10), 3625-3639. https://doi.org/10.1083/jcb.201807019 Langmead, B., & Salzberg, S. L. (2012). Fast gapped-read alignment with Bowtie 2. Nat Methods, 9(4), 357-359. https://doi.org/10.1038/nmeth.1923 Lee, S. E., Kim, J. M., Jeong, M. K., Zouboulis, C. C., & Lee, S. H. (2013). 11beta-hydroxysteroid dehydrogenase type 1 is expressed in human sebaceous glands and regulates glucocorticoid-induced lipid synthesis and toll-like receptor 2 expression in SZ95 sebocytes. Br J Dermatol, 168(1), 47-55. https://doi.org/10.1111/bjd.12009 Leng, N., Dawson, J. A., Thomson, J. A., Ruotti, V., Rissman, A. I., Smits, B. M., Haag, J. D., Gould, M. N., Stewart, R. M., & Kendziorski, C. (2013). EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments. Bioinformatics, 29(8), 1035-1043. https://doi.org/10.1093/bioinformatics/btt087 Li, B., & Dewey, C. N. (2011). RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics, 12, 323. https://doi.org/10.1186/1471-2105-12-323 Li, F. Y., Weng, I. C., Lin, C. H., Kao, M. C., Wu, M. S., Chen, H. Y., & Liu, F. T. (2019). Helicobacter pylori induces intracellular galectin-8 aggregation around damaged lysosomes within gastric epithelial cells in a host O-glycan-dependent manner. Glycobiology, 29(2), 151-162. https://doi.org/10.1093/glycob/cwy095 Li, Z. J., Choi, D. K., Sohn, K. C., Seo, M. S., Lee, H. E., Lee, Y., Seo, Y. J., Lee, Y. H., Shi, G., Zouboulis, C. C., Kim, C. D., Lee, J. H., & Im, M. (2014). Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes. J Invest Dermatol, 134(11), 2747-2756. https://doi.org/10.1038/jid.2014.221 Liang, C. C., You, L. R., Chang, J. L., Tsai, T. F., & Chen, C. M. (2009). Transgenic mice exhibiting inducible and spontaneous Cre activities driven by a bovine keratin 5 promoter that can be used for the conditional analysis of basal epithelial cells in multiple organs. J Biomed Sci, 16, 2. https://doi.org/10.1186/1423-0127-16-2 Liao, X., Sharma, N., Kapadia, F., Zhou, G., Lu, Y., Hong, H., Paruchuri, K., Mahabeleshwar, G. H., Dalmas, E., Venteclef, N., Flask, C. A., Kim, J., Doreian, B. W., Lu, K. Q., Kaestner, K. H., Hamik, A., Clement, K., & Jain, M. K. (2011). Kruppel-like factor 4 regulates macrophage polarization. J Clin Invest, 121(7), 2736-2749. https://doi.org/10.1172/JCI45444 Liu, F. T., Yang, R. Y., & Hsu, D. K. (2012). Galectins in acute and chronic inflammation. Ann N Y Acad Sci, 1253, 80-91. https://doi.org/10.1111/j.1749-6632.2011.06386.x Liu, Q., Siloto, R. M., Lehner, R., Stone, S. J., & Weselake, R. J. (2012). Acyl-CoA:diacylglycerol acyltransferase: molecular biology, biochemistry and biotechnology. Prog Lipid Res, 51(4), 350-377. https://doi.org/10.1016/j.plipres.2012.06.001 Liu, W., Hsu, D. K., Chen, H. Y., Yang, R. Y., Carraway, K. L., 3rd, Isseroff, R. R., & Liu, F. T. (2012). Galectin-3 regulates intracellular trafficking of EGFR through Alix and promotes keratinocyte migration. J Invest Dermatol, 132(12), 2828-2837. https://doi.org/10.1038/jid.2012.211 Llewellyn, B. D. (1970). An improved Sirius red method for amyloid. J Med Lab Technol, 27(3), 308-309. https://www.ncbi.nlm.nih.gov/pubmed/4097661 Lo, Y. H., Li, C. S., Chen, H. L., Chiang, C. Y., Huang, C. C., Tu, T. J., Lo, T. H., Choy, D. F., Arron, J. R., Chen, H. Y., & Liu, F. T. (2021). Galectin-8 Is Upregulated in Keratinocytes by IL-17A and Promotes Proliferation by Regulating Mitosis in Psoriasis. J Invest Dermatol, 141(3), 503-511 e509. https://doi.org/10.1016/j.jid.2020.07.021 Lookingbill, D. P., Horton, R., Demers, L. M., Egan, N., Marks, J. G., Jr., & Santen, R. J. (1985). Tissue production of androgens in women with acne. J Am Acad Dermatol, 12(3), 481-487. https://doi.org/10.1016/s0190-9622(85)70067-9 Lucky, A. W., McGuire, J., Rosenfield, R. L., Lucky, P. A., & Rich, B. H. (1983). Plasma androgens in women with acne vulgaris. J Invest Dermatol, 81(1), 70-74. https://doi.org/10.1111/1523-1747.ep12539043 Mastrofrancesco, A., Ottaviani, M., Cardinali, G., Flori, E., Briganti, S., Ludovici, M., Zouboulis, C. C., Lora, V., Camera, E., & Picardo, M. (2017). Pharmacological PPARgamma modulation regulates sebogenesis and inflammation in SZ95 human sebocytes. Biochem Pharmacol, 138, 96-106. https://doi.org/10.1016/j.bcp.2017.04.030 Masuda, K., Katoh, N., Okuda, F., & Kishimoto, S. (2003). Increased levels of serum interleukin-16 in adult type atopic dermatitis. Acta Derm Venereol, 83(4), 249-253. https://doi.org/10.1080/00015550310016472 Melnik, B. C. (2016). Pro-inflammatory sebocyte growth and survival signalling in acne vulgaris are reversed by pro-apoptotic isotretinoin signalling. Exp Dermatol, 25(9), 676-677. https://doi.org/10.1111/exd.13032 Mosmann, T. R., & Coffman, R. L. (1989). TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol, 7, 145-173. https://doi.org/10.1146/annurev.iy.07.040189.001045 Nakahigashi, K., Doi, H., Otsuka, A., Hirabayashi, T., Murakami, M., Urade, Y., Zouboulis, C. C., Tanizaki, H., Egawa, G., Miyachi, Y., & Kabashima, K. (2012). PGD2 induces eotaxin-3 via PPARgamma from sebocytes: a possible pathogenesis of eosinophilic pustular folliculitis. J Allergy Clin Immunol, 129(2), 536-543. https://doi.org/10.1016/j.jaci.2011.11.034 Nervi, S. J., Schwartz, R. A., & Dmochowski, M. (2006). Eosinophilic pustular folliculitis: a 40 year retrospect. J Am Acad Dermatol, 55(2), 285-289. https://doi.org/10.1016/j.jaad.2006.02.034 Olzmann, J. A., & Carvalho, P. (2019). Dynamics and functions of lipid droplets. Nat Rev Mol Cell Biol, 20(3), 137-155. https://doi.org/10.1038/s41580-018-0085-z Owczarek, W., Paplinska, M., Targowski, T., Jahnz-Rozyk, K., Paluchowska, E., Kucharczyk, A., & Kasztalewicz, B. (2010). Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. Cytokine, 50(2), 181-185. https://doi.org/10.1016/j.cyto.2010.02.016 Paz, I., Sachse, M., Dupont, N., Mounier, J., Cederfur, C., Enninga, J., Leffler, H., Poirier, F., Prevost, M. C., Lafont, F., & Sansonetti, P. (2010). Galectin-3, a marker for vacuole lysis by invasive pathogens. Cell Microbiol, 12(4), 530-544. https://doi.org/10.1111/j.1462-5822.2009.01415.x Phipps, S., Ying, S., Wangoo, A., Ong, Y. E., Levi-Schaffer, F., & Kay, A. B. (2002). The relationship between allergen-induced tissue eosinophilia and markers of repair and remodeling in human atopic skin. J Immunol, 169(8), 4604-4612. https://doi.org/10.4049/jimmunol.169.8.4604 Querol Cano, L., Tagit, O., Dolen, Y., van Duffelen, A., Dieltjes, S., Buschow, S. I., Niki, T., Hirashima, M., Joosten, B., van den Dries, K., Cambi, A., Figdor, C. G., & van Spriel, A. B. (2019). Intracellular Galectin-9 Controls Dendritic Cell Function by Maintaining Plasma Membrane Rigidity. iScience, 22, 240-255. https://doi.org/10.1016/j.isci.2019.11.019 Rabinovich, G. A., & Toscano, M. A. (2009). Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation. Nat Rev Immunol, 9(5), 338-352. https://doi.org/10.1038/nri2536 Riffelmacher, T., Clarke, A., Richter, F. C., Stranks, A., Pandey, S., Danielli, S., Hublitz, P., Yu, Z., Johnson, E., Schwerd, T., McCullagh, J., Uhlig, H., Jacobsen, S. E. W., & Simon, A. K. (2017). Autophagy-Dependent Generation of Free Fatty Acids Is Critical for Normal Neutrophil Differentiation. Immunity, 47(3), 466-480 e465. https://doi.org/10.1016/j.immuni.2017.08.005 Salma, N., Xiao, H., Mueller, E., & Imbalzano, A. N. (2004). Temporal recruitment of transcription factors and SWI/SNF chromatin-remodeling enzymes during adipogenic induction of the peroxisome proliferator-activated receptor gamma nuclear hormone receptor. Mol Cell Biol, 24(11), 4651-4663. https://doi.org/10.1128/MCB.24.11.4651-4663.2004 Sansone, G., & Reisner, R. M. (1971). Differential rates of conversion of testosterone to dihydrotestosterone in acne and in normal human skin--a possible pathogenic factor in acne. J Invest Dermatol, 56(5), 366-372. https://doi.org/10.1111/1523-1747.ep12261252 Schneider, M. R., & Paus, R. (2010). Sebocytes, multifaceted epithelial cells: lipid production and holocrine secretion. Int J Biochem Cell Biol, 42(2), 181-185. https://doi.org/10.1016/j.biocel.2009.11.017 Shan, B., Wang, X., Wu, Y., Xu, C., Xia, Z., Dai, J., Shao, M., Zhao, F., He, S., Yang, L., Zhang, M., Nan, F., Li, J., Liu, J., Liu, J., Jia, W., Qiu, Y., Song, B., Han, J. J., . . . Liu, Y. (2017). The metabolic ER stress sensor IRE1alpha suppresses alternative activation of macrophages and impairs energy expenditure in obesity. Nat Immunol, 18(5), 519-529. https://doi.org/10.1038/ni.3709 Shimoda, K., van Deursen, J., Sangster, M. Y., Sarawar, S. R., Carson, R. T., Tripp, R. A., Chu, C., Quelle, F. W., Nosaka, T., Vignali, D. A., Doherty, P. C., Grosveld, G., Paul, W. E., & Ihle, J. N. (1996). Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature, 380(6575), 630-633. https://doi.org/10.1038/380630a0 Smith, K. R., & Thiboutot, D. M. (2008). Thematic review series: skin lipids. Sebaceous gland lipids: friend or foe? J Lipid Res, 49(2), 271-281. https://doi.org/10.1194/jlr.R700015-JLR200 Strauss, J. S., Kligman, A. M., & Pochi, P. E. (1962). The effect of androgens and estrogens on human sebaceous glands. J Invest Dermatol, 39, 139-155. https://doi.org/10.1038/jid.1962.94 Su, C. G., Wen, X., Bailey, S. T., Jiang, W., Rangwala, S. M., Keilbaugh, S. A., Flanigan, A., Murthy, S., Lazar, M. A., & Wu, G. D. (1999). A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response. J Clin Invest, 104(4), 383-389. https://doi.org/10.1172/JCI7145 Subbaramaiah, K., Lin, D. T., Hart, J. C., & Dannenberg, A. J. (2001). Peroxisome proliferator-activated receptor gamma ligands suppress the transcriptional activation of cyclooxygenase-2. Evidence for involvement of activator protein-1 and CREB-binding protein/p300. J Biol Chem, 276(15), 12440-12448. https://doi.org/10.1074/jbc.M007237200 Szanto, A., Balint, B. L., Nagy, Z. S., Barta, E., Dezso, B., Pap, A., Szeles, L., Poliska, S., Oros, M., Evans, R. M., Barak, Y., Schwabe, J., & Nagy, L. (2010). STAT6 transcription factor is a facilitator of the nuclear receptor PPARgamma-regulated gene expression in macrophages and dendritic cells. Immunity, 33(5), 699-712. https://doi.org/10.1016/j.immuni.2010.11.009 Takahashi, N., Kawada, T., Yamamoto, T., Goto, T., Taimatsu, A., Aoki, N., Kawasaki, H., Taira, K., Yokoyama, K. K., Kamei, Y., & Fushiki, T. (2002). Overexpression and ribozyme-mediated targeting of transcriptional coactivators CREB-binding protein and p300 revealed their indispensable roles in adipocyte differentiation through the regulation of peroxisome proliferator-activated receptor gamma. J Biol Chem, 277(19), 16906-16912. https://doi.org/10.1074/jbc.M200585200 Takeda, K., Tanaka, T., Shi, W., Matsumoto, M., Minami, M., Kashiwamura, S., Nakanishi, K., Yoshida, N., Kishimoto, T., & Akira, S. (1996). Essential role of Stat6 in IL-4 signalling. Nature, 380(6575), 627-630. https://doi.org/10.1038/380627a0 Thiboutot, D. (2004). Regulation of human sebaceous glands. J Invest Dermatol, 123(1), 1-12. https://doi.org/10.1111/j.1523-1747.2004.t01-2-.x Thomsen, S. F. (2014). Atopic dermatitis: natural history, diagnosis, and treatment. ISRN Allergy, 2014, 354250. https://doi.org/10.1155/2014/354250 Thurston, T. L., Wandel, M. P., von Muhlinen, N., Foeglein, A., & Randow, F. (2012). Galectin 8 targets damaged vesicles for autophagy to defend cells against bacterial invasion. Nature, 482(7385), 414-418. https://doi.org/10.1038/nature10744 Tontonoz, P., & Spiegelman, B. M. (2008). Fat and beyond: the diverse biology of PPARgamma. Annu Rev Biochem, 77, 289-312. https://doi.org/10.1146/annurev.biochem.77.061307.091829 Toth, B. I., Olah, A., Szollosi, A. G., Czifra, G., & Biro, T. (2011). "Sebocytes' makeup": novel mechanisms and concepts in the physiology of the human sebaceous glands. Pflugers Arch, 461(6), 593-606. https://doi.org/10.1007/s00424-011-0941-6 Tsao, C. H., Hsieh, W. C., Lin, F. J., Yang, R. Y., Chang, M. T., Apaya, M. K., Shyur, L. F., Ke, L. Y., Zouboulis, C. C., & Liu, F. T. (2023). The Critical Role of Galectin-12 in Modulating Lipid Metabolism in Sebaceous Glands. J Invest Dermatol, 143(6), 913-924 e914. https://doi.org/10.1016/j.jid.2022.11.012 Tsao, C. H., Hsieh, W. C., Yang, R. Y., Lo, Y. H., Tu, T. J., Ke, L. Y., Zouboulis, C. C., & Liu, F. T. (2022). Galectin-12 modulates sebocyte proliferation and cell cycle progression by regulating cyclin A1 and CDK2. Glycobiology, 32(1), 73-82. https://doi.org/10.1093/glycob/cwab100 Vladoiu, M. C., Labrie, M., & St-Pierre, Y. (2014). Intracellular galectins in cancer cells: potential new targets for therapy (Review). Int J Oncol, 44(4), 1001-1014. https://doi.org/10.3892/ijo.2014.2267 Volmer, R., van der Ploeg, K., & Ron, D. (2013). Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A, 110(12), 4628-4633. https://doi.org/10.1073/pnas.1217611110 Wan, L., Lin, H. J., Huang, C. C., Chen, Y. C., Hsu, Y. A., Lin, C. H., Lin, H. C., Chang, C. Y., Huang, S. H., Lin, J. M., & Liu, F. T. (2016). Galectin-12 enhances inflammation by promoting M1 polarization of macrophages and reduces insulin sensitivity in adipocytes. Glycobiology, 26(7), 732-744. https://doi.org/10.1093/glycob/cww013 Weng, I. C., Chen, H. L., Lo, T. H., Lin, W. H., Chen, H. Y., Hsu, D. K., & Liu, F. T. (2018). Cytosolic galectin-3 and -8 regulate antibacterial autophagy through differential recognition of host glycans on damaged phagosomes. Glycobiology, 28(6), 392-405. https://doi.org/10.1093/glycob/cwy017 Wilfling, F., Wang, H., Haas, J. T., Krahmer, N., Gould, T. J., Uchida, A., Cheng, J. X., Graham, M., Christiano, R., Frohlich, F., Liu, X., Buhman, K. K., Coleman, R. A., Bewersdorf, J., Farese, R. V., Jr., & Walther, T. C. (2013). Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets. Dev Cell, 24(4), 384-399. https://doi.org/10.1016/j.devcel.2013.01.013 Wills-Karp, M., Luyimbazi, J., Xu, X., Schofield, B., Neben, T. Y., Karp, C. L., & Donaldson, D. D. (1998). Interleukin-13: central mediator of allergic asthma. Science, 282(5397), 2258-2261. https://doi.org/10.1126/science.282.5397.2258 Wrobel, A., Seltmann, H., Fimmel, S., Muller-Decker, K., Tsukada, M., Bogdanoff, B., Mandt, N., Blume-Peytavi, U., Orfanos, C. E., & Zouboulis, C. C. (2003). Differentiation and apoptosis in human immortalized sebocytes. J Invest Dermatol, 120(2), 175-181. https://doi.org/10.1046/j.1523-1747.2003.12029.x Wu, Y. Y., Takata, M., Rehman, I., & Rees, J. L. (2000). The temporal and spatial distribution of p21WAF expression in skin appendages. Br J Dermatol, 142(4), 694-701. https://doi.org/10.1046/j.1365-2133.2000.03414.x Xue, H., Yang, R. Y., Tai, G., & Liu, F. T. (2016). Galectin-12 inhibits granulocytic differentiation of human NB4 promyelocytic leukemia cells while promoting lipogenesis. J Leukoc Biol, 100(4), 657-664. https://doi.org/10.1189/jlb.1HI0316-134R Yang, F., Liu, Y., Ren, H., Zhou, G., Yuan, X., & Shi, X. (2019). ER-stress regulates macrophage polarization through pancreatic EIF-2alpha kinase. Cell Immunol, 336, 40-47. https://doi.org/10.1016/j.cellimm.2018.12.008 Yang, R. Y., Hsu, D. K., Yu, L., Chen, H. Y., & Liu, F. T. (2004). Galectin-12 is required for adipogenic signaling and adipocyte differentiation. J Biol Chem, 279(28), 29761-29766. https://doi.org/10.1074/jbc.M401303200 Yang, R. Y., Hsu, D. K., Yu, L., Ni, J., & Liu, F. T. (2001). Cell cycle regulation by galectin-12, a new member of the galectin superfamily. J Biol Chem, 276(23), 20252-20260. https://doi.org/10.1074/jbc.M010914200 Yang, R. Y., Xue, H., Yu, L., Velayos-Baeza, A., Monaco, A. P., & Liu, F. T. (2016). Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis. PLoS One, 11(4), e0153534. https://doi.org/10.1371/journal.pone.0153534 Yang, R. Y., Yu, L., Graham, J. L., Hsu, D. K., Lloyd, K. C., Havel, P. J., & Liu, F. T. (2011). Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice. Proc Natl Acad Sci U S A, 108(46), 18696-18701. https://doi.org/10.1073/pnas.1109065108 Yang, W. L., & Frucht, H. (2001). Activation of the PPAR pathway induces apoptosis and COX-2 inhibition in HT-29 human colon cancer cells. Carcinogenesis, 22(9), 1379-1383. https://doi.org/10.1093/carcin/22.9.1379 Yen, C. L., Stone, S. J., Koliwad, S., Harris, C., & Farese, R. V., Jr. (2008). Thematic review series: glycerolipids. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res, 49(11), 2283-2301. https://doi.org/10.1194/jlr.R800018-JLR200 Yu, G., Wang, L. G., Han, Y., & He, Q. Y. (2012). clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS, 16(5), 284-287. https://doi.org/10.1089/omi.2011.0118 Yuan, Q., Campanella, G. S., Colvin, R. A., Hamilos, D. L., Jones, K. J., Mathew, A., Means, T. K., & Luster, A. D. (2006). Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells. Eur J Immunol, 36(10), 2700-2714. https://doi.org/10.1002/eji.200636112 Yuliana, A., Daijo, A., Jheng, H. F., Kwon, J., Nomura, W., Takahashi, H., Ara, T., Kawada, T., & Goto, T. (2019). Endoplasmic Reticulum Stress Impaired Uncoupling Protein 1 Expression via the Suppression of Peroxisome Proliferator-Activated Receptor gamma Binding Activity in Mice Beige Adipocytes. Int J Mol Sci, 20(2). https://doi.org/10.3390/ijms20020274 Huang, Y.H. (2016) The Role of Galectin-12 in Regulating Inflammatory Responses in Human Sebocytes. National Taiwan University. Master Thesis. AiritiLibrary. Zhang, C., Chinnappan, M., Prestwood, C. A., Edwards, M., Artami, M., Thompson, B. M., Eckert, K. M., Vale, G., Zouboulis, C. C., McDonald, J. G., & Harris-Tryon, T. A. (2021). Interleukins 4 and 13 drive lipid abnormalities in skin cells through regulation of sex steroid hormone synthesis. Proc Natl Acad Sci U S A, 118(38). https://doi.org/10.1073/pnas.2100749118 Zhang, K., Wang, S., Malhotra, J., Hassler, J. R., Back, S. H., Wang, G., Chang, L., Xu, W., Miao, H., Leonardi, R., Chen, Y. E., Jackowski, S., & Kaufman, R. J. (2011). The unfolded protein response transducer IRE1alpha prevents ER stress-induced hepatic steatosis. EMBO J, 30(7), 1357-1375. https://doi.org/10.1038/emboj.2011.52 Zhang, Q., Seltmann, H., Zouboulis, C. C., & Konger, R. L. (2006). Involvement of PPARgamma in oxidative stress-mediated prostaglandin E(2) production in SZ95 human sebaceous gland cells. J Invest Dermatol, 126(1), 42-48. https://doi.org/10.1038/sj.jid.5700028 Zouboulis, C. C., Angres, S., & Seltmann, H. (2011). Regulation of stearoyl-coenzyme A desaturase and fatty acid delta-6 desaturase-2 expression by linoleic acid and arachidonic acid in human sebocytes leads to enhancement of proinflammatory activity but does not affect lipogenesis. Br J Dermatol, 165(2), 269-276. https://doi.org/10.1111/j.1365-2133.2011.10340.x Zouboulis, C. C., Baron, J. M., Bohm, M., Kippenberger, S., Kurzen, H., Reichrath, J., & Thielitz, A. (2008). Frontiers in sebaceous gland biology and pathology. Exp Dermatol, 17(6), 542-551. https://doi.org/10.1111/j.1600-0625.2008.00725.x Zouboulis, C. C., Korge, B., Akamatsu, H., Xia, L. Q., Schiller, S., Gollnick, H., & Orfanos, C. E. (1991). Effects of 13-cis-retinoic acid, all-trans-retinoic acid, and acitretin on the proliferation, lipid synthesis and keratin expression of cultured human sebocytes in vitro. J Invest Dermatol, 96(5), 792-797. https://doi.org/10.1111/1523-1747.ep12471782 Zouboulis, C. C., Oeff, M. K., Hiroi, N., Makrantonaki, E., & Bornstein, S. R. (2021). Involvement of Pattern Recognition Receptors in the Direct Influence of Bacterial Components and Standard Antiacne Compounds on Human Sebaceous Gland Cells. Skin Pharmacol Physiol, 34(1), 19-29. https://doi.org/10.1159/000513259 Zouboulis, C. C., Picardo, M., Ju, Q., Kurokawa, I., Torocsik, D., Biro, T., & Schneider, M. R. (2016). Beyond acne: Current aspects of sebaceous gland biology and function. Rev Endocr Metab Disord, 17(3), 319-334. https://doi.org/10.1007/s11154-016-9389-5 Zouboulis, C. C., Seltmann, H., Neitzel, H., & Orfanos, C. E. (1999). Establishment and characterization of an immortalized human sebaceous gland cell line (SZ95). J Invest Dermatol, 113(6), 1011-1020. https://doi.org/10.1046/j.1523-1747.1999.00771.x | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/89810 | - |
| dc.description.abstract | 皮脂腺是一種全分泌腺腺體，其主要功能是分泌以油脂為主體的皮脂，維持皮膚的屏障功能。脂質產生調節失常會導致部分皮膚疾病，特別是以皮膚乾燥龜裂為特徵的異位性皮膚炎的惡化。儘管，在脂質的生合成上，皮脂腺已有相當充分的研究，但鮮少有研究評估皮脂腺在皮膚免疫反應中的作用。而在本篇研究中，我們發現皮脂腺和皮脂細胞表達介白素（Interleukin，IL）-4受體，並在接受介白素-4刺激後產生大量的Th2相關促發炎介質，表明皮脂腺具有免疫調節的作用。半乳糖凝集素(Galectin)-12是在皮脂腺細胞中表達的脂肪生成因子，同時也影響了皮脂腺的分化和增殖。透過抑制皮脂細胞的半乳糖凝集素-12表達，我們發現半乳糖凝集素-12調節了細胞暴露於介白素-4時的免疫反應，並透過上調過氧化物酶體增殖物活化受體-γ (Peroxisome Proliferator Activated Receptors-γ，PPARγ)來促使趨化激素-CCL26表達。此外，半乳糖凝集素-12還抑制內質網壓力反應(Endoplasmic reticulum stress，ER stress)因子的表達，當使用藥物誘發皮脂腺細胞中的內質網壓力反應時，介白素-4引發的CCL26表現遭到抑制，這表明半乳糖凝集素-12抑制了內質網壓力反應來維持介白素-4相關的信號傳遞。我們也使用半乳糖凝集素-12敲除小鼠證實，半乳糖凝集素-12維持了介白素-4誘導的皮脂腺肥大和皮膚炎的發展。因此，我們認為半乳糖凝集素-12通過調節皮脂腺內的氧化物酶體增殖物活化受體-γ表達和內質網壓力反應來調節皮膚免疫反應。 | zh_TW |
| dc.description.abstract | Sebaceous glands are holocrine glands that produce sebum, which primarily contains lipids that help maintain the barrier function of the skin. Dysregulated lipid production contributes to the progression of some diseases characterized by dry skin, including atopic dermatitis. Although the lipid production of sebaceous glands has been well studied, few studies have assessed their role in skin immune responses. We found that sebaceous glands and sebocytes expressed interleukin (IL)-4 receptor and produced high levels of Th2-associated inflammatory mediators following IL-4 treatment, suggesting immunomodulatory effects. Galectin-12 is a lipogenic factor expressed in sebocytes that affects their differentiation and proliferation. Using galectin-12-knockdown sebocytes, we demonstrated that galectin-12 regulated the immune response in cells exposed to IL-4 and promoted CCL26 expression by upregulating PPARγ. Moreover, galectin-12 suppresses the expression of endoplasmic reticulum (ER) stress-response molecules and CCL26 upregulation by IL-4 was reversed following sebocyte treatment with inducers of ER stress, suggesting that galectin-12 controls IL-4 signaling by suppressing ER stress. Using galectin-12-knockout mice, we demonstrated that galectin-12 positively regulated the IL-4-induced enlargement of the sebaceous glands and the development of an atopic dermatitis-like phenotype. Thus, galectin-12 regulates the skin immune response through PPARγ expression and ER events within sebaceous glands. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-09-22T16:12:56Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-09-22T16:12:56Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 論文口試委員審定書 i
謝辭 ii 中文摘要及關鍵詞 iii Abstract v Table of Contents vii Chapter 1. INTRODUCTION 1 1.1 Galectins 2 1.1.1 Galectins 2 1.1.2 Galetcin-12 4 1.2 Sebaceous glands 6 1.2.1 Sebaceous glands 6 1.2.2 Sebaceous glands, sebum and skin barrier function 7 1.2.3 Sebaceous glands and immune disorders 9 1.2.4 Sebaceous glands and atopic dermatitis 10 Chapter 2. RATIONALE 13 Chapter 3. MATERIALS AND METHODS 15 3.1 Cell cultures and reagents 16 3.2 Generation of galectin-12-knockdown SZ95 cells by siRNA transfection 16 3.3 RNA preparation, cDNA synthesis, and quantitative PCR 17 3.4 Analysis of RNA-Seq Data 18 3.5 Flow cytometry 19 3.6 Enzyme-linked immunosorbent assay (ELISA) 20 3.7 Immunoblot 20 3.8 Animals 21 3.9 Intradermal injections of IL-4 22 3.10 Oil Red O staining of sebaceous glands 22 3.11 Immunohistochemistry, immunofluorescence, and histology 23 3.12 Epicutaneous (EC) sensitization 24 3.13 Statistical analysis 24 Chapter 4. RESULTS 26 4.1 Sebaceous glands and immortalize sebocyte cell line (SZ95) express Th2 cytokine receptor 27 4.2 The Th2-associated transducer protein STAT6 in sebocytes is activated by IL-4 but not IL-13 28 4.3 Sebocytes are activated by IL-4, resulting in mediator release 29 4.4 Inflammatory mediator production in sebocytes is regulated by galectin-12 30 4.5 Inflammatory mediator production regulated by galectin-12 is independent of signaling protein expression 31 4.6 CCL26 production in vivo is regulated by galectin-12 32 4.7 CCL26 expression is PPARγ dependent 33 4.8 Galectin-12 regulates CCL26 expression by inducing PPARγ 33 4.9 Galectin-12 knockdown enhances the endoplasmic reticulum (ER) stress response 34 4.10 Galectin-12 knockdown enhances the IRE1α and PERK pathways in the endoplasmic reticulum (ER) stress response 35 4.11 Galectin-12 ablation attenuates sebaceous gland hyperplasia by IL-4 36 4.12 Galectin-12 ablation attenuates ear swelling and inflammatory responses induced by IL-4 37 4.13 Galectin-12 KO mice exhibit a less prominent atopic dermatitis-like phenotype associated with eosinophils 37 Chapter 5. DISCUSSION 39 5.1 The relationship between IL-4, PPARγ and sebaceous gland functions in Th2 disease 40 5.2 Galectin-12 controls cellular behavior through the ER event 45 Chapter 6. REFERENCES 50 Chapter 7. FIGURES 64 Figure 1. Sebaceous glands and immortalize sebocyte cell line (SZ95) express Th2 cytokine receptor 65 Figure 2. The Th2-associated transducer protein STAT6 in sebocytes is activated by IL-4 but not IL-13 66 Figure 3. Sebocytes are activated by IL-4, resulting in mediator release 67 Figure 4. Inflammatory mediator production in sebocytes is regulated by galectin-12 69 Figure 5. Inflammatory mediator production regulated by galectin-12 is independent of signaling protein expression 70 Figure 6. CCL26 production in vivo is regulated by galectin-12 71 Figure 7. CCL26 expression is PPARγ dependent 73 Figure 8. Galectin-12 regulates CCL26 expression by inducing PPARγ 75 Figure 9. Galectin-12 knockdown enhances the endoplasmic reticulum (ER) stress response 77 Figure 10. Galectin-12 knockdown enhances the IRE1α and PERK pathways in the endoplasmic reticulum (ER) stress response 79 Figure 11. Galectin-12 ablation attenuates sebaceous gland hyperplasia by IL-4 80 Figure 12. Galectin-12 ablation attenuates ear swelling and inflammatory responses induced by IL-4 82 Figure 13. Galectin-12 KO mice exhibit a less prominent atopic dermatitis-like phenotype associated with eosinophils 84 Figure 14. A Working model of the regulatory function of galectin-12 in sebocytes in response to IL-4 treatment 85 Chapter 8. APPENDIX 88 8.1. Galectin-12 KO mice exhibit a less prominent atopic dermatitis-like phenotype (Huang, 2016) 89 8.2. Galectin-12 Regulates Immune Responses in the skin through Sebaceous glands. (Published by Elsevier, Inc. on behalf of the Society for Investigative Dermatology) 90 | - |
| dc.language.iso | en | - |
| dc.subject | 皮脂腺 | zh_TW |
| dc.subject | 氧化物酶體增殖物活化受體-γ | zh_TW |
| dc.subject | 半乳糖凝集素-12 | zh_TW |
| dc.subject | 趨化激素-CCL26 | zh_TW |
| dc.subject | 異位性皮膚炎 | zh_TW |
| dc.subject | Galectin-12 | en |
| dc.subject | PPARγ | en |
| dc.subject | CCL26 | en |
| dc.subject | Sebaceous gland | en |
| dc.subject | Atopic dermatitis | en |
| dc.title | 半乳糖凝集素-12透過皮脂腺調節皮膚之免疫反應 | zh_TW |
| dc.title | Galectin-12 Regulates Immune Responses in the Skin through Sebaceous Glands | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-2 | - |
| dc.description.degree | 博士 | - |
| dc.contributor.oralexamcommittee | 伍安怡;顧家綺;林琬琬;林國儀 | zh_TW |
| dc.contributor.oralexamcommittee | Betty A. Wu-Hsieh;Chia-Chi Ku;Wan-Wan Lin;Kuo-I Lin | en |
| dc.subject.keyword | 皮脂腺,半乳糖凝集素-12,氧化物酶體增殖物活化受體-γ,趨化激素-CCL26,異位性皮膚炎, | zh_TW |
| dc.subject.keyword | Sebaceous gland,Galectin-12,PPARγ,CCL26,Atopic dermatitis, | en |
| dc.relation.page | 109 | - |
| dc.identifier.doi | 10.6342/NTU202302983 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2023-08-04 | - |
| dc.contributor.author-college | 醫學院 | - |
| dc.contributor.author-dept | 免疫學研究所 | - |
| dc.date.embargo-lift | 2028-08-04 | - |
| 顯示於系所單位： | 免疫學研究所 | |
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