請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/88229
標題: | 以長春新鹼給藥前後的血小板數評估犬隻多中心型淋巴瘤的預後 Prognostic evaluation of platelet counts before and after vincristine administration in canine multicentric lymphoma |
作者: | 熊紀梅 Chi-Mei Hsiung |
指導教授: | 王尚麟 Shang-Lin Wang |
關鍵字: | 犬,多中心型淋巴瘤,長春新鹼,血小板數, canine,multicentric lymphoma,vincristine,platelet counts, |
出版年 : | 2023 |
學位: | 碩士 |
摘要: | 人類醫學中,血小板的升高和實體腫瘤的生長、轉移以及不良預後有關。近年,更進一步觀察到癌症病患血小板的變化趨勢與生存時間的相關性。犬隻多中心型淋巴腫瘤,其為血液腫瘤,因此相較於實體腫瘤,對血小板的影響可能更為複雜。目前在人類醫學以及獸醫領域,對於血小板作為淋巴腫瘤的預後因子,尚未有共識。治療淋巴腫瘤的藥物中,長春新鹼,可增加周邊血液中血小板的數量。因此我們以犬淋巴腫瘤、血小板和長春新鹼之間的相互關聯,來探討犬隻多中心型淋巴腫瘤病患,施打長春新鹼前及後,血小板的表現,是否可作為預後的預測因子。本篇是回溯型研究,共納入79隻多中心淋巴腫瘤患犬。我們利用給藥前後血小板的絕對值,以及搭配給予長春新鹼後,血小板數量的增減等方式,進行各種分組,比較血小板給予長春新鹼前後的變化和預後的相關性。結果表示,治療前無血小板增多的病患;治療前或後,血小板數絕對值的多寡和預後無顯著相關;治療後,血小板的增加或是減少,和預後亦無顯著相關。而給予長春新鹼後,血小板數顯著上升,且血小板低下的病患比例相較於治療前,顯著下降。本篇結論,多中心型淋巴瘤患犬,治療前呈現血小板低下的病患,仍可以安全地使用長春新鹼作為首次化療藥物,其可顯著增加血小板數量,且降低血小板低下病患的比例。另外,在多中心淋巴腫瘤患犬,給予長春新鹼前後,血小板的絕對值以及變化幅度,不能作為預後的指標。未來相關的研究,仍需更多大型試驗來證實。 Canine multicentric lymphoma, being a hematologic malignancy, may have a more complex impact on platelet counts compared to solid tumors. Currently, there is no consensus in human medicine and veterinary medicine regarding platelet counts as prognostic factors in lymphoma. Vincristine, a commonly used drug in lymphoma treatment, has been shown to increase platelet counts in peripheral blood. Therefore, we conducted a study to investigate the relationship between canine multicentric lymphoma, platelet counts, and vincristine administration. We aimed to determine whether the expression of platelets before and after vincristine administration could serve as prognostic factors in dogs with multicentric lymphoma. We included 79 multicentric lymphoma dogs retrospectively. The grouping based on absolute platelet counts before and after vincristine administration, as well as the grouping based on the difference in platelet counts before and after administration, did not show any significant differences in prognosis. Additionally, we found a significant increase in platelet counts after vincristine administration. In canine multicentric lymphoma patients with baseline thrombocytopenia, vincristine can still be confidently used as a first-line chemotherapy drug. Further research is needed to determine whether the trend of platelet changes in dogs with multicentric lymphoma can serve as a prognostic indicator. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/88229 |
DOI: | 10.6342/NTU202301538 |
全文授權: | 同意授權(限校園內公開) |
顯示於系所單位: | 臨床動物醫學研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-111-2.pdf 目前未授權公開取用 | 1.15 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。