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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李翔傑 | zh_TW |
dc.contributor.advisor | Hsiang-Chieh Lee | en |
dc.contributor.author | 蔡廷彥 | zh_TW |
dc.contributor.author | Ting-Yen Tsai | en |
dc.date.accessioned | 2023-05-18T17:11:53Z | - |
dc.date.available | 2023-11-10 | - |
dc.date.copyright | 2023-06-07 | - |
dc.date.issued | 2022 | - |
dc.date.submitted | 2002-01-01 | - |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/87346 | - |
dc.description.abstract | 在本篇論文中第一部分,我們使用了掃頻式同調斷層掃描術(Swept-Source Optical Coherence Tomography, SS-OCT)進行小鼠內耳耳蝸之成像以及光學特性分析。首先我們架設了SS-OCT的軟硬體,軟體部分採用了C++的程式語言來進行儀器的操作以及資料擷取並且利用MFC設計出我們的操作介面。硬體部分分別利用了中心波長1.06微米與1.3微米的掃頻式雷射架設了兩套SS-OCT來進行樣本的成像與量化分析。第二部分則是我們使用了中心波長1.03微米的高折射率差光柵垂直共振腔面射型雷射(High Contrast Grating Vertical Cavity Surface Emitting Laser, HCG-VCSEL)作為SS-OCT系統的光源以達到成像使用。這是首次利用此HCG-VCSEL於SS-OCT的應用,此光源提供了等效500 kHz的掃頻速率並在此速速度下有著 48 nm的掃描頻寬,在硬體部份由於此HCG-VCSEL屬於原型機並無校準時脈訊號(k-clock),因此我們架設了邁克生干涉儀(Michelson Interferometer) 作為校準訊號,再結合原先所架設之SS-OCT系統,我們進行了手指皮膚以及老鼠血管造影成像(Optical Coherence Tomography Angiography, OCTA)的資料擷取與成像。透過此方式我們成功的架設首套HCG-VCSEL SS-OCT並且量測其偏振特性(Uniformity of the Polarization)、靈敏度(Sensitivity)、滾降雜訊比(Roll-off, R-number)以及系統成像解析度,上述成果呈現相當完善且優異的數據資料以及成像結果。 | zh_TW |
dc.description.abstract | In the first part of this dissertation, we used Swept-Source Optical Coherence Tomography (SS-OCT) to acquire image and analyze the optical properties of the mouse cochlea. First of all, we set up the software and hardware of SS-OCT. The software part adopts C++ programming language to control the instrument and acquire data and use MFC library to design our user graphic interface (GUI). In the hardware part, two SS-OCT systems were built up using wavelength-swept lasers with center wavelengths of 1.06 μm and 1.3 μm, respectively, for imaging and quantitative analysis of samples. The second part is that we use a High Contrast Grating Vertical Cavity Surface Emitting Laser (HCG-VCSEL) with a center wavelength of 1.03 μm as a light source of the SS-OCT system. This is the first time utilizing a HCG-VCSEL in SS-OCT. This HCG-VCSEL provides an effective swept rate of 500 kHz and a tuning range 48 nm. Due to the HCG-VCSEL is a prototype and has no calibrated clock signal (k-clock), we set up a Michelson Interferometer, which provides a calibration signal for wavelength calibration, then combined it with the SS-OCT system previously developed. With this dual-channel SS-OCT, we acquired the OCT imaging of fingernail junction and mouse ear OCT angiography (OCTA) imaging. By this method, we successfully built the first HCG-VCSEL based SS-OCT and measured its uniformity of the polarization, sensitivity, roll-off, R-number, and demonstration of OCT and OCTA imaging. The above results present fairly complete analysis data for system performance and excellent imaging results. | en |
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dc.description.provenance | Made available in DSpace on 2023-05-18T17:11:53Z (GMT). No. of bitstreams: 0 | en |
dc.description.tableofcontents | 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS v LIST OF FIGURE viii LIST OF TABLE xv Chapter 1 Introduction 1 1.1 Hearing and Ear Disorders 1 1.1.1 Hearing Loss and SNHL 1 1.1.2 Cochlear Implant 3 1.2 Introduction to Optical Coherence Tomography 5 1.3 Research Motivation 8 1.4 Scope of Dissertation 10 Chapter 2 Swept-source OCT 11 2.1 Overview 11 2.2 Swept-source OCT Theory 13 2.2.1 Axial Resolution 14 2.2.2 Signal to Noise Ratio and Roll-off 15 2.2.3 Imaging Depth and Sampling Rate 16 Chapter 3 Introduction to Swept-source Laser for SS-OCT 17 3.1 Overview 17 3.2 Existing Swept-source Laser 18 3.2.1 MEMS External Cavity Laser 18 3.2.2 Fourier Domain Mode-Locked Lasers (FDML) 21 3.2.3 Optically Pump Tunable MEMS-VCSEL 23 3.2.4 Electrically Pump Tunable MEMS-VCSEL 26 3.3 High Contrast Grating (HCG) VCSEL 28 Chapter 4 Ex Vivo OCT Imaging of the Mouse Cochlea 31 4.1 Overview 31 4.2 1.06 and 1.3 μm SS-OCT Imaging System Overview 32 4.2.1 Optical Frequency Clock Optimization 35 4.3 Animal Model Preparation 37 4.4 OCT imaging of Mouse Cochlea 38 4.4.1 PBS-preserved Mouse Cochlear OCT Imaging 40 4.4.2 EDTA-preserved Mouse Cochlear OCT Imaging 42 4.4.3 OCT Imaging of Mouse Cochlear with the Introduced Metal Electrode 44 4.5 Optical Properties of the Mouse Cochlea 46 4.5.1 Contrast Metric Quantitatively 51 4.5.2 Imaging Penetration Depth Analysis 53 4.6 Discussion 55 Chapter 5 HCG-VCSEL SS-OCT Imaging of Dermatology and Mouse Ear 58 5.1 Overview 58 5.2 HCG-VCSEL SS-OCT Imaging System Overview 59 5.2.1 Signal Processing 64 5.2.2 Axial Resolution and Lateral Resolution 65 5.2.3 Sensitivity with Different Optical Delay 66 5.2.4 R-number 70 5.2.5 Uniformity of the Polarization 71 5.2.6 Cable Matching between Calibration and OCT Interferometers 75 5.3 Animal Model Preparation 76 5.4 OCT Imaging of HCG-VCSEL SS-OCT System 77 5.4.1 OCT Imaging of Finger Nail Junction and Tape 77 5.4.2 OCTA Imaging of Mouse Ear 80 5.5 OCT Imaging Comparison of HCG-VCSEL and DBR-VCSEL SS-OCT System 83 5.5 Discussion 87 Chapter 6 Conclusion and Future Work 90 6.1 Conclusion 90 6.2 Future Work 93 Reference 96 Appendix 106 | - |
dc.language.iso | en | - |
dc.title | 光學同調斷層掃描術用於耳鼻喉科應用之可行性研究 | zh_TW |
dc.title | Optical coherence tomography for Otorhinolaryngology applications: feasibility study | en |
dc.type | Thesis | - |
dc.date.schoolyear | 111-1 | - |
dc.description.degree | 博士 | - |
dc.contributor.oralexamcommittee | 陳信傑;孫家偉;蔡睿哲;黃中宜;郭浩中 | zh_TW |
dc.contributor.oralexamcommittee | Hsin-Chien Chen;Chia-Wei Sun;Jui-che Tsai;Michael C. Y Huang;Hao-Chung Kuo | en |
dc.subject.keyword | 光學同調斷層掃描術,高折射率差光柵垂直共振腔面射型雷射,耳蝸,掃頻式雷射,血管造影, | zh_TW |
dc.subject.keyword | optical coherence tomography,optical coherence tomography angiography,HCG-VCSEL,SS-OCT,swept-source,cochlea, | en |
dc.relation.page | 106 | - |
dc.identifier.doi | 10.6342/NTU202204279 | - |
dc.rights.note | 同意授權(限校園內公開) | - |
dc.date.accepted | 2022-10-17 | - |
dc.contributor.author-college | 電機資訊學院 | - |
dc.contributor.author-dept | 光電工程學研究所 | - |
dc.date.embargo-lift | 2024-10-13 | - |
顯示於系所單位: | 光電工程學研究所 |
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ntu-111-1.pdf 目前未授權公開取用 | 4.63 MB | Adobe PDF | 檢視/開啟 |
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