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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘子明 | |
| dc.contributor.author | Chih-Chen Huang | en |
| dc.contributor.author | 黃之丞 | zh_TW |
| dc.date.accessioned | 2021-05-20T19:59:32Z | - |
| dc.date.available | 2012-08-12 | |
| dc.date.available | 2021-05-20T19:59:32Z | - |
| dc.date.copyright | 2010-08-12 | |
| dc.date.issued | 2010 | |
| dc.date.submitted | 2010-05-21 | |
| dc.identifier.citation | 蘇遠志與黃冬梨 (1981) 紅麴色素之動物飼養試驗。國立台灣大學農學院研究報告。21：98-112。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8668 | - |
| dc.description.abstract | 放射線治療為有效控制腫瘤的癌症治療方式。放射線雖然能抑制癌細胞增生和毒殺癌細胞，但也會因發炎與纖維化反應而對正常組織造成傷害。因此，如何減少放射線治療衍生的副作用為一重要課題。紅麴 (Monascus) 為中國傳統發酵真菌，運用在食品上已有數千年的歷史，其二次代謝產物經現代科學研究證實具有降低膽固醇、抗發炎、抗腫瘤與抑制腫瘤轉移等功效，適合輔助放射線治療減輕副作用。本研究分為體內動物實驗和體外細胞實驗兩部分，探討紅麴山藥酒萃物 (ethanol extract of red mold dioscorea, RMDE) 是否具有緩解放射線治療衍生的副作用之功效。實驗結果顯示，RMDE 的餵食，能增加放射線治療後小鼠的體重和攝食量，並且抑制腫瘤的復發。此外，RMDE 能緩解放射線所引起脾臟腫大之情形，血清促發炎激素 (tumor necrosis factor-α, TNF-α; interleukin-1β, IL-1β; interleukin-6, IL-6)、促纖維化激素 (transforming growth factor-β1, TGF-β1) 和血管內皮生長因子 (vascular endothelial growth factor, VEGF) 也因 RMDE 的餵食，具有顯著性降低的現象。由組織病理切片結果得知，RMDE 對於小鼠肺、肝和腎臟並無任何的影響。在細胞實驗方面，RMDE 中的 ankaflavin 和 citrinin 對於小鼠皮膚初代細胞和 B16-F0 並不具明顯抑制效果，而 monascin 對於小鼠皮膚初代細胞不具明顯抑制，但可以有效抑制癌細胞 (B16-F0) 的生長。在放射線誘導細胞損傷模式中，紅麴山藥酒萃物和其功效成分 ankaflavin 能抑制放射線所誘發 TNF-α、IL-1β、IL-6 和 TGF-β1 mRNA 大量表現之情形，monascin 對 IL-1β、IL-6 和 TGF-β1 mRNA 表現具抑制作用，但對於 TNF-α 則不具影響。綜合以上，紅麴山藥酒萃物能緩解放射線治療衍生的副作用，適合輔助臨床癌症治療。 | zh_TW |
| dc.description.abstract | Radiotherapy is frequently used as part of cancer treatment to achieve tumor control. Apart from inducing anti-proliferative and cell-killing effects in tumor tissue, radiotherapy also provokes normal tissue damage such as inflammation and fibrosis. Therefore, how to alleviating the side effects of radiotherapy is a crucial problem. The Monascus species is a Chinese traditional fermentation fungus used on food for over thousands of years in China. The secondary metabolites of Monascus in the contemporary research were confirmed the suppression cholesterol production, anti-inflammation, anti-tumor and suppression tumor metastasis. Accordingly, Monascus metabolites can apply to radiotherapy to alleviate the side effects. In this study, we investigated whether ethanol extract of red mold dioscorea (RMDE) attenuates radiation-induced normal tissue damage in vivo and in vitro. Results showed that oral administration of RMDE can increase animal body weight and food intake but suppress tumor regression. Besides, radiation-induced splenomegaly was significantly alleviated by RMDE. The pro-inflammatory (i.e. tumor necrosis factor-α, TNF-α; interleukin-1β, IL-1β; interleukin-6, IL-6), pro-fibrotic (i.e. transforming growth factor-β1, TGF-β1) and angiogenesis (i.e. vascular endothelial growth factor, VEGF) maker in serum of RMDE treatment group was significantly lower than control group. Furthermore, the results of histopathological slices of lung, liver and kidney in each group did not show any significant difference from histopathological finding. In vitro assays, the cytotoxic assay showed that RMDE have more cytotoxic to B16-F0 cells than skin primary cells. Ankaflavin, monascin and citrinin are non-effect in skin primary cells. Monascin can inhibit B16-F0 proliferation. According to the radiation-induced cell damage model, RMDE and ankaflavin treatment can inhibit TNF-α, IL-1β, IL-6 and TGF-β1 mRNA expression and monascin can inhibit IL-1β, IL-6 and TGF-β1 mRNA expression but not TNF-α. These features of RMDE have made it an attractive candidate to moderate the side effects in clinical radiotherapy. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T19:59:32Z (GMT). No. of bitstreams: 1 ntu-99-R97b47101-1.pdf: 5347370 bytes, checksum: a90354ffbad282e0a07f850163915ae5 (MD5) Previous issue date: 2010 | en |
| dc.description.tableofcontents | 致謝 I
縮寫表 III 中文摘要 V Abstract VI 目錄 VII 圖目錄 X 表目錄 XII 第一章 前言 01 第二章 文獻回顧 03 一、紅麴 (Monascus) 03 (一) 紅麴之歷史回顧 03 (二) 紅麴之分類與特性 03 (三) 紅麴代謝產物與其生理功效 04 1. 膽固醇合成抑制劑 (monacolins) 04 2. 紅麴色素 (Monascus pigment) 06 3. 神經傳導與降血壓物質 (γ-aminobutyric acid, GABA) 07 4. 抗氧化物質 (dimerumic acid) 07 5. 橘黴素 (citrinin) 08 二、放射線治療 (radiotherapy, RT) 08 (一) 放射線之分類 09 (二) 放射線治療之原理 09 (三) 放射線治療衍生的副作用 (side effects) 10 1. 放射線引起的發炎反應 13 2. 放射線引起的纖維化反應 14 3. 放射線引起的血管新生 16 三、研究目的與大綱 17 第三章 材料與方法 19 一、實驗材料 19 (一) 常用儀器 19 (二) 藥品與試劑 20 (三) 菌株與基質 21 二、實驗方法 21 (一) 紅麴菌株之培養 21 (二) 紅麴山藥之製備 21 (三) 紅麴山藥酒萃物之製備 21 (四) 紅麴山藥酒萃物之成分分析 22 (五) 動物實驗 22 1. 動物飼養與照料 22 2. 動物實驗分組與劑量之訂定 22 3. C57BL/6 小鼠放射線治療模式之建立 23 4. 實驗動物之犧牲 (sacrifice) 25 5. 血清促發炎激素 (IL-1β、IL-6 和 TNF-α) 分析 29 6. 血清纖維化指標 TGF-β1 分析 30 7. 血清血管新生指標 VEGF 分析 30 (六) 細胞實驗 31 1. 細胞培養 31 2. 細胞凍存 31 3. 初代細胞之分離 31 4. 細胞毒性試驗 32 5. 放射線誘導細胞發炎模式之建立 32 6. 紅麴山藥萃取物與其純物質對於放射線誘發之發炎反應探討 33 7. 總 RNA 之萃取 33 8. 總 cDNA 之合成 34 9. 引子 (primer) 之設計 34 10. 聚合酶鏈反應 (polymerase chain reaction, PCR) 條件 34 11. DNA的洋菜膠體電泳分析 34 (七) 生物統計分析方法 36 第四章 結果與討論 37 一、動物實驗 37 (一) 紅麴山藥酒萃物對於放射線療程後小鼠體重與攝食量之影響 37 (二) 紅麴山藥酒萃物對於放射線療程後小鼠腹水之影響 41 (三) 紅麴山藥酒萃物對於放射線療程後小鼠腫瘤之變化 44 (四) 紅麴山藥酒萃物對於放射線治療後小鼠組織器官之影響 47 (五) 紅麴山藥酒萃物對於放射線療程後小鼠血清之影響 56 1. 血清促發炎激素 (IL-1β、IL-6 和 TNF-α) 分析 56 2. 轉換生長因子-β1 (transforming growth factor β1, TGF-β1) 分析 61 3. 血管內皮生長因子 ( vascular endothelial growth factor, VEGF) 分析 61 二、細胞實驗 63 (一) 比較紅麴山藥酒萃物及其純物質對於黑色素細胞瘤 (B16-F0) 和皮膚初代細胞 (skin primary cell) 之影響 63 (二) 放射線誘導 Raw 264.7 細胞發炎模式之建立 66 (三) 紅麴山藥酒萃物及其純物質對於放射線誘發 Raw 264.7 細胞發炎之影響 69 (四) 紅麴山藥酒萃物及其純物質對於放射線誘發 TGF-β1 之影響 76 (五) 紅麴山藥酒萃物緩解放射線治療衍生副作用之作用機制 76 第五章 綜合討論 80 第六章 參考文獻 83 | |
| dc.language.iso | zh-TW | |
| dc.title | 紅麴山藥酒精萃取物緩解放射線治療衍生之副作用 | zh_TW |
| dc.title | The moderation of radiotherapy side effects by ethanol extract of red mold dioscorea | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 98-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蘇遠志,黃建雄,廖啟成,蔡英傑 | |
| dc.subject.keyword | 放射線治療,紅麴,副作用,發炎,纖維化, | zh_TW |
| dc.subject.keyword | radiotherapy,Monascus,side effects,inflammation,fibrosis, | en |
| dc.relation.page | 95 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2010-05-23 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 微生物與生化學研究所 | zh_TW |
| 顯示於系所單位： | 微生物學科所 | |
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