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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 賈景山 | |
dc.contributor.author | Yu-Hsin Chang | en |
dc.contributor.author | 張妤欣 | zh_TW |
dc.date.accessioned | 2021-05-20T19:59:13Z | - |
dc.date.available | 2015-09-09 | |
dc.date.available | 2021-05-20T19:59:13Z | - |
dc.date.copyright | 2010-09-09 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-06-23 | |
dc.identifier.citation | Aarvak, T., M. Chabaud, et al. (1999). 'Change in the Th1/Th2 phenotype of memory T-cell clones from rheumatoid arthritis synovium.' Scand J Immunol 50(1): 1-9.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8644 | - |
dc.description.abstract | 發炎反應是近期被發現的一個致癌重要因子,而發炎為什麼會促進癌症的形成目前還沒有定論,可能是由於發炎會產生趨化物、細胞激素,會刺激細胞增生和抑制凋亡,另外也會產生過氧化物損害DNA。一些發炎相關的細胞激素以及 Th17 cell、Treg cell、巨噬細胞相關的細胞激素也和癌症有相關性。但這些細胞激素在口腔癌組織的表現量,以及對口腔癌的預後和臨床病理嚴重性的相關性仍不明確,是臨床研究值得探討的問題。
本研究收集手術切除之16個口腔癌腫瘤組織、4個非腫瘤組織,藉由抽取細菌16S rDNA,檢測是否有細菌的存在,以及萃取癌症組織RNA,觀察發炎相關之細胞激素的表現量,依照各激素的功能將其分為四組,分別是Treg、Th17、macrophage和chemokine四組。結果顯示il-1β (p=0.018)、 tnf-α (p=0.008)、 il-6 (p=0.018)、 tgf-β (p=0.03)和ccl-7 (p=0.012) 在腫瘤組織當中有顯著上升,而ccl-21 (p=0.023)、foxp3 (p=0.038)和il-17 (p=0.028)在非腫瘤組織中的表現量高於腫瘤組織。因此我們推論發炎激素及CCL-7,一種單核球趨化激素,和腫瘤的發展有相關,他們可以吸引更多發炎相關細胞進入腫瘤微環境中;在非癌症組織中高度表現的IL-17可清除細胞外細菌,而調節型T細胞的轉錄因子Foxp3可藉由它們免疫抑制的功能來降低非腫瘤組織內的發炎反應。 | zh_TW |
dc.description.abstract | Inflammation is an important risk factor of carcinogenesis. The mechanism of inflammation leading to carcinogenesis is still unclear, but inflammatory chemokines or cytokines may play some roles to stimulate cancer cell proliferation or inhibit apoptosis. Inflammatory reactions may also release differnt reactive oxygen species leading to DNA damage. Chemokines and cytokines, particulary those associated with Th17, regulatory T cells and macrophages were related to cancer initiation and progression. But the expression level of these chemokines or cytokines and their relationship to the prognosis and clinicopathological status of oral cancer is still unknown.
A total of 16 oral squamous cell carcinoma (OSCC) tissue and 4 non-cancer tissue were included in this study. The bacterial 16S ribosomal DNA was detected by PCR, and the expression level of cytokines and chemokines were quantitated by real-time PCR. The expression of il-1β (p=0.018), tnf-α (p=0.008), il-6 (p=0.018), tgf-β (p=0.03), and ccl-7 (p=0.012) are higher in OSCC tissue whereas ccl-21 (p=0.023), foxp3 (p=0.038) and il-17 (p=0.028) are higher in non-cancer tissue. Proinflammatory cytokines and CCL-7 may recruit more inflammatory cells into cancer microenvironment and contribute to tumor progression. IL-17, which was highly expressed in non-cancer tissue, could play important role in control extracellular bacterial infection, and Foxp3, a Treg transqription factor may disminish the inflammatory response by their immunosuppression function. | en |
dc.description.provenance | Made available in DSpace on 2021-05-20T19:59:13Z (GMT). No. of bitstreams: 1 ntu-99-R97422014-1.pdf: 734581 bytes, checksum: 116e3bc77ac06f934a3f561172c625d4 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 目錄 I
中文摘要 1 Abstract 2 第一章、緒論 3 第一節、相關研究背景 3 一、口腔鱗狀細胞癌的發生率 3 二、發炎與癌症之相關性 3 三、細菌促進癌症的發生 4 四、細菌、發炎及癌症之相關性 5 五、口腔內細菌的作用機轉 6 六、輔助型T細胞-17(Th17 cells)在發炎反應中的扮演的角色 9 七、調節型T細胞(regulatory T cells, Tregs)在發炎及癌症組織中的作用 12 八、腫瘤相關巨噬細胞(Tumor-associated macrophages)在癌症組織當中扮演的角色 14 第二節、實驗目的 17 第二章、實驗方法與材料 18 第一節、檢體的收集與來源 18 第二節、口腔鱗狀上皮細胞癌病患腫瘤組織及非腫瘤組織之DNA及RNA萃取 19 第三節、RNA之反轉錄 19 第四節、細菌DNA之聚合酶鏈鎖反應 20 第五節、同步定量聚合酶連鎖反應(real-time PCR, RT-PCR) 21 第六節、結果分析 21 第三章、結果 24 一、細菌DNA聚合酶鏈鎖反應之結果 24 二、口腔癌腫瘤及非腫瘤組織的細胞激素和趨化激素表現量比較 24 三、口腔癌腫瘤內各種激素表現量之間的相關性以及對應臨床病理分期結果 24 四、頰黏膜癌腫瘤組織及非腫瘤之頰黏膜組織的細胞激素和趨化激素表現量比較 26 五、牙齦癌腫瘤組織及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 27 六、非腫瘤之頰黏膜組織 及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 27 第四章 討論 28 一、口腔癌腫瘤及非腫瘤組織的細胞激素和趨化激素表現量比較 28 二、口腔癌腫瘤內各種激素表現量之間的相關性以及對應臨床病理分期結果 28 三、頰黏膜癌腫瘤組織及非腫瘤之頰黏膜組織的細胞激素和趨化激素表現量比較 30 四、牙齦癌腫瘤組織及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 31 五、非腫瘤之頰黏膜組織及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 31 六、結論 31 第六章、參考文獻 33 圖表 52 表一:樣本臨床病理資料 52 表二:各種細胞激素及分子的引子(primer) 53 表三:口腔癌腫瘤及非腫瘤組織的細胞激素和趨化激素表現量和臨床病理資料統計 55 表四:口腔癌腫瘤組織內細胞激素和趨化激素表現量和臨床病理資料統計 56 各種激素表現量對照病理分期 56 各種激素表現量對照癌症部位 57 表五: 58 表六:頰黏膜癌腫瘤組織及非腫瘤頰黏膜組織內細胞激素和趨化激素表現量和臨床病理資料統計 59 表七:牙齦癌腫瘤組織及智齒遠心側牙齦黏膜組織內細胞激素和趨化激素表現量和臨床病理資料統計 60 表八:非腫瘤頰黏膜組織及智齒遠心側牙齦組織內細胞激素和趨化激素表現量和臨床病理資料統計 61 圖一 62 圖二:口腔癌腫瘤及非腫瘤組織的細胞激素和趨化激素表現量比較 63 圖三:癌症組織中Treg相關激素間的相關性(具中度相關性以上) 64 圖四:癌症組織中Th17相關激素間的相關性(具中度相關性以上) 65 圖五:癌症組織中單核球及巨噬細胞相關激素間的相關性(具中度相關性以上) 66 圖六:癌症組織中趨化激素間的相關性(具中度相關性以上) 68 圖七:癌症組織中Foxp3及IL-17表現量的相關性 69 圖八:頰黏膜癌腫瘤組織及非腫瘤頰黏膜組織的細胞激素和趨化激素表現量比較 70 圖九:牙齦癌腫瘤組織及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 71 圖十:非腫瘤頰黏膜組織及智齒遠心側牙齦組織的細胞激素和趨化激素表現量比較 72 | |
dc.language.iso | zh-TW | |
dc.title | 在口腔鱗狀上皮細胞癌微環境中和發炎相關之細胞激素的探討 | zh_TW |
dc.title | The Expression and Role of Inflammatory Cytokines in Oral Squamous Cell Carcinoma | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.coadvisor | 李正? | |
dc.contributor.oralexamcommittee | 江俊斌,張龍昌,高壽延 | |
dc.subject.keyword | 口腔癌,發炎,細菌,調節型T細胞,Th17細胞,巨噬細胞, | zh_TW |
dc.subject.keyword | oral cancer,inflammation,bacteria,Tregs,Th17,macrophage, | en |
dc.relation.page | 72 | |
dc.rights.note | 同意授權(全球公開) | |
dc.date.accepted | 2010-06-23 | |
dc.contributor.author-college | 牙醫專業學院 | zh_TW |
dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
顯示於系所單位: | 臨床牙醫學研究所 |
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