利用高通量篩選資料排序食品內動物用藥殘留的內分泌干擾風險-以新北市為例

Abstract

因應人口增加，蛋白質來源需求量提高，於有限的空間環境內飼養經濟動物，為避免動物間傳染病的傳播及穩定畜牧生產量及品質，動物用藥的使用成為不可避免的管理措施。動物用藥種類繁多且使用範圍廣泛，在我們日常飲食中皆有動物用藥的暴露風險，透過化學品優先排序有助於毒性測試及健康風險評估，然而仍有些動物用藥之毒性數據或內分泌干擾特性尚未明確。本研究以新北市政府衛生局動物用藥殘留抽驗結果及國家攝食資料庫之攝食量進行分析，以隨機人體暴露和劑量模擬高通量模型，模擬日常飲食中動物用藥的總暴露量，透過風險排序列出需特別關注的之食品類別或動物用藥，並比對高通量試驗ToxCast/Tox21(InvitroDB, ver 3.1) 數據庫探討動物用藥對於內分泌干擾的作用。研究結果顯示，內分泌干擾作用非動物用藥殘留首要關注事項，動物用藥殘留對於人體之健康風險尚於可接受範圍。未來在規畫食安管理計畫時，可參考本研究架構，運用新興健康風險評估工具研擬管理策略。

Infectious and vector-borne diseases are detrimental to animal health and welfare, which would cause economic loss and diminish food supplies. The intervention using veterinary drugs has become an inevitable approach to ensure food security and the stable development of animal husbandry in Taiwan. Chemical prioritization is crucial to allocate resources for further toxicity testing and health risk assessment; however, several knowledge gaps do exist regarding the dietary risk of veterinary drug residues in food. The toxicity data and endocrine-active potential of veterinary drugs and their aggregate exposure to the Taiwanese population remain unclear. Therefore, this study aims to prioritize the endocrine-disrupting risks of veterinary drug residues in Taiwan, where the aggregate exposure assessment was achieved using a stochastic human exposure and dose simulation high-throughput model (SHEDS-HT) and the endocrine-active potential via 12 nuclear receptors was investigated using a high-throughput screening (HTS) database ToxCast/Tox21 (InvitroDB, ver 3.1). Our results revealed that the endocrine-disrupting property is not the primary concern for most veterinary drugs. Additionally, the veterinary drug residues in food do not pose a significant health risk to the Taiwanese population. This case study demonstrated that applying new approach methods (NAMs) can foster chemical prioritization and inform regulatory decision-making.