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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 李君浩(Jiun-Haw Lee) | |
dc.contributor.author | Yi-Ru Li | en |
dc.contributor.author | 李佾儒 | zh_TW |
dc.date.accessioned | 2023-03-19T22:16:08Z | - |
dc.date.copyright | 2022-09-23 | |
dc.date.issued | 2022 | |
dc.date.submitted | 2022-09-21 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/84573 | - |
dc.description.abstract | 奈米金屬結構激發表面電漿子共振(Surface Plasmon Resonance, SPR)感測器,具有非標定、高通量檢測特性非常適合化學及生物感測應用,生物樣品常用於金、銀等金屬。因金對生物體本身無毒性,所以適合應用於大量製造拋棄式感測晶片。然而gold金屬具有較小的虛部介電常數及較短的光學消逝波,並可提升金奈米金屬結構的檢測能力以及較低的檢測極限。在本論文中,我們利用射出成形技術製作以聚苯乙烯(polystyrene)聚合物為基板鍍金,形成金奈米金屬狹縫結構(gold-nanoslits)本體。我們進一步使用COMSOL模擬軟體來探討光場現象並觀察gold-nanoslits的光譜趨勢,並鋪上直徑100nm polystyrene球體模擬場型波長位移趨勢以及對比度信號(IGR)。而目前嚴重急性呼吸系統綜合症冠狀病毒-2 (SARS-CoV-2) 的持續全球大流行已導致對其相關診斷和醫學治療的積極研究。雖然定量逆轉錄聚合酶鏈反應 (qRT-PCR) 是檢測SARS-CoV-2病毒基因的最可靠方法,但須要針對特定抗病毒抗體的血清學來檢測,所以費時和耗力。本研究工作中,利用表面電漿子共振成像 (SPRi) 的原理。用金奈米結構的傳感器模擬的病毒大小能夠用於生物醫學應用的無標記檢測。然而,高通量和低成本的製造技術是應該解決的主要問題。gold-nanoslits生物晶片上有25 個陣列的折射率分辨率的變異係數為 0.55%。利用自參考雙色分析可以提高平均可檢測折射率 0.85×10-4 RIU的信噪比,並將檢測極限(LOD)平均值提高到2.96×10-5 RIU。我們開發的金奈米結構的生物晶片之表面電漿子共振成像掃描機線光源平台系統以及智慧型手機OLED-yellow面光源平台都已成功展示對SARS-CoV-2病毒檢測的高度靈敏、快速和低成本的診斷能力。結果表明,目前25孔傳感平台的可檢測折射率變化為2.96×10−5 RIU,SARS-CoV-2 Virus-Like Particles檢測LOD僅在1pg/mL~1ng/mL ≦15分鐘檢測時間和80μL樣品量。以上量測儀器實驗分析有:LED光譜儀分析、LED光源掃描機雙色CCD影像分析、OLED-yellow面光源手機CMOS影像分析。 | zh_TW |
dc.description.abstract | Surface Plasmon Resonance (SPR) sensors excited by nano-metal structures have non-calibration, high-throughput detection characteristics and are very suitable for chemical and biological sensing applications. Biological samples are often used for metals such as gold and silver. Because gold is not toxic to living organisms, it is suitable for the mass production of disposable sensing chips. However, gold metal has a smaller imaginary dielectric constant and a shorter optical evanescent wave, which can improve the detection capability and lower the detection limit of gold nano-metal structures. This thesis uses injection molding technology to fabricate gold-plated polystyrene polymer substrates to form the gold-nanoslits body. We further use the COMSOL simulation software to explore the light field phenomenon, observe the gold-nanoslits spectral trend, and overlay the 100nm diameter polystyrene sphere to simulate the field type wavelength shift trend and the contrast signal (IGR). The ongoing global pandemic of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has led to active research on its associated diagnosis and medical treatment. Although quantitative reverse transcription polymerase chain reaction (qRT-PCR) is the most reliable method to detect SARS-CoV-2 viral genes, it requires serology for specific antiviral antibodies, which is time-consuming and labor-intensive. This work utilizes the principle of surface plasmon resonance imaging (SPRi). Virus sizes simulated with gold nanostructured sensors enable label-free detection for biomedical applications. However, high-throughput and low-cost fabrication techniques are the main issues that should be addressed. The coefficient of variation for refractive index resolution of 25 arrays on a gold-nanoslits bio-wafer was 0.55%. The use of self-referencing two-color analysis can improve the signal-to-noise ratio of the average detectable refractive index of 0.85×10-4 RIU and the limit of detection (LOD) average to 2.96×10-5 RIU. The surface plasmon resonance imaging scanner line light source platform system of the gold nanostructured biochip and the smartphone OLED-yellow surface light source platform has successfully demonstrated the sensitive and rapid detection of the SARS-CoV-2 virus. And low-cost diagnostic capabilities. The results show that the detectable refractive index change of the current 25-well sensing platform is 2.96×10−5 RIU, and the detection LOD of SARS-CoV-2 Virus-Like Particles is only 1pg/mL~1ng/mL≦15min detection time and 80μL sample size. The experimental analysis of the above measuring instruments includes: LED spectrometer analysis, LED light source scanner two-color CCD image analysis, and OLED-yellow surface light source mobile phone CMOS image analysis. | en |
dc.description.provenance | Made available in DSpace on 2023-03-19T22:16:08Z (GMT). No. of bitstreams: 1 U0001-1909202218274400.pdf: 13893520 bytes, checksum: c23286136e7b74f7b27216d042f99d30 (MD5) Previous issue date: 2022 | en |
dc.description.tableofcontents | 口試委員會審定書 i 中文摘要 ii 英文摘要 iv 目錄 vi 圖目錄 ix 表目錄 xviii 第一章 緒論 1 1.1 研究背景 1 1.2 研究動機與目的 14 第二章 表面電漿子共振理論 20 2.1表面電漿子共振簡介 20 2.2表面電漿子共振原理 20 2.3表面電漿子耦合共振模態之原理 28 2.4金屬奈米狹縫之Fano共振訊號模態與原理 31 2.5金屬奈米狹縫光學特性 35 第三章 實驗設備和金屬奈米結構製作流程與量測系統 39 3.1電子束微影(E-Beam Lithography)技術簡介 39 3.2光阻使用種類分析與介紹 40 3.3反應式離子蝕刻技術簡介 41 3.4奈米壓印技術 43 3.5奈米結構射出成型技術 44 3.6真空熱蒸鍍膜設備系統 46 3.7商用穿透光譜晶片ITO載台溫控及恆溫系統 47 3.8氧電漿(O2 Plasma)系統 49 3.9原子力顯微鏡(AFM) 51 3.10接觸角(Contact Angle) 55 3.11商用掃描機系統(EPSON) 58 3.12高分子與小分子有機發光二極體簡介 59 3.13色度圖(CIE XYZ色度座標) 60 第四章 COMSOL有限元素法(FEM)理論計算 61 4.1有限元素法簡介 61 第五章 金屬奈米結構結合PLED作為背光源之SPR原理 66 5.1鋁金屬奈米封端狹縫結合PLED背光光源增益 66 第六章 生物樣品備製與表面修飾 70 6.1VLP生產製作方法及原理 70 6.2 Latex beads,amine-modified polystyrene 71 6.3 修飾硫醇化Protein G的自組裝層作為免疫傳感器之表面支架 72 第七章 LED光源光譜之生物晶片檢測 74 7.1硫醇-PS(PS-thiol) beads接金奈米金屬狹縫光譜分析 74 7.2蛋白質抗體抗原接金奈米金屬狹縫光譜分析 79 7.3 ITO表面溫控以及外在恆溫金屬奈米狹縫光譜分析 80 第八章 LED掃描機影像之生物晶片檢測病毒與IgG之研究 81 8.1PC塑膠射出成形技術製作SPR生物感測晶片陣列 81 8.2射出成型技術製作奈米結構檢測晶片之流程 82 8.3利用商用EPSON掃描機做為檢測系統 85 8.4色彩圖像檢測原理 86 8.5 COMSOL模擬PS~100nm beads在金奈米金屬狹縫上之光譜分析 91 8.6分析與量測 96 8.7直接檢測類似病毒顆粒(平均粒徑約0.1μm)與分析 103 8.8 Anti-Mouse IgG與IgG from mouse serum量測 107 第九章 OLED-yellow面光源與手機CMOS影像病毒檢測 111 9.1 OLED-yellow面光源硫醇-PS~100nm beads以及病毒分析與量測 111 第十章 結論 118 參考文獻 120 | |
dc.language.iso | zh-TW | |
dc.title | 利用電漿子體奈米結構之色彩圖像直接檢測類似病毒的顆粒 | zh_TW |
dc.title | Direct Detection of Virus-Like Particles Using Color Images of Plasmonic Nanostructures | en |
dc.type | Thesis | |
dc.date.schoolyear | 110-2 | |
dc.description.degree | 博士 | |
dc.contributor.author-orcid | 0000-0001-9254-1362 | |
dc.contributor.advisor-orcid | 李君浩(0000-0003-3888-0595) | |
dc.contributor.coadvisor | 魏培坤(Pei-Kuen Wei) | |
dc.contributor.coadvisor-orcid | 魏培坤(0000-0002-3002-0526) | |
dc.contributor.oralexamcommittee | 鄭郅言(Ji-Yen Cheng),胡哲銘(Che-Min Hu),邱南福(Nan-Fu Chiu),李翔傑(Hsiang-Chieh Lee) | |
dc.contributor.oralexamcommittee-orcid | 鄭郅言(0000-0001-7623-7555),胡哲銘(0000-0002-0988-7029),邱南福(0000-0003-1995-5483) | |
dc.subject.keyword | nanoslits奈米結構,表面電漿子共振,SPRi,無標記檢測,SARS-CoV-2 Virus-Like Particles, | zh_TW |
dc.subject.keyword | nanoslits Nanostructures,Surface Plasmon Resonance,SPRi,Label-Free Detection,SARS-CoV-2 Virus-Like Particles, | en |
dc.relation.page | 128 | |
dc.identifier.doi | 10.6342/NTU202203598 | |
dc.rights.note | 同意授權(限校園內公開) | |
dc.date.accepted | 2022-09-22 | |
dc.contributor.author-college | 電機資訊學院 | zh_TW |
dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
dc.date.embargo-lift | 2022-09-23 | - |
顯示於系所單位: | 光電工程學研究所 |
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U0001-1909202218274400.pdf 授權僅限NTU校內IP使用(校園外請利用VPN校外連線服務) | 13.57 MB | Adobe PDF | 檢視/開啟 |
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