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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 董成淵(Chen-Yuan Dong) | |
dc.contributor.author | Che-Wei Chang | en |
dc.contributor.author | 張哲維 | zh_TW |
dc.date.accessioned | 2023-03-19T22:05:17Z | - |
dc.date.copyright | 2022-07-13 | |
dc.date.issued | 2022 | |
dc.date.submitted | 2022-07-10 | |
dc.identifier.citation | [1] Walsh, Joseph C et al. “The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.” Antioxidants & redox signaling vol. 21,10 (2014): 1516-54. doi:10.1089/ars.2013.5378 R. C. Gonzalez, R. E. Woods, Digital Image Processing second edition, Prentice Hall, 2002 [2] Li, Hai-Xia et al. “Expression of αvβ6 integrin and collagen fibre in oral squamous cell carcinoma: association with clinical outcomes and prognostic implications.” Journal of oral pathology & medicine: official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology vol. 42,7 (2013): 547-56. doi:10.1111/jop.12044 [3] Machida, H et al. “Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study.” Endoscopy vol. 36,12 (2004): 1094-8. doi:10.1055/s-2004-826040 [4] Gono, Kazuhiro. “Narrow Band Imaging: Technology Basis and Research and Development History.” Clinical endoscopy vol. 48,6 (2015): 476-80. doi:10.5946/ce.2015.48.6.476 [5] Si, Yong-Feng et al. “A study on the value of narrow-band imaging (NBI) for the general investigation of a high-risk population of nasopharyngeal carcinoma (NPC).” World journal of surgical oncology vol. 16,1 126. 4 Jul. 2018, doi:10.1186/s12957-018-1423-5 [6] Wurster, Lara M et al. “Comparison of optical coherence tomography angiography and narrow-band imaging using a bimodal endoscope.” Journal of biomedical optics vol. 25,3 (2019): 1-5. doi:10.1117/1.JBO.25.3.032003 [7] Wei, Wei et al. “Microvascular imaging and monitoring of human oral cavity lesions in vivo by swept-source OCT-based angiography.” Lasers in medical science vol. 33,1 (2018): 123-134. doi:10.1007/s10103-017-2350-3 [8] Davoudi, Bahar et al. “Noninvasive in vivo structural and vascular imaging of human oral tissues with spectral domain optical coherence tomography.” Biomedical optics express vol. 3,5 (2012): 826-39. doi:10.1364/BOE.3.000826 [9] Hecht, Eugene. Optics / Eugene Hecht. 4th ed., Addison-Wesley, 2002. [10] Goldstein, Dennis H. Polarized Light Dennis H. Goldstein. 3rd ed., CRC Press, 2011. [11] Eugene Hecht, 'Note on an Operational Definition of the Stokes Parameters', American Journal of Physics 38, 1156-1158 (1970) [12] Boudoux, Caroline. Fundamentals of Biomedical Optics: from Light Interactions with Cells to Complex Imaging Systems / Caroline Boudoux. 1st edition., Pollux, 2017. [13] Prahl, Scott, “Optical Absorption of Hemoglobin,” 4 March 1998, https://omlc.org/spectra/hemoglobin/summary.html [14] Pelli, Denis G, and Peter Bex. “Measuring contrast sensitivity.” Vision research vol. 90 (2013): 10-4. doi:10.1016/j.visres.2013.04.015 [15] Peeters, Veerle, S Aime, and Stefaan De Smedt. “Molecular Recognition of Oxy- and Deoxy-Hemoglobin by Paramagnetic Gd(iii) Complexes in Red Blood Cells.” M.S. thesis, Ghent University Faculty of pharmaceutical sciences Laboratory of general biochemistry and physical pharmacy, Università Degli Studi Di Torino School of Pharmacy 2013. [16] Dervieux, Emmanuel et al. “Measuring hemoglobin spectra: searching for carbamino-hemoglobin.” Journal of biomedical optics vol. 25,10 (2020): 105001. doi:10.1117/1.JBO.25.10.105001 [17] Mustari, Afrina et al. “Agarose-based Tissue Mimicking Optical Phantoms for Diffuse Reflectance Spectroscopy.” Journal of visualized experiments: JoVE ,138 57578. 22 Aug. 2018, doi:10.3791/57578 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/84141 | - |
dc.description.abstract | 光在生物組織中有複雜的散射現象。我們希望可以透過偏光的影像,來提升異方性物質,像是膠原蛋白的對比度。另外,我們利用不同窄頻的光線來照射血液樣本,希望可以尋找特定的窄頻幫助我們分辨血氧的程度,提升影像的可見度。 | zh_TW |
dc.description.abstract | Light transport in biological tissues has a complicated mechanism. With the help of polarimetry, we attempt to distinguish anisotropic object such as collagen from the isotropic tissues. Further, by measuring optical phantoms at various wavelengths, we seek proper wavelengths to further distinguish the oxygenation level of blood vessels. We design this apparatus in hopes of enhancing the visibility of endoscopy for oral and esophageal cancers. This way we could better assist doctors in the diagnosis of cancer or other diseases. | en |
dc.description.provenance | Made available in DSpace on 2023-03-19T22:05:17Z (GMT). No. of bitstreams: 1 U0001-0707202208414700.pdf: 3262125 bytes, checksum: c08f3c9c2ffa2ba340c5fb0d32f253fa (MD5) Previous issue date: 2022 | en |
dc.description.tableofcontents | 口試委員會審定書 # 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF TABLES ix Chapter 1 Introduction 1 1.1 Angiogenesis and collagen deposition in oral cancer 1 1.1.1 Hypoxia and prognosis of oral cancer 1 1.1.2 Role of collagen in the development of HNSCC 1 1.2 Optical diagnosis of head and neck squamous cell carcinoma (HNSCC) 2 1.2.1 Narrow band imaging 2 1.2.2 Optical coherence tomography 2 1.3 Narrow band and polarization imaging in cancer diagnosis 3 Chapter 2 Physical principles 4 2.1 Polarization properties of light 4 2.1.1 Stokes’ parameters formalism 4 2.2 Light-matter interaction 6 2.2.1 Molecular absorption 6 2.2.2 Scattering 7 2.3 Oximetry 12 2.3.1 Beer-Lambert’s law 12 2.3.2 Absorption spectra of oxyhemoglobin and deoxyhemoglobin 13 2.3.3 Oxygen saturation 13 2.4 Contrast 14 Chapter 3 Materials and methods 16 3.1 Optical models 16 3.1.1 Preparation of hemoglobin solutions 16 3.1.2 Tendon 18 3.1.3 Milk solution as tissue phantom 18 3.2 Optical arrangement for oximetric imaging 19 3.2.1 Light source, optical components, and detector 19 3.2.2 Oximetric imaging 21 3.3 Optical setup for polarimetric imaging 23 Chapter 4 Results 26 4.1 Wavelength-dependent contrast of oxy- and deoxy- hemoglobin solutions 26 4.1.1 Spectra for oxygenated and deoxygenated hemoglobin solutions 26 4.1.2 Stability of the LED light source 28 4.1.3 Specular reflection 29 4.1.4 Oximetric imaging 31 4.2 Polarization imaging of tendon in turbid medium 33 4.2.1 Milk phantom under white light 33 4.2.2 White light 37 4.2.3 640 nm wavelength monochromatic light source 40 Chapter 5 Conclusion 48 REFERENCE 49 | |
dc.language.iso | en | |
dc.title | 血氧與偏光影像於頭頸癌的應用 | zh_TW |
dc.title | Optical Diagnosis of HNSCC by Oximetric and Polarimetric Imaging | en |
dc.type | Thesis | |
dc.date.schoolyear | 110-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 婁培人(Pei-Jen Lou),林玫君(Mei-Chun Lin),陳顯禎(Shean-Jen Chen) | |
dc.subject.keyword | 血氧,血紅素光譜,偏光,膠原蛋白,組織散射,頭頸癌,口腔癌, | zh_TW |
dc.subject.keyword | oximetry,hemoglobin spectrum,polarization,collagen,tissue scattering,HNSCC,oral cancer, | en |
dc.relation.page | 51 | |
dc.identifier.doi | 10.6342/NTU202201320 | |
dc.rights.note | 同意授權(限校園內公開) | |
dc.date.accepted | 2022-07-11 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 物理學研究所 | zh_TW |
dc.date.embargo-lift | 2022-07-13 | - |
顯示於系所單位: | 物理學系 |
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