Skip navigation

DSpace

機構典藏 DSpace 系統致力於保存各式數位資料(如:文字、圖片、PDF)並使其易於取用。

點此認識 DSpace
DSpace logo
English
中文
  • 瀏覽論文
    • 校院系所
    • 出版年
    • 作者
    • 標題
    • 關鍵字
    • 指導教授
  • 搜尋 TDR
  • 授權 Q&A
    • 我的頁面
    • 接受 E-mail 通知
    • 編輯個人資料
  1. NTU Theses and Dissertations Repository
  2. 公共衛生學院
  3. 公共衛生碩士學位學程
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83308
完整後設資料紀錄
DC 欄位值語言
dc.contributor.advisor郭年真zh_TW
dc.contributor.advisorNien-Chen Kuoen
dc.contributor.author翁逸翔zh_TW
dc.contributor.authorYi-Xiang Wengen
dc.date.accessioned2023-03-08T17:02:31Z-
dc.date.available2023-11-10-
dc.date.copyright2023-05-29-
dc.date.issued2023-
dc.date.submitted2023-02-01-
dc.identifier.citation劉介宇, 洪永泰, 莊義利, 陳怡如, 翁文舜, 劉季鑫, & 梁賡義. (2006). 台灣地區鄉鎮市區發展類型應用於大型健康調查抽樣設計之研究 [Incorporating Development Stratification of Taiwan Townships into Sampling Design of Large Scale Health Interview Survey]. 健康管理學刊, 4(1), 1-22. https://doi.org/10.29805/jhm.200606.0001
張晉胤. (2016). 台灣失智症病患不同病程之醫療費用及利用情形 (Publication Number 2016年) 臺北醫學大學]. AiritiLibrary.
朱育增, & 吳肖琪. (2010). 回顧與探討次級資料適用之共病測量方法 [A Review of claims-based Comorbidity Measures]. 台灣公共衛生雜誌, 29(1), 8-21. https://doi.org/10.6288/tjph2010-29-01-02
陳安履, 周暉哲, 陳美如, 謝旭東, 高凰珠, 王映雪, & 林舜穀. (2019). 末期失智症之中西醫整合照護 [Integrating Traditional Chinese Medicine for the Care for Late-Stage Dementia]. 北市醫學雜誌, 16, 97-109. https://doi.org/10.6200/tcmj.201910/sp_16.0011
吳佩芸, 廖建彰, & 施純全. (2020). 中藥治療中風後失智症的療效評估:一項回溯性世代研究 [The Therapeutic Assessment of Chinese Herbal Medicine on Post-Stroke Dementia: A Retrospective Cohort study]. 中醫藥研究論叢, 23(3), 17-34. https://doi.org/10.6516/tjtcm.202012_23(3).0002
吳育庭, & 楊銘欽. (2020). 針灸對中風後血管型失智症病人之效果評估:以全國性資料分析為例 [Evaluation of the Efficacy of Acupuncture on Vascular Dementia after Stroke in Taiwan: a population-based study]. 中醫藥雜誌, 31(1), 31-47. https://doi.org/10.6940/jcm.202006_31(1).04
王佳玉, 花茂棽, 邱銘章, 朱怡娟, 陳獻宗, 葉炳強, 柯慧貞, 陸汝斌, & 彭家勛. (2003). 簡式智能評估 (MMSE) 與臨床失智量表 (CDR) 在評估阿茲海默型失智症之比較. In: 臺灣精神醫學.
Ahn, H. I., & Hyun, M. K. (2019). Effectiveness of integrative medicine program for dementia prevention on cognitive function and depression of elderly in a public health center. Integr Med Res, 8(2), 133-137. https://doi.org/10.1016/j.imr.2019.04.008
Arai, H., Hashimoto, N., Sumitomo, K., Takase, T., & Ishii, M. (2018). Disease state changes and safety of long-term donepezil hydrochloride administration in patients with Alzheimer's disease: Japan-Great Outcome of Long-term trial with Donepezil (J-GOLD). Psychogeriatrics, 18(5), 402-411. https://doi.org/10.1111/psyg.12340
Arvanitakis, Z., Shah, R. C., & Bennett, D. A. (2019). Diagnosis and Management of Dementia: Review. Jama, 322(16), 1589-1599. https://doi.org/10.1001/jama.2019.4782
Bell, J. F., Fitzpatrick, A. L., Copeland, C., Chi, G., Steinman, L., Whitney, R. L., Atkins, D. C., Bryant, L. L., Grodstein, F., Larson, E., Logsdon, R., & Snowden, M. (2015). Existing data sets to support studies of dementia or significant cognitive impairment and comorbid chronic conditions. Alzheimers Dement, 11(6), 622-638. https://doi.org/10.1016/j.jalz.2014.07.002
Birks, J. S. (2006). Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database of Systematic Reviews(1). https://doi.org/10.1002/14651858.CD005593
Burback, D., Molnar, F. J., St John, P., & Man-Son-Hing, M. (1999). Key methodological features of randomized controlled trials of Alzheimer's disease therapy. Minimal clinically important difference, sample size and trial duration. Dement Geriatr Cogn Disord, 10(6), 534-540. https://doi.org/10.1159/000017201
Chen, K. H., Yeh, M. H., Livneh, H., Chen, B. C., Lin, I. H., Lu, M. C., Tsai, T. Y., & Yeh, C. C. (2017). Association of traditional Chinese medicine therapy and the risk of dementia in patients with hypertension: a nationwide population-based cohort study. BMC Complement Altern Med, 17(1), 178. https://doi.org/10.1186/s12906-017-1677-4
Chen, Y., Tysinger, B., Crimmins, E., & Zissimopoulos, J. M. (2019). Analysis of dementia in the US population using Medicare claims: Insights from linked survey and administrative claims data. Alzheimers Dement (N Y), 5, 197-207. https://doi.org/10.1016/j.trci.2019.04.003
Courtney, C., Farrell, D., Gray, R., Hills, R., Lynch, L., Sellwood, E., Edwards, S., Hardyman, W., Raftery, J., Crome, P., Lendon, C., Shaw, H., & Bentham, P. (2004). Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet, 363(9427), 2105-2115. https://doi.org/10.1016/s0140-6736(04)16499-4
Hong, J. Y., Lan, T. Y., Tang, G. J., Tang, C. H., Chen, T. J., & Lin, H. Y. (2015). Gout and the risk of dementia: a nationwide population-based cohort study. Arthritis Res Ther, 17(1), 139. https://doi.org/10.1186/s13075-015-0642-1 可參考配對、影響因子
Huang, M. H., Tsai, C. F., Cheng, C. M., Lin, Y. S., Lee, W. J., Kuo, Y. S., Chan, Y. E., & Fuh, J. L. (2022). Predictors of emergency department visit among people with dementia in Taiwan. Arch Gerontol Geriatr, 101, 104701. https://doi.org/10.1016/j.archger.2022.104701
Hunt, L. J., Lee, S. J., Harrison, K. L., & Smith, A. K. (2018). Secondary Analysis of Existing Datasets for Dementia and Palliative Care Research: High-Value Applications and Key Considerations. J Palliat Med, 21(2), 130-142. https://doi.org/10.1089/jpm.2017.0309
Kao, S. L., Wang, J. H., Chen, S. C., Li, Y. Y., Yang, Y. L., & Lo, R. Y. (2021). Impact of Comorbidity Burden on Cognitive Decline: A Prospective Cohort Study of Older Adults with Dementia. Dement Geriatr Cogn Disord, 50(1), 43-50. https://doi.org/10.1159/000514651
Lee, E., Gatz, M., Tseng, C., Schneider, L. S., Pawluczyk, S., Wu, A. H., & Deapen, D. (2019). Evaluation of Medicare Claims Data as a Tool to Identify Dementia. J Alzheimers Dis, 67(2), 769-778. https://doi.org/10.3233/jad-181005
Lin, S.-K., Wang, P.-H., Huang, C.-H., Kuo, Y.-H., Lai, J.-N., & Cheng-Chung Wei, J. (2021). Association between Traditional Chinese medicine and a lower risk of dementia in patients with major depression: A case-control study. J Ethnopharmacol, 278, 114291. https://doi.org/https://doi.org/10.1016/j.jep.2021.114291
Lin, S. K., Lin, P. H., Hsu, R. J., Chuang, H. C., & Liu, J. M. (2017). Traditional Chinese medicine therapy reduces the catheter indwelling risk in dementia patients with difficult voiding symptoms. J Ethnopharmacol, 203, 120-126. https://doi.org/10.1016/j.jep.2017.03.040
Lin, S. K., Lo, P. C., Chen, W. C., & Lai, J. N. (2019). Integrating traditional Chinese medicine healthcare into dementia care plan by reducing the need for special nursing care and medical expenses. Medicine (Baltimore), 98(7), e14468. https://doi.org/10.1097/md.0000000000014468
Lin, S. K., Tsai, Y. T., Lai, J. N., & Wu, C. T. (2015). Demographic and medication characteristics of traditional Chinese medicine users among dementia patients in Taiwan: a nationwide database study. J Ethnopharmacol, 161, 108-115. https://doi.org/10.1016/j.jep.2014.12.015
Lin, S. K., Tsai, Y. T., Lo, P. C., & Lai, J. N. (2016). Traditional Chinese medicine therapy decreases the pneumonia risk in patients with dementia. Medicine (Baltimore), 95(37), e4917. https://doi.org/10.1097/md.0000000000004917
Lin, S. K., Tzeng, J. N., & Lai, J. N. (2019). The core pattern of Chinese herbal formulae and drug-herb concurrent usage in patients with dementia. Medicine (Baltimore), 98(4), e13931. https://doi.org/10.1097/md.0000000000013931
Lin, S. K., Yan, S. H., Lai, J. N., & Tsai, T. H. (2016). Patterns of Chinese medicine use in prescriptions for treating Alzheimer's disease in Taiwan. Chin Med, 11, 12. https://doi.org/10.1186/s13020-016-0086-9
Lu, Z. K., Xiong, X., Wang, X., & Wu, J. (2021). Gender Disparities in Anti-dementia Medication Use among Older Adults: Health Equity Considerations and Management of Alzheimer's Disease and Related Dementias. Front Pharmacol, 12, 706762. https://doi.org/10.3389/fphar.2021.706762
May, B. H., Feng, M., Hyde, A. J., Hügel, H., Chang, S. Y., Dong, L., Guo, X., Zhang, A. L., Lu, C., & Xue, C. C. (2018). Comparisons between traditional medicines and pharmacotherapies for Alzheimer disease: A systematic review and meta-analysis of cognitive outcomes. Int J Geriatr Psychiatry, 33(3), 449-458. https://doi.org/10.1002/gps.4830
Niznik, J. D., Zhao, X., He, M., Aspinall, S. L., Hanlon, J. T., Nace, D., Thorpe, J. M., & Thorpe, C. T. (2019). Factors Associated With Deprescribing Acetylcholinesterase Inhibitors in Older Nursing Home Residents With Severe Dementia. J Am Geriatr Soc, 67(9), 1871-1879. https://doi.org/10.1111/jgs.15985
Pei, H., Ma, L., Cao, Y., Wang, F., Li, Z., Liu, N., Liu, M., Wei, Y., & Li, H. (2020). Traditional Chinese Medicine for Alzheimer's Disease and Other Cognitive Impairment: A Review. Am J Chin Med, 48(3), 487-511. https://doi.org/10.1142/s0192415x20500251
Quan, H., Sundararajan, V., Halfon, P., Fong, A., Burnand, B., Luthi, J. C., Saunders, L. D., Beck, C. A., Feasby, T. E., & Ghali, W. A. (2005). Coding algorithms for defining comorbidities in ICD-9-CM and ICD-10 administrative data. Med Care, 43(11), 1130-1139. https://doi.org/10.1097/01.mlr.0000182534.19832.83
Shih, C. C., Yeh, C. C., Hu, C. J., Lane, H. L., Tsai, C. C., Chen, T. L., & Liao, C. C. (2017). Risk of dementia in patients with non-haemorrhagic stroke receiving acupuncture treatment: a nationwide matched cohort study from Taiwan's National Health Insurance Research Database. BMJ Open, 7(6), e013638. https://doi.org/10.1136/bmjopen-2016-013638
Shih, C. C., Yeh, C. C., Yang, J. L., Lane, H. L., Huang, C. J., Lin, J. G., Chen, T. L., & Liao, C. C. (2019). Reduced use of emergency care and hospitalization in patients with post-stroke cognitive impairment treated with traditional Chinese medicine. Qjm, 112(6), 437-442. https://doi.org/10.1093/qjmed/hcz044
Solomon, A., Dobranici, L., Kåreholt, I., Tudose, C., & Lăzărescu, M. (2011). Comorbidity and the rate of cognitive decline in patients with Alzheimer dementia. Int J Geriatr Psychiatry, 26(12), 1244-1251. https://doi.org/10.1002/gps.2670
Villani, S., Ferraro, O. E., Poloni, T. E., & Guaita, A. (2022). Dementia and Risk Factors: Results from a Prospective, Population-Based Cohort Study. Life (Basel), 12(7). https://doi.org/10.3390/life12071055
Wang, Y. Y., Yu, S. F., Xue, H. Y., Li, Y., Zhao, C., & Jin, Y. H. (2020). Effectiveness and Safety of Acupuncture for the Treatment of Alzheimer's Disease: A Systematic Review and Meta-Analysis. Front Aging Neurosci, 12, 98. https://doi.org/10.3389/fnagi.2020.00098
Wayne, P. M., Walsh, J. N., Taylor-Piliae, R. E., Wells, R. E., Papp, K. V., Donovan, N. J., & Yeh, G. Y. (2014). Effect of tai chi on cognitive performance in older adults: systematic review and meta-analysis. J Am Geriatr Soc, 62(1), 25-39. https://doi.org/10.1111/jgs.12611
Zhang, Y., Noh, K., & Song, W. (2019). Chinese herbal medicines on cognitive function and activity of daily living in senior adults with Alzheimer's disease: a systematic review and meta-analysis. Integr Med Res, 8(2), 92-100. https://doi.org/10.1016/j.imr.2019.04.006
Zheng, W., Su, Z., Liu, X., Zhang, H., Han, Y., Song, H., Lu, J., Li, K., & Wang, Z. (2018). Modulation of functional activity and connectivity by acupuncture in patients with Alzheimer disease as measured by resting-state fMRI. PLoS One, 13(5), e0196933. https://doi.org/10.1371/journal.pone.0196933
Zhou, J., Peng, W., Xu, M., Li, W., & Liu, Z. (2015). The effectiveness and safety of acupuncture for patients with Alzheimer disease: a systematic review and meta-analysis of randomized controlled trials. Medicine (Baltimore), 94(22), e933. https://doi.org/10.1097/md.0000000000000933
Zhu, C. W., Cosentino, S., Ornstein, K. A., Gu, Y., Andrews, H., & Stern, Y. (2017). Interactive Effects of Dementia Severity and Comorbidities on Medicare Expenditures. J Alzheimers Dis, 57(1), 305-315. https://doi.org/10.3233/jad-161077
Zucchella, C., Sinforiani, E., Tamburin, S., Federico, A., Mantovani, E., Bernini, S., Casale, R., & Bartolo, M. (2018). The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment. Front Neurol, 9, 1058. https://doi.org/10.3389/fneur.2018.01058
-
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83308-
dc.description.abstract研究背景:依據台灣失智症協會2011年失智症流行病學調查結果顯示,我國目前約有30萬名失智症病患,盛行率達1.29%,亦即65歲以上老人每13人即有1名失智症患者,隨著社會高齡化進展,失智症病人的治療與所衍伸相關的問題將越來越受重視,可以預見成為全球重大公共衛生問題之一。經由過去研究結果發現,中醫治療對失智症病人各面項病況有不同程度的幫助,然而此類研究大多使用健保資料庫分析,缺乏較直觀的預後測量指標,或無利用失智症疾病診斷碼與相關認知功能測驗數據,精確篩選失智症病患。
研究目的:本研究欲探討中醫醫療利用對失智症病人日常生活功能、認知功能以及醫療費用之影響。
研究方法:本研究使用長庚醫院醫學研究資料庫,探討2004至2021年失智症患者之中醫利用情形,對於後續2年日常生活功能、認知功能以及醫療費用之影響。並針對年齡、性別、教育程度、就醫院區、共病症指數、居住都市化程度、失智症西藥使用情形、失智症嚴重程度等變項採用傾向分數配對方法,使組間分布較為一致,減少選樣偏差。因依變項有重複測量情形,故使用廣義估計方程式控制社會人口特質、地區特質、失智西藥治療後,檢測中醫醫療利用對依變項的影響。
研究結果:經配對後共441位研究對象,中醫介入組90位、非中醫介入組351位,多變項迴歸分析結果,中醫介入失智症的病人相較非中醫介入組,簡短智能測驗分數變化量每年會增加0.608分,而每年臨床失智分期分數變化量為非中醫利用組的0.702倍,皆達統計上顯著水準。中醫介入後每年之門診費用較無介入組增加14,766元,住院費用增加9,728元,總醫療費用增加24,477元,且達統計顯著差異。
結論:中醫介入會延緩失智症病人的簡短智能分數的下降,對於病人的臨床失智症分期分數有延緩上升趨勢,皆達統計顯著。中醫介入會增加失智症病人的醫療費用,尤其是門診醫療費用部分。若將來制定失智症相關政策時,可將中醫介入治療失智病人納入考量,並建議一年使用中醫門診治療須達6次以上。
zh_TW
dc.description.abstractObjectives: According to the 2011 dementia epidemiological survey conducted by the Taiwan Dementia Association, there are currently about 300,000 dementia patients in Taiwan, with a prevalence rate of 1.29%, that is, 1 out of every 13 people over the age of 65 Dementia patients, with the progress of aging society, the treatment of dementia patients and related issues will receive more and more attention, and it can be predicted to become one of the major public health problems in the world. Past research results have found that Chinese medicine treatment can help dementia patients to varying degrees. However, most of these studies use health insurance database analysis, lack of more intuitive prognostic indicators, or make good use of dementia disease diagnosis codes and related cognitive function test data to accurately screen dementia patients. This study aims to explore the influence of traditional Chinese medicine (TCM) medical utilization on the daily life function, cognitive function and medical expenses of dementia patients.
Methods: This study used CGRD (Chang Gung Medical Research Database) to explore the influence of TCM utilization by dementia patients from 2004 to 2021 on the daily life function, cognitive function and medical expenses in the following 2 years. The propensity score matching method was adopted for variables such as age, gender, education level, hospital area, comorbidity index, degree of urbanization of residence, use of western medicine for dementia, and severity of dementia to make the distribution between groups more consistent and reduce sampling bias. Due to repeated measurement of the dependent variable, the generalized estimating equation was used to control the socio-demographic characteristics, regional characteristics, and dementia western medicine treatment to detect the influence of TCM medical utilization on the dependent variable.
Results: After matching, a total of 441 research subjects were included, 90 in the TCM intervention group and 351 in the non-TCM intervention group. The results of multivariate regression analysis showed that compared with the non-TCM intervention group, the scores of short intelligence test scores changed each year in the TCM intervention group will increase by 0.608 points, and the annual change in clinical dementia stage scores is 0.702 times that of the non-TCM utilization group, both reaching statistically significant levels. After TCM intervention, the annual outpatient expenses increased by NT$14,766, the hospitalization expenses increased by NT$9,728, and the total medical expenses increased by NT$24,477 compared with the non-intervention group, and the difference was statistically significant.
Conclusions: TCM intervention can delay the decline of brief intelligence scores of dementia patients, and delay the rise of patients' clinical dementia stage scores, both of which are statistically significant. The intervention of TCM will increase the medical expenses of dementia patients, especially the outpatient medical expenses. If policies related to dementia are formulated in the future, TCM intervention in the treatment of dementia patients can be taken into consideration, and it is recommended to use TCM outpatient treatment for more than 6 times a year.
en
dc.description.provenanceSubmitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-03-08T17:02:31Z
No. of bitstreams: 0
en
dc.description.provenanceMade available in DSpace on 2023-03-08T17:02:31Z (GMT). No. of bitstreams: 0en
dc.description.tableofcontents中文摘要 i
Abstract ii
目錄 iv
圖目錄 vi
表目錄 vii
第一章 緒論 1
第一節 實習單位簡介 1
第二節 研究背景與動機 2
第二章 文獻探討 5
第一節 中醫藥對於失智症療效之臨床研究 5
第二節 中醫藥對於失智症照護成效之次級資料研究 7
第三節 失智症病患在中醫藥利用的影響因子分析 11
第四節 中醫藥利用對於失智症病人照護成效的影響因子分析 13
第五節 失智症病人的醫療費用相關文獻 16
第三章 研究設計與方法 18
第一節 研究設計與對象 19
第二節 研究架構 22
第三節 研究假說 23
第四節 資料來源 24
第五節 研究變項及其測量 25
第六節 資料處理 30
第七節 統計分析 32
第八節 實習形式 33
第四章 研究結果 34
第一節 描述性統計 34
第二節 中醫介入對失智症病人的照護成效之推論性統計 40
第三節 中醫介入對失智症的醫療費用之推論性統計 44
第五章 討論 49
第一節 研究結果討論 49
第二節 假說驗證 56
第三節 研究限制 57
第六章 結論與建議 58
附錄1 失智症及其相關ICD-9診斷碼 60
附錄2 失智症及其相關ICD-10診斷碼 61
參考文獻 62
-
dc.language.isozh_TW-
dc.subject中醫zh_TW
dc.subject費用zh_TW
dc.subject簡易智能測驗(MMSE)zh_TW
dc.subject失智評分量表(CDR)zh_TW
dc.subject失智症zh_TW
dc.subjectMedical Expensesen
dc.subjectClinical Dementia Rating (CDR)en
dc.subjectTraditional Chinese Medicineen
dc.subjectDementiaen
dc.subjectMini-Mental Status Examination(MMSE)en
dc.title中醫介入對失智症照護成效及醫療費用之影響zh_TW
dc.titleThe Effect of Traditional Chinese Medicine on Outcomes and Costs of Dementia Careen
dc.title.alternativeThe Effect of Traditional Chinese Medicine on Outcomes and Costs of Dementia Care-
dc.typeThesis-
dc.date.schoolyear111-1-
dc.description.degree碩士-
dc.contributor.oralexamcommittee楊建中;徐文俊zh_TW
dc.contributor.oralexamcommitteeChien-Chung Yang;Wen-Chuin Hsuen
dc.subject.keyword失智症,中醫,失智評分量表(CDR),簡易智能測驗(MMSE),費用,zh_TW
dc.subject.keywordDementia,Traditional Chinese Medicine,Clinical Dementia Rating (CDR),Mini-Mental Status Examination(MMSE),Medical Expenses,en
dc.relation.page65-
dc.identifier.doi10.6342/NTU202300169-
dc.rights.note未授權-
dc.date.accepted2023-02-02-
dc.contributor.author-college公共衛生學院-
dc.contributor.author-dept公共衛生碩士學位學程-
顯示於系所單位:公共衛生碩士學位學程

文件中的檔案:
檔案 大小格式 
ntu-111-1.pdf
  未授權公開取用
1.33 MBAdobe PDF
顯示文件簡單紀錄


系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。

社群連結
聯絡資訊
10617臺北市大安區羅斯福路四段1號
No.1 Sec.4, Roosevelt Rd., Taipei, Taiwan, R.O.C. 106
Tel: (02)33662353
Email: ntuetds@ntu.edu.tw
意見箱
相關連結
館藏目錄
國內圖書館整合查詢 MetaCat
臺大學術典藏 NTU Scholars
臺大圖書館數位典藏館
本站聲明
© NTU Library All Rights Reserved