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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 郭育良 | zh_TW |
| dc.contributor.advisor | Yue-Liang Guo | en |
| dc.contributor.author | 楊翊昇 | zh_TW |
| dc.contributor.author | Yi-Sheng Yang | en |
| dc.date.accessioned | 2023-03-01T17:07:33Z | - |
| dc.date.available | 2023-11-10 | - |
| dc.date.copyright | 2023-05-29 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-02-03 | - |
| dc.identifier.citation | Akdis, C. A. (2021). Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? Nat Rev Immunol, 21(11), 739-751. https://doi.org/10.1038/s41577-021-00538-7
Anderson, H. R., Gupta, R., Strachan, D. P., & Limb, E. S. (2007). 50 years of asthma: UK trends from 1955 to 2004. Thorax, 62(1), 85-90. https://doi.org/10.1136/thx.2006.066407 Asher, M. e., Keil, U., Anderson, H., Beasley, R., Crane, J., Martinez, F., Mitchell, E., Pearce, N., Sibbald, B., & Stewart, A. (1995). International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods. European Respiratory Journal, 8(3), 483-491. Asher, M. I., Montefort, S., Björkstén, B., Lai, C. K., Strachan, D. P., Weiland, S. K., & Williams, H. (2006). Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys. Lancet, 368(9537), 733-743. https://doi.org/10.1016/s0140-6736(06)69283-0 Ashida, Y., & Denda, M. (2003). Dry environment increases mast cell number and histamine content in dermis in hairless mice. Br J Dermatol, 149(2), 240-247. https://doi.org/10.1046/j.1365-2133.2003.05408.x Ashida, Y., Ogo, M., & Denda, M. (2001). Epidermal interleukin‐1α generation is amplified at low humidity: implications for the pathogenesis of inflammatory dermatoses. British Journal of Dermatology, 144(2), 238-243. Baek, J. O., Hong, S., Son, D. K., Lee, J. R., Roh, J. Y., & Kwon, H. J. (2013). Analysis of the prevalence of and risk factors for atopic dermatitis using an ISAAC questionnaire in 8,750 Korean children. Int Arch Allergy Immunol, 162(1), 79-85. https://doi.org/10.1159/000351403 Breysse, P. N., Diette, G. B., Matsui, E. C., Butz, A. M., Hansel, N. N., & McCormack, M. C. (2010). Indoor air pollution and asthma in children. Proc Am Thorac Soc, 7(2), 102-106. https://doi.org/10.1513/pats.200908-083RM Byremo, G., Rød, G., & Carlsen, K. H. (2006). Effect of climatic change in children with atopic eczema. Allergy, 61(12), 1403-1410. https://doi.org/10.1111/j.1398-9995.2006.01209.x Chen, B. Y., Chan, C. C., Han, Y. Y., Wu, H. P., & Guo, Y. L. (2012). The risk factors and quality of life in children with allergic rhinitis in relation to seasonal attack patterns. Paediatr Perinat Epidemiol, 26(2), 146-155. https://doi.org/10.1111/j.1365-3016.2011.01203.x Chen, B. Y., Chen, C. H., Chuang, Y. C., Wu, Y. H., Pan, S. C., & Guo, Y. L. (2019a). Changes in the relationship between ambient fine particle concentrations and childhood lung function over 5 years. Environ Res, 179(Pt B), 108809. https://doi.org/10.1016/j.envres.2019.108809 Chen, B. Y., Chen, C. H., Chuang, Y. C., Wu, Y. H., Pan, S. C., & Guo, Y. L. (2019b). Changes in the relationship between childhood asthma and ambient air pollution in Taiwan: Results from a nationwide survey repeated 5 years apart. Pediatr Allergy Immunol, 30(2), 188-194. https://doi.org/10.1111/pai.12999 Corey, J. P., Kaiseruddin, S., & Gungor, A. (1997). Prevalence of mold-specific immunoglobulins in a Midwestern allergy practice. Otolaryngol Head Neck Surg, 117(5), 516-520. https://doi.org/10.1016/s0194-5998(97)70024-x Cravello, B., & Ferri, A. (2008). Relationships between skin properties and environmental parameters. Skin Research and Technology, 14(2), 180-186. Denda, M., Sato, J., Masuda, Y., Tsuchiya, T., Koyama, J., Kuramoto, M., Elias, P. M., & Feingold, K. R. (1998). Exposure to a dry environment enhances epidermal permeability barrier function. J Invest Dermatol, 111(5), 858-863. https://doi.org/10.1046/j.1523-1747.1998.00333.x Drucker, A. M., Wang, A. R., Li, W. Q., Sevetson, E., Block, J. K., & Qureshi, A. A. (2017). The Burden of Atopic Dermatitis: Summary of a Report for the National Eczema Association. J Invest Dermatol, 137(1), 26-30. https://doi.org/10.1016/j.jid.2016.07.012 Engebretsen, K., Johansen, J., Kezic, S., Linneberg, A., & Thyssen, J. (2016). The effect of environmental humidity and temperature on skin barrier function and dermatitis. Journal of the European Academy of Dermatology and Venereology, 30(2), 223-249. Fleischer, A. B., Jr. (2019). Atopic dermatitis: the relationship to temperature and seasonality in the United States. Int J Dermatol, 58(4), 465-471. https://doi.org/10.1111/ijd.14289 Gilles, S., Akdis, C., Lauener, R., Schmid-Grendelmeier, P., Bieber, T., Schäppi, G., & Traidl-Hoffmann, C. (2018). The role of environmental factors in allergy: A critical reappraisal. Exp Dermatol, 27(11), 1193-1200. https://doi.org/10.1111/exd.13769 Guo, Q., Xiong, X., Liang, F., Tian, L., Liu, W., Wang, Z., & Pan, X. (2019). The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time-series analysis. J Eur Acad Dermatol Venereol, 33(12), 2362-2370. https://doi.org/10.1111/jdv.15820 Guo, Y. L., Lin, Y. C., Sung, F. C., Huang, S. L., Ko, Y. C., Lai, J. S., Su, H. J., Shaw, C. K., Lin, R. S., & Dockery, D. W. (1999). Climate, traffic-related air pollutants, and asthma prevalence in middle-school children in taiwan. Environ Health Perspect, 107(12), 1001-1006. https://doi.org/10.1289/ehp.991071001 Haahtela, T., Holgate, S., Pawankar, R., Akdis, C. A., Benjaponpitak, S., Caraballo, L., Demain, J., Portnoy, J., & von Hertzen, L. (2013). The biodiversity hypothesis and allergic disease: world allergy organization position statement. World Allergy Organ J, 6(1), 3. https://doi.org/10.1186/1939-4551-6-3 Haahtela, T., Lindholm, H., Björkstén, F., Koskenvuo, K., & Laitinen, L. A. (1990). Prevalence of asthma in Finnish young men. Bmj, 301(6746), 266-268. https://doi.org/10.1136/bmj.301.6746.266 Han, Y. Y., Lee, Y. L., & Guo, Y. L. (2009). Indoor environmental risk factors and seasonal variation of childhood asthma. Pediatr Allergy Immunol, 20(8), 748-756. https://doi.org/10.1111/j.1399-3038.2009.00871.x Hill, D. A., & Spergel, J. M. (2018). The atopic march: Critical evidence and clinical relevance. Ann Allergy Asthma Immunol, 120(2), 131-137. https://doi.org/10.1016/j.anai.2017.10.037 Hosoi, J., Hariya, T., Denda, M., & Tsuchiya, T. (2000). Regulation of the cutaneous allergic reaction by humidity. Contact Dermatitis, 42(2), 81-84. Hu, Y., Jiang, F., Tan, J., Liu, S., Li, S., Wu, M., Yan, C., Yu, G., Hu, Y., Yin, Y., & Tong, S. (2021). Environmental Exposure and Childhood Atopic Dermatitis in Shanghai: A Season-Stratified Time-Series Analysis. Dermatology, 1-8. https://doi.org/10.1159/000514685 Karagün, E., Yıldız, P., & Cangür, Ş. (2021). Effects of climate and air pollution factors on outpatient visits for eczema: a time series analysis. Arch Dermatol Res, 313(1), 49-55. https://doi.org/10.1007/s00403-020-02115-9 Katagiri, C., Sato, J., Nomura, J., & Denda, M. (2003). Changes in environmental humidity affect the water-holding property of the stratum corneum and its free amino acid content, and the expression of filaggrin in the epidermis of hairless mice. J Dermatol Sci, 31(1), 29-35. https://doi.org/10.1016/s0923-1811(02)00137-8 Kathuria, P., & Silverberg, J. I. (2016). Association of pollution and climate with atopic eczema in US children. Pediatr Allergy Immunol, 27(5), 478-485. https://doi.org/10.1111/pai.12543 Klinnert, M. D., Nelson, H. S., Price, M. R., Adinoff, A. D., Leung, D. Y., & Mrazek, D. A. (2001). Onset and persistence of childhood asthma: predictors from infancy. Pediatrics, 108(4), E69. https://doi.org/10.1542/peds.108.4.e69 Ko, Y. C. (1996). [Air pollution and its health effects on residents in Taiwanese communities]. Kaohsiung J Med Sci, 12(12), 657-669. Krämer, U., Weidinger, S., Darsow, U., Möhrenschlager, M., Ring, J., & Behrendt, H. (2005). Seasonality in symptom severity influenced by temperature or grass pollen: results of a panel study in children with eczema. J Invest Dermatol, 124(3), 514-523. https://doi.org/10.1111/j.0022-202X.2005.23625.x Krusche, J., Basse, S., & Schaub, B. (2020). Role of early life immune regulation in asthma development. Semin Immunopathol, 42(1), 29-42. https://doi.org/10.1007/s00281-019-00774-z Kwak, C., & Clayton-Matthews, A. (2002). Multinomial logistic regression. Nursing research, 51(6), 404-410. Langan, S. M., Bourke, J. F., Silcocks, P., & Williams, H. C. (2006). An exploratory prospective observational study of environmental factors exacerbating atopic eczema in children. Br J Dermatol, 154(5), 979-980. https://doi.org/10.1111/j.1365-2133.2006.07153.x Langan, S. M., Irvine, A. D., & Weidinger, S. (2020). Atopic dermatitis. Lancet, 396(10247), 345-360. https://doi.org/10.1016/s0140-6736(20)31286-1 Langan, S. M., Silcocks, P., & Williams, H. C. (2009). What causes flares of eczema in children? Br J Dermatol, 161(3), 640-646. https://doi.org/10.1111/j.1365-2133.2009.09320.x Lee, P. C., Liu, L. L., Sun, Y., Chen, Y. A., Liu, C. C., Li, C. Y., Yu, H. L., & Ritz, B. (2016). Traffic-related air pollution increased the risk of Parkinson's disease in Taiwan: A nationwide study. Environ Int, 96, 75-81. https://doi.org/10.1016/j.envint.2016.08.017 Lee, Y. L., Li, C. W., Sung, F. C., & Guo, Y. L. (2007). Increasing prevalence of atopic eczema in Taiwanese adolescents from 1995 to 2001. Clin Exp Allergy, 37(4), 543-551. https://doi.org/10.1111/j.1365-2222.2007.02690.x Lee, Y. L., Li, C. W., Sung, F. C., Yu, H. S., Sheu, H. M., & Guo, Y. L. (2007). Environmental factors, parental atopy and atopic eczema in primary-school children: a cross-sectional study in Taiwan. Br J Dermatol, 157(6), 1217-1224. https://doi.org/10.1111/j.1365-2133.2007.08215.x Lee, Y. L., Shaw, C. K., Su, H. J., Lai, J. S., Ko, Y. C., Huang, S. L., Sung, F. C., & Guo, Y. L. (2003). Climate, traffic-related air pollutants and allergic rhinitis prevalence in middle-school children in Taiwan. Eur Respir J, 21(6), 964-970. https://doi.org/10.1183/09031936.03.00094602 Lee, Y. L., Su, H. J., Sheu, H. M., Yu, H. S., & Guo, Y. L. (2008). Traffic-related air pollution, climate, and prevalence of eczema in Taiwanese school children. J Invest Dermatol, 128(10), 2412-2420. https://doi.org/10.1038/jid.2008.110 Li, A., Fan, L., Xie, L., Ren, Y., & Li, L. (2018). Associations between air pollution, climate factors and outpatient visits for eczema in West China Hospital, Chengdu, south-western China: a time series analysis. J Eur Acad Dermatol Venereol, 32(3), 486-494. https://doi.org/10.1111/jdv.14730 Li, H., Zhang, Z., Zhang, H., Guo, Y., & Yao, Z. (2021). Update on the Pathogenesis and Therapy of Atopic Dermatitis. Clin Rev Allergy Immunol. https://doi.org/10.1007/s12016-021-08880-3 Li, Q., Yang, Y., Chen, R., Kan, H., Song, W., Tan, J., Xu, F., & Xu, J. (2016). Ambient Air Pollution, Meteorological Factors and Outpatient Visits for Eczema in Shanghai, China: A Time-Series Analysis. Int J Environ Res Public Health, 13(11). https://doi.org/10.3390/ijerph13111106 Lichtenstein, L. M., Ishizaka, K., Norman, P. S., Sobotka, A. K., & Hill, B. M. (1973). IgE antibody measurements in ragweed hay fever. Relationship to clinical severity and the results of immunotherapy. J Clin Invest, 52(2), 472-482. https://doi.org/10.1172/jci107204 Metintas, S., & Kurt, E. (2010). Geo-climate effects on asthma and allergic diseases in adults in Turkey: results of PARFAIT study. Int J Environ Health Res, 20(3), 189-199. https://doi.org/10.1080/09603120903456828 Mitchell, E. A. (1985). International trends in hospital admission rates for asthma. Arch Dis Child, 60(4), 376-378. https://doi.org/10.1136/adc.60.4.376 Narla, S., & Silverberg, J. I. (2020). The Role of Environmental Exposures in Atopic Dermatitis. Curr Allergy Asthma Rep, 20(12), 74. https://doi.org/10.1007/s11882-020-00971-z Nemoto-Hasebe, I., Akiyama, M., Nomura, T., Sandilands, A., McLean, W. H., & Shimizu, H. (2009). Clinical severity correlates with impaired barrier in filaggrin-related eczema. J Invest Dermatol, 129(3), 682-689. https://doi.org/10.1038/jid.2008.280 Noh, S. R., Kim, J. S., Kim, E. H., Jeon, B. H., Kim, J. H., Kim, Y. M., Kim, J., Han, Y., Ahn, K., & Cheong, H. K. (2019). Spectrum of susceptibility to air quality and weather in individual children with atopic dermatitis. Pediatr Allergy Immunol, 30(2), 179-187. https://doi.org/10.1111/pai.13005 Papadopoulou, A., Hatziagorou, E., Matziou, V. N., Grigoropoulou, D. D., Panagiotakos, D. B., Tsanakas, J. N., Gratziou, C., & Priftis, K. N. (2011). Comparison in asthma and allergy prevalence in the two major cities in Greece: the ISAAC phase II survey. Allergol Immunopathol (Madr), 39(6), 347-355. https://doi.org/10.1016/j.aller.2010.10.003 Patella, V., Florio, G., Palmieri, M., Bousquet, J., Tonacci, A., Giuliano, A., & Gangemi, S. (2020). Atopic dermatitis severity during exposure to air pollutants and weather changes with an Artificial Neural Network (ANN) analysis. Pediatr Allergy Immunol, 31(8), 938-945. https://doi.org/10.1111/pai.13314 Paudel, B., Chu, T., Chen, M., Sampath, V., Prunicki, M., & Nadeau, K. C. (2021). Increased duration of pollen and mold exposure are linked to climate change. Scientific reports, 11(1), 1-12. Pei-Chih, W., Huey-Jen, S., & Chia-Yin, L. (2000). Characteristics of indoor and outdoor airborne fungi at suburban and urban homes in two seasons. Sci Total Environ, 253(1-3), 111-118. https://doi.org/10.1016/s0048-9697(00)00423-x Pesce, G., Marcon, A., Carosso, A., Antonicelli, L., Cazzoletti, L., Ferrari, M., Fois, A. G., Marchetti, P., Olivieri, M., Pirina, P., Pocetta, G., Tassinari, R., Verlato, G., Villani, S., & de Marco, R. (2015). Adult eczema in Italy: prevalence and associations with environmental factors. J Eur Acad Dermatol Venereol, 29(6), 1180-1187. https://doi.org/10.1111/jdv.12784 Platts-Mills, T. A. (2015). The allergy epidemics: 1870-2010. J Allergy Clin Immunol, 136(1), 3-13. https://doi.org/10.1016/j.jaci.2015.03.048 Renz, H., & Skevaki, C. (2021). Early life microbial exposures and allergy risks: opportunities for prevention. Nat Rev Immunol, 21(3), 177-191. https://doi.org/10.1038/s41577-020-00420-y Rook, G. A., Adams, V., Hunt, J., Palmer, R., Martinelli, R., & Brunet, L. R. (2004). Mycobacteria and other environmental organisms as immunomodulators for immunoregulatory disorders. Springer Semin Immunopathol, 25(3-4), 237-255. https://doi.org/10.1007/s00281-003-0148-9 Sargen, M. R., Hoffstad, O., & Margolis, D. J. (2014). Warm, humid, and high sun exposure climates are associated with poorly controlled eczema: PEER (Pediatric Eczema Elective Registry) cohort, 2004-2012. J Invest Dermatol, 134(1), 51-57. https://doi.org/10.1038/jid.2013.274 Sasaki, T., Furusyo, N., Shiohama, A., Takeuchi, S., Nakahara, T., Uchi, H., Hirota, T., Tamari, M., Shimizu, N., Ebihara, T., Amagai, M., Furue, M., Hayashi, J., & Kudoh, J. (2014). Filaggrin loss-of-function mutations are not a predisposing factor for atopic dermatitis in an Ishigaki Island under subtropical climate. J Dermatol Sci, 76(1), 10-15. https://doi.org/10.1016/j.jdermsci.2014.06.004 Sato, J., Denda, M., Chang, S., Elias, P. M., & Feingold, K. R. (2002). Abrupt decreases in environmental humidity induce abnormalities in permeability barrier homeostasis. J Invest Dermatol, 119(4), 900-904. https://doi.org/10.1046/j.1523-1747.2002.00589.x Silverberg, J. I. (2017). Public Health Burden and Epidemiology of Atopic Dermatitis. Dermatol Clin, 35(3), 283-289. https://doi.org/10.1016/j.det.2017.02.002 Silverberg, J. I., Hanifin, J., & Simpson, E. L. (2013). Climatic factors are associated with childhood eczema prevalence in the United States. J Invest Dermatol, 133(7), 1752-1759. https://doi.org/10.1038/jid.2013.19 Siroux, V., Boudier, A., Nadif, R., Lupinek, C., Valenta, R., & Bousquet, J. (2019). Association between asthma, rhinitis, and conjunctivitis multimorbidities with molecular IgE sensitization in adults. Allergy, 74(4), 824-827. https://doi.org/10.1111/all.13676 Solé, D., Camelo-Nunes, I. C., Wandalsen, G. F., Mallozi, M. C., & Naspitz, C. K. (2006). Prevalence of atopic eczema and related symptoms in Brazilian schoolchildren: results from the International Study of Asthma and Allergies in Childhood (ISAAC) phase 3. J Investig Allergol Clin Immunol, 16(6), 367-376. Strachan, D. P. (1989). Hay fever, hygiene, and household size. Bmj, 299(6710), 1259-1260. https://doi.org/10.1136/bmj.299.6710.1259 Su, H. J., Wu, P. C., Chen, H. L., Lee, F. C., & Lin, L. L. (2001). Exposure assessment of indoor allergens, endotoxin, and airborne fungi for homes in southern Taiwan. Environ Res, 85(2), 135-144. https://doi.org/10.1006/enrs.2000.4113 The suggestion of child and adolescent Body Mass Index. The Health Promotion Administration, Ministry of Health and Welfare, Taiwan. Retrieved 2022.08.09 from https://www.hpa.gov.tw/Pages/Detail.aspx?nodeid=542&pid=9547 Tsai, J.-H., Chen, S.-H., Chen, S.-F., & Chiang, H.-L. (2021). Air Pollutant Emission Abatement of the Fossil-Fuel Power Plants by Multiple Control Strategies in Taiwan. Energies, 14(18), 5716. Urrutia-Pereira, M., Guidos-Fogelbach, G., & Solé, D. (2022). Climate changes, air pollution and allergic diseases in childhood and adolescence. Jornal de pediatria, 98, 47-54. Wang, J., Zhao, Z., Zhang, Y., Li, B., Huang, C., Zhang, X., Deng, Q., Lu, C., Qian, H., Yang, X., Sun, Y., Sundell, J., & Norbäck, D. (2019). Asthma, allergic rhinitis and eczema among parents of preschool children in relation to climate, and dampness and mold in dwellings in China. Environ Int, 130, 104910. https://doi.org/10.1016/j.envint.2019.104910 Weiland, S. K., Hüsing, A., Strachan, D. P., Rzehak, P., & Pearce, N. (2004). Climate and the prevalence of symptoms of asthma, allergic rhinitis, and atopic eczema in children. Occup Environ Med, 61(7), 609-615. https://doi.org/10.1136/oem.2002.006809 Wen, H. J., Chen, P. C., Chiang, T. L., Lin, S. J., Chuang, Y. L., & Guo, Y. L. (2009). Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. Br J Dermatol, 161(5), 1166-1172. https://doi.org/10.1111/j.1365-2133.2009.09412.x Williams, J. R., Burr, M. L., & Williams, H. C. (2004). Factors influencing atopic dermatitis-a questionnaire survey of schoolchildren's perceptions. Br J Dermatol, 150(6), 1154-1161. https://doi.org/10.1111/j.1365-2133.2004.05869.x Wu, Y.-S., Tsai, C.-Y., Chang, K.-H., & Chiang, C.-F. (2021). Impact of Air Pollutants Emitted by Taichung Power Plant on Atmospheric PM2. 5 in Central Taiwan. Aerosol and Air Quality Research, 21(4), 200358. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/83289 | - |
| dc.description.abstract | 背景與研究目的：
異位性皮膚炎是一種兒童常見的慢性皮膚發炎疾病，受到環境因子影響極深，且其發作特性非常多元，雖然過去許多研究都顯示環境溫度、濕度等氣候因素與疾病發作相關，然而結果卻相當不一致，造成疾病預防及介入措施上的困難。每位異位性皮膚炎兒童的疾病特性有所不同，在過去的環境研究中，卻鮮少將病童的不同季節發作特性納入考量。本研究旨在探討異位性皮膚炎兒童的不同季節發作特性，及分析其相關的氣候因子，以針對不同病童採取更好的環境介入對策。 研究方法： 本研究於2016-17年間，從全國各縣市分別抽取一所國民小學及一所國民中學進行兒童過敏情形、居住環境及人口學問卷調查，並由鄰近空氣汙染測站資料進行環境因子暴露評估。針對異位性皮膚炎兒童之過去12個月疾病發作情形，進行加權移動平均及主成分分析，將病童歸納出不同季節發作類型，並以多類別羅吉斯回歸及廣義估計方程式檢驗氣候因子對於不同發作類型之效應。 研究結果： 本研究共調查全國11,585位兒童，其中17.6%兒童回報過去12個月有異位性皮膚炎發作情形，並可分類出四種季節發作模式：春季好發者、夏秋季好發者、冬季好發者以及多季節好發者。父母教育程度較高以及有過敏疾病史、家中有牆壁黴菌、蟑螂、或是漏水者皆為兒童現存有異位性皮膚炎症狀的重要因子。在校正可能的干擾因子後，環境溫度以及相對濕度對於異位性皮膚炎季節發作模式分類有顯著效應，春季好發者與潮溼的冬季特性相關；夏秋季好發者與炎熱的夏秋季特性相關；冬季好發者，則與乾燥的氣候特性相關。 結論: 本研究發現現存異位性皮膚炎症狀之兒童有不同的季節發作模式，且根據其季節發作模式，相關的氣候特性也不相同，暗示著每個異位性皮膚炎兒童，可能對於不同的環境暴露有相異的易感受性，可作為未來發作預防及環境介入措施之重要參考。 | zh_TW |
| dc.description.abstract | BACKGROUND AND AIM:
Atopic dermatitis (AD) is a prevalent childhood condition involving many people. The attack pattern has been quite diverse. Few studies have classified AD children into subgroups according to seasonal attack pattern. This study explores the methods to group AD children into seasonal attack patterns, and examines hereditary and climate factors on each subgroup in children with AD. METHODS: In Taiwanese children from one elementary and one middle schools in each of the cities/counties, allergic status, hereditary and living environmental factors were surveyed in 2016, as well as air pollutants by air monitoring stations. Among those with current AD, principal component analyses on weighted moving average of monthly attack score was applied to categorize AD attack subtypes. Multinomial logistic regression (MLR) and Generalized Estimating Equation (GEE) models were used to study the effects of environmental exposure on each AD attack subgroups. RESULTS: A total of 11,585 children were surveyed, and 17.6% of children reportedly had AD attack in the past 1 year. Among them, four attack patterns were identified: spring, summer/fall, winter and perennial. Parental atopic diseases and higher education, moldy wall, cockroaches and water damage in residence are important factors for children with current AD. After adjusting potential confounders, the average temperature and relative humidity were statistically significant in the classification of AD subtypes. Among seasonal attack patterns, spring-attack AD was associated with wet winter climate feature; summer-fall-attack with hot summer climate feature; winter-attack with dry climate feature during whole year. CONCLUSIONS: Distinguished attack patterns are identified in children with current AD. Depending on individual attack subtypes, climatic factors can be different, which suggest that each child with AD has different susceptibility to various climate features | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-03-01T17:07:33Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2023-03-01T17:07:33Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審訂書 1
謝辭 2 中文摘要 3 英文摘要 5 目錄 7 第一章、研究背景及目的 9 1.1異位性皮膚炎的背景及介紹 9 1.2異位性皮膚炎的環境因子 10 1.3異位性皮膚炎及過敏疾病的季節發作特性 11 1.4研究目的 11 第二章、研究方法 13 2.1研究設計及對象 13 2.2兒童過敏及健康情形評估 13 2.3兒童環境暴露評估及人口學特質 14 2.4研究分析 16 第三章、研究結果 17 3.1兒童人口學特質及室內環境因子 17 3.2兒童異位性皮膚炎之季節發作趨勢及其盛行率. 18 3.3氣候因子對於不同兒童異位性皮膚炎發作模式的多類別羅吉斯回歸 19 3.4氣候因子對於各個兒童異位性皮膚炎發作模式的廣義估計方程式 20 第四章、討論及建議 23 第五章、研究結論 26 參考文獻 27 Conflict of interests & Funding information 38 附錄 39 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 異位性皮膚炎 | zh_TW |
| dc.subject | 多類別羅吉斯回歸 | zh_TW |
| dc.subject | 廣義估計方程式 | zh_TW |
| dc.subject | 氣候因子 | zh_TW |
| dc.subject | 季節發作模式 | zh_TW |
| dc.subject | climatic factors | en |
| dc.subject | seasonal attack pattern | en |
| dc.subject | atopic dermatitis | en |
| dc.subject | GEE | en |
| dc.subject | MLR | en |
| dc.title | 兒童異位性皮膚炎之季節發作模式與相關氣候因子 | zh_TW |
| dc.title | The seasonal attack patterns of childhood atopic dermatitis are associated with different climatic factors | en |
| dc.title.alternative | The seasonal attack patterns of childhood atopic dermatitis are associated with different climatic factors | - |
| dc.type | Thesis | - |
| dc.date.schoolyear | 111-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 楊孝友;朱家瑜;陳啟信 | zh_TW |
| dc.contributor.oralexamcommittee | Hsiao-Yu Yang;Chia-Yu Chu;Chi-Hsien Chen | en |
| dc.subject.keyword | 季節發作模式,異位性皮膚炎,氣候因子,廣義估計方程式,多類別羅吉斯回歸, | zh_TW |
| dc.subject.keyword | seasonal attack pattern,atopic dermatitis,climatic factors,GEE,MLR, | en |
| dc.relation.page | 47 | - |
| dc.identifier.doi | 10.6342/NTU202300234 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2023-02-03 | - |
| dc.contributor.author-college | 公共衛生學院 | - |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | - |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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