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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 魏嘉徵(Chia-Cheng Wei) | |
| dc.contributor.author | Ko-Chun Cheng | en |
| dc.contributor.author | 鄭可君 | zh_TW |
| dc.date.accessioned | 2022-11-25T07:45:42Z | - |
| dc.date.available | 2023-09-03 | |
| dc.date.copyright | 2021-09-29 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-06 | |
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Assessment of metabolites and AhR and CYP1A1 mRNA expression subsequent to prenatal exposure to inhaled benzo[a]pyrene. International Journal of Developmen……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82490 | - |
| dc.description.abstract | "隨著人口快速高齡化，老化對健康所造成的影響日益被重視，老化是生物體內循序漸進且不可逆的複雜過程，主要源自於體內自由基累積所導致的氧化壓力上升，此過程常伴隨疾病發生以及生理機能的退化，最終使生物體走向死亡。苯並芘 (benzo[a]pyrene, BaP) 是一種多環芳香族碳氫化合物，為有機物質不完全燃燒的產物，存在於空氣、柴油機廢氣以及燒烤肉類中，BaP已被國際癌症研究機構列為Group 1致癌物，先前研究指出，BaP對生物體具有發育、生殖、基因以及免疫毒性，然而其在生物體老化及相關機制之研究則相對較少，故本篇研究利用秀麗隱桿線蟲 (Caenorhabditis elegans) 為模式生物，探討暴露BaP對生物體老化之影響以及背後相關分子調控機制；而橘皮素 (tangeretin, TAN) 為一種多甲氧基黃酮，先前文獻指出TAN具抗氧化、抗肥胖以及抗癌等功效，故本研究進一步探討在共同暴露BaP與TAN之條件下，TAN是否具減緩由BaP所造成的老化相關毒性之功效。本研究將C. elegans暴露BaP 96小時後，觀察其體長以及運動行為 (body bends及head thrashes) 之變化，另外，為更了解暴露BaP對C. elegans老化之影響，將C. elegans暴露BaP至成蟲第8天，並於成蟲第1、2、4、6及8天，觀察其老化相關指標如咽喉收縮頻率、polyglutamine (polyQ) 累積量、體內活性氧化物質 (reactive oxygen species, ROS) 累積情形、抵抗熱壓力能力以及壽命變化。此外，為了解其背後相關分子機制，進一步測定老化相關基因mRNA表達量，並利用轉基因種C. elegans暴露BaP至成蟲第8天，於成蟲第1、4及8天，觀察其對sod-3、gst-4及hsp-16.2表達量之影響。同時藉由TAN的介入探討其對減緩C. elegans因BaP所誘發的老化指標衰退程度。實驗結果發現，暴露10 μM BaP會顯著降低C. elegans體長；而暴露1及10 μM BaP會降低C. elegans之head thrashes，但不影響body bends。在老化相關指標部分，暴露1及10 μM BaP會隨老化顯著提升C. elegans體內polyQ累積並抑制C. elegans咽喉收縮頻率；暴露10 μM BaP會顯著縮短C. elegans壽命、提升C. elegans體內ROS累積量以及降低C. elegans對熱壓力之抵抗能力。分子機制部分，暴露 BaP 會影響C. elegans老化相關基因如ctl-1、ctl-2、hsp-16.2、hsp16.49及hsp-70的mRNA表達量，轉基因種C. elegans部分，sod-3及gst-4表達量會隨老化被抑制。同時，TAN的介入可減緩C. elegans因BaP所誘發的head thrashes與咽喉收縮頻率等老化指標衰退程度。根據本研究結果，暴露BaP確實會對C. elegans老化相關指標造成負面影響，顯示BaP對生物體老化之毒性效應。綜合上述，本研究提供BaP相關毒理資訊以及後續可能的預防保健方式。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T07:45:42Z (GMT). No. of bitstreams: 1 U0001-3108202121212500.pdf: 2594245 bytes, checksum: bd9dcc97358ee61c8702fd552b4198b3 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "碩士學位論文口試委員會審定書 i 誌謝 ii 摘要 iii Abstract v Graphic Abstract vii Highlights viii 目 錄 ix 圖目錄 xii 表目錄 xiii 1. 研究動機 1 2. 文獻回顧與研究目的 2 2.1 苯並芘 (benzo[a]pyrene, BaP) 2 2.2 BaP之生物毒性 3 2.2.1 BaP之吸收、分布、代謝與排除 3 2.2.2 BaP之基因毒性 3 2.2.3 BaP之生殖毒性 4 2.2.4 BaP之生長發育毒性 4 2.2.5 BaP之免疫毒性 5 2.2.6 BaP之致癌性 6 2.3 多甲氧基黃酮 8 2.3.1 橘皮素 (tangeretin, TAN) 8 2.4 秀麗隱桿線蟲 (Caenorhabditis elegans) 與老化 10 2.4.1 C. elegans 10 2.4.2老化與自由基理論 10 2.4.3 以C. elegans探討老化現象 11 2.5 研究目的 12 3. 材料與方法 13 3.1 實驗架構流程圖 13 3.2 藥品試劑 14 3.3 C. elegans品系與培養條件 14 3.4 BaP對C. elegans生長影響之試驗 14 3.5 BaP對C. elegans運動行為影響之試驗 15 3.6 BaP對C. elegans咽喉收縮頻率 (pharyngeal pumping rates) 影響之試驗 15 3.7 BaP對C. elegans體內聚麩醯胺酸 (polyglutamine, polyQ) 累積影響之試驗 15 3.8 BaP對C. elegans壽命影響之試驗 16 3.9 BaP對C. elegans體內活性氧物質 (ROS) 累積影響之試驗 16 3.10 BaP對C. elegans抵抗熱壓力影響之試驗 17 3.11即時定量聚合酶鏈鎖反應 (qRT-PCR) 17 3.12 BaP對C. elegans sod-3、gst-4及hsp-16.2表達量影響之試驗 18 3.13共同暴露BaP與TAN對C. elegans之head thrashes與pharyngeal pumping rates影響之試驗 18 3.14統計分析 19 4. 結果與討論 20 4.1 BaP對C. elegans生長之影響 20 4.2 BaP對C. elegans運動行為之影響 22 4.3 BaP對C. elegans pharyngeal pumping rates之影響 24 4.4 BaP對C. elegans體內polyQ累積之影響 26 4.5 BaP對C. elegans壽命之影響 29 4.6 BaP對C. elegans體內ROS累積之影響 32 4.7 BaP對C. elegans抵抗熱壓力之影響 34 4.8 BaP對C. elegans老化相關基因表達量之影響 (qRT-PCR) 38 4.9 BaP對C. elegans sod-3、gst-4與hsp-16.2表達量之影響 40 4.10 共同暴露BaP與TAN對C. elegans的head thrashes與pharyngeal pumping rates之影響 43 5. 結論 46 6. 建議 47 7. 參考文獻 49 8. 附錄 65 附錄一、引子序列 65 附錄二、成蟲第8天C. elegans體內polyQ累積情形 66 附錄三、成蟲第8天C. elegans sod-3、gst-4與hsp-16.2 GFP表達情形 67 附錄四、暴露BaP對C. elegans排泄週期之影響 68" | |
| dc.language.iso | zh-TW | |
| dc.subject | 氧化壓力 | zh_TW |
| dc.subject | 橘皮素 | zh_TW |
| dc.subject | 秀麗隱桿線蟲 | zh_TW |
| dc.subject | 苯並芘 | zh_TW |
| dc.subject | 老化 | zh_TW |
| dc.subject | tangeretin | en |
| dc.subject | aging | en |
| dc.subject | benzo[a]pyrene | en |
| dc.subject | Caenorhabditis elegans | en |
| dc.subject | oxidative stress | en |
| dc.title | 探討暴露苯並芘加速秀麗隱桿線蟲老化之毒性效應及調控機制 | zh_TW |
| dc.title | Evaluation of toxic effects of benzo[a]pyrene on aging process and the underlying mechanism in Caenorhabditis elegans | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 潘敏雄(Ming-Hsiung Pan) | |
| dc.contributor.oralexamcommittee | 何元順(Hsin-Tsai Liu),洪偉倫(Chih-Yang Tseng) | |
| dc.subject.keyword | 老化,苯並芘,秀麗隱桿線蟲,氧化壓力,橘皮素, | zh_TW |
| dc.subject.keyword | aging,benzo[a]pyrene,Caenorhabditis elegans,oxidative stress,tangeretin, | en |
| dc.relation.page | 68 | |
| dc.identifier.doi | 10.6342/NTU202102917 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-07 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 食品安全與健康研究所 | zh_TW |
| dc.date.embargo-lift | 2023-09-03 | - |
| 顯示於系所單位： | 食品安全與健康研究所 | |
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