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  1. NTU Theses and Dissertations Repository
  2. 醫學院
  3. 臨床醫學研究所
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82252
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dc.contributor.advisor陳祈玲(Chi-Ling Chen)
dc.contributor.authorYing-Chun Linen
dc.contributor.author林盈均zh_TW
dc.date.accessioned2022-11-25T06:34:24Z-
dc.date.copyright2021-11-11
dc.date.issued2021
dc.date.submitted2021-10-21
dc.identifier.citation1. Tsujimoto R, Abe Y, Arima K, Nishimura T, Tomita M, Yonekura A, Miyamoto T, Matsubayashi S, Tanaka N, Aoyagi K, Osaki M. Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women. BMC Musculoskelet Disord. 2016 Dec 1;17(1):493. doi: 10.1186/s12891-016-1343-x. PMID: 27905911; PMCID: PMC5133758. 2. Konstantinou K, Dunn KM. Sciatica: review of epidemiological studies and prevalence estimates. Spine (Phila Pa 1976). 2008 Oct 15;33(22):2464-72. doi: 10.1097/BRS.0b013e318183a4a2. PMID: 18923325. 3. Anderson GBJ. Epidemiology of spinal disorders. In: Frymoyer JW, editor. The adult spine: principles and practice. New York: Raven; 1991. p. 110–46. 4. Berry JA, Elia C, Saini HS, Miulli DE. A Review of Lumbar Radiculopathy, Diagnosis, and Treatment. Cureus. 2019 Oct 17;11(10):e5934. doi: 10.7759/cureus.5934. PMID: 31788391; PMCID: PMC6858271. 5. 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Pairuchvej S, Arirachakaran A, Keorochana G, Wattanapaiboon K, Atiprayoon S, Phatthanathitikarn P, Kongtharvonskul J. The short and midterm outcomes of lumbar transforaminal epidural injection with preganglionic and postganglionic approach in lumbosacral radiculopathy: a systematic review and meta-analysis. Neurosurg Rev. 2018 Oct;41(4):909-916. doi: 10.1007/s10143-017-0826-z. Epub 2017 Feb 6. PMID: 28168618. 9. Van Boxem K, Cheng J, Patijn J, van Kleef M, Lataster A, Mekhail N, Van Zundert J. 11. Lumbosacral radicular pain. Pain Pract. 2010 Jul-Aug;10(4):339-58. doi: 10.1111/j.1533-2500.2010.00370.x. Epub 2010 May 17. PMID: 20492580. 10. Park JW, Nam HS, Cho SK, Jung HJ, Lee BJ, Park Y. Kambin's Triangle Approach of Lumbar Transforaminal Epidural Injection with Spinal Stenosis. Ann Rehabil Med. 2011 Dec;35(6):833-43. doi: 10.5535/arm.2011.35.6.833. Epub 2011 Dec 30. PMID: 22506212; PMCID: PMC3309379. 11. Huntoon MA, Martin DP. Paralysis after transforaminal epidural injection and previous spinal surgery. Reg Anesth Pain Med. 2004 Sep-Oct;29(5):494-5. doi: 10.1016/j.rapm.2004.05.002. PMID: 15372396. 12. Botwin KP, Gruber RD, Bouchlas CG, Torres-Ramos FM, Freeman TL, Slaten WK. Complications of fluoroscopically guided transforaminal lumbar epidural injections. Arch Phys Med Rehabil. 2000 Aug;81(8):1045-50. doi: 10.1053/apmr.2000.7166. PMID: 10943753. 13. Furman MB, Berkwits L, Cohen I, Goodman B, Kirschner J, Lee TS, et al. Atlas of image-guided spinal procedures (2nd edn). Philadelphia, PA: Elsevier Inc.; 2018. pp. 205–215. 14. Slipman CW, Chow DW. Therapeutic spinal corticosteroid injections for the management of radiculopathies. Phys Med Rehabil Clin N Am. 2002 Aug;13(3):697-711. doi: 10.1016/s1047-9651(02)00004-9. PMID: 12380554. 15. Botwin KP, Gruber RD, Bouchlas CG, Torres-Ramos FM, Sanelli JT, Freeman ED, Slaten WK, Rao S. Fluoroscopically guided lumbar transformational epidural steroid injections in degenerative lumbar stenosis: an outcome study. Am J Phys Med Rehabil. 2002 Dec;81(12):898-905. doi: 10.1097/00002060-200212000-00003. PMID: 12447088. 16. Kwon JW, Kim SJ. The role of epidural contrast distribution in predicting the effectiveness of steroid and local anesthetic injection in patients with lumbar spinal stenosis. J Back Musculoskelet Rehabil. 2018 Feb 6;31(1):75-83. doi: 10.3233/BMR-169674. PMID: 28759948. 17. Ackerman WE 3rd, Ahmad M. The efficacy of lumbar epidural steroid injections in patients with lumbar disc herniations. Anesth Analg. 2007 May;104(5):1217-22, tables of contents. doi: 10.1213/01.ane.0000260307.16555.7f. PMID: 17456677. 18. Tecer D, Adiguzel E, Koroglu O, Tan AK, Taskaynatan MA. Can Epidural Contrast Dispersal Pattern Help to Predict the Outcome of Transforaminal Epidural Steroid Injections in Patients with Lumbar Radicular Pain. World Neurosurg. 2018 Aug;116:e394-e398. doi: 10.1016/j.wneu.2018.04.214. Epub 2018 May 9. PMID: 29751191. 19. Liu JH, Soo CW, Lin YC, Lin CS. An alternative approach for lumbar transforaminal epidural steroid injection-Far lateral approach. Pain Pract. 2021 Jul 18. doi: 10.1111/papr.13060. Epub ahead of print. PMID: 34275177. 20. Ruetten S, Komp M, Godolias G. An extreme lateral access for the surgery of lumbar disc herniations inside the spinal canal using the full-endoscopic uniportal transforaminal approach-technique and prospective results of 463 patients. Spine (Phila Pa 1976). 2005 Nov 15;30(22):2570-8. doi: 10.1097/01.brs.0000186327.21435.cc. PMID: 16284597. 21. Ruetten S, Komp M, Merk H, Godolias G. Use of newly developed instruments and endoscopes: full-endoscopic resection of lumbar disc herniations via the interlaminar and lateral transforaminal approach. J Neurosurg Spine. 2007 Jun;6(6):521-30. doi: 10.3171/spi.2007.6.6.2. PMID: 17561740. 22. Dougados M, Simon P, Braun J, Burgos-Vargas R, Maksymowych WP, Sieper J, van der Heijde D. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis. 2011 Feb;70(2):249-51. doi: 10.1136/ard.2010.133488. Epub 2010 Sep 9. PMID: 20829199. 23. AMDG 2015 Interagency guideline on prescribing opioids for pain. Developed by the Washington state agency medical director group (AMDG) in collaboration with an expert advisory panel, actively practicing providors, public stakeholders, and senior state official. www.agencymeddirectors.wa.gov 24. McCaffery M, Pasero C: Pain: Clinical Manual, St. Louis, 1999, Mosby, pp.139-140. McCaffery M, Portenoy RK: Nonopioids: Acetaminophen and nonsteroidal antiinflammatory drugs. pp. 129-160. 25. Paidin M, Hansen P, McFadden M, Kendall R. Contrast dispersal patterns as a predictor of clinical outcome with transforaminal epidural steroid injection for lumbar radiculopathy. PM R. 2011 Nov;3(11):1022-7. doi: 10.1016/j.pmrj.2011.07.020. Epub 2011 Oct 5. PMID: 21974903. 26. Choi J, Kim N, Smuck M, Lee SH. Effect of Injectate Viscosity on Epidural Distribution in Lumbar Transforaminal Epidural Steroid Injection. Pain Res Manag. 2019 Mar 3;2019:2651504. doi: 10.1155/2019/2651504. PMID: 30944685; PMCID: PMC6421806. 27. Ghai B, Gupta AK, Makkar JK, Dhatt SS. Contrast Medium Volume Needed to Reach Anterior Epidural Space via the Kambin Triangle or Subpedicular Approach for Transforaminal Epidural Injection. Pain Physician. 2020 Jul;23(4):383-392. PMID: 32709173. 28. Botwin K, Natalicchio J, Brown LA. Epidurography contrast patterns with fluoroscopic guided lumbar transforaminal epidural injections: a prospective evaluation. Pain Physician. 2004 Apr;7(2):211-5. PMID: 16868594. 29. Manchikanti L, Cash KA, Pampati V, Damron KS, McManus CD. Evaluation of lumbar transforaminal epidural injections with needle placement and contrast flow patterns: a prospective, descriptive report. Pain Physician. 2004 Apr;7(2):217-23. PMID: 16868595. 30. Gupta R, Singh S, Kaur S, Singh K, Aujla K. Correlation between Epidurographic Contrast Flow Patterns and Clinical Effectiveness in Chronic Lumbar Discogenic Radicular Pain Treated with Epidural Steroid Injections Via Different Approaches. Korean J Pain. 2014 Oct;27(4):353-9. doi: 10.3344/kjp.2014.27.4.353. Epub 2014 Oct 1. PMID: 25317285; PMCID: PMC4196501. 31. Kim WJ, Shin HY, Yoo SH, Park HS. Comparison of Epidural Spreading Patterns and Clinical Outcomes of Transforaminal Epidural Steroid Injection with High-Volume Injectate via the Subpedicular Versus the Retrodiscal Approach. Pain Physician. 2018 May;21(3):269-278. PMID: 29871371. 32. Lee J, Jo D, Song S, Park D, Kim D, Oh J. Effect of Needle Tip Position on Contrast Media Dispersion Pattern in Transforaminal Epidural Injection Using Kambin's Triangle Approach. J Pain Res. 2020 Nov 10;13:2869-2878. doi: 10.2147/JPR.S270450. PMID: 33204148; PMCID: PMC7667514. 33. Candido KD, Katz JA, Chinthagada M, McCarthy RA, Knezevic NN. Incidence of intradiscal injection during lumbar fluoroscopically guided transforaminal and interlaminar epidural steroid injections. Anesth Analg. 2010 May 1;110(5):1464-7. doi: 10.1213/ANE.0b013e3181d6bd12. PMID: 20418306. 34. Hong JH, Kim SY, Huh B, Shin HH. Analysis of inadvertent intradiscal and intravascular injection during lumbar transforaminal epidural steroid injections: a prospective study. Reg Anesth Pain Med. 2013 Nov-Dec;38(6):520-5. doi: 10.1097/AAP.0000000000000010. PMID: 24141875. 35. Hong JH, Lee SM, Bae JH. Analysis of Inadvertent Intradiscal Injections during Lumbar Transforaminal Epidural Injection. Korean J Pain. 2014 Apr;27(2):168-73. doi: 10.3344/kjp.2014.27.2.168. Epub 2014 Mar 28. PMID: 24748946; PMCID: PMC3990826. 36. Kim C, Moon CJ, Choi HE, Park Y. Retrodiscal approach of lumbar epidural block. Ann Rehabil Med. 2011 Jun;35(3):418-26. doi: 10.5535/arm.2011.35.3.418. Epub 2011 Jun 30. PMID: 22506153; PMCID: PMC3309211. 37. Levi D, Horn S, Corcoran S. The Incidence of Intradiscal, Intrathecal, and Intravascular Flow During the Performance of Retrodiscal (Infraneural) Approach for Lumbar Transforaminal Epidural Steroid Injections. Pain Med. 2016 Aug;17(8):1416-22. doi: 10.1093/pm/pnv067. Epub 2015 Dec 24. PMID: 26814293. 38. Park CH, Lee SH, Park HS. Lumbar retrodiscal versus post-ganglionic transforaminal epidural steroid injection for the treatment of lumbar intervertebral disc herniations. Pain Physician. 2011 Jul-Aug;14(4):353-60. PMID: 21785478. 39. Lee JW, Kim SH, Choi JY, Yeom JS, Kim KJ, Chung SK, Kim HJ, Kim C, Kwack KS, Kwon JW, Moon SG, Jun WS, Kang HS. Transforaminal epidural steroid injection for lumbosacral radiculopathy: preganglionic versus conventional approach. Korean J Radiol. 2006 Apr-Jun;7(2):139-44. doi: 10.3348/kjr.2006.7.2.139. PMID: 16799275; PMCID: PMC2667587. 40. Jeong HS, Lee JW, Kim SH, Myung JS, Kim JH, Kang HS. Effectiveness of transforaminal epidural steroid injection by using a preganglionic approach: a prospective randomized controlled study. Radiology. 2007 Nov;245(2):584-90. doi: 10.1148/radiol.2452062007. PMID: 17940309. 41. Smith CC, McCormick ZL, Mattie R, MacVicar J, Duszynski B, Stojanovic MP. The Effectiveness of Lumbar Transforaminal Injection of Steroid for the Treatment of Radicular Pain: A Comprehensive Review of the Published Data. Pain Med. 2020 Mar 1;21(3):472-487. doi: 10.1093/pm/pnz160. PMID: 31343693. 42. Farrar JT, Young JP Jr, LaMoreaux L, Werth JL, Poole MR. Clinical importance of changes in chronic pain intensity measured on an 11-point numerical pain rating scale. Pain. 2001 Nov;94(2):149-158. doi: 10.1016/S0304-3959(01)00349-9. PMID: 11690728. 43. Pfirrmann CW, Oberholzer PA, Zanetti M, Boos N, Trudell DJ, Resnick D, Hodler J. Selective nerve root blocks for the treatment of sciatica: evaluation of injection site and effectiveness--a study with patients and cadavers. Radiology. 2001 Dec;221(3):704-11. doi: 10.1148/radiol.2213001635. PMID: 11719666. 44. Furman MB, Fetzer MR, Gilhool JJ. On contrast dispersal patterns as a predictor of clinical outcome with transforaminal epidural steroid injection for lumbar radiculopathy. PM R. 2011 Nov;3(11):1028-9. doi: 10.1016/j.pmrj.2011.10.010. PMID: 22108229. 45. Kim C, Choi HE, Kang S. Contrast spreading patterns in retrodiscal transforaminal epidural steroid injection. Ann Rehabil Med. 2012 Aug;36(4):474-9. doi: 10.5535/arm.2012.36.4.474. Epub 2012 Aug 27. PMID: 22977772; PMCID: PMC3438413. 46. Govind J. Lumbar radicular pain. Aust Fam Physician. 2004 Jun;33(6):409-12. PMID: 15253601. 47. Ghahreman A, Bogduk N. Predictors of a favorable response to transforaminal injection of steroids in patients with lumbar radicular pain due to disc herniation. Pain Med. 2011 Jun;12(6):871-9. doi: 10.1111/j.1526-4637.2011.01116.x. Epub 2011 May 3. PMID: 21539702. 48. Choi SJ, Song JS, Kim C, Shin MJ, Ryu DS, Ahn JH, Jung SM, Park MS. The use of magnetic resonance imaging to predict the clinical outcome of non-surgical treatment for lumbar intervertebral disc herniation. Korean J Radiol. 2007 Mar-Apr;8(2):156-63. doi: 10.3348/kjr.2007.8.2.156. PMID: 17420633; PMCID: PMC2626775. 49. Benny BV, Patel MY. Predicting epidural steroid injections with laboratory markers and imaging techniques. Spine J. 2014 Oct 1;14(10):2500-8. doi: 10.1016/j.spinee.2014.04.003. Epub 2014 Apr 15. PMID: 24743064. 50. Golish SR, Hanna LS, Bowser RP, Montesano PX, Carragee EJ, Scuderi GJ. Outcome of lumbar epidural steroid injection is predicted by assay of a complex of fibronectin and aggrecan from epidural lavage. Spine (Phila Pa 1976). 2011 Aug 15;36(18):1464-9. doi: 10.1097/BRS.0b013e3181f40e88. PMID: 21224775. 51. Scuderi GJ, Cuellar JM, Cuellar VG, Yeomans DC, Carragee EJ, Angst MS. Epidural interferon gamma-immunoreactivity: a biomarker for lumbar nerve root irritation. Spine (Phila Pa 1976). 2009 Oct 1;34(21):2311-7. doi: 10.1097/BRS.0b013e3181af06b6. PMID: 19934811. 52. Ackerman WE 3rd, Zhang JM. Serum hs-CRP as a useful marker for predicting the efficacy of lumbar epidural steroid injections on pain relief in patients with lumbar disc herniations. J Ky Med Assoc. 2006 Jul;104(7):295-9. PMID: 16886882. 53. Park CH, Lee SH. Prognostic usefulness of high sensitivity C-reactive protein for transforaminal epidural steroid injection in patients with radicular pain. Pain Med. 2011 Feb;12(2):219-23. doi: 10.1111/j.1526-4637.2010.01039.x. Epub 2011 Jan 11. PMID: 21223500.
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82252-
dc.description.abstract"背景: 椎間盤突出合併神經根病變是常見的退化性脊椎疾患。經椎間孔硬脊膜上類固醇注射是以實證為基礎的臨床指引所推薦的其中一種用以緩解腰椎神經根病變疼痛的治療方式。已知良好的顯影劑分布與有效的疼痛控制相關,但最佳的注射方式或技術尚未被確立。 目的: 欲確定一種新式的經椎間孔硬脊膜上類固醇注射—遠外側入路的經椎間孔硬脊膜上類固醇注射,其顯影劑分布與疼痛控制的成效。 方法: 本研究迴溯性收錄在西元2010年1月到2020年8月之間,因為椎間盤突出合併腰椎神經根病變於本院疼痛科接受同一位疼痛專科醫師施作經椎間孔硬脊膜上類固醇注射的所有病人。其中,接受傳統經椎間孔硬脊膜上類固醇注射的病人被視為對照組,而接受遠外側入路的經椎間孔硬脊膜上類固醇注射的病人被視為實驗組。所有病人的基本資料、X光透視下顯影劑的分布、注射前後的疼痛數字評定量表、注射前後的止痛藥使用和併發症等均會被搜集與分析。 結果: 期間收錄143位對照組與237位實驗組,共380位病人納入分析。除了椎間盤脫出(p = 0.01)和脊椎側彎(p = 0.04)的比例不同以外,兩組其他的基本特徵都相似。實驗組有較佳的顯影劑分布(p < 0.01),此結果經校正後依然存在(p < 0.001)。兩組均未發生鞘內腔注射,但實驗組椎間盤內注射的發生率較高(10% vs. 3%, p = 0.008)。相較於注射前,兩組的疼痛分數與止痛藥劑量均顯著下降,但兩組之間未達統計顯著差異。在中介分析中,遠外側入路的經椎間孔硬脊膜上類固醇注射與注射後一個月的疼痛控制相關。 結論: 相較於傳統注射方式,遠外側入路的經椎間孔硬脊膜上類固醇注射有較佳的顯影劑分布與注射後一個月的疼痛控制。期待未來有前瞻性研究來確認此分析的結果。"zh_TW
dc.description.provenanceMade available in DSpace on 2022-11-25T06:34:24Z (GMT). No. of bitstreams: 1
U0001-2010202116554100.pdf: 5395481 bytes, checksum: bc37938244766969188468ff9eeda7ec (MD5)
Previous issue date: 2021
en
dc.description.tableofcontents"
dc.language.isoen
dc.subject經椎間孔硬脊膜上類固醇注射zh_TW
dc.subject疼痛數字評定量表zh_TW
dc.subject腰椎zh_TW
dc.subject神經根病變zh_TW
dc.subject椎間盤突出zh_TW
dc.subject顯影劑分布zh_TW
dc.subjectnumeric rating scale (NRS)en
dc.subjectcontrast distributionen
dc.subjectherniated intervertebral disc (HIVD)en
dc.subjectradiculopathyen
dc.subjectlumbaren
dc.subjectTransforaminal epidural steroid injection (TFESI)en
dc.title遠外側入路的經椎間孔硬脊膜上類固醇注射在椎間盤突出併腰椎神經根壓迫的病人之功效—迴溯性分析zh_TW
dc.titleThe efficacy of far lateral approach for transforaminal epidural steroid injection in patients with HIVD with lumbar radiculopathy–a retrospective analysisen
dc.date.schoolyear109-2
dc.description.degree碩士
dc.contributor.author-orcid0000-0002-8629-5449
dc.contributor.oralexamcommittee林至芃(Hsin-Tsai Liu),林嘉祥(Chih-Yang Tseng)
dc.subject.keyword經椎間孔硬脊膜上類固醇注射,腰椎,神經根病變,椎間盤突出,疼痛數字評定量表,顯影劑分布,zh_TW
dc.subject.keywordTransforaminal epidural steroid injection (TFESI),lumbar,radiculopathy,herniated intervertebral disc (HIVD),numeric rating scale (NRS),contrast distribution,en
dc.relation.page257
dc.identifier.doi10.6342/NTU202103937
dc.rights.note未授權
dc.date.accepted2021-10-22
dc.contributor.author-college醫學院zh_TW
dc.contributor.author-dept臨床醫學研究所zh_TW
dc.date.embargo-lift2025-10-20-
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