請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82222完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 武敬和(Ching-Ho Wu) | |
| dc.contributor.author | Tzu-Yi Chao | en |
| dc.contributor.author | 趙子宜 | zh_TW |
| dc.date.accessioned | 2022-11-25T06:33:55Z | - |
| dc.date.copyright | 2022-02-25 | |
| dc.date.issued | 2022 | |
| dc.date.submitted | 2022-01-21 | |
| dc.identifier.citation | Schmitz S, Glanemann B, Garden OA, Brooks H, Chang YM, Werling D, et al. A Prospective, Randomized, Blinded, Placebo-Controlled Pilot Study on the Effect of Enterococcus faecium on Clinical Activity and Intestinal Gene Expression in Canine Food-Responsive Chronic Enteropathy. J Vet Intern Med. 2015 Mar FAO/WHO, Report on Joint FAO/WHO Expert Consultation on Evaluation of Health and Nutritional Properties of Probiotics in Food Including Powder Milk with Live Lactic Acid Bacteria, Cordoba, Argentina. 2001. Isolauri E, Sütas Y, Kankaanpää P, Arvilommi H, Salminen S. Probiotics: effects on immunity. Am J Clin Nutr. 2001 Feb 1;73(2):444s-450s. Sanders ME. Probiotics: Considerations for Human Health. Nutr Rev. 2003 Mar 1;61(3):91–9. Macpherson AJ, Uhr T. Induction of Protective IgA by Intestinal Dendritic Cells Carrying Commensal Bacteria. Science (80- ). 2004 Mar 12;303(5664):1662–5. Bybee SN, Scorza AV, Lappin MR. Effect of the Probiotic Enterococcus faecium SF68 on Presence of Diarrhea in Cats and Dogs Housed in an Animal Shelter. J Vet Intern Med. 2011/06/20. 2011 Jul;25(4):856–60. Hart ML, Suchodolski JS, Steiner JM, Webb CB. Open-label trial of a multi-strain synbiotic in cats with chronic diarrhea. J Feline Med Surg. 2012 Jan 5;14(4):240–5. Sauter SN, Benyacoub J, Allenspach K, Gaschen F, Ontsouka E, Reuteler G, et al. Effects of probiotic bacteria in dogs with food responsive diarrhoea treated with an elimination diet*. J Anim Physiol Anim Nutr (Berl). 2006 Aug 1;90(7–8):269–77. Peng JY, Horng YB, Wu CH, Chang CY, Chang YC, Tsai PS, et al. Evaluation of antiviral activity of Bacillus licheniformis-fermented products against porcine epidemic diarrhea virus. AMB Express. 2019;9(1):191. Bastos TS, de Lima DC, Souza CMM, Maiorka A, de Oliveira SG, Bittencourt LC, et al. Bacillus subtilis and Bacillus licheniformis reduce faecal protein catabolites concentration and odour in dogs. BMC Vet Res. 2020;16(1):116. Matei MC, Popovici CP, Neagu D, Buza V, Szakacs AR, Ștefanut LC. Hematological Aspects on Dogs with Apparent Dysbiosis after Bacillus Subtilis, Bacillus Licheniformis and Pediococcus Acidilactici Probiotic Administration- Pilot Study. Bull Univ Agric Sci Vet Med Cluj-Napoca Vet Med. 2020 Nov 22;77(2):72. Ettinger SJ, Feldman EC, Cote E. Textbook of Veterinary Internal Medicine. 8th ed. Elsevier health sciences; 2017. Allenspach K. Diagnosis of Small Intestinal Disorders in Dogs and Cats. Vet Clin Small Anim Pract. 2013 Nov 1;43(6):1227–40. Dandrieux JRS. Inflammatory bowel disease versus chronic enteropathy in dogs: are they one and the same? J Small Anim Pract. 2016 Nov 1;57(11):589–99. Jergens AE, Schreiner CA, Frank DE, Niyo Y, Ahrens FE, Eckersall PD, et al. A Scoring Index for Disease Activity in Canine Inflammatory Bowel Disease. J Vet Intern Med. 2003 May 1;17(3):291–7. Jergens AE, Crandell JM, Evans R, Ackermann M, Miles KG, Wang C. A Clinical Index for Disease Activity in Cats with Chronic Enteropathy. J Vet Intern Med. 2010 Sep 1;24(5):1027–33. Jergens AE, Crandell J, Morrison JA, Deitz K, Pressel M, Ackermann M, et al. Comparison of Oral Prednisone and Prednisone Combined with Metronidazole for Induction Therapy of Canine Inflammatory Bowel Disease: A Randomized-Controlled Trial. J Vet Intern Med. 2010 Mar 1;24(2):269–77. Otoni CC, Heilmann RM, García-Sancho M, Sainz A, Ackermann MR, Suchodolski JS, et al. Serologic and fecal markers to predict response to induction therapy in dogs with idiopathic inflammatory bowel disease. J Vet Intern Med. 2018/04/06. 2018 May;32(3):999–1008. Tørnqvist-Johnsen C, Campbell S, Gow A, Bommer NX, Salavati S, Mellanby RJ. Investigation of the efficacy of a dietetic food in the management of chronic enteropathies in dogs. Vet Rec. 2020 Jan 1;186(1):26–26. Marchesi MC, Timpano CC, Busechian S, Rueca, Fabrizio CP and. The role of diet in managing inflamatory bowel disease affected dogs: A retrospective cohort study on 76 cases. Vet Ital. 2017 Dec 29;53:297–302. Nakashima K, Hiyoshi S, Ohno K, Uchida K, Goto-Koshino Y, Maeda S, et al. Prognostic factors in dogs with protein-losing enteropathy. Vet J. 2015;205(1):28–32. Allenspach K, Wieland B, Gröne A, Gaschen F. Chronic Enteropathies in Dogs: Evaluation of Risk Factors for Negative Outcome. J Vet Intern Med. 2007 Jul 1;21(4):700–8. Nagata N, Ohta H, Yokoyama N, Teoh Y Bin, Nisa K, Sasaki N, et al. Clinical characteristics of dogs with food‐responsive protein‐losing enteropathy. J Vet Intern Med. 2020 Mar 1;34(2):659–68. Grellet A, Heilmann RM, Lecoindre P, Feugier A, Day MJ, Peeters D, et al. Fecal calprotectin concentrations in adult dogs with chronic diarrhea. Am J Vet Res. 2013 May;74(5):706–11. Gianella P, Lotti U, Bellino C, Bresciani F, Cagnasso A, Fracassi F, et al. Clinicopathologic and prognostic factors in short- and long-term surviving dogs with protein-losing enteropathy. Schweiz Arch Tierheilkd. 2017 Mar 5;159(3):163–9. Mitze S, Moser K, Teske E, Bomhard W, Stockhaus C. Correlation between the FCEAI and diagnostic para meters in chronic enteropathies in 147 cats (2006–2012). Tierärztliche Prax Ausgabe K Kleintiere / Heimtiere. 2017 Jan 10;45(06):390–6. Castro-López J, Ramis A, Planellas M, Teles M, Pastor J. Cyclooxygenase-2 immunoexpression in intestinal epithelium and lamina propria of cats with inflammatory bowel disease and low grade alimentary lymphoma. BMC Vet Res. 2018;14(1):158. Kathrani A, Fascetti AJ, Larsen JA, Maunder C, Hall EJ. Whole-Blood Taurine Concentrations in Cats With Intestinal Disease. J Vet Intern Med. 2017/06/19. 2017 Jul;31(4):1067–73. Rossi G, Jergens A, Cerquetella M, Berardi S, Di Cicco E, Bassotti G, et al. Effects of a probiotic (SLAB51TM) on clinical and histologic variables and microbiota of cats with chronic constipation/megacolon: a pilot study. Benef Microbes. 2018 Jan 29;9(1):101–10. Oelschlaeger TA. Mechanisms of probiotic actions – A review. Int J Med Microbiol. 2010;300(1):57–62. de Vrese M, Schrezenmeir J. Probiotics, Prebiotics, and Synbiotics. In: Stahl U, Donalies UEB, Nevoigt E, editors. Berlin, Heidelberg: Springer Berlin Heidelberg; 2008. p. 1–66. Fenimore A, Martin L, Lappin MR. Evaluation of Metronidazole With and Without Enterococcus Faecium SF68 in Shelter Dogs With Diarrhea. Top Companion Anim Med. 2017 Sep;32(3):100–3. Dandrieux JRS, Mansfield CS. Chronic Enteropathy In Canines: Prevalence, Impact And Management Strategies. Vet Med (Auckland, NZ). 2019 Dec 6;10:203–14. Pascher M, Hellweg P, Khol-Parisini A, Zentek J. Effects of a probiotic Lactobacillus acidophilus strain on feed tolerance in dogs with non-specific dietary sensitivity. Arch Anim Nutr. 2008 Apr 1;62(2):107–16. Rossi G, Pengo G, Caldin M, Palumbo Piccionello A, Steiner JM, Cohen ND, et al. Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in Dogs with Idiopathic Inflammatory Bowel Disease. Chamaillard M, editor. PLoS One. 2014 Apr 10;9(4):e94699. D’Angelo S, Fracassi F, Bresciani F, Galuppi R, Diana A, Linta N, et al. Effect of Saccharomyces boulardii in dogs with chronic enteropathies: double-blinded, placebo-controlled study. Vet Rec. 2018 Mar 1;182(9):258–258. Sorokulova I. Modern Status and Perspectives of Bacillus Bacteria as Probiotics. J Probiotics Heal. 2013 Jan 1;01. Lee NK, Kim WS, Paik HD. Bacillus strains as human probiotics: characterization, safety, microbiome, and probiotic carrier. Food Sci Biotechnol. 2019 Oct 8;28(5):1297–305. Casula G, Cutting SM. Bacillus probiotics: spore germination in the gastrointestinal tract. Appl Environ Microbiol. 2002 May;68(5):2344–52. Muras A, Romero M, Mayer C, Otero A. Biotechnological applications of Bacillus licheniformis. Crit Rev Biotechnol. 2021 May 19;41(4):609–27. Abarike ED, Cai J, Lu Y, Yu H, Chen L, Jian J, et al. Effects of a commercial probiotic BS containing Bacillus subtilis and Bacillus licheniformis on growth, immune response and disease resistance in Nile tilapia, Oreochromis niloticus. Fish Shellfish Immunol. 2018;82:229–38. Gobi N, Vaseeharan B, Chen J-C, Rekha R, Vijayakumar S, Anjugam M, et al. Dietary supplementation of probiotic Bacillus licheniformis Dahb1 improves growth performance, mucus and serum immune parameters, antioxidant enzyme activity as well as resistance against Aeromonas hydrophila in tilapia Oreochromis mossambicus. Fish Shellfish Immunol. 2018;74:501–8. Azarin H, Aramli MS, Imanpour MR, Rajabpour M. Effect of a Probiotic Containing Bacillus licheniformis and Bacillus subtilis and Ferroin Solution on Growth Performance, Body Composition and Haematological Parameters in Kutum (Rutilus frisii kutum) Fry. Probiotics Antimicrob Proteins. 2015 Mar 28;7(1):31–7. Raida MK, Larsen JL, Nielsen ME, Buchmann K. Enhanced resistance of rainbow trout, Oncorhynchus mykiss (Walbaum), against Yersinia ruckeri challenge following oral administration of Bacillus subtilis and B. licheniformis (BioPlus2B). J Fish Dis. 2003 Aug 1;26(8):495–8. Li K, Zheng T, Tian Y, Xi F, Yuan J, Zhang G, et al. Beneficial effects of Bacillus licheniformis on the intestinal microflora and immunity of the white shrimp, Litopenaeus vannamei. Biotechnol Lett. 2007;29(4):525–30. Zhang Q, Tan B, Mai K, Zhang W, Ma H, Ai Q, et al. Dietary administration of Bacillus (B. licheniformis and B. subtilis) and isomaltooligosaccharide influences the intestinal microflora, immunological parameters and resistance against Vibrio alginolyticus in shrimp, Penaeus japonicus (Decapoda: Penaeidae). Aquac Res. 2011 Jun 1;42(7):943–52. Kumar NR, Raman RP, Jadhao SB, Brahmchari RK, Kumar K, Dash G. Effect of dietary supplementation of Bacillus licheniformis on gut microbiota, growth and immune response in giant freshwater prawn, Macrobrachium rosenbergii (de Man, 1879). Aquac Int. 2013;21(2):387–403. Zhang CN, Li XF, Xu WN, Jiang GZ, Lu K Le, Wang LN, et al. Combined effects of dietary fructooligosaccharide and Bacillus licheniformis on innate immunity, antioxidant capability and disease resistance of triangular bream (Megalobrama terminalis). Fish Shellfish Immunol. 2013 Nov;35(5):1380–6. Zhao Y, Zeng D, Wang H, Qing X, Sun N, Xin J, et al. Dietary Probiotic Bacillus licheniformis H2 Enhanced Growth Performance, Morphology of Small Intestine and Liver, and Antioxidant Capacity of Broiler Chickens Against Clostridium perfringens–Induced Subclinical Necrotic Enteritis. Probiotics Antimicrob Proteins. 2020 Sep 12;12(3):883–95. Deng W, Dong XF, Tong JM, Zhang Q. The probiotic Bacillus licheniformis ameliorates heat stress-induced impairment of egg production, gut morphology, and intestinal mucosal immunity in laying hens1. Poult Sci. 2012;91(3):575–82. Liu X, Yan H, Lv L, Xu Q, Yin C, Zhang K, et al. Growth Performance and Meat Quality of Broiler Chickens Supplemented with Bacillus licheniformis in Drinking Water. Asian-Australasian J Anim Sci. 2012/05/01. 2012 May;25(5):682–9. Knap I, Lund B, Kehlet AB, Hofacre C, Mathis G. Bacillus licheniformis Prevents Necrotic Enteritis in Broiler Chickens. Avian Dis. 2010 Jun;54(2):931–5. Alexopoulos C, Georgoulakis IE, Tzivara A, Kritas SK, Siochu A, Kyriakis SC. Field evaluation of the efficacy of a probiotic containing Bacillus licheniformis and Bacillus subtilis spores, on the health status and performance of sows and their litters. J Anim Physiol Anim Nutr (Berl). 2004 Dec 1;88(11–12):381–92. Kritas SK, Govaris A, Christodoulopoulos G, Burriel AR. Effect of Bacillus licheniformis and Bacillus subtilis Supplementation of Ewe’s Feed on Sheep Milk Production and Young Lamb Mortality. J Vet Med Ser A. 2006 May 1;53(4):170–3. Hung DY, Cheng YH, Chen WJ, Hua KF, Pietruszka A, Dybus A, et al. Bacillus licheniformis-Fermented Products Reduce Diarrhea Incidence and Alter the Fecal Microbiota Community in Weaning Piglets. Anim an open access J from MDPI. 2019 Dec 13;9(12):1145. Matei MC, Buza V, Neagu D, Popovici CP, Szakacs AR, Ştefănuț LC. Does the probiotic combination of Bacillus subtilis, Bacillus licheniformis and Pediococcus acidilactici influence the biochemical parameters on healthy dogs? Lucr Stiint Stiint Agric a Banat Timisoara, Med Vet. 2020;53(3):36–47. Purina Fecal Scoring Chart [Internet]. Purinainstitute. [cited 2021 Jun 1]. Available from: https://www.purinainstitute.com/sites/g/files/auxxlc381/files/2021-04/fecal-chart.pdf Marteau P. Safety aspects of probiotic products. Näringsforskning. 2001 Dec 1;45(1):22–4. FAO/WHO. Guidelines for the evaluation of probiotics in food. Food and Agriculture Organization of the United Nations and World Health Organization Working Group Report. 2002; Kothari D, Patel S, Kim SK. Probiotic supplements might not be universally-effective and safe: A review. Biomed Pharmacother. 2019 Mar;111:537–47. Sorokulova IB, Pinchuk I V, Denayrolles M, Osipova IG, Huang JM, Cutting SM, et al. The Safety of Two Bacillus Probiotic Strains for Human Use. Dig Dis Sci. 2008;53(4):954–63. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82222 | - |
| dc.description.abstract | 慢性下痢是各年齡及各種別的伴侶動物之常見臨床症狀，但其成因眾多且不一定能在進行基本臨床檢查後得到最終診斷，給予益生菌以改善腸道環境為治療選項之一。益生菌為人類醫學的常見治療方式或作為食品添加保健品，近年在獸醫伴侶動物領域也有少數相關研究，但數量仍相對稀少且多為犬隻研究。 地衣芽孢桿菌則為一新興益生菌菌種，其對於多種水產及經濟動物的有益效用已被證實，但對於犬貓的臨床效果和安全性仍未明瞭。故此研究欲將地衣芽孢桿菌試用於非寄生蟲感染之慢性下痢犬貓，並評估其對於臨床及實驗室指標之影響。 在第一階段前驅試驗中，共納入了8隻下痢貓及16隻非下痢貓，並在實驗組中給予為期七天的益生菌試用。在第二階段臨床試驗中，納入15隻下痢犬及14隻下痢貓，並延長益生菌試用期至十四天。試驗期間會進行血液學及糞便檢驗，也會經飼主問卷評分來評估動物之臨床狀況。整體臨床活動狀況會透過調整後的貓慢性腸病活動指數和犬慢性腸病臨床活動指數進行評估。 進行益生菌服用試驗後，所有動物均無觀察到明顯不良臨床反應，血液學檢查數值也無顯著改變。整體臨床狀況及糞便軟硬度則多有不等程度的改善，其中在第二階段實驗中試用有添加魚粉之益生菌的貓隻在整體臨床評分有顯著進步、試用純益生菌的犬隻在糞便評分及整體臨床評分也皆有顯著改善。 實驗結果顯示此地衣芽孢桿菌製成之益生菌，應用於犬貓身上能被其廣泛接受、具安全性而無明顯不良反應。另外實驗結果也顯示此益生菌在伴侶動物身上具臨床成效，故期望對於具有非寄生蟲感染之慢性下痢症狀的犬貓，可提供以作為疾病舒緩選項之一。然未來研究上仍需招募更多受試者並進行嚴格的安慰劑對照設計實驗來精確評估此益生菌對伴侶動物的益處，且其機制、實際建議劑量與服用時間仍待更進一步研究來探討。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T06:33:55Z (GMT). No. of bitstreams: 1 U0001-2101202203380800.pdf: 3609104 bytes, checksum: cf3bb231e2dad7cb8ffee5ba38734930 (MD5) Previous issue date: 2022 | en |
| dc.description.tableofcontents | 口試委員審定書 i 致謝 ii 中文摘要 iii ABSTRACT v CONTENTS viii LIST OF FIGURES xii LIST OF TABLES xiv Chapter 1 Introduction 1 Chapter 2 Literature Review 3 2.1 Chronic Diarrhea and Chronic Enteropathy in Companion Animals 3 2.1.1 Chronic Diarrhea 3 2.1.2 Chronic Enteropathy 4 2.2 Scoring Index for Dogs and Cats with Chronic Enteropathy 5 2.2.1 Canine Inflammatory Bowel Disease Activity Index (CIBDAI) 6 2.2.2 Canine Chronic Enteropathy Clinical Activity Index (CCECAI) 7 2.2.3 Feline Chronic Enteropathy Activity Index (FCEAI) 8 2.3 Probiotics for Diarrhea in Companion Animals 9 2.4 Bacillus licheniformis as Probiotics 13 2.4.1 Introduction of Bacillus licheniformis 13 2.4.2 Bacillus licheniformis for Veterinary Use 13 2.5 Purpose 15 Chapter 3 Material and Methods 17 3.1 Experimental design 17 3.2 Subjects 17 3.3 Experimental procedure 18 3.4 Data collection 23 3.4.1 Laboratory examinations 25 3.4.1.1 Blood examination 25 3.4.1.2 Fecal examination 25 3.4.2 Clinical evaluations 26 3.4.2.1 Modified FCEAI 26 3.4.2.2 CCECAI 27 3.4.2.3 Modified Purina fecal score 28 3.5 Statistical analysis 29 Chapter 4 Results 31 4.1 First phase trial 31 4.1.1 Cats 31 4.1.1.1 Subjects 31 4.1.1.2 Fecal examination 32 4.1.1.3 Blood examination 32 4.1.1.4 Modified FCEAI 33 4.1.1.5 Fecal score 34 4.2 Second phase trial 35 4.2.1 Cats 35 4.2.1.1 Subjects 35 4.2.1.2 Fecal examination 36 4.2.1.3 Blood examination 36 4.2.1.4 Modified FCEAI 37 4.2.1.5 Fecal score 38 4.2.2 Dogs 38 4.2.2.1 Subjects 38 4.2.2.2 Fecal examination 39 4.2.2.3 Blood examination 40 4.2.2.4 CCECAI 41 4.2.2.5 Fecal score 41 4.3 Comparison of the two D-BL groups of the cats in different phases 42 Chapter 5 Discussion 55 5.1 Probiotics administration 55 5.1.1 Acceptability 55 5.1.2 Side effects 55 5.2 Alternations after the administration of probiotics 56 5.2.1 Hematological and biochemical variables 56 5.2.2 Fecal occult blood 58 5.2.3 Fecal score 59 5.2.4 Modified FCEAI score and CCEAI score 61 5.3 Comparison between the different phases and the different breeds 63 5.3.1 Cats in the first and the second phases trial 63 5.3.2 Dogs and cats in the second phase trial 64 5.4 Future Prospect 65 5.5 Limitations 66 Chapter 6 Conclusion 69 REFERENCES 70 | |
| dc.language.iso | en | |
| dc.subject | 犬 | zh_TW |
| dc.subject | 地衣芽孢桿菌 | zh_TW |
| dc.subject | 貓 | zh_TW |
| dc.subject | 慢性下痢 | zh_TW |
| dc.subject | 糞便評分 | zh_TW |
| dc.subject | 貓慢性腸病活動指數 | zh_TW |
| dc.subject | 犬慢性腸病臨床活動指數 | zh_TW |
| dc.subject | canine chronic enteropathy clinical activity index | en |
| dc.subject | Bacillus licheniformis | en |
| dc.subject | feline chronic enteropathy activity index | en |
| dc.subject | chronic diarrhea | en |
| dc.subject | feline | en |
| dc.subject | fecal score | en |
| dc.subject | canine | en |
| dc.title | 地衣芽孢桿菌於下痢犬貓臨床及實驗室指標之影響 | zh_TW |
| dc.title | Effects of Bacillus licheniformis on clinical and laboratory parameters in cats and dogs with chronic diarrhea | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張惠雯(Tung-Chieh Chen),蔡沛學(Ting-Ting Hwang),(Shao-Yun Fang) | |
| dc.subject.keyword | 地衣芽孢桿菌,犬,貓,慢性下痢,糞便評分,貓慢性腸病活動指數,犬慢性腸病臨床活動指數, | zh_TW |
| dc.subject.keyword | Bacillus licheniformis,canine,feline,chronic diarrhea,fecal score,feline chronic enteropathy activity index,canine chronic enteropathy clinical activity index, | en |
| dc.relation.page | 75 | |
| dc.identifier.doi | 10.6342/NTU202200132 | |
| dc.rights.note | 未授權 | |
| dc.date.accepted | 2022-01-22 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| dc.date.embargo-lift | 2027-01-01 | - |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-2101202203380800.pdf 未授權公開取用 | 3.52 MB | Adobe PDF | 檢視/開啟 |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。