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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82102完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 黃威翔(Wei-Hsiang Huang) | |
| dc.contributor.author | Pei-Wen Liao | en |
| dc.contributor.author | 廖珮雯 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:35:53Z | - |
| dc.date.available | 2026-10-22 | |
| dc.date.copyright | 2021-11-05 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-25 | |
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Value of β-APP and NF-L as markers in evaluation of rat diffuse axonal injury. Journal of third military medical university, 22. Xiang, L., Zhou, G., Su, P., Xia, S., Han, B., Wang, Y., Zhang, T. (2013). Could postmortem hemorrhage occur in the brain?: a preliminary study on the establishment and investigation of postmortem hypostatic hemorrhage using rabbit models. The American journal of forensic medicine and pathology, 34(2), 147-149. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82102 | - |
| dc.description.abstract | 創傷性腦傷(Traumatic brain injury)是獸醫法醫案件中最常見的死因之一，而創傷性軸突損傷(Traumatic axonal injury)幾乎普遍繼發於創傷性腦傷。β-澱粉樣蛋白前驅蛋白(βamyloid precursor protein)的免疫化學染色和陽性訊號型態的判讀在人類法醫學中是診斷早期軸突損傷的準則。在動物中，關於βAPP的文獻僅有數篇，而幾乎沒有關於犬貓的相關研究。因此，本研究旨在透過βAPP診斷動物的創傷性腦傷，並嘗試釐清TAI中組織病理及免疫化學染色與腦傷嚴重程度的關聯。在此研究中，樣本來源為常規法醫解剖中收集的貓大體。其中被診斷有創傷性腦傷的個體會被依照傷害程度分成兩組，而沒有發現創傷性腦傷的個體則分到控制組。樣本會收集每個個體的整顆腦，經妥善固定後依標準化的方式切片後選取代表性的區域進行判讀。腦組織會經過組織病理檢查、βAPP陽性訊號（軸突球）會經計數並和腦傷的嚴重程度做統計上的對照。此研究中共採樣39隻有創傷性腦傷的貓和20隻無腦傷的貓。結果顯示，診斷創傷性腦傷的病例中，64.1%有軸突損傷的陽性訊號，軸突球計數的總合(Axonal bulb count)在嚴重腦傷中，相較於較輕微腦傷會顯著地增加，且在胼胝體、大腦白質及海馬迴中區域性軸突球計數的總合亦存在著嚴重腦傷較輕度腦傷中顯著增加的趨勢。統計的數值中，腦傷過後產生陽性軸突球訊號的最短時間介於0.5至2小時間。貓隻中，最常表現創傷性軸突損傷的區域為大腦白質，而後是小腦白質及腦幹，代表著大腦白質對於偵測創傷性軸突損傷很敏感。此外，軸突球計數可能在對撞傷的情況下具有額外診斷價值。總結來說，此研究可謂伴侶動物創傷性軸突損傷中一具有前瞻性的研究。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:35:53Z (GMT). No. of bitstreams: 1 U0001-2210202116072300.pdf: 16339031 bytes, checksum: 9478acac2fcd2c6811912c1dac2032b0 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "序言／謝辭 II 中文摘要 IV ABSTRACT V TABLE OF CONTENTS VII LIST OF TABLES XIII LIST OF FIGURES XVI 1. INTRODUCTION 1 1.1. TRAUMATIC BRAIN INJURY AND TRAUMATIC AXONAL INJURY 1 1.1.1. THE IMPORTANCE OF TRAUMATIC BRAIN INJURY AND THE CLASSIFICATION 1 1.1.1.1. CLASSIFICATION OF TBI BY THE MECHANISM AND THE LOCATION 1 1.1.1.2. CLASSIFICATION OF TBI BY THE PATHOLOGICAL CHANGES 2 1.1.1.3. TRAUMATIC AXONAL INJURY (TAI) IN TBI 3 1.1.1.3.1. STUDIES ABOUT THE MECHANISM AND THE PATHOLOGICAL CHANGES OF TAI 4 1.1.2. DIAGNOSIS OF TAI UNDER HISTOPATHOLOGICAL EXAMINATION AND THE LIMITATION 6 1.2. DETECTION OF TAI USING IHC MARKERS 7 1.2.1. BETA-AMYLOID PRECURSOR PROTEIN (ΒAPP) 8 1.2.1.1. STRUCTURE, FUNCTION, AND PATHOLOGICAL CHANGES IN TAI 8 1.2.1.2. IMMUNOREACTIVITY OF ΒAPP IN ADDITION TO TAI 9 1.2.2. OTHER IMMUNOHISTOCHEMICAL MARKERS FOR TAI 11 1.2.2.1. 68KDA NEUROFILAMENT (NF) 11 1.2.2.2. CALPAIN-DERIVED ALPHA-II SPECTRIN N-TERMINAL FRAGMENT (SNTF) 11 1.2.2.3. HYPERPHOSPHORYLATED TAU PROTEIN (P-TAU) 12 1.2.3. THE ADVANTAGE AND LIMITATION OF ΒAPP FOR DETECTING TAI 13 1.3. LITERATURE REVIEW OF ΒAPP USED FOR DIAGNOSING TAI IN FIELDS OF LABORATORY ANIMALS AND VETERINARY MEDICINE 13 1.4. ΒAPP IHC USING FOR CORRELATING DIFFERENT PARAMETERS IN TBI/TAI 15 1.4.1. STUDIES IN HUMAN MEDICINE 15 1.4.2. STUDIES USING ANIMAL MODELS 17 1.5. ΒAPP USED TO DETECT TAI IN CEREBROSPINAL FLUID (CSF) 19 1.6. ΒAPP IN POSTMORTEM CHANGES 20 1.7. RESEARCH NICHE 21 1.8. HYPOTHESIS AND AIMS OF THE STUDY 22 2. MATERIALS AND METHODS 25 2.1. CASE COLLECTION AND GROUPING 25 2.1.1. TWO SUBGROUPS IN THE TRAUMA GROUP 26 2.1.2. BRAIN SECTIONS SELECTION 27 2.2. IMMUNOHISTOCHEMISTRY OF ΒAPP 27 2.3. INTERPRETATION AND EVALUATION OF ΒAPP SIGNALS 28 2.3.1. THE PRESENCE OR ABSENCE OF ΒAPP POSITIVE SIGNALS BETWEEN TRAUMA AND CONTROL GROUPS 30 2.3.2. AXONAL RETRACTION BULB COUNT IN DIFFERENT REGIONS OF THE WHOLE BRAIN 30 2.4. STATISTICAL ANALYSIS 30 3. RESULTS 33 3.1. GENERAL CASE INFORMATION 33 3.1.1. THE OVERALL CASE ANALYSIS 33 3.1.2. CASES OF WHICH A TOTAL OF SIX BRAIN SECTIONS WERE COLLECTED 34 3.2. CAUSES OF DEATH 34 3.2.1. CAUSES OF DEATH IN THE TRAUMA GROUP (SEE TABLE 5) 34 3.2.2. CAUSES OF DEATH IN THE CONTROL GROUP (SEE TABLE 5) 35 3.3. ΒAPP IHC IN CAT BRAINS: DIFFERENT PATTERNS AND INTERNAL CONTROLS 36 3.4. THE HISTOPATHOLOGICAL FINDINGS UNDER H E STAIN IN CATS WITH TBI AND AXONAL INJURY (AI) 37 3.5. INCIDENCE RATE AND AXONAL RETRACTION BULB (ABC) COUNT OF AXONAL INJURY (AI) 39 3.5.1. INCIDENCE RATE AND ABC OF AI WHEN EVALUATING CORPUS CALLOSUM AND MEDULLA OBLONGATA 39 3.5.2. INCIDENCE AND ABC OF AI WHEN THE SIX SECTIONS WERE EVALUATED 40 3.6. POSITIVE ΒAPP SIGNALS IN CONTROL CASES 42 3.7. POST-TRAUMATIC INTERVAL (PTI) 43 3.8. PRESENCE OF ACTUAL SUPERFICIAL LESIONS UNDER H E STAIN IN SUSPECTED TBI CASES 44 3.9. THE DIRECTION OF THE TBI AND THE PRESENCE OF TAI 45 4. DISCUSSION 48 4.1. TAI COULD BE DETECTED BY ΒAPP IHC IN CATS. 48 4.2. INTERPRETATION OF THE GEOGRAPHIC PATTERN 50 4.3. CORRELATION BETWEEN TBI SEVERITY AND TAI 51 4.3.1. THE GROUPING ERRORS 52 4.3.2. THE INABILITY TO DIFFERENTIATE ETIOLOGIES OF AXONAL INJURY 53 4.3.3. THE CORRELATION BETWEEN TBI AND TAI 53 4.4. COMPARING BETWEEN 2 EVALUATING METHODS (2 SECTIONS VERSUS 6 SECTIONS) 55 4.5. COMMON LOCATIONS OF TAI IN CATS WITH TBI 56 4.6. INTERPRETATION OF POSITIVE ΒAPP SIGNALS IN CONTROL CASES 58 4.6.1. A DETAILED DISCUSSION OF POSITIVE ΒAPP SIGNALS IN THE CONTROL GROUP: THE CAT NO. 59 59 4.6.2. A DETAILED DISCUSSION OF POSITIVE ΒAPP SIGNALS IN THE CONTROL GROUP: THE CAT NO. 50 61 4.7. POST-TRAUMATIC INTERVAL (PTI) 64 4.8. DIAGNOSTIC VALUE OF ΒAPP IHC IN VETERINARY FORENSIC MEDICINE 65 4.8.1. A VALUABLE TOOL FOR DETERMINING THE CAUSE OF DEATH IN VETERINARY FORENSIC CASES: AN EXAMPLE 65 4.8.2. A HELPFUL TOOL OF APPROACHING POST-TRAUMATIC SURVIVAL TIME AND PRECLUDING THE POSTMORTEM AND FREEZING ARTIFACTS 66 4.8.2.1. ABSENT REAL SUPERFICIAL LESIONS WITH THE PRESENCE OF ΒAPP POSITIVE SIGNALS: THE CAT NO. 7 67 4.8.2.2. SEVERE HEAD INJURIES WITHOUT THE PRESENCE OF ΒAPP POSITIVE SIGNALS (TAI): THE CAT NO. 14 68 4.8.3. A CLUE FOR CLARIFYING THE MECHANISM AND THE TRAUMA TYPE OF TBI 70 4.9. THE LIMITATIONS 72 5. CONCLUSIONS 75 ACKNOWLEDGMENT 77 REFERENCES 139 " | |
| dc.language.iso | en | |
| dc.subject | 貓 | zh_TW |
| dc.subject | 動物法醫學 | zh_TW |
| dc.subject | 軸突損傷 | zh_TW |
| dc.subject | 法醫神經病理 | zh_TW |
| dc.subject | 創傷性腦傷 | zh_TW |
| dc.subject | veterinary forensic medicine | en |
| dc.subject | axonal injury | en |
| dc.subject | traumatic brain injury | en |
| dc.subject | forensic neuropathology | en |
| dc.subject | feline | en |
| dc.title | 以β－澱粉樣前驅蛋白作為貓創傷性軸突損傷生物標記之評估 | zh_TW |
| dc.title | A Study on Beta Amyloid Precursor Protein as a Biomarker for Traumatic Axonal Injury in Cats | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 林正忠(Hsin-Tsai Liu),劉振軒(Chih-Yang Tseng),潘志信 | |
| dc.subject.keyword | 動物法醫學,法醫神經病理,貓,創傷性腦傷,軸突損傷, | zh_TW |
| dc.subject.keyword | veterinary forensic medicine,forensic neuropathology,feline,traumatic brain injury,axonal injury, | en |
| dc.relation.page | 150 | |
| dc.identifier.doi | 10.6342/NTU202104039 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-26 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 分子暨比較病理生物學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-10-20 | - |
| 顯示於系所單位： | 分子暨比較病理生物學研究所 | |
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