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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 龔秀妮(Hsiu-Ni Kung) | |
| dc.contributor.author | Yu-Jui Lin | en |
| dc.contributor.author | 林妤叡 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:35:44Z | - |
| dc.date.available | 2026-10-29 | |
| dc.date.copyright | 2021-11-12 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-27 | |
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(碩士論文). 實踐大學, 台北市，台灣. 蔡崇煌, 陳靖棻, 蔡新聲, 黃青真. (2010). 苦瓜於血糖控制之功效及安全性回顧. [Bitter Gourd (Momordica charantia): A Review of Its Efficacy and Safety for Glucose Homeostasis]. 臺灣營養學會雜誌, 35(3), 115-126. doi:10.6691/nsj.201009_35(3).0004 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82094 | - |
| dc.description.abstract | "由飲食所引起的代謝症候群(Metabolic syndrome, MS)是現今盛行的流行病之一，攝食過多的果糖會引起非酒精性脂肪肝病(Nonalcoholic fatty liver disease, NAFLD)造成發炎反應和肝損傷，而具備抗發炎功效的天然萃取物有保護肝臟的潛力。山苦瓜葉(Momordica charantia L. var. abbreviate Seringe)的富含三萜類化合物萃取物(triterpenoid-enriched extract, TEE)含有生物活性成分，在先前研究發現能改善CCl4 誘導的小鼠肝纖維化現象。本研究欲探討 TEE 對高果糖飲食誘導肝損傷的保護機制。 細胞模式上發現 TEE 可緩解由 LPS 引起巨噬細胞的發炎現象，同時也能改善TGFβ 所引起的星狀細胞活化及纖維化，表示 TEE 具備抗發炎及抗纖維化的功效。另外也發現肝細胞在給予果糖處理後會提高脂肪酸生成與降低脂肪酸氧化相關蛋白質，使過多三酸甘油酯堆積形成油滴，引起發炎反應影響周遭細胞，如星狀細胞受到發炎因子的刺激活化，增加膠原蛋白的生成；此外果糖也會引起巨噬細胞活化，然而在給予 TEE 前處理皆有緩解效果。動物模式上則是將C57BL/6 公鼠給予三種不同的飲食條件，分別為 60%高果糖飼料、30%果糖飲用水、以及60%高脂飼料搭配 30%果糖飲用水，持續 14 週以引起 NAFLD 的相關症狀；同時每日餵食 TEE 並觀察其保護功效。本研究發現高果糖飲食會增加小鼠的體重變化量、提升血清中 AST 及 ALT 指標、增加尾靜脈血壓，並從組織蛋白與切片觀察到脂肪堆積形成脂肪肝、肝臟發炎及肝纖維化等損傷，而餵食TEE 皆能改善由高果糖飲食所引起的肝損傷現象。 由蛋白質表現量分析的結果，推測 TEE 是透過調控與發炎相關的 NLRP3 inflammasome 以及 STAT3 等途徑，降低三酸甘油酯生成與膠原蛋白堆積，藉此改善高果糖飲食誘導小鼠代謝性疾病及肝損傷的進展。由此可知，具抗發炎能力的 TEE 可做為治療高果糖飲食誘導非酒精性脂肪肝病的潛在天然萃取物。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:35:44Z (GMT). No. of bitstreams: 1 U0001-2510202116154400.pdf: 6105639 bytes, checksum: 793c9bdf8107bb32b08e922d376694db (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "目錄 口試委員會審定書 B 中文摘要 E ABSTRACT F 縮寫表 H 目錄 K 圖目錄 O 表目錄 Q 第一章 緒論 1 第二章 文獻回顧 2 第一節 肝臟 2 一、基本結構 2 二、生理功能 6 第二節 非酒精性脂肪肝病 8 一、概況簡介 8 二、病程發展 8 三、診斷方法 15 四、影響成因 17 五、治療方法 18 第三節 高果糖飲食 19 一、歷史簡介 19 二、代謝機制 19 三、過量影響 22 四、形式差異 28 第四節 山苦瓜葉萃取物 29 一、山苦瓜(Bitter melon, BM) 29 二、生理活性 29 三、山苦瓜葉萃取物(Bitter melon leaf extract, BMLE) 31 第五節 研究目的 32 一、研究假說 32 二、實驗架構 32 第三章 材料方法 33 第一節 材料與儀器 33 一、富含三萜類萃取物(triterpenoid-enriched extract, TEE) 33 二、動物實驗 33 三、細胞實驗 34 四、實驗藥品 35 五、試劑儀器 36 第二節 製備山苦瓜葉萃取物 37 一、烘乾磨粉 37 二、粗萃取物BMLE製備 37 三、萃取物TEE製備 37 第三節 動物實驗 39 一、實驗動物 39 二、實驗設計 39 第四節 細胞實驗 44 一、細胞培養 44 二、實驗設計 44 第五節 實驗技術 47 測血糖數值 Blood glucose 47 胰島素耐受性測試 Intraperitoneal insulin tolerance test 47 小鼠滾輪測試儀 Rotarod 47 拉力測試儀 Grip Strength Meter 48 腸道通透性試驗Intestinal Permeability Assay 48 小鼠尾靜脈血壓儀 Blood pressure 48 肝臟三酸甘油酯 Triglyceride 49 血清及尿液生化分析 49 尿蛋白 Urine protein 52 尿比重 Specific gravity 52 石蠟包埋與切片 53 冷凍包埋與切片 53 蘇木精-伊紅染色法 Hematoxylin-Eosin stain 54 馬森三色染色法 Masson's Trichrome stain 55 油紅染色法 Oil red O stain 56 細胞計數 Cell counting 57 結晶紫染色法 Crystal Violet 57 細胞存活率測試 MTT assay 57 格里斯試驗 Griess assay 58 免疫細胞化學染色法 Immunocytochemistry 58 西方墨點法 Western Blot 59 第六節 統計分析 62 第四章 結果 63 第一節 TEE在巨噬細胞模式中具有抗發炎的效果 63 第二節 比較果糖餵食形式對高果糖飲食誘導小鼠模式的影響 63 第三節 TEE緩解高果糖飲食誘導NAFLD 65 第四節 TEE抑制高果糖飲食引起的肝臟脂肪堆積 67 第五節 TEE抑制高果糖飲食引起的發炎反應與纖維化現象 68 第六節 TEE改善果糖引起肝細胞的脂質累積 69 第七節 TEE改善果糖引起肝細胞的發炎現象 70 第八節 TEE改善果糖引起星狀細胞的活化與纖維化 71 第九節 TEE緩解果糖引起巨噬細胞的活化 72 第十節 TEE對TGFΒ誘導性狀細胞纖維化具有保護效果 72 第五章 討論 73 第一節 高果糖誘導動物模式 73 第二節 果糖餵食形式的影響 74 第三節 果糖飲食對於空腹血糖並無影響 75 第四節 TEE對高果糖飲食誘導小鼠之脂肪組織的影響 75 第五節 以細胞實驗模擬高果糖環境誘導脂質合成作用 76 第六節 以CONDITION MEDIUM模擬肝臟中的真實環境 77 第七節 從飲食及熱量攝取差異探討肝臟中KHK-C的表現量 77 第八節 探討TEE與STAT3訊息途徑的關係 78 第六章 結論 80 第七章 附圖 81 第八章 參考文獻 121 第九章 附錄 133 圖目錄 圖2- 1 人類及小鼠肝臟外觀圖 2 圖2- 2 肝小葉模式圖 3 圖2- 3 肝小葉功能性分區圖 5 圖2- 4 NAFLD的病程發展 8 圖2- 5 NASH相關發炎反應途徑 11 圖2- 6 NASH病理切片分級系統 15 圖2- 7 果糖與葡萄糖的代謝途徑 21 圖2- 8 果糖誘導NAFLD 22 圖2- 9 果糖引起氧化壓力及發炎反應的途徑 24 圖3- 1 山苦瓜葉萃取物製備流程 38 圖3- 2 細胞實驗模式圖 44 圖3- 3 小鼠滾輪測試儀 47 圖3- 4 小鼠尾靜脈血壓儀 48 圖7- 1 TEE對LPS引起巨噬細胞活化的模式中具有抗發炎效果 82 圖7- 2 比較果糖餵食形式對高果糖飲食誘導小鼠的影響 84 圖7- 3 TEE緩解高果糖飲食誘導NAFLD 90 圖7- 4 TEE抑制高果糖飲食引起的肝臟脂肪堆積 96 圖7- 5 TEE抑制高果糖飲食引起的發炎反應與纖維化現象 100 圖7- 6 TEE改善果糖引起肝細胞的脂質累積 104 圖7- 7 TEE改善果糖引起肝細胞的發炎現象 110 圖7- 8 TEE改善果糖引起星狀細胞的活化與纖維化 114 圖7- 9 TEE緩解果糖引起巨噬細胞的活化 118 圖7- 10 TEE對TGFβ誘導性狀細胞纖維化具有保護效果 120 圖9- 1 不同餵食形式對高果糖飲食誘導小鼠生理功能的影響差異 134 圖9- 2 TEE對高果糖飲食誘導小鼠之血清及尿液生化指標的影響 136 圖9- 3 TEE對高果糖飲食誘導小鼠之脂肪組織重量的影響 138 圖9- 4 細胞存活率測試 142 圖9- 5 純果糖處理不易引起肝細胞內三酸甘油酯的堆積 154 圖9- 6 TEE的薄層色譜分析結果 156 表目錄 表3- 1動物實驗組別設計 40 表3- 2 動物實驗各組別的三大營養素成分表 41 表3- 3高糖飼料(D02022704i)成分、營養素組成及熱量百分比 42 表3- 4高脂飼料(D12492)成分、營養素組成及熱量百分比 43 表3- 5 SDS-Page配方 60 表3- 6 西方墨點法溶液配製表 60 表3- 7西方墨點法抗體列表 61 表7- 1果糖餵食形式對高果糖飲食誘導小鼠之體重變化的影響 87 表7- 2果糖餵食形式對高果糖飲食誘導小鼠之飲食及能量攝取的影響 87 表7- 3果糖餵食形式對高果糖飲食誘導小鼠之飲食三大營養素比例 87 表7- 4果糖餵食形式對高果糖飲食誘導小鼠之臟器絕對重量及相對重量的影響 88 表7- 5果糖餵食形式對高果糖飲食誘導小鼠之脂肪組織絕對重量及相對重量的影響 88 表7- 6 TEE對高果糖飲食誘導小鼠之體重變化的影響 93 表7- 7 TEE對高果糖飲食誘導小鼠之飲食及能量攝取的影響 93 表7- 8 TEE對高果糖飲食誘導小鼠之飲食三大營養素比例 93 表7- 9 TEE對高果糖飲食誘導小鼠之臟器絕對重量及相對重量的影響 94 表7- 10 TEE對高果糖飲食誘導小鼠之脂肪組織絕對重量及相對重量的影響 94" | |
| dc.language.iso | zh-TW | |
| dc.subject | TEE | zh_TW |
| dc.subject | 高果糖飲食 | zh_TW |
| dc.subject | 非酒精脂肪肝病 | zh_TW |
| dc.subject | 天然萃取物 | zh_TW |
| dc.subject | triterpenoid-enriched extract (TEE) | en |
| dc.subject | high-fructose diet | en |
| dc.subject | NAFLD | en |
| dc.subject | natural extract | en |
| dc.title | 山苦瓜葉萃取物對高果糖飲食誘導非酒精性肝病之保護作用 | zh_TW |
| dc.title | The protective role of wild bitter melon leaf extract against high-fructose diet induced NAFLD in mice | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡帛蓉(Hsin-Tsai Liu),周逸鵬(Chih-Yang Tseng),許書豪 | |
| dc.subject.keyword | 高果糖飲食,非酒精脂肪肝病,天然萃取物,TEE, | zh_TW |
| dc.subject.keyword | high-fructose diet,NAFLD,natural extract,triterpenoid-enriched extract (TEE), | en |
| dc.relation.page | 156 | |
| dc.identifier.doi | 10.6342/NTU202104154 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-28 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 解剖學暨細胞生物學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-10-29 | - |
| 顯示於系所單位： | 解剖學暨細胞生物學科所 | |
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| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-2510202116154400.pdf 未授權公開取用 | 5.96 MB | Adobe PDF | 檢視/開啟 |
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