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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82088完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張麗冠(Li-Kwan Chang) | |
| dc.contributor.author | Ding-Li Wang | en |
| dc.contributor.author | 王頂立 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:35:36Z | - |
| dc.date.available | 2026-10-20 | |
| dc.date.copyright | 2021-11-02 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-26 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82088 | - |
| dc.description.abstract | EB 病毒 (Epstein-Barr virus) 是第四型人類皰疹病毒 (Human γ-herpesvirus 4)，會感染 90% 以上的人口，與伯奇氏淋巴瘤 (Burkitt's lymphoma)、霍奇金淋巴瘤 (Hodgkin's lymphoma) 及鼻咽癌 (Nasopharyngeal carcinoma) 等疾病相關。EB 病毒的外鞘殼體 (capsid) 是由主外鞘殼體蛋白質VCA為基質，中間由BDLF1、BORF1這兩個次外鞘殼體蛋白質連結，最後再以小外鞘殼體蛋白質BFRF3結合在外所構成，而 BFRF3 在 EB 病毒外鞘殼體組裝過程中是不可或缺的。本研究室先前發現 Tripate motif 5 alpha（TRIM5α） 除了作為反轉錄病毒的限制因子之外，還可透過泛素化修飾Rta，進而抑制 EB 病毒的再活化。因此，本研究的目的是要探討 TRIM5α 是否會透過泛素化修飾而影響 BFRF3 的功能。首先，本研究發現 TRIM5α 會與 BFRF3 結合，並促進其進行泛素化修飾。透過使用蛋白酶體抑制劑 MG132 以及自噬小體抑制劑 chloroquine，結果發現 BFRF3是以蛋白酶體降解途徑為主。然而，對泛素化修飾的分析得知 TRIM5α 是會促進 BFRF3 的 K63 鍵結的泛素化長鏈修飾，而 K63 鍵結的泛素化長鏈誘導的生理作用通常與 p62 的自噬途徑相關，而本研究也發現 BFRF3 會與 p62 在體內與體外皆會結合。因此在未來會以免疫螢光與蔗糖梯度離心等技術近一步釐清 TRIM5α 泛素化修飾 BFRF3 與 p62 自噬途徑的關聯，以及後續對病毒殼體組裝的影響。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:35:36Z (GMT). No. of bitstreams: 1 U0001-2610202105554500.pdf: 3049548 bytes, checksum: fe50091e361924cfc88d45b80de64f82 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "誌謝 i 摘要 ii ABSTRACT iii 目錄 iv 圖目錄 vii 表目錄 vii 附錄目錄 vii 前言 1 一、EB 病毒 1 EB 病毒與其起源 1 EB 病毒的感染方式 1 EB 病毒的生活史 2 EB 病毒的外鞘殼體（nucleocapsid） 3 EB 病毒小外鞘殼體蛋白質 BFRF3 的重要性 4 二、泛素化修飾 (Ubiquitination) 5 泛素化修飾機制 5 泛素化修飾鍵結種類與生理功能 5 三、TRIM5α 6 TRIM 蛋白質家族與 TRIM5α 6 TRIM5α 的背景 7 TRIM5α 限制反轉錄病毒的方式 7 TRIM5α 各 Domain 發生突變的影響 8 TRIM5α 亦能抑制皰疹病毒的感染 9 TRIM5α 與泛素化修飾 9 四、蛋白質降解 (Protein degradation) 9 泛素–蛋白酶體降解系統 (ubiquitin-proteasome system, UPS) 9 自噬作用 (Autophagy) 10 選擇性自噬作用 (Selective autophagy) 12 TRIMosome 12 研究動機與目的 13 材料與方法 14 一、細胞株 14 二、細菌 14 三、質體與抗體 14 四、細胞轉染 (Transfection) 14 五、慢病毒感染 (Lentivirus infection) 14 六、SDS-PAGE蛋白質膠體電泳及西方墨點法 (Western blot analysis) 15 七、GST 融合蛋白質沉降分析 (GST Pull-down) 15 八、變性免疫沉澱分析 (Denature immunoprecipitation assay) 16 九、免疫共沉澱分析 (Immunoprecipitation assay) 16 十、蛋白質穩定性測定 (Protein stability analysis) 17 結果 18 一、TRIM5α 會與 BFRF3 直接結合 18 二、TRIM5α 會促進 BFRF3 的泛素化修飾 18 三、BFRF3 傾向經由Proteasome 途徑被降解 19 四、TRIM5α 提升 BFRF3 的蛋白質穩定性 19 五、TRIM5α 促進 BFRF3 的 K-63 鍵結的泛素化修飾 20 六、BFRF3 與 p62 的結合 20 討論 22 一、TRIM5α 是 BFRF3 的泛素連接酶 E3 22 二、TRIM5α 提升 BFRF3 的蛋白質穩定性 23 三、TRIM5α 對於 BFRF3 可能的影響 24 四、TRIM5α 與 BFRF3 之間可能存在著未知的蛋白質 24 五、BFRF3 走向自噬作用降解途徑的可能性 25 圖表 28 表 1、EB 病毒與皰疹病毒科 (HSV、KSHV) 的同源外鞘殼體蛋白質對照表 28 表 2、本研究使用的質體 29 表 3、本研究使用的抗體 31 圖 1、EB 病毒的溶裂期進程 32 圖 2、TRIM5α 抑制 EB 病毒溶裂期進程的機制 33 圖 3、TRIM5α 與 BFRF3 的結合 34 圖 4、TRIM5α 與 BFRF3 的泛素化修飾 35 圖 5、BFRF3 的自噬作用及蛋白酶體降解途徑分析 36 圖 6、TRIM5α 會增強 BFRF3 的蛋白質穩定性 37 圖 7、TRIM5α 對 BFRF3 泛素化鏈結修飾的分析 39 圖 8、BFRF3 與 p62 的結合 40 參考文獻 41 附錄 55 附錄 1、EB病毒的外鞘殼體結構圖以及各外鞘殼體蛋白質分佈 55 附錄 2、HSV 外鞘殼體組裝過程 56 附錄 3、BFRF3 是 EB 病毒外鞘殼體組裝不可或缺的存在 57 附錄 4、BFRF3 蛋白質序列 58 附錄 5、TRIM 蛋白質家族的結構 59 附錄 6、TRIM5α 結合 HIV-1 病毒顆粒的結構 60 附錄 7、TRIMosome 的結構 61" | |
| dc.language.iso | zh-TW | |
| dc.subject | TRIM5α | zh_TW |
| dc.subject | 泛素化修飾 | zh_TW |
| dc.subject | 自噬作用 | zh_TW |
| dc.subject | BFRF3 | zh_TW |
| dc.subject | Epstein-Barr 病毒 | zh_TW |
| dc.subject | Autophagy | en |
| dc.subject | Epstein-Barr virus | en |
| dc.subject | TRIM5α | en |
| dc.subject | BFRF3 | en |
| dc.subject | Ubiquitination | en |
| dc.title | TRIM5α對EB病毒BFRF3的影響 | zh_TW |
| dc.title | Influence of TRIM5α on Epstein-Barr virus BFRF3 | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉世東(Hsin-Tsai Liu),李重霈(Chih-Yang Tseng),廖憶純,羅凱尹 | |
| dc.subject.keyword | Epstein-Barr 病毒,TRIM5α,BFRF3,泛素化修飾,自噬作用, | zh_TW |
| dc.subject.keyword | Epstein-Barr virus,TRIM5α,BFRF3,Ubiquitination,Autophagy, | en |
| dc.relation.page | 62 | |
| dc.identifier.doi | 10.6342/NTU202104197 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-27 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| dc.date.embargo-lift | 2026-10-20 | - |
| 顯示於系所單位： | 生化科技學系 | |
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