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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82087完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳家揚(CHIA-YANG CHEN) | |
| dc.contributor.author | Sheng-Che Tseng | en |
| dc.contributor.author | 曾聖哲 | zh_TW |
| dc.date.accessioned | 2022-11-25T05:35:35Z | - |
| dc.date.available | 2023-10-26 | |
| dc.date.copyright | 2021-11-09 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-26 | |
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Eriksen KT, Raaschou-Nielsen O, Sørensen M, Roursgaard M, Loft S, Møller P: Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells. Mutation Research/Genetic Toxicology and Environmental Mutagenesis 2010, 700(1-2):39-43. 7. Keller and Heckman, Denmark’s PFAS Ban in Paper and Cardboard Effective in July 2020 2020, https://www.packaginglaw.com/news/denmarks-pfas-ban-paper- and-cardboard-effective-july-2020. 8. Yuan G, Peng H, Huang C, Hu J: Ubiquitous Occurrence of Fluorotelomer Alcohols in Eco-Friendly Paper-Made Food-Contact Materials and Their Implication for Human Exposure. Environ Sci Technol 2016, 50(2):942-950. 9. Herzke D, Olsson E, Posner S: Perfluoroalkyl and polyfluoroalkyl substances (PFASs) in consumer products in Norway - a pilot study. Chemosphere 2012, 88(8):980-987. 10. Ahrens L, Bundschuh M: Fate and effects of poly- and perfluoroalkyl substances in the aquatic environment: a review. Environ Toxicol Chem 2014, 33(9):1921- 1929. 11. Jahnke A, Berger U, Ebinghaus R, Temme C: Latitudinal gradient of airborne polyfluorinated alkyl substances in the marine atmosphere between Germany and South Africa (53 degrees N-33 degrees S). Environ Sci Technol 2007, 41(9):3055- 3061. 12. D'Eon JC, Mabury SA: Production of perfluorinated carboxylic acids (PFCAs) from the biotransformation of polyfluoroalkyl phosphate surfactants (PAPS): exploring routes of human contamination. Environ Sci Technol 2007, 41(13):4799-4805. 13. Young CJ, Furdui VI, Franklin J, Koerner RM, Muir DC, Mabury SA: Perfluorinated acids in Arctic snow: new evidence for atmospheric formation. Environ Sci Technol 2007, 41(10):3455-3461. 14. Mamsen LS, Bjorvang RD, Mucs D, Vinnars MT, Papadogiannakis N, Lindh CH, Andersen CY, Damdimopoulou P: Concentrations of perfluoroalkyl substances (PFASs) in human embryonic and fetal organs from first, second, and third trimester pregnancies. Environ Int 2019, 124:482-492. 15. Stein CR, McGovern KJ, Pajak AM, Maglione PJ, Wolff MS: Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12-19 y: National Health and Nutrition Examination Survey. Pediatr Res 2016, 79(2):348-357. 16. Hartmann C, Raffesberg W, Scharf S, Uhl M: Research Article. Perfluoroalkylated substances in human urine: results of a biomonitoring pilot study. Biomonitoring 2017, 4(1):1-10. 17. Hu XC, Dassuncao C, Zhang X, Grandjean P, Weihe P, Webster GM, Nielsen F, Sunderland EM: Can profiles of poly- and Perfluoroalkyl substances (PFASs) in human serum provide information on major exposure sources? Environ Health 2018, 17(1):11. 18. Martinez-Moral MP, Tena MT: Determination of perfluorocompounds in popcorn packaging by pressurised liquid extraction and ultra-performance liquid chromatography-tandem mass spectrometry. Talanta 2012, 101:104-109. 19. Poothong S, Boontanon SK, Boontanon N: Determination of perfluorooctane sulfonate and perfluorooctanoic acid in food packaging using liquid chromatography coupled with tandem mass spectrometry. J Hazard Mater 2012, 205-206:139-143. 20. Quinete N, Wu Q, Zhang T, Yun SH, Moreira I, Kannan K: Specific profiles of perfluorinated compounds in surface and drinking waters and accumulation in mussels, fish, and dolphins from southeastern Brazil. Chemosphere 2009, 77(6):863-869. 21. Gawor A, Shunthirasingham C, Hayward SJ, Lei YD, Gouin T, Mmereki BT, Masamba W, Ruepert C, Castillo LE, Shoeib M et al: Neutral polyfluoroalkyl substances in the global atmosphere. Environ Sci Process Impacts 2014, 16(3):404-413. 22. Hung H, Katsoyiannis AA, Brorstrom-Lunden E, Olafsdottir K, Aas W, Breivik K, Bohlin-Nizzetto P, Sigurdsson A, Hakola H, Bossi R et al: Temporal trends of Persistent Organic Pollutants (POPs) in arctic air: 20 years of monitoring under the Arctic Monitoring and Assessment Programme (AMAP). Environ Pollut 2016, 217:52-61. 23. Dinglasan-Panlilio MJ, Mabury SA: Significant residual fluorinated alcohols present in various fluorinated materials. Environ Sci Technol 2006, 40(5):1447- 1453. 24. Jahnke A, Ahrens L, Ebinghaus R, Temme C: Urban versus remote air concentrations of fluorotelomer alcohols and other polyfluorinated alkyl substances in Germany. Environ Sci Technol 2007, 41(3):745-752. 25. Sinclair E, Kim SK, Akinleye HB, Kannan K: Quantitation of gas-phase perfluoroalkyl surfactants and fluorotelomer alcohols released from nonstick cookware and microwave popcorn bags. Environ Sci Technol 2007, 41(4):1180- 1185. 26. Schlummer M, Gruber L, Fiedler D, Kizlauskas M, Muller J: Detection of fluorotelomer alcohols in indoor environments and their relevance for human exposure. Environ Int 2013, 57-58:42-49. 27. Prevedouros K, Cousins IT, Buck RC, Korzeniowski SH: Sources, fate and transport of perfluorocarboxylates. Environ Sci Technol 2006, 40(1):32-44. 28. Wang N, Szostek B, Buck RC, Folsom PW, Sulecki LM, Gannon JT: 8-2 fluorotelomer alcohol aerobic soil biodegradation: pathways, metabolites, and metabolite yields. Chemosphere 2009, 75(8):1089-1096. 29. Dinglasan MJ, Ye Y, Edwards EA, Mabury SA: Fluorotelomer alcohol biodegradation yields poly- and perfluorinated acids. Environ Sci Technol 2004, 38(10):2857-2864. 30. O'Connor JC, Munley SM, Serex TL, Buck RC: Evaluation of the reproductive and developmental toxicity of 6:2 fluorotelomer alcohol in rats. Toxicology 2014, 317:6-16. 31. Serex T, Anand S, Munley S, Donner EM, Frame SR, Buck RC, Loveless SE: Toxicological evaluation of 6:2 fluorotelomer alcohol. Toxicology 2014, 319:1-9. 32. Butt CM, Muir DC, Mabury SA: Biotransformation pathways of fluorotelomer- based polyfluoroalkyl substances: a review. Environ Toxicol Chem 2014, 33(2):243-267. 33. 賴怡潔, 陳家揚: Comparison of Gas Chromatography and Ultra-performance Liquid Chromatography Coupled with Tandem Mass Spectrometry for Determining Perfluorinated Chemicals. 國立臺灣大學環境衛生研究所 2013, 碩士論文 34. Gonzalez-Barreiro C, Martinez-Carballo E, Sitka A, Scharf S, Gans O: Method optimization for determination of selected perfluorinated alkylated substances in water samples. Anal Bioanal Chem 2006, 386(7-8):2123-2132. 35. Chu S, Letcher RJ: Analysis of fluorotelomer alcohols and perfluorinated sulfonamides in biotic samples by liquid chromatography-atmospheric pressure photoionization mass spectrometry. J Chromatogr A 2008, 1215(1-2):92-99. 36. Barber JL, Berger U, Chaemfa C, Huber S, Jahnke A, Temme C, Jones KC: Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe. J Environ Monit 2007, 9(6):530-541. 37. Tittlemier SA, Pepper K, Edwards L, Tomy G: Development and characterization of a solvent extraction-gas chromatographic/mass spectrometric method for the analysis of perfluorooctanesulfonamide compounds in solid matrices. J Chromatogr A 2005, 1066(1-2):189-195. 38. Lehmler HJ: Synthesis of environmentally relevant fluorinated surfactants--a review. Chemosphere 2005, 58(11):1471-1496. 39. Wang N, Szostek B, Buck RC, Folsom PW, Sulecki LM, Capka V, Berti WR, Gannon JT: Fluorotelomer alcohol biodegradation-direct evidence that perfluorinated carbon chains breakdown. Environ Sci Technol 2005, 39(19):7516-7528. 40. Stock NL, Lau FK, Ellis DA, Martin JW, Muir DC, Mabury SA: Polyfluorinated telomer alcohols and sulfonamides in the North American troposphere. Environ Sci Technol 2004, 38(4):991-996. 41. 夏瑞敏, 陳家揚: Quantitation of Environmental Pollutants in Urine and Serum Using Ultra-performance Liquid Chromatography Tandem Mass Spectrometry 國立臺灣大學環境衛生研究所 2019, 碩士論文 42. Dagnino S, Strynar MJ, McMahen RL, Lau CS, Ball C, Garantziotis S, Webster TF, McClean MD, Lindstrom AB: Identification of Biomarkers of Exposure to FTOHs and PAPs in Humans Using a Targeted and Nontargeted Analysis Approach. Environ Sci Technol 2016, 50(18):10216-10225. 43. Fraser AJ, Webster TF, Watkins DJ, Nelson JW, Stapleton HM, Calafat AM, Kato K, Shoeib M, Vieira VM, McClean MD: Polyfluorinated compounds in serum linked to indoor air in office environments. Environ Sci Technol 2012, 46(2):1209-1215. 44. Nilsson H, Karrman A, Rotander A, van Bavel B, Lindstrom G, Westberg H: Biotransformation of fluorotelomer compound to perfluorocarboxylates in humans. Environ Int 2013, 51:8-12. 45. Llorca M, Farre M, Pico Y, Muller J, Knepper TP, Barcelo D: Analysis of perfluoroalkyl substances in waters from Germany and Spain. Sci Total Environ 2012, 431:139-150. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/82087 | - |
| dc.description.abstract | "全氟烷基化合物(perfluoroalkyl substances, PFASs)具有抗油防水的特性，因此被廣泛用於各種工業、民生消費品的製造。然而，它也是目前已知的內分泌干擾物之一，相關的暴露可能會導致人體不良健康效應，例:肝毒性、認知發展障礙。 對此，現今已有多國明定規範，限制長碳鏈全氟烷基化合物的使用，取而代之的是具有相似特性之氟調聚合醇類和全氟磺胺類的使用。因此，評估人體此二類物質的內在暴露劑量非常重要，而生物偵測為較合適的方法，血清檢測可反映化學物質平時在人體的濃度，尿液檢測則可指出化學物質短期的代謝情形，故本篇研究以血清和尿液作為生物基質以代表人體的內在劑量。本研究為開發以大氣壓氣相層析/串 聯 式 質 譜 儀 (atmospheric pressure gas chromatography coupled tandem mass spectrometer, APGC-MS/MS)對於血清及尿液中 4 種氟調聚合醇和 1 種全氟磺胺類物質的分析方法並用於調查我國兒童的暴露情形(265 個血清及 298 個尿液樣本)。本研究最適化 APGC-MS/MS 各項參數並評估基質效應和萃取效率且進行準確度 (accuracy)和精密度(precision)的方法確效。各化學物質在血清中之基質效應(matrix effect)為 81%-96%，萃取效率(extraction efficiency)為 73%-94%;在尿液中之基質效應為 76%-118%，萃取效率為 83%-91%。方法確效的部分，在三種不同濃度下(分別為 10、50 和 100 ng/mL)之回收率(recovery)皆高於 85%且精密度(%CV)皆低於 15% (n = 5)，線性範圍為 0.5-500 ng/mL。此方法已應用於來自臺大兒童醫院 (National Taiwan University Children Hospital, NTUCH)的實際樣本，結果顯示在血液中普遍有檢出 6:2 FTOH、8:2 FTOH 和 10:2 FTOH，而尿液的檢出率相對較低且僅有檢出 8:2 FTOH 和 10:2 FTOH。以濃度資料搭配問卷資料中的「家中是否有鋪設地毯」和「飲料包裝材質」兩部分分別進行 Student’s t-test 檢定，結果皆顯示未有顯著相關性(at p-value < 0.05)，但此二類化學物的代謝物之關注仍須重視。綜合以上，本研究開發的方法適用於血清與尿液中氟調聚合醇與全氟磺胺類化合物的檢測，且此研究是使用大氣壓氣相層析游離/串聯式質譜儀，而非過去多數文獻所使用的液相層析/串聯式質譜儀搭配不同的游離源;本研究分析方法於血清和尿液中 8:2 FTOH 具有較低的方法定量極限，為過去文獻數值的八倍低，意即較好的偵測靈敏度。此方法能提供後續相關的人體暴露評估一些方向以監測人體的暴露情形，協助改善世人的健康狀況。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T05:35:35Z (GMT). No. of bitstreams: 1 U0001-2610202111090300.pdf: 6694550 bytes, checksum: 49be26b6c2b77540a38a081df01b7f55 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "致謝............................................................................... i 中文摘要.......................................................................... ii ABSTRACT ......................................................................... iv Chapter 1 Introduction............................................................ 1 1.1 Perfluoroalkyl substances (PFASs) ................................................................................. 1 1.2 Fluorotelomer Alcohols ................................................................................. 3 1.3 Perfluorinated Sulfonamides ................................................................................. 4 1.4 Objectives .................................................................. 5 Chapter 2 Methods................................................................. 7 2.1 Reagents and materials........................................................ 7 2.2 Instruments................................................................... 8 2.3 Sample collection and storage................................................. 8 2.4 Sample preparation ........................................................... 9 2.4.1 Serum sample preparation ................................................... 9 2.4.2 Urine sample preparation................................................ 10 2.5 Instrumental analysis ....................................................... 10 2.5.1 Optimization of MS/MS parameters for analytes .............................. 11 2.5.2 Optimization of APGC-MS/MS analytical conditions ........................... 11 2.6 Method validation ............................................................ 12 2.6.1 Identification, quantification, and data analysis ......................... 12 2.6.2 Matrix effect and extraction efficiency.................................... 13 2.6.3 Assessment of precision and accuracy .................................... 14 2.6.4 Quality assurance and quality control ...................................... 15 2.7 Statistical analysis ......................................................... 16 Chapter 3 Results and Discussions........................................... 17 3.1 MS/MS parameter ............................................................. 17 3.2 Method validation ......................................................... 17 3.2.1 IDLs, IQLs, and calibration ranges ........................................ 17 3.2.2 LODs and LOQs............................................................ 18 3.2.3 Matrix effect and extraction efficiency.................................... 19 3.2.4 Precision and accuracy ................................................ 20 3.3 Real samples ................................................................ 21 Chapter 4 Conclusions............................................................. 24 Reference......................................................................... 26 Figures .......................................................................... 31 Tables........................................................................... 41" | |
| dc.language.iso | en | |
| dc.subject | 氟調聚合醇 | zh_TW |
| dc.subject | 全氟磺胺類化合物 | zh_TW |
| dc.subject | 大氣壓氣相層析儀 | zh_TW |
| dc.subject | 血清 | zh_TW |
| dc.subject | 全氟烷基化合物 | zh_TW |
| dc.subject | 尿液 | zh_TW |
| dc.subject | perfluoroalkyl substances | en |
| dc.subject | urine | en |
| dc.subject | serum | en |
| dc.subject | atmospheric pressure gas chromatography | en |
| dc.subject | perfluorinated sulfonamides | en |
| dc.subject | fluorotelomer alcohols | en |
| dc.title | 以大氣壓氣相層析/串聯式質譜儀分析血清與尿液中氟調聚合醇與全氟磺胺類化合物 | zh_TW |
| dc.title | Determination of Fluorotelomer Alcohols and Perfluorinated Sulfonamides in Serum and Urine Using Atmospheric Pressure Gas Chromatography/Tandem Mass Spectrometry | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳保中(Hsin-Tsai Liu),陳鑫昌(Chih-Yang Tseng),陳美惠 | |
| dc.subject.keyword | 全氟烷基化合物,氟調聚合醇,全氟磺胺類化合物,大氣壓氣相層析儀,血清,尿液, | zh_TW |
| dc.subject.keyword | perfluoroalkyl substances,fluorotelomer alcohols,perfluorinated sulfonamides,atmospheric pressure gas chromatography,serum,urine, | en |
| dc.relation.page | 51 | |
| dc.identifier.doi | 10.6342/NTU202104207 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-27 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
| dc.date.embargo-lift | 2023-10-26 | - |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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