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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 吳恩賜(Joshua Oon Soo Goh) | |
| dc.contributor.author | Yi-Chuang Lin | en |
| dc.contributor.author | 林以莊 | zh_TW |
| dc.date.accessioned | 2021-05-20T00:49:54Z | - |
| dc.date.available | 2020-08-26 | |
| dc.date.available | 2021-05-20T00:49:54Z | - |
| dc.date.copyright | 2020-08-26 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-08-17 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8194 | - |
| dc.description.abstract | 位於海馬迴中之網格細胞與位置細胞是為建立認知地圖之空間表徵。於本研究中，我們假設於導航期間，價值決策之能動性將加強發生於交界處與地標處之決策事件之權重，進而提升導航表現。此發生於交界處與地標處，或稱空間節點之編碼，提供了海馬迴神經細胞額外之權重，以編碼空間成為結構性之節點地圖。基於此假設，我們檢驗了於學習及提取期間，空間地圖於內部（自由導航）與外部（引導導航）產生之導航行為下之神經反應。我們招募了二十一位受試者於虛擬迷宮中分別進行自由導航、與引導導航之功能性磁振造影（fMRI）實驗。學習期間，於自由導航之情況下，受試者自由習得地標位置；於引導導航之情況下，受試者觀看影片引導其習得地標位置。提取期間，受試者判定目的地標之方向、距離、並且導航至目的地標始自不同之地點。我們觀察到於提取期間，引導導航相較於自由導航，受試者需花費更多時間導航至目的地標，並且展現更頻繁之失誤。關鍵腦區包含學習期間之輔助運動皮質區、與學習及提取期間之海馬迴，於自由導航之下，展現較引導導航下更高對於空間節點之神經反應；學習期間之顳中迴與提取期間之前、後扣帶迴皮質，於引導導航之下，展現較自由導航下更高對於空間節點之神經反應。特別來說，前海馬迴於學習期間自由導航下，展現較引導導航下更高對於空間節點之神經反應；後海馬迴則表現於提取期間引導導航下，較自由導航下更高由距離誤判比率調控對於距離判斷之神經反應。總結而言，我們展示於空間導航期間，價值決策能動性對於前海馬迴建構空間節點訊息之重要性。 | zh_TW |
| dc.description.abstract | Grid and place cell activity in the hippocampus (HC) instantiate cognitive map representations of space. In this study, we hypothesized that agency in navigational decision-making enhances navigational performances via emphasis on decision events at junctions and landmarks. Such coding of junctions and landmarks, or spatial nodes, provides HC neurons with additional weighting to encode plain space into structured node maps. To this end, we evaluated neural responses during learning and retrieving spatial maps under conditions of internally (Free) vs. externally (Tour) generated navigational movements. Twenty-one participants underwent functional magnetic resonance imaging (fMRI) spatial navigational experiments in virtual mazes under Free and Tour conditions. In the Free condition, participants learned landmark locations by free navigation. During retrieval, participants determined directions and distances and navigated to target landmarks from various start locations. In the Tour condition, participants viewed videos guiding them through the landmarks then did the same retrieval test. Navigation to target landmarks during retrieval took longer and failed more often for Tour than Free conditions. Critically, supplementary motor area responses during learning and HC responses during learning and retrieval to spatial nodes were higher for Free than Tour conditions. Middle temporal gyrus responses during learning, anterior and posterior cingulate cortex responses during retrieval to spatial nodes were higher for Tour than Free conditions. In particular, anterior HC responses to spatial nodes during learning were higher for Free than Tour conditions. In addition, posterior HC response modulation by distance mis-estimation during retrieval was greater for Tour than Free conditions. In sum, we demonstrate that agency in making navigational decisions is important for spatial node formation in anterior HC. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T00:49:54Z (GMT). No. of bitstreams: 1 U0001-1508202000162100.pdf: 62484940 bytes, checksum: e8c31bc5b74b8c2bfe785b3993b59d03 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 口試委員審定書 i 誌謝 ii 中文摘要 iv Abstract v Content vii Introduction 1 Grid and Place Cells Represent Space in Animal Hippocampus 2 Grid and Place Cells are also in the Human Hippocampus 4 Navigational Agency Modulates Spatial Map Representations 7 Theory: Decision Making Circuits Provide Basis to Label Internal Brain Activity States in Navigational Agency 9 Hypothesis: Map Learning with Navigational Decisions Enhances Spatial Representations 11 Methods 14 Participants 14 Stimuli 14 Virtual Environment Visuals, Interface, and Parameters 14 Debriefing and Questionnaire 16 Procedure 16 Familiarization 17 Formal Experiment 19 Debriefing and Questionnaire 20 Behavioral Error Rates During Retrieval Analysis 20 Brain Imaging Acquisition 21 fMRI Data Preprocessing 22 First Level Model of Learning Phase Neural Responses 23 First Level Model of Retrieval Phase Neural Responses 24 Second Level Model of Neural Responses 24 Region of Interest (ROI) Definition and Analysis 25 Results 26 Behavioral Results 26 Learning Patterns in Free and Tour Conditions 26 Better Map Retrieval Performances in Free than Tour 26 Functional Imaging Results 27 Differences of Neural Responses During Free and Tour Learning 27 Differences of Neural Responses During Free and Tour Retrieval 28 Specific Spatial Environments Represented in ROIs 29 Specific Neural Responses in Hippocampal Subregions 30 Correlations Between Hippocampal Responses and Behavioral Performances 30 Discussion 32 Navigational Agency Enhances Navigational Performances 32 Decision Making Provides Basis to Label Internal Brain Activity States in Navigational Agency 34 Dissociation Between Anterior and Posterior Hippocampus in Decision Making Based Navigational Neural Representations 36 Limitations and Implications 37 References 39 Figures 47 Figure 1. Hypothesized Brain Activations During Learning 47 Figure 2. Hypothesized Brain Activations During Retrieval 48 Figure 3. Virtual Environment Settings 49 Figure 4. Familiarization Procedure and Design 50 Figure 5. Formal Experiment Procedure and Design 51 Figure 6. a priori anatomical hippocampal ROIs 52 Figure 7. Learning Paths in Free and Tour Conditions of Single Subject 53 Figure 8. Learning Patterns in Free and Tour Conditions 54 Figure 9. Behavioral Error Rates 55 Figure 10. Behavioral Durations 56 Figure 11. Differences of Neural Responses During Free and Tour Learning 57 Figure 12. Differences of Neural Responses at Different Location States During Free and Tour Learning 58 Figure 13. Differences of Neural Responses at Different Location States During Free and Tour Retrieval 59 Figure 14. Differences of Neural Responses During Free and Tour Retrieval Judgements 60 Figure 15. Specific Spatial Environments Represented in ROIs 61 Figure 16. Specific Neural Responses in Hippocampal Subregions 62 Figure 17. Correlations Between Hippocampal Responses and Behavioral Performances 63 Tables 64 Table 1. Learning Patterns in Free and Tour Conditions 64 Table 2. ANOVA Table of Error Rates 65 Table 3. Paired T Test Table of Error Rates in Free and Tour Conditions 66 Table 4. Paired T Test Table of Direction Judgement Error Rate 67 Table 5. Paired T Test Table of Distance Judgement Error Rate 68 Table 6. Paired T Test Table of Navigational Error Rate 69 Table 7. ANOVA Table of Durations 70 Table 8. Paired T Test Table of Durations in Free and Tour Conditions 71 Table 9. Paired T Test Table of Direction Judgement Duration 72 Table 10. Paired T Test Table of Distance Judgement Duration 73 Table 11. Paired T Test Table of Navigational Duration 74 Table 12. Differences of Neural Responses During Free and Tour Learning 75 Table 13. Differences of Neural Responses At Different Location States During Free and Tour Learning 76 Table 14. Differences of Neural Responses At Different Location States During Free and Tour Retrieval 77 Table 15. Differences of Neural Responses During Free and Tour Retrieval Judgements 78 Table 16. Specific Spatial Environments Represented in ROIs 79 Table 17. Specific Neural Responses in Hippocampal Subregions 80 | |
| dc.language.iso | en | |
| dc.title | 導航能動性提升空間環境之神經表徵 | zh_TW |
| dc.title | Navigational Agency Enhances Neural Representations of Spatial Environments | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 張玉玲(Yu-Ling Chang),黃植懋(Chih-Mao Huang) | |
| dc.subject.keyword | 空間導航,價值決策,網格細胞,位置細胞,海馬迴,功能性磁振造影, | zh_TW |
| dc.subject.keyword | Spatial navigation,Decision making,Grid cell,Place cell,Hippocampus,fMRI, | en |
| dc.relation.page | 80 | |
| dc.identifier.doi | 10.6342/NTU202003498 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2020-08-17 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 腦與心智科學研究所 | zh_TW |
| 顯示於系所單位： | 腦與心智科學研究所 | |
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