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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 郭柏秀(Po-Hsiu Kuo) | |
| dc.contributor.author | Shih-Kai Kevin Lin | en |
| dc.contributor.author | 林詩凱 | zh_TW |
| dc.date.accessioned | 2022-11-25T03:03:50Z | - |
| dc.date.available | 2026-08-26 | |
| dc.date.copyright | 2021-10-01 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-19 | |
| dc.identifier.citation | Ahmed, A. I. A., van der Heijden, F. M. M. A., van den Berkmortel, H., Kramers, K. (2011). A man who wanted to commit suicide by hanging himself: An adverse effect of ciprofloxacin. General Hospital Psychiatry, 33(1), 82.e5-82.e7. https://doi.org/10.1016/j.genhosppsych.2010.07.002 Ai, D., Pan, H., Li, X., Gao, Y., Liu, G., Xia, L. C. (2019). Identifying Gut Microbiota Associated With Colorectal Cancer Using a Zero-Inflated Lognormal Model. Frontiers in Microbiology, 10. https://doi.org/10.3389/fmicb.2019.00826 Amarenco, G. (2014). Bristol Stool Chart: Étude prospective et monocentrique de « l’introspection fécale » chez des sujets volontaires. Progrès en Urologie, 24(11), 708–713. https://doi.org/10.1016/j.purol.2014.06.008 American Psychiatric Association. (2013). Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). American Psychiatric Association. https://doi.org/10.1176/appi.books.9780890425596 Anderson, M. J. (2017). Permutational Multivariate Analysis of Variance (PERMANOVA). In Wiley StatsRef: Statistics Reference Online (pp. 1–15). American Cancer Society. https://doi.org/10.1002/9781118445112.stat07841 Arroll, B., Elley, C. R., Fishman, T., Goodyear-Smith, F. A., Kenealy, T., Blashki, G., Kerse, N., MacGillivray, S. (2009). Antidepressants versus placebo for depression in primary care. Cochrane Database of Systematic Reviews. https://doi.org/10.1002/14651858.CD007954 Barbui, C., Cipriani, A., Patel, V., Ayuso-Mateos, J. L., van Ommeren, M. (2011). Efficacy of antidepressants and benzodiazepines in minor depression: Systematic review and meta-analysis. British Journal of Psychiatry, 198(1), 11–16. https://doi.org/10.1192/bjp.bp.109.076448 Beck, A. T., Steer, R. A., Carbin, M. G. (1988). Psychometric properties of the Beck Depression Inventory: Twenty-five years of evaluation. Clinical Psychology Review, 8(1), 77–100. https://doi.org/10.1016/0272-7358(88)90050-5 BECK, A. T., WARD, C. H., MENDELSON, M., MOCK, J., ERBAUGH, J. (1961). An Inventory for Measuring Depression. Archives of General Psychiatry, 4(6), 561–571. https://doi.org/10.1001/archpsyc.1961.01710120031004 Bharwani, A., Bala, A., Surette, M., Bienenstock, J., Vigod, S. N., Taylor, V. H. (2020). Gut Microbiome Patterns Associated With Treatment Response in Patients With Major Depressive Disorder: Changements du microbiote intestinal associés à la réponse au traitement chez des patients souffrant de trouble dépressif majeur. The Canadian Journal of Psychiatry, 65(4), 278–280. https://doi.org/10.1177/0706743719900464 Biedermann, L., Zeitz, J., Mwinyi, J., Sutter-Minder, E., Rehman, A., Ott, S. J., Steurer-Stey, C., Frei, A., Frei, P., Scharl, M., Loessner, M. J., Vavricka, S. R., Fried, M., Schreiber, S., Schuppler, M., Rogler, G. (2013). Smoking Cessation Induces Profound Changes in the Composition of the Intestinal Microbiota in Humans. PLoS ONE, 8(3), e59260. https://doi.org/10.1371/journal.pone.0059260 Boutard, M., Cerisy, T., Nogue, P.-Y., Alberti, A., Weissenbach, J., Salanoubat, M., Tolonen, A. C. (2014). Functional Diversity of Carbohydrate-Active Enzymes Enabling a Bacterium to Ferment Plant Biomass. PLoS Genetics, 10(11). https://doi.org/10.1371/journal.pgen.1004773 Chou, Y.-C., Chu, C.-H., Wu, M.-H., Hsu, G.-C., Yang, T., Chou, W.-Y., Huang, H.-P., Lee, M.-S., Yu, C.-P., Yu, J.-C., Sun, C.-A. (2011). Dietary intake of vitamin B(6) and risk of breast cancer in Taiwanese women. Journal of Epidemiology, 21(5), 329–336. https://doi.org/10.2188/jea.JE20100188 Collins, M. D., Lawson, P. A., Willems, A., Cordoba, J. J., Fernandez-Garayzabal, J., Garcia, P., Cai, J., Hippe, H., Farrow, J. A. E. (1994). The Phylogeny of the Genus Clostridium: Proposal of Five New Genera and Eleven New Species Combinations. International Journal of Systematic Bacteriology, 44(4), 812–826. https://doi.org/10.1099/00207713-44-4-812 Corsetti, M., De Nardi, P., Di Pietro, S., Passaretti, S., Testoni, P. A., Staudacher, C. (2009). Rectal Distensibility and Symptoms After Stapled and Milligan–Morgan Operation for Hemorrhoids. Journal of Gastrointestinal Surgery, 13(12), 2245–2251. https://doi.org/10.1007/s11605-009-0983-7 Cresci, G. A., Bawden, E. (2015). Gut Microbiome: What We Do and Don’t Know. Nutrition in Clinical Practice, 30(6), 734–746. https://doi.org/10.1177/0884533615609899 Cryan, J. F., Dinan, T. G. (2012). Mind-altering microorganisms: The impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience, 13(10), 701–712. https://doi.org/10.1038/nrn3346 Cussotto, S., Strain, C. R., Fouhy, F., Strain, R. G., Peterson, V. L., Clarke, G., Stanton, C., Dinan, T. G., Cryan, J. F. (2019). Differential effects of psychotropic drugs on microbiome composition and gastrointestinal function. Psychopharmacology, 236(5), 1671–1685. https://doi.org/10.1007/s00213-018-5006-5 Dethloff, F., Vargas, F., Elijah, E., Quinn, R., Park, D. I., Herzog, D. P., Müller, M. B., Gentry, E. C., Knight, R., Gonzalez, A., Dorrestein, P. C., Turck, C. W. (2020). Paroxetine Administration Affects Microbiota and Bile Acid Levels in Mice. Frontiers in Psychiatry, 11, 518. https://doi.org/10.3389/fpsyt.2020.00518 Distrutti, E., Monaldi, L., Ricci, P., Fiorucci, S. (2016). Gut microbiota role in irritable bowel syndrome: New therapeutic strategies. World Journal of Gastroenterology, 22(7), 2219–2241. https://doi.org/10.3748/wjg.v22.i7.2219 Dong, T. S., Gupta, A. (2019). Influence of Early Life, Diet, and the Environment on the Microbiome. Clinical Gastroenterology and Hepatology, 17(2), 231–242. https://doi.org/10.1016/j.cgh.2018.08.067 Eckburg, P. B. (2005). Diversity of the Human Intestinal Microbial Flora. Science, 308(5728), 1635–1638. https://doi.org/10.1126/science.1110591 Endicott, J. (1986). Schedule for Affective Disorders and Schizophrenia: Regular and Change Versions. In N. Sartorius T. A. Ban (Eds.), Assessment of Depression (pp. 316–323). Springer. https://doi.org/10.1007/978-3-642-70486-4_27 Flint, H. J., Scott, K. P., Louis, P., Duncan, S. H. (2012). The role of the gut microbiota in nutrition and health. Nature Reviews. Gastroenterology Hepatology, 9(10), 577–589. https://doi.org/10.1038/nrgastro.2012.156 Flowers, S. A., Evans, S. J., Ward, K. M., McInnis, M. G., Ellingrod, V. L. (2017). Interaction Between Atypical Antipsychotics and the Gut Microbiome in a Bipolar Disease Cohort. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, 37(3), 261–267. https://doi.org/10.1002/phar.1890 Fournier, J. C., DeRubeis, R. J., Hollon, S. D., Dimidjian, S., Amsterdam, J. D., Shelton, R. C., Fawcett, J. (2010). Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis. JAMA, 303(1), 47. https://doi.org/10.1001/jama.2009.1943 Francino, M. P. (2016). Antibiotics and the Human Gut Microbiome: Dysbioses and Accumulation of Resistances. Frontiers in Microbiology, 6. https://doi.org/10.3389/fmicb.2015.01543 Grassi, L., Biancosino, B., Pavanati, M., Agostini, M., Manfredini, R. (2001). Depression or Hypoactive Delirium? A Report of Ciprofloxacin-Induced Mental Disorder in a Patient with Chronic Obstructive Pulmonary Disease. Psychotherapy and Psychosomatics, 70(1), 58–59. https://doi.org/10.1159/000056226 Guardiola-Lemaitre, B., De Bodinat, C., Delagrange, P., Millan, M. J., Munoz, C., Mocaër, E. (2014). Agomelatine: Mechanism of action and pharmacological profile in relation to antidepressant properties. British Journal of Pharmacology, 171(15), 3604–3619. https://doi.org/10.1111/bph.12720 Huang, C., Alimova, Y., Myers, T., Ebersole, J. (2011). Short- and medium-chain fatty acids exhibit antimicrobial activity for oral microorganisms. Archives of Oral Biology, 56, 650–654. https://doi.org/10.1016/j.archoralbio.2011.01.011 Hughes, J. B., Hellmann, J. J., Ricketts, T. H., Bohannan, B. J. M. (2001). Counting the Uncountable: Statistical Approaches to Estimating Microbial Diversity. Applied and Environmental Microbiology, 67(10), 4399–4406. https://doi.org/10.1128/AEM.67.10.4399-4406.2001 Imhann, F., Vich Vila, A., Bonder, M. J., Lopez Manosalva, A. G., Koonen, D. P. Y., Fu, J., Wijmenga, C., Zhernakova, A., Weersma, R. K. (2017). The influence of proton pump inhibitors and other commonly used medication on the gut microbiota. Gut Microbes, 8(4), 351–358. https://doi.org/10.1080/19490976.2017.1284732 Jackson, M. A., Verdi, S., Maxan, M.-E., Shin, C. M., Zierer, J., Bowyer, R. C. E., Martin, T., Williams, F. M. K., Menni, C., Bell, J. T., Spector, T. D., Steves, C. J. (2018). Gut microbiota associations with common diseases and prescription medications in a population-based cohort. Nature Communications, 9(1), 2655. https://doi.org/10.1038/s41467-018-05184-7 Jandhyala, S. M. (2015). Role of the normal gut microbiota. World Journal of Gastroenterology, 21(29), 8787. https://doi.org/10.3748/wjg.v21.i29.8787 Jennings, L. (2018). Antidepressants. In G. T. Grossberg L. J. Kinsella (Eds.), Clinical Psychopharmacology for Neurologists: A Practical Guide (pp. 45–71). Springer International Publishing. https://doi.org/10.1007/978-3-319-74604-3_4 Jiang, H., Ling, Z., Zhang, Y., Mao, H., Ma, Z., Yin, Y., Wang, W., Tang, W., Tan, Z., Shi, J., Li, L., Ruan, B. (2015). Altered fecal microbiota composition in patients with major depressive disorder. Brain, Behavior, and Immunity, 48, 186–194. https://doi.org/10.1016/j.bbi.2015.03.016 Jilani, T. N., Gibbons, J. R., Faizy, R. M., Saadabadi, A. (2021). Mirtazapine. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK519059/ Keller, M. B., Trivedi, M. H., Thase, M. E., Shelton, R. C., Kornstein, S. G., Nemeroff, C. B., Friedman, E. S., Gelenberg, A. J., Kocsis, J. H., Dunner, D. L., Dunlop, B. W., Hirschfeld, R. M., Rothschild, A. J., Ferguson, J. M., Schatzberg, A. F., Zajecka, J. M., Pedersen, R., Yan, B., Ahmed, S., … Ninan, P. T. (2007). The Prevention of Recurrent Episodes of Depression with Venlafaxine for Two Years (PREVENT) Study: Outcomes from the Acute and Continuation Phases. Biological Psychiatry, 62(12), 1371–1379. https://doi.org/10.1016/j.biopsych.2007.04.040 Kelly, J. R., Borre, Y., O’ Brien, C., Patterson, E., El Aidy, S., Deane, J., Kennedy, P. J., Beers, S., Scott, K., Moloney, G., Hoban, A. E., Scott, L., Fitzgerald, P., Ross, P., Stanton, C., Clarke, G., Cryan, J. F., Dinan, T. G. (2016). Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. Journal of Psychiatric Research, 82, 109–118. https://doi.org/10.1016/j.jpsychires.2016.07.019 Kennedy, P. J., Cryan, J. F., Dinan, T. G., Clarke, G. (2014). Irritable bowel syndrome: A microbiome-gut-brain axis disorder? World Journal of Gastroenterology : WJG, 20(39), 14105–14125. https://doi.org/10.3748/wjg.v20.i39.14105 Koh, H., Lee, M. J., Kim, M. J., Shin, J. I., Chung, K. S. (2010). Simple diagnostic approach to childhood fecal retention using the Leech score and Bristol stool form scale in medical practice. Journal of Gastroenterology and Hepatology, 25(2), 334–338. https://doi.org/10.1111/j.1440-1746.2009.06015.x Kuo, P.-H., Chung, Y.-C. E. (2019). Moody microbiome: Challenges and chances. Journal of the Formosan Medical Association, 118, S42–S54. https://doi.org/10.1016/j.jfma.2018.09.004 Lacy, B. E., Patel, N. K. (2017). Rome Criteria and a Diagnostic Approach to Irritable Bowel Syndrome. Journal of Clinical Medicine, 6(11). https://doi.org/10.3390/jcm6110099 Lau, S. K. P., Woo, P. C. Y., Woo, G. K. S., Fung, A. M. Y., Wong, M. K. M., Chan, K., Tam, D. M. W., Yuen, K. (2004). Eggerthella hongkongensis sp. Nov. And eggerthella sinensis sp. Nov., two novel Eggerthella species, account for half of the cases of Eggerthella bacteremia. Diagnostic Microbiology and Infectious Disease, 49(4), 255–263. https://doi.org/10.1016/j.diagmicrobio.2004.04.012 Lee, R., Huang, Y.-T., Liao, C.-H., Chuang, T.-Y., Wang, W.-J., Lee, S.-W., Lee, L.-N., Hsueh, P.-R. (2012). Clinical and Microbiological Characteristics of Bacteremia Caused by Eggerthella, Paraeggerthella, and Eubacterium Species at a University Hospital in Taiwan from 2001 to 2010. Journal of Clinical Microbiology, 50, 2053–2055. https://doi.org/10.1128/JCM.00548-12 Lewis, S. J., Heaton, K. W. (1997). Stool form scale as a useful guide to intestinal transit time. Scandinavian Journal of Gastroenterology, 32(9), 920–924. https://doi.org/10.3109/00365529709011203 Liśkiewicz, P., Pełka-Wysiecka, J., Kaczmarczyk, M., Łoniewski, I., Wroński, M., Bąba-Kubiś, A., Skonieczna-Żydecka, K., Marlicz, W., Misiak, B., Samochowiec, J. (2019). Fecal Microbiota Analysis in Patients Going through a Depressive Episode during Treatment in a Psychiatric Hospital Setting. Journal of Clinical Medicine, 8(2), 164. https://doi.org/10.3390/jcm8020164 Liu, Y., Zhang, L., Wang, X., Wang, Z., Zhang, J., Jiang, R., Wang, X., Wang, K., Liu, Z., Xia, Z., Xu, Z., Nie, Y., Lv, X., Wu, X., Zhu, H., Duan, L. (2016). Similar Fecal Microbiota Signatures in Patients With Diarrhea-Predominant Irritable Bowel Syndrome and Patients With Depression. Clinical Gastroenterology and Hepatology, 14(11), 1602-1611.e5. https://doi.org/10.1016/j.cgh.2016.05.033 Lopetuso, L. R., Scaldaferri, F., Petito, V., Gasbarrini, A. (2013). Commensal Clostridia: Leading players in the maintenance of gut homeostasis. Gut Pathogens, 5, 23. https://doi.org/10.1186/1757-4749-5-23 Lopez-Munoz, F., Alamo, C. (2009). Monoaminergic Neurotransmission: The History of the Discovery of Antidepressants from 1950s Until Today. Current Pharmaceutical Design, 15(14), 1563–1586. https://doi.org/10.2174/138161209788168001 Lukić, I., Getselter, D., Ziv, O., Oron, O., Reuveni, E., Koren, O., Elliott, E. (2019). Antidepressants affect gut microbiota and Ruminococcus flavefaciens is able to abolish their effects on depressive-like behavior. Translational Psychiatry, 9(1), 133. https://doi.org/10.1038/s41398-019-0466-x Lyte, M., Daniels, K. M., Schmitz-Esser, S. (2019). Fluoxetine-induced alteration of murine gut microbial community structure: Evidence for a microbial endocrinology-based mechanism of action responsible for fluoxetine-induced side effects. PeerJ, 7, e6199. https://doi.org/10.7717/peerj.6199 Macedo, D., Filho, A. J. M. C., Soares de Sousa, C. N., Quevedo, J., Barichello, T., Júnior, H. V. N., Freitas de Lucena, D. (2017). Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness. Journal of Affective Disorders, 208, 22–32. https://doi.org/10.1016/j.jad.2016.09.012 Makki, K., Deehan, E. C., Walter, J., Bäckhed, F. (2018). The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host Microbe, 23(6), 705–715. https://doi.org/10.1016/j.chom.2018.05.012 Mallick, H., Rahnavard, A., McIver, L. J., Ma, S., Zhang, Y., Nguyen, L. H., Tickle, T. L., Weingart, G., Ren, B., Schwager, E. H., Chatterjee, S., Thompson, K. N., Wilkinson, J. E., Subramanian, A., Lu, Y., Waldron, L., Paulson, J. N., Franzosa, E. A., Bravo, H. C., Huttenhower, C. (2021). Multivariable Association Discovery in Population-scale Meta-omics Studies [Preprint]. Microbiology. https://doi.org/10.1101/2021.01.20.427420 Marken, P. A., Munro, J. S. (2000). Selecting a Selective Serotonin Reuptake Inhibitor: Clinically Important Distinguishing Features. Primary Care Companion to The Journal of Clinical Psychiatry, 2(6), 205–210. Matt, S. M., Allen, J. M., Lawson, M. A., Mailing, L. J., Woods, J. A., Johnson, R. W. (2018). Butyrate and Dietary Soluble Fiber Improve Neuroinflammation Associated With Aging in Mice. Frontiers in Immunology, 9. https://doi.org/10.3389/fimmu.2018.01832 McGovern, A. S., Hamlin, A. S., Winter, G. (2019). A review of the antimicrobial side of antidepressants and its putative implications on the gut microbiome. Australian New Zealand Journal of Psychiatry, 53(12), 1151–1166. https://doi.org/10.1177/0004867419877954 Mínguez Pérez, M., Benages Martínez, A. (2009). The Bristol scale—A useful system to assess stool form? Revista Espanola De Enfermedades Digestivas: Organo Oficial De La Sociedad Espanola De Patologia Digestiva, 101(5), 305–311. Mosca, A., Leclerc, M., Hugot, J. P. (2016). Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem? Frontiers in Microbiology, 7. https://doi.org/10.3389/fmicb.2016.00455 Munoz-Bellido, J. L., Munoz-Criado, S., Garcı̀a-Rodrı̀guez, J. A. (2000). Antimicrobial activity of psychotropic drugs: Selective serotonin reuptake inhibitors. International Journal of Antimicrobial Agents, 14(3), 177–180. https://doi.org/10.1016/S0924-8579(99)00154-5 Mutlu, E. A., Gillevet, P. M., Rangwala, H., Sikaroodi, M., Naqvi, A., Engen, P. A., Kwasny, M., Lau, C. K., Keshavarzian, A. (2012). Colonic microbiome is altered in alcoholism. American Journal of Physiology. Gastrointestinal and Liver Physiology, 302(9), G966-978. https://doi.org/10.1152/ajpgi.00380.2011 Nakayama, J., Watanabe, K., Jiang, J., Matsuda, K., Chao, S.-H., Haryono, P., La-ongkham, O., Sarwoko, M.-A., Sujaya, I. N., Zhao, L., Chen, K.-T., Chen, Y.-P., Chiu, H.-H., Hidaka, T., Huang, N.-X., Kiyohara, C., Kurakawa, T., Sakamoto, N., Sonomoto, K., … Lee, Y.-K. (2015). Diversity in gut bacterial community of school-age children in Asia. Scientific Reports, 5(1), 8397. https://doi.org/10.1038/srep08397 Naseribafrouei, A., Hestad, K., Avershina, E., Sekelja, M., Linløkken, A., Wilson, R., Rudi, K. (2014). Correlation between the human fecal microbiota and depression. Neurogastroenterology and Motility: The Official Journal of the European Gastrointestinal Motility Society, 26(8), 1155–1162. https://doi.org/10.1111/nmo.12378 National Collaborating Centre for Nursing and Supportive Care (UK). (2008). Irritable Bowel Syndrome in Adults: Diagnosis and Management of Irritable Bowel Syndrome in Primary Care. Royal College of Nursing (UK). http://www.ncbi.nlm.nih.gov/books/NBK51953/ Natividad, J. M. M., Verdu, E. F. (2013). Modulation of intestinal barrier by intestinal microbiota: Pathological and therapeutic implications. Pharmacological Research, 69(1), 42–51. https://doi.org/10.1016/j.phrs.2012.10.007 Raisman, R., Briley, M., Langer, S. Z. (1979). Specific tricyclic antidepressant binding sites in rat brain. Nature, 281(5727), 148–150. https://doi.org/10.1038/281148a0 Raskov, H., Burcharth, J., Pommergaard, H.-C., Rosenberg, J. (2016). Irritable bowel syndrome, the microbiota and the gut-brain axis. Gut Microbes, 7(5), 365–383. https://doi.org/10.1080/19490976.2016.1218585 Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G., Gasbarrini, A., Mele, M. (2019). What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases. Microorganisms, 7(1), 14. https://doi.org/10.3390/microorganisms7010014 Ritchie, H., Roser, M. (2018). Mental Health. Our World in Data. https://ourworldindata.org/mental-health Rush, A. J., Trivedi, M. H., Wisniewski, S. R., Nierenberg, A. A., Stewart, J. W., Warden, D., Niederehe, G., Thase, M. E., Lavori, P. W., Lebowitz, B. D., McGrath, P. J., Rosenbaum, J. F., Sackeim, H. A. (2006). Acute and Longer-Term Outcomes in Depressed Outpatients Requiring One or Several Treatment Steps: A STAR*D Report. Am J Psychiatry, 13. Santarsieri, D., Schwartz, T. (2015). Antidepressant efficacy and side-effect burden: A quick guide for clinicians. Drugs in Context, 4, 1–12. https://doi.org/10.7573/dic.212290 Shin, A., Preidis, G. A., Shulman, R., Kashyap, P. C. (2019). The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders. Clinical Gastroenterology and Hepatology: The Official Clinical Practice Journal of the American Gastroenterological Association, 17(2), 256–274. https://doi.org/10.1016/j.cgh.2018.08.054 Shin, J. J., Saadabadi, A. (2021). Trazodone. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK470560/ Sim, K., Lau, W. K., Sim, J., Sum, M. Y., Baldessarini, R. J. (2016). Prevention of Relapse and Recurrence in Adults with Major Depressive Disorder: Systematic Review and Meta-Analyses of Controlled Trials. International Journal of Neuropsychopharmacology, 19(2), pyv076. https://doi.org/10.1093/ijnp/pyv076 Simpson, C. A., Diaz-Arteche, C., Eliby, D., Schwartz, O. S., Simmons, J. G., Cowan, C. S. M. (2021). The gut microbiota in anxiety and depression – A systematic review. Clinical Psychology Review, 83, 101943. https://doi.org/10.1016/j.cpr.2020.101943 Singh, R. K., Chang, H.-W., Yan, D., Lee, K. M., Ucmak, D., Wong, K., Abrouk, M., Farahnik, B., Nakamura, M., Zhu, T. H., Bhutani, T., Liao, W. (2017). Influence of diet on the gut microbiome and implications for human health. Journal of Translational Medicine, 15(1), 73. https://doi.org/10.1186/s12967-017-1175-y Skonieczna-Żydecka, K., Łoniewski, I., Misera, A., Stachowska, E., Maciejewska, D., Marlicz, W., Galling, B. (2019). Second-generation antipsychotics and metabolism alterations: A systematic review of the role of the gut microbiome. Psychopharmacology, 236(5), 1491–1512. https://doi.org/10.1007/s00213-018-5102-6 Stackebrandt, E., Kramer, I., Swiderski, J., Hippe, H. (1999). Phylogenetic basis for a taxonomic dissection of the genus Clostridium. FEMS Immunology Medical Microbiology, 24(3), 253–258. https://doi.org/10.1111/j.1574-695X.1999.tb01291.x Stahl, S. M., Pradko, J. F., Haight, B. R., Modell, J. G., Rockett, C. B., Learned-Coughlin, S. (2004). A Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor. Primary Care Companion to The Journal of Clinical Psychiatry, 6(4), 159–166. Sudo, N., Chida, Y., Aiba, Y., Sonoda, J., Oyama, N., Yu, X.-N., Kubo, C., Koga, Y. (2004). Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice: Commensal microbiota and stress response. The Journal of Physiology, 558(1), 263–275. https://doi.org/10.1113/jphysiol.2004.063388 Sun, L., Zhang, H., Cao, Y., Wang, C., Zhao, C., Wang, H., Cui, G., Wang, M., Pan, Y., Shi, Y., Nie, Y. (2019). Fluoxetine ameliorates dysbiosis in a depression model induced by chronic unpredicted mild stress in mice. International Journal of Medical Sciences, 16(9), 1260–1270. https://doi.org/10.7150/ijms.37322 Tomizawa, Y., Kurokawa, S., Ishii, D., Miyaho, K., Ishii, C., Sanada, K., Fukuda, S., Mimura, M., Kishimoto, T. (2021). Effects of Psychotropics on the Microbiome in Patients With Depression and Anxiety: Considerations in a Naturalistic Clinical Setting. International Journal of Neuropsychopharmacology, 24(2), 97–107. https://doi.org/10.1093/ijnp/pyaa070 Vujkovic-Cvijin, I., Sklar, J., Jiang, L., Natarajan, L., Knight, R., Belkaid, Y. (2020). Host variables confound gut microbiota studies of human disease. Nature, 587(7834), 448–454. https://doi.org/10.1038/s41586-020-2881-9 Walsh, J., Griffin, B. T., Clarke, G., Hyland, N. P. (2018). Drug–gut microbiota interactions: Implications for neuropharmacology. British Journal of Pharmacology, 175(24), 4415–4429. https://doi.org/10.1111/bph.14366 Wang, H.-J., Liang, X.-M., Yu, Z.-L., Zhou, L.-Y., Lin, S.-R., Geraint, M. (2004). A Randomised, Controlled Comparison of Low-Dose Polyethylene Glycol 3350 plus Electrolytes with Ispaghula Husk in the Treatment of Adults with Chronic Functional Constipation. Clinical Drug Investigation, 24(10), 569–576. https://doi.org/10.2165/00044011-200424100-00002 Wang, X., Li, H., Bezemer, T. M., Hao, Z. (2016). Drivers of bacterial beta diversity in two temperate forests. Ecological Research, 31(1), 57–64. https://doi.org/10.1007/s11284-015-1313-z Whittaker, R. H. (1960). Vegetation of the Siskiyou Mountains, Oregon and California. Ecological Monographs, 30(3), 279–338. https://doi.org/10.2307/1943563 Whittaker, R. H. (1972). EVOLUTION AND MEASUREMENT OF SPECIES DIVERSITY. TAXON, 21(2–3), 213–251. https://doi.org/10.2307/1218190 WHO-MSD-MER-2017.2-eng.pdf. (n.d.). Retrieved May 28, 2021, from https://apps.who.int/iris/bitstream/handle/10665/254610/WHO-MSD-MER-2017.2-eng.pdf Zhang, W., Qu, W., Wang, H., Yan, H. (2021). Antidepressants fluoxetine and amitriptyline induce alterations in intestinal microbiota and gut microbiome function in rats exposed to chronic unpredictable mild stress. Translational Psychiatry, 11(1), 131. https://doi.org/10.1038/s41398-021-01254-5 Zheng, P., Zeng, B., Zhou, C., Liu, M., Fang, Z., Xu, X., Zeng, L., Chen, J., Fan, S., Du, X., Zhang, X., Yang, D., Yang, Y., Meng, H., Li, W., Melgiri, N. D., Licinio, J., Wei, H., Xie, P. (2016). Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism. Molecular Psychiatry, 21(6), 786–796. https://doi.org/10.1038/mp.2016.44 Zhernakova, A., Kurilshikov, A., Bonder, M. J., Tigchelaar, E. F., Schirmer, M., Vatanen, T., Mujagic, Z., Vila, A. V., Falony, G., Vieira-Silva, S., Wang, J., Imhann, F., Brandsma, E., Jankipersadsing, S. A., Joossens, M., Cenit, M. C., Deelen, P., Swertz, M. A., LifeLines cohort study, … Fu, J. (2016). Population-based metagenomics analysis reveals markers for gut microbiome composition and diversity. Science (New York, N.Y.), 352(6285), 565–569. https://doi.org/10.1126/science.aad3369 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81798 | - |
| dc.description.abstract | "憂鬱症是一種相當嚴重的精神疾病之一，它造成了全世界巨大的疾病負擔。抗憂鬱藥是用於治療憂鬱症的精神藥物之一，常見處方有選擇性血清素再吸收抑製劑和血清素-去甲腎上腺素再吸收抑製劑 (SSRIs/SNRIs)。先前的老鼠和人類研究表明，憂鬱症和 SSRI/SNRI的使用與腸道微生物群組成以及特定細菌種類的改變有關。我們的研究旨在探索憂鬱症病人中，使用 SSRIs 或 SNRIs 藥物與未使用抗憂鬱藥或使用其他類型抗憂鬱藥的腸道微生物群差異。 我們的研究分析 139 名有憂鬱症狀的患者(包含鬱症，與經歷鬱期的躁鬱症患者)的腸道微生物群特徵。我們通過病歷搜索、修改後的中文版終生精神疾病診斷晤談手冊、貝克憂鬱量表 (BDI) 和食物頻率問卷 (FFQ) 收集了受試者的抗憂鬱藥使用情況、基本人口統計學特徵（包括飲食習慣）以及情緒狀況。在 16S rRNA 定序（Illumina Miseq 平台）之前，通過 QIAamp DNA Mini Kit 或苯酚 - 氯仿提取方法從糞便樣本中提取微生物群的DNA。藉由藥物使用資訊及記錄，受試者被分到SSRI/SNRI組、其他類型抗憂鬱藥組和無使用抗憂鬱藥組。此外，考慮到SSRIs和SNRIs在3～12個月內可達到治療效果，我們更進一步將SSRI/SNRI組分為短、中、長的時間組。我們比較了組間的 alpha 和 beta 多樣性，並進行多變量回歸以找出有顯著差異的菌種。 與未接受抗憂鬱藥的患者相比，接受抗憂鬱鬱藥治療（SSRI/SNRI 或其他類型）的患者的 alpha 多樣性較低 (未達統計顯著)。在 beta 多樣性中，統計結果顯示 SSRI/SNRI 組和未使用抗憂鬱藥組之間存在顯著差異（p=0.0037, unweighted Uni-Frac distance）。 此外，當比較 SSRI/SNRI 組和未使用抗憂鬱藥組時，梭菌屬 (Clostridium) 以及一個來自瘤胃菌科 (Ruminococcaceae) 的菌屬有顯著差異，這兩隻菌的豐富度也隨著使用SSRIs或SNRIs的時間變長而減少。另一方面，當比較 SSRI/SNRI 組和其他類型抗憂鬱藥組時，球菌(Coprococcus)、瘤胃球菌 (Ruminococcus)、類伊格爾茲氏菌屬 (Paraeggerthella)和乳酸菌 (Lactonifactor) 有顯著差異。在細菌間的相關性分析中，SSRI/SNRI 組和未使用抗憂鬱藥組有類似的相關模式，而在其他類型抗憂鬱組中出現了更多負相關菌群。 此外，與其他抗憂鬱類型組和未使用抗憂鬱藥組相比，SSRI/SNRI 組細菌間的相關性相對降低許多。 總結來說，我們發現使用抗憂鬱藥的菌種多樣性相對較低，而使用抗憂鬱藥病患的腸道菌相組成與未使用任何抗憂鬱藥治療的病患的組成有顯著差異，我們更深入並發現瘤胃球菌科的兩個屬可能會受到 SSRI或SNRI 的使用而被影響，並隨時間遞減。由於 SSRI/SNRI 使用時間亞組的分類是基於其達到藥效以及持續療效的時間，因此應進一步探討這些菌群與症狀嚴重程度以及藥效之間的關聯。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T03:03:50Z (GMT). No. of bitstreams: 1 U0001-0908202120332600.pdf: 2541756 bytes, checksum: 05dd32123831a9d82e2c5c6340019c42 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "中文摘要 2 Abstract 4 1. Introduction 10 1.1. Affective disorders 10 1.2. Diagnosis tools for affective disorders 11 1.3. Global burden of affective disorder depression 11 1.4. Antidepressants for depression treatment 12 1.5. Human gut microbiota and gut-brain axis 13 1.6. Gut microbiota diversity 14 1.7. Gut microbiota related factors 16 1.8. Depression and gut microbiota 17 1.9. Antidepressants and gut microbiota 19 1.10. Study aim 21 2. Materials and methods 22 2.1. Subject recruitment 22 2.2. Medication status assessment 22 2.3. Basic demographic and clinical characteristics assessment 23 2.4. Mood and severity assessment 24 2.5. Dietary assessment 24 2.6. Stool leaflet and Bristol stool form scale 25 2.7. Feces collection 25 2.8. Stool DNA extraction and 16S rDNA gene sequence 26 2.9. Statistical analysis 27 3. Results 31 3.1. Basic demographic, dietary, clinical characteristics, and stool related variables 31 3.2. Sequenced data of gut microbiota 32 3.3. Gut microbiota composition analysis between different medication types 32 3.4. Correlation between bacterial taxa in different medication types 34 4. Discussion 35 5. References 48" | |
| dc.language.iso | en | |
| dc.subject | 鬱期 | zh_TW |
| dc.subject | SSRI/SNRI | zh_TW |
| dc.subject | 抗憂鬱藥 | zh_TW |
| dc.subject | 抗菌效果 | zh_TW |
| dc.subject | 腸道生態多樣性 | zh_TW |
| dc.subject | 腸道微生物 | zh_TW |
| dc.subject | gut microbiota | en |
| dc.subject | antimicrobial effects | en |
| dc.subject | gut microbial diversity | en |
| dc.subject | SSRI/SNRI | en |
| dc.subject | depression | en |
| dc.subject | Antidepressants | en |
| dc.title | 探討當代抗憂鬱藥與腸道菌相組成之相關性 | zh_TW |
| dc.title | Exploring the gut microbiota targets in relation to the use of contemporary antidepressants | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳錫中(Hsin-Tsai Liu),陳介章(Chih-Yang Tseng),盧子彬 | |
| dc.subject.keyword | 抗憂鬱藥,腸道微生物,鬱期,SSRI/SNRI,腸道生態多樣性,抗菌效果, | zh_TW |
| dc.subject.keyword | Antidepressants,gut microbiota,depression,SSRI/SNRI,gut microbial diversity,antimicrobial effects, | en |
| dc.relation.page | 89 | |
| dc.identifier.doi | 10.6342/NTU202102226 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-08-19 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
| dc.date.embargo-lift | 2026-08-26 | - |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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|---|---|---|---|
| U0001-0908202120332600.pdf 此日期後於網路公開 2026-08-26 | 2.48 MB | Adobe PDF |
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