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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81797完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 李翔傑(Hsiang-Chieh Lee) | |
| dc.contributor.author | Ting-Hao Chen | en |
| dc.contributor.author | 陳庭皓 | zh_TW |
| dc.date.accessioned | 2022-11-25T03:03:48Z | - |
| dc.date.available | 2023-09-07 | |
| dc.date.copyright | 2021-11-06 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-11 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81797 | - |
| dc.description.abstract | 光學同調斷層掃描血管造影術可以提供快速、立體和非侵入式的組織微血管系統之成像。本論文將介紹多種光學同調斷層掃描血管造影術演算法並應用在小動物模型之中。這些演算法使用光學同調斷層掃描術信號的訊息，包括相位、強度或複數值。另外，為了研究ㄧ維掃描速率和掃描間隔時間如何影響光學同調斷層掃描血管造影術的對比度和動態範圍，我們開發了中心波長位於 1.06 微米之掃頻光源式光學同調斷層掃描術系統，使用兩個光源實現100 kHz 或 200 kHz ㄧ維縱向深度掃描速率。光學同調斷層掃描血管造影術可以識別更複雜的小鼠耳朵微血管網絡，當掃描間隔時間相對較長時（例如 12.5 ms比上6.25 ms）。另一方面，由相同掃描間隔時間（例如 12.5 ms）與不同ㄧ維掃描速率產生的光學同調斷層掃描血管造影術影像集也被加以比較。以 100 kHzㄧ維掃描速率獲取的光學同調斷層掃描血管造影術影像顯示出比其他成像方式更精細的微血管系統。我們也針對以不同ㄧ維掃描速率和掃描間隔時間重建的光學同調斷層掃描血管造影術影像的對比度進行了定量分析，這些量化包括血管面積、總血管長度和連接點密度等。 此外，傳統的光學同調斷層掃描術之儀器設置不適合對行為自由的動物進行成像，因為該系統龐大而笨重。這些缺點限制了光學同調斷層掃描術在神經科學中更廣泛的應用，因為研究人員對動物進行大腦成像時，只能是在麻醉下或是將大腦保持在固定位置。因此，在本論文中，亦提出了 1.3 µm 微型頭戴式光學同調斷層掃描術成像裝置，其具有400 kHzㄧ維掃描速率並允許在自由移動狀態下對小鼠大腦進行連續成像。該裝置利用微機電系統掃描技術和高速波長掃描光源，以實現鼠腦的高速光學同調斷層掃描術成像。另外，為了觀察大腦活動與相關生理條件之間的關係，我們使用光學同調斷層掃描血管造影術來獲取不同生理條件下小鼠大腦的微血管訊息。這些生理條件包括麻醉、清醒中和活動狀態以及電刺激狀態。因此，本裝置的發明將能延伸光學同調斷層掃描術在行為神經科學中的血流動力學或血管生成研究領域的應用。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-25T03:03:48Z (GMT). No. of bitstreams: 1 U0001-1008202116130500.pdf: 6315449 bytes, checksum: 1b6189a631ce1e1471f667d47e400393 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 謝辭 i 中文摘要 ii Abstract iv Table of Contents vi List of Figures xi List of Tables xviii Chapter 1. Introduction 1 1.1 Functional Brain Imaging 1 1.2 Introduction to Optical Coherence Tomography 6 1.3 Functional Optical Coherence Tomography 13 1.3.1 Polarization-Sensitive Optical Coherence Tomography 13 1.3.2 Spectroscopic Optical Coherence Tomography 16 1.3.3 Optical Coherence Elastography 18 1.3.4 Optical Doppler Tomography 20 1.3.5 Optical Coherence Tomography Angiography 25 1.4 Scope of the Dissertation 29 Chapter 2. Basic Theory of Optical Coherence Tomography 31 2.1 Overview 31 2.2 Mathematical Background 31 2.3 Time-Domain Optical Coherence Tomography 39 2.4 Fourier-Domain Optical Coherence Tomography 48 2.4.1 Swept-Source Optical Coherence Tomography 53 2.4.2 Spectral-Domain Optical Coherence Tomography 57 2.5 Evaluation of OCT System 61 2.5.1 Axial Resolution 61 2.5.2 Lateral Resolution and Depth of Focus 62 2.5.3 Sensitivity 64 Chapter 3. Introduction to Optical Coherence Tomography Angiography 67 3.1 Overview 67 3.2 FD-OCT Signal Processing 67 3.3 OCTA Algorithms 73 3.3.1 Phase-based OCTA 75 3.3.1.1 Phase-Resolved Doppler 75 3.3.1.2 Phase Variance 80 3.3.2 Intensity-based OCTA 80 3.3.2.1 Correlation Mapping 81 3.3.2.2 Decorrelation Method 82 3.3.2.3 Speckle Variance 83 3.3.3 Complex Value-based OCTA 84 3.3.3.1 Optical Microangiography 84 3.3.3.2 Doppler Phase Variance 85 3.3.3.3 Complex Differential Variance 86 3.4 Variable Interscan Time Analysis 87 Chapter 4. In Vivo High-Speed Swept-Source OCT (SS-OCT) Imaging of the Mouse Ear Skin 94 4.1 Motivation 94 4.2 Imaging System Description 95 4.2.1 SS-OCT Imaging System 95 4.2.2 Resolution and Roll-off 98 4.3 Animal Imaging Procedures 99 4.4 OCTA Imaging Analysis 103 4.4.1 OCTA Images with Different Interscan Time 104 4.4.2 Quantitative and Statistical Analysis 106 4.4.3 OCTA Images with Different OCTA Algorithms 116 4.5 Discussion 120 Chapter 5. In Vivo High-Speed Miniature Head-mounted OCT (MH-OCT) Imaging in the Mouse brain 128 5.1 Motivation 128 5.2 Imaging System Description 131 5.2.1 MH-OCT Imaging System 131 5.2.2 Unidirectional and Bidirectional Scanning Signal Patterns 136 5.3 Animal Imaging Procedures 139 5.4 OCTA Imaging Analysis 141 5.4.1 OCTA Images 141 5.4.2 Comparison of OCTA contrast 146 5.4.2.1 Quantitative and Statistical Analysis 146 5.4.2.2 Variable Interscan Time Analysis 149 5.4.2.3 Variable Interstate Analysis 153 5.4.2.4 Comparison between Unidirectional and Bidirectional OCTA 157 5.5 Discussion 162 Chapter 6. Conclusion and Future Work 167 6.1 Conclusion 167 6.2 Future Work 169 References 175 Appendix 192 | |
| dc.language.iso | en | |
| dc.subject | 光學同調斷層掃描術 | zh_TW |
| dc.subject | 光學同調斷層掃描血管造影術 | zh_TW |
| dc.subject | 掃頻光源 | zh_TW |
| dc.subject | 影像處理 | zh_TW |
| dc.subject | 微機電系統 | zh_TW |
| dc.subject | microelectromechanical system | en |
| dc.subject | optical coherence tomography | en |
| dc.subject | optical coherence tomography angiography | en |
| dc.subject | swept source | en |
| dc.subject | image processing | en |
| dc.title | 利用光學同調斷層掃描血管造影術於小動物模型之量化微血管成像分析 | zh_TW |
| dc.title | Quantitative Microvascular Imaging Analysis of the Small Animal Model with Optical Coherence Tomography Angiography Technology | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 蔡孟燦(Hsin-Tsai Liu),李正匡(Chih-Yang Tseng),蔡睿哲,潘明楷 ,安野嘉晃 | |
| dc.subject.keyword | 光學同調斷層掃描術,光學同調斷層掃描血管造影術,掃頻光源,影像處理,微機電系統, | zh_TW |
| dc.subject.keyword | optical coherence tomography,optical coherence tomography angiography,swept source,image processing,microelectromechanical system, | en |
| dc.relation.page | 192 | |
| dc.identifier.doi | 10.6342/NTU202102248 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-08-11 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
| dc.date.embargo-lift | 2023-09-07 | - |
| 顯示於系所單位： | 光電工程學研究所 | |
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| U0001-1008202116130500.pdf | 6.17 MB | Adobe PDF | 檢視/開啟 |
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