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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81379完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 翁德怡(Te-I Weng) | |
| dc.contributor.author | Yi-Fang Wu | en |
| dc.contributor.author | 吳宜芳 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:46:39Z | - |
| dc.date.available | 2021-07-20 | |
| dc.date.available | 2022-11-24T03:46:39Z | - |
| dc.date.copyright | 2021-07-20 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-12 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81379 | - |
| dc.description.abstract | 近年來新興濫用藥物成長快速，其中合成卡西酮已經成為主要的濫用藥物之一且種類繁多，因此使分析合成卡西酮變得更加重要也具有挑戰性。目前偵測合成卡西酮的方法主要仰賴液相層析搭配串聯式質譜儀，其偵測極限一般可達0.1~0.5 奈克/毫升(ng/ml)，也可以同時偵測多種合成卡西酮。為求準確定量，同位素內標準品常被用來校正基質效應產生之偏差。然而，並非所有新興合成卡西酮都能在市面上找到相對應之內標準品，並且大部份可以獲得的內標準品也非常昂貴，這也使得合成卡西酮的準確定量受到阻礙。化學同位素標記法可以提升逆相層析滯留效果與偵測靈敏度。丹磺醯肼(dansyl hydrazine)已經用來標記許多化合物如酮類、固醇類、有羰基或醛基的物質，並可提升偵測度。合成卡西酮皆具有貝他位置酮基，適合丹磺醯肼衍生提升其偵測靈敏度。同時，藉由使用不同穩定同位素之丹磺醯肼(C12 與C13)，可以合成同位素內標準品做為絕對定量之用。 本研究針對其衍生效率，在反應時間、溫度與試劑種類進行最佳化。衍生後產物透過串聯式質譜儀就各項質譜參數進行離子對之最佳化，取得最佳之多重反應監測離子對後則進行層析條件最佳化。最終分析條件經過一系列之方法確效，包括線性、準確度、精確度及穩定度。我們使用31個合成卡西酮來檢視衍生化策略，其中有10個合成卡西酮的偵測極限達到飛克/毫升 (fg/ml) 等級，確校結果顯示判定係數皆大於0.996，準確度介於78~123%，精確度之相對標準偏差值皆小於18%。藉由化學同位素標記法，我們開發出更高靈敏度且可以同時準確定量31個合成卡西酮的方法。同時，透過大體積稀釋尿液模擬極低濃度環境，如社區汙水系統，用以評估此一方法之應用性。這一方法預期可應用於汙水系統並提供監測特定地區的非法濫用藥物使用狀況。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:46:39Z (GMT). No. of bitstreams: 1 U0001-1207202110440900.pdf: 1673437 bytes, checksum: 48288064da84b8dfc072b907090aef6e (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 中文摘要 1 Abstract 2 Ch1. Introduction 10 1.1 New psychoactive substances 10 1.2 Origin of cathinones 11 1.3 Psychoactive effects of synthetic cathinones 11 1.4 Characters of synthetic cathinones 13 1.5 Synthetic cathinones in Taiwan 14 1.6 Detection of cathinones 15 1.7 Chemical isotope labeling (CIL) 16 1.8 Sewage-based epidemiology (SBE) 17 1.9 Aim of this study 18 Ch2. Material and methods 19 2.1 Chemicals 19 2.2 Sample preparation and labeling procedure 19 2.3 LC-MS/MS conditions 20 2.4 Method validation 21 2.5 Simulation of sewage water 22 2.6 Data analysis 22 Ch3. Result and discussion 22 3.1 Optimization of labeling conditions 22 3.2 Optimization of LC gradients 25 3.3 Optimization of MRM transition 26 3.4 Sensitivity evaluation 27 3.5 Method validation 28 3.6 Method application 29 Ch.4 Conclusion 30 Ch.5 Figures 31 Ch.6 Tables 43 References 58 | |
| dc.language.iso | en | |
| dc.subject | 新興濫用藥物 | zh_TW |
| dc.subject | 質譜 | zh_TW |
| dc.subject | 合成卡西酮 | zh_TW |
| dc.subject | 化學同位素標記法 | zh_TW |
| dc.subject | 汙水系統 | zh_TW |
| dc.subject | synthetic cathinones | en |
| dc.subject | chemical isotope labeling | en |
| dc.subject | mass spectrometry | en |
| dc.subject | sewage-based epidemiology | en |
| dc.subject | new psychoactive substances | en |
| dc.title | 透過同位素標誌技術建立超靈敏之合成卡西酮分析方法 | zh_TW |
| dc.title | Development of ultra-sensitive method using chemical isotope labeling to determine synthetic cathinones with liquid chromatography-triple quadrupole mass spectrometry | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 陳冠元(Guan-Yuan Chen) | |
| dc.contributor.oralexamcommittee | 蔡伊琳(Hsin-Tsai Liu),(Chih-Yang Tseng) | |
| dc.subject.keyword | 新興濫用藥物,合成卡西酮,化學同位素標記法,汙水系統,質譜, | zh_TW |
| dc.subject.keyword | new psychoactive substances,synthetic cathinones,chemical isotope labeling,sewage-based epidemiology,mass spectrometry, | en |
| dc.relation.page | 64 | |
| dc.identifier.doi | 10.6342/NTU202101396 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-13 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 法醫學研究所 | zh_TW |
| 顯示於系所單位： | 法醫學科所 | |
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