請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81251完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 趙坤茂(Kun-Mao Chao) | |
| dc.contributor.author | Chih-wei Chiang | en |
| dc.contributor.author | 姜智偉 | zh_TW |
| dc.contributor.author | f02945053 | |
| dc.date.accessioned | 2022-11-24T03:38:44Z | - |
| dc.date.available | 2021-08-10 | |
| dc.date.available | 2022-11-24T03:38:44Z | - |
| dc.date.copyright | 2021-08-10 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-28 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81251 | - |
| dc.description.abstract | "本研究目的是探索光熱效應下所產生相互作用的多孔結構聚合物水凝膠對類風溼性關節炎(Rheumatoid arthritis, RA)的影響。類風溼性關節炎為自體免疫疾病，主要致病機轉是自體免疫系統主動攻擊身上的關節滑膜進而造成關節傷害。雷奈酸鍶(Strontiun ranelate, SrR)是一種口服抗骨質疏鬆藥物，具有雙重生物效果可以抑制骨吸收並促進骨生成。當雷奈酸鍶被製作成奈米化，可以增加表面積並提高吸收效率。聚乙烯亞胺聚吡咯(Polyethylenimine-Polypyrrole, PEI-PPY)聚合物具有光熱效應特性，在近紅外線 (Near Infra-red, NIR)刺激下可以產生熱能。新型非侵入性近紅外線具有優良的光熱轉換效應，可以利用熱能改變水膠物理及化學特性，此將協助奈米藥物在體內細胞間的移動，除此之外，熱能也會刺激局部血液循環協助將局部發炎物移除。文獻指出口服雷奈酸鍶不只可以抑制類風濕性關節炎症狀。口服雷奈酸鍶亦可以減緩退化性關節炎症狀。在此項研究中，我們製作具有光熱效應的雷奈酸鍶奈米粒子，包覆在新型態光熱溫感性水膠以利於局部應用於類風溼性關節炎治療。首先我們先以多種檢測方式測量此水膠聚合物的物理化學特性，並分別於體內及體外證實此水膠聚合物具有抗發炎作用。此外，我們再利用大鼠作先驅式類風溼性關節炎動物實驗，證實此水膠聚合物可以有效抑制類風溼性關節炎於大鼠膝關節，並為可吸收生物相容性無生物毒性聚合物。我們期望透過此研究可以開發出新型生物相容性水膠的應用於未來類風溼性關節炎治療方式。" | zh_TW |
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| dc.description.tableofcontents | "Acknowledgement…………………………………………………………………….…ii Chinese abstract…………………………………………………………………...……iii English abstract……………………………………………………………………...….iv Contents…………………………………………………………………………………vi List of Figures …………………………………………………………………….……..x List of Tables……………………………………………………………………...……xii 1. Introduction……………………………………………………………………….…..1 1.1 Research Motivation………………………………….………………………...1 1.2 Research Background…………………………………………………………..1 1.3 Research Importance……………………………………………………...……3 1.4 Research Purpose……………………………………………………………….4 2. Literature Review……………………………………………………………………..4 2.1 Rheumatoid Arthritis…………………………………………………...………4 2.2 Strontium Ranelate……………………………………………………………..6 2.3 Injectable Polymeric Materials…………………………………………………7 2.4 Application of Local Drug………………………………………………..……9 2.5 Photothermal Effect……………………………………………………….…..10 2.6 Application of Biomedical Electronics and Bioengineering in Nanotechnologyy……………………………………………………………………….11 2.6.1 In Vivo Imaging System…….…………………………………...…….11 2.6.2 Thermography…………………………………………….…………...12 2.6.3 ImageJ………..………………………………………………….…….13 2.6.4 USCF Chimera….……….……………………….….…………..….…14 3. Material and Method……………………………………………………….…..……15 3.1 Experiment Procedure………………………………………………….……..15 3.2 Experiment Instruments………………………………………………….…...16 3.3 Experimental Materials……………………………………….……..……..…18 3.3.1 MC-NP preparation……………………………………………….…...18 3.3.2 MC-NP-N-SrR preparation……………………………….………...…19 3.4 Physiochemical Characteristics of MC-NP-N-SrR………………….….….....19 3.4.1 Surface Charge…………………………………………………...……19 3.4.2 Photothermal Effect……………………………………………..……20 3.4.3 Molecular Dynamic Stimulation……………………………….….….20 3.4.4 Identification of Composition of MC-NP-N-SrR………………….…20 3.4.5 Rheology Test and Gelation Time…………………………………….21 3.4.6 Adhesive Force and Polymeric Material Resistance……………….....22 3.5 In Vitro Test……………………………………………………..……………22 3.5.1 In Vitro Drug Release Test…………………………………..….…….22 3.5.2 In Vitro Cell Viability Test…………………………………..………..23 3.5.3 In Vitro Reactive Oxygen Species Test……………………………….24 3.6 In Vivo Test………………………………………………………..………….25 3.6.1 Animal Model for Rheumatoid Arthritis………………………………25 3.6.2 Photothermal Reaction In Vivo………………………………...……...26 3.6.3 In Vivo Imaging System……………………………………..………..26 3.6.4 In Vivo ROS Test………………………………………..…..…….…..26 3.6.5 Histology and Toxicity Evaluation………………………………….…27 3.7 Statistical Method…………………………………………………………......27 4. Result and Discussion……………………………………………………..………..27 4.1 Physiochemical Characteristics of MC-NP-N-SrR………………….….……28 4.1.1 Zeta Potential of MC-NP………………………………………..…….28 4.1.2 Photothermal Effect of PPY-based NP in Hydrogel……………..…….29 4.1.3 Molecular Dynamic Simulation of MC-PEI Complex………….….…30 4.1.4 NMR of MC, NP, and MC-NP……………………..…………….....…31 4.1.5 FTIR of MC, NP, and MC-NP……………………………………..….32 4.1.6 XRD of MC, NP, and MC-NP…………………………………….…..36 4.1.7 Gelation Time of Different Test Materials….……………………..….34 4.1.8 Relationship Between the Concentration of Sr and the Gelation Time of MC-NaCl Hydrogel………………………………………………………….……36 4.1.9 Polymeric Material Resistance and Adhesiveness………….…………37 4.2 In Vitro Test………………………………………………………….…..……39 4.2.1 Cumulative Release Rate………………………………………...…….39 4.2.2 Cell Viability Test in Different Culture Mediums………….………….41 4.2.3 LPS-induced ROS Test in Different Culture Mediums………………..44 4.3 In Vivo Test…………………………………………………………….……..48 4.3.1 IVIS Images for In Vivo Drug Release…………………………..……48 4.3.2 Thermal Camera Images for In Vivo Drug Release………………….49 4.3.3 Qualitative Evaluation of Inflammatory Extent in RA Animal Model……………………………………………………………………………..50 4.3.4 Quantitative Evaluation of Inflammatory Extent in RA Animal Model……………………………………………………………………….…….52 4.3.5 Results of Histology and Toxicity Test……………………………..…54 5.Conclusion……………………………………………………………………………56 5.1 Summary………………………………………………………………………56 5.2 Evaluation……………………………………………………..………………56 5.3 Future Work………………………………………………………..………….57 References……………………………………………………………………………...58 Appendix……………………………………………………………………………….70 " | |
| dc.language.iso | en | |
| dc.subject | 聚乙烯亞胺聚吡咯奈米粒子 | zh_TW |
| dc.subject | 類風溼性關節炎 | zh_TW |
| dc.subject | 雷奈酸鍶 | zh_TW |
| dc.subject | 光熱效應 | zh_TW |
| dc.subject | 甲基纖維素 | zh_TW |
| dc.subject | strontium ranelate | en |
| dc.subject | Polyethylenimine-Polypyrrole | en |
| dc.subject | methylcellulose | en |
| dc.subject | rheumatoid arthritis | en |
| dc.subject | photothermal effect | en |
| dc.title | 雷奈酸鍶與聚乙烯亞胺-聚吡咯奈米顆粒結合甲基纖維素水凝膠局部應用於類風濕性關節炎動物模型 | zh_TW |
| dc.title | The local application of Strontium Ranelate with Methylcellulose hydrogel and Polyethylenimine-Polypyrrole nanoparticle on Rheumatoid arthritis of animal model | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 莊爾文(Hsin-Tsai Liu),傅楸善(Chih-Yang Tseng),歐陽彥正,張瑞峰 | |
| dc.subject.keyword | 類風溼性關節炎,雷奈酸鍶,光熱效應,甲基纖維素,聚乙烯亞胺聚吡咯奈米粒子, | zh_TW |
| dc.subject.keyword | rheumatoid arthritis,strontium ranelate,photothermal effect,methylcellulose,Polyethylenimine-Polypyrrole, | en |
| dc.relation.page | 71 | |
| dc.identifier.doi | 10.6342/NTU202101818 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-29 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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