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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蔡坤憲(Kun-Hsien Tsai) | |
| dc.contributor.author | Pei-Yun Deng | en |
| dc.contributor.author | 鄧珮芸 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:29:51Z | - |
| dc.date.available | 2022-07-31 | |
| dc.date.available | 2022-11-24T03:29:51Z | - |
| dc.date.copyright | 2021-09-16 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-08-23 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/81086 | - |
| dc.description.abstract | 農地生態系常見小型哺乳動物包括囓齒類和鼩鼱類，種類繁多且扮演陸域生態系中重要角色，更常被視為環境品質之指標物種。其繁殖力強、可能傳播病原體和媒介受病原體感染之外寄生蟲等特性易造成農業經濟和公共衛生之危害，因此需落實鼠類相關防治與長期監測工作。臺灣過往為防範野鼠啃咬所造成的農損，因而訂定「滅鼠週」，採用農地定期施放毒餌滅鼠之策略，以達到降低鼠類族群數量之目的。然而，使用滅鼠藥所造成的二次毒害事件頻傳，例如猛禽死亡等，行政院農業委員會動植物防疫檢疫局遂於2015年取消滅鼠週活動。有鑑於小型哺乳類動物之族群增長與疾病傳播風險，需定期分析其相關病原體，以建立預警機制。2019至2020年間，於嘉義的鹿草鄉和義竹鄉、台南的鹽水區和學甲區等四個地點，以含食餌之捕鼠籠誘捕，每二個月捕捉一次。所採集之小型哺乳類動物以形態和分子方法進行鑑定，並透過分子檢驗分析外寄生蟲跳蚤和小型哺乳類動物脾臟檢體所攜帶病原體之狀況。調查期間總計捕獲302隻共七種小型哺乳類動物，收集274個鼠脾臟檢體及外寄生跳蚤共有160隻。利用聚合酶鏈鎖反應 (Polymerase Chain Reaction; PCR) 分別增幅立克次體 (rickettsiae) 之檸檬酸合成酶基因 (gltA)、體表蛋白基因 (ompB)，巴通氏菌 (bartonellae) 之檸檬酸合成酶基因 (gltA )、RNA聚合酶β亞基 (rpoB)、細胞分裂蛋白基因 (ftsZ)，以及無形體科 (Anaplasmataceae) 之16S rDNA、23S-5S之內轉錄間隔區 (23S-5S ITS)。鼠蚤蟲體及鼠脾檢體未偵測到立克次體(Rickettsia spp.)；鼠蚤和鼠脾感染巴通氏菌之陽性率分別為78.75% (126/160) 及19.3% (53/274)。使用限制性片段長度多態性分析 (PCR-RFLP)，鑑別出五類群巴通氏菌有Bartonella rochalimae-like、B. tribocorum-like、B. elizabethae-like、B. queenslandensis-like和 Bartonella spp. 等；鼠蚤與鼠脾攜帶無形體科之陽性率分為41.25 % (66/160) 及26.6% (73/274)。研究結果顯示，於鼠蚤及鼠脾中均檢驗出Bartonella rochalimae-like，陽性率分為59.5% (75/126) 及7.5% (4/53)。透過定期野鼠調查與病原體檢測以提供相關資料，有助於未來訂定政策及鼠媒疾病防治策略。 | zh_TW |
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| dc.description.tableofcontents | 致謝i 中文摘要 ii Abstract iii Content v List of Figure vii List of Table viii Chapter 1 Introduction 1 1.1 Rodent-borne diseases in Taiwan 1 1.2 Rickettsiae 2 1.2.1 Rickettsioses 2 1.2.2 Different groups of rickettsiae 2 1.2.3 Flea-borne rickettsioses 3 1.3 Bartonellae 3 1.4 The family Anaplasmataceae 5 1.4.1 Ehrlichiosis 5 1.4.2 Anaplasmosis 5 1.5 Populations of field rodents 6 1.5.1 Populations of field rodents in Taiwan 6 1.5.2 Anti-rodent week 6 1.5.3 Non-cultivated arable fields 7 1.6 Study aim 8 Chapter 2 Materials and methods 9 2.1 Ethic statement 9 2.2 Small mammals trapping 9 2.3 Specimen 10 2.3.1 Flea 10 2.3.2 Spleen 10 2.4 DNA extraction 11 2.5 Polymerase chain reaction (PCR) 12 2.6 PCR-RFLP analysis 14 2.7 Phylogenetic analysis 15 Chapter 3 Results 18 3.1 Small mammals’ species 18 3.2 Flea species and prevalence 18 3.3 Detection of Rickettsia spp. 19 3.4 Detection of Bartonella spp. 19 3.4.1 PCR analysis 19 3.4.2 PCR- RFLP analysis 20 3.4.3 Sequence analysis of the ftsZ and rpoB genes 21 3.5 Detection of Anaplasmataceae 22 3.6 Phylogenetic analysis 22 Chapter 4 Discussion 24 Chapter 5 Conclusions 30 References 31 | |
| dc.language.iso | en | |
| dc.subject | 小型哺乳類動物 | zh_TW |
| dc.subject | 限制性片段長度多態性 | zh_TW |
| dc.subject | 巴通氏菌 | zh_TW |
| dc.subject | 立克次體 | zh_TW |
| dc.subject | Bartonella | en |
| dc.subject | Rickettsia | en |
| dc.subject | RFLP | en |
| dc.subject | small mammals | en |
| dc.title | 臺灣嘉南地區田間小型哺乳類動物及其外寄生跳蚤媒介立克次體和巴通氏菌之檢測 | zh_TW |
| dc.title | Detection of Rickettsia spp. and Bartonella spp. in fleas and small mammals in Chiayi and Tainan area in Taiwan | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 吳文哲(Hsin-Tsai Liu),王錫杰(Chih-Yang Tseng),林春福 | |
| dc.subject.keyword | 小型哺乳類動物,立克次體,巴通氏菌,限制性片段長度多態性, | zh_TW |
| dc.subject.keyword | small mammals,Rickettsia,Bartonella,RFLP, | en |
| dc.relation.page | 60 | |
| dc.identifier.doi | 10.6342/NTU202102514 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-08-24 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-1908202115110700.pdf 授權僅限NTU校內IP使用（校園外請利用VPN校外連線服務） | 1.77 MB | Adobe PDF |
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