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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80780完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中(Pau-Chung Chen) | |
| dc.contributor.author | Ting-Jui Liu | en |
| dc.contributor.author | 劉庭睿 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:16:19Z | - |
| dc.date.available | 2021-11-03 | |
| dc.date.available | 2022-11-24T03:16:19Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-12 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80780 | - |
| dc.description.abstract | "背景/目的 在全氟碳化物 Perfluoroalkyl and Polyfluoroalkyl Substances (PFAS)是環境中常見的持久性有機污染物，像是有全氟辛酸 perfluorooctanoic acid (PFOA)、全氟辛 烷磺酸鹽perfluorooctane sulfonate (PFOS)、全氟壬酸 perfluorononanoic acid (PFNA)及全氟十一酸 perfluoroundecanoic acid (PFUnDA)。全氟碳化物質廣泛存在 且動物研究表明，PFAS 會影響兒童的神經發展與智商，然而產前 PFAS 暴露是 否影響更多兒童的智商得分的影響尚不清楚。 方法 我們的研究使用的族群是來自臺灣出生世代追蹤調查研究(Taiwan Birth Panel Study I)，在出生時收集臍帶血測量全氟碳化物的濃度，用極致液相層析/串聯式 質譜儀分析臍帶血中全氟碳化物的濃度。並在隨訪過程中，我們於孩童七歲時進 行魏氏兒童智力測驗第四版試卷測驗評估兒童智商分數。 結果 在我們的研究中，臍帶血中的包括 PFOA、PFOS、PFNA、PFUnDA 的濃度平均 數分別為 2.33、5.12、7.38 和 16.00 ng/mL。研究族群中的孩童智力測驗分數 intelligence quotient total(IQ total)平均數為 113.0，全量表智商 full scale intelligence quotient (FSIQ)平均數為 109.9。在連續變量迴歸模型中，產前暴露 PFOA 濃度對 於兒童智商分數呈現正相關，且產前暴露 PFOA 濃度對知覺推裡指數(PRI)有統 計顯著(β=12.035, p<0.05);產前暴露 PFUnDA 濃度對於智商分數呈現負相關， 且產前暴露 PFUnDA 濃度對處理速度指數(PSI)指數分數有統計顯著(β=-5.634, p<0.05)。 結論 我們的研究表明，產前暴露 PFOA 及 PFUnDA 與孩童智商有關。暴露 PFOA會影響知覺推裡指數(PRI)和 PFUnDA 會影響處理速度指數(PSI)。產前 PFAS 暴露可能對兒童智力發展有重要作用。這些暴露的健康風險需要更進一步探索。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:16:19Z (GMT). No. of bitstreams: 1 U0001-0910202115370500.pdf: 2576233 bytes, checksum: db30adaae3a29ec7975a24a855ff1740 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書 I.II 誌謝 i 摘要 ii ABSTRACT iii 目錄 v 表目錄 vi 圖目錄 vii 第一章 介紹 1 第二章 材料與方法 4 1.1 研究設計與研究族群 4 1.2 魏氏兒童智力量表第四版中文版The Chinese version of Wechsler’s Intelligence Scale for Children-IV 5 1.3 中文版兒童早期家庭環境評估量表The Home Observation for Measurement of the Environments (HOME) Inventory 7 1.4 分析方法 8 1.5 統計分析 9 第三章 結果 10 第四章 討論 12 第五章 結論 15 參考文獻 16 | |
| dc.language.iso | zh-TW | |
| dc.subject | 神經發展 | zh_TW |
| dc.subject | 產前暴露 | zh_TW |
| dc.subject | 全氟碳化物 | zh_TW |
| dc.subject | 智商 | zh_TW |
| dc.subject | 魏氏兒童智力測驗第四版 | zh_TW |
| dc.subject | prenatal exposure | en |
| dc.subject | perfluoroalkyl substances (PFAS) | en |
| dc.subject | intelligence quotient (IQ) | en |
| dc.subject | Wechsler intelligence scale (WSIC-IV) | en |
| dc.subject | neurodevelopment | en |
| dc.title | 產前暴露全氟碳化物與孩童智商的相關性 | zh_TW |
| dc.title | Prenatal exposure to perfluoroalkyl substances and children’s intelligence quotient (IQ) | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 何文照(Hsin-Tsai Liu),陳美惠(Chih-Yang Tseng),楊曜旭 | |
| dc.subject.keyword | 產前暴露,全氟碳化物,智商,魏氏兒童智力測驗第四版,神經發展, | zh_TW |
| dc.subject.keyword | prenatal exposure,perfluoroalkyl substances (PFAS),intelligence quotient (IQ),Wechsler intelligence scale (WSIC-IV),neurodevelopment, | en |
| dc.relation.page | 32 | |
| dc.identifier.doi | 10.6342/NTU202103633 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-12 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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