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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80726完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張博鈞(Po-Chun Chang) | |
| dc.contributor.author | Tsai Ching Yu | en |
| dc.contributor.author | 蔡晴伃 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:14:16Z | - |
| dc.date.available | 2021-11-03 | |
| dc.date.available | 2022-11-24T03:14:16Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-27 | |
| dc.identifier.citation | Abrahamsson, I., and T. Berglundh. 2009. 'Effects of different implant surfaces and designs on marginal bone-level alterations: a review', Clin Oral Implants Res, 20 Suppl 4: 207-15. Abrahamsson, I., T. Berglundh, E. Linder, N. P. Lang, and J. Lindhe. 2004. 'Early bone formation adjacent to rough and turned endosseous implant surfaces. An experimental study in the dog', Clin Oral Implants Res, 15: 381-92. Akagawa, Y., Y. Ichikawa, H. Nikai, and H. Tsuru. 1993. 'Interface histology of unloaded and early loaded partially stabilized zirconia endosseous implant in initial bone healing', J Prosthet Dent, 69: 599-604. Alberktsson, T. 1982. 'Ultrastructural analysis of the interface zone of titanium and gold implants', Clinical Applications of Biomaterials: 167-77. Albrektsson, T., and B. Albrektsson. 1987. 'Osseointegration of bone implants. A review of an alternative mode of fixation', Acta Orthop Scand, 58: 567-77. Albrektsson, T., P. I. Branemark, H. A. Hansson, and J. Lindstrom. 1981. 'Osseointegrated titanium implants. Requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man', Acta Orthop Scand, 52: 155-70. Albrektsson, T., and H. A. Hansson. 1986. 'An ultrastructural characterization of the interface between bone and sputtered titanium or stainless steel surfaces', Biomaterials, 7: 201-5. Albrektsson, T., H. A. Hansson, and B. Ivarsson. 1985. 'Interface analysis of titanium and zirconium bone implants', Biomaterials, 6: 97-101. Albrektsson, Tomas, P. I. Brånemark, Hans-Arne Hansson, Bengt Kasemo, Kåre Larsson, Ingmar Lundström, Douglas H. McQueen, and Richard Skalak. 1983. 'The interface zone of inorganic implantsIn vivo: Titanium implants in bone', Annals of Biomedical Engineering, 11: 1-27. Allen, P. F., A. S. McMillan, and D. Walshaw. 2001. 'A patient-based assessment of implant-stabilized and conventional complete dentures', J Prosthet Dent, 85: 141-7. Barter, S., P. Stone, and U. Bragger. 2012. 'A pilot study to evaluate the success and survival rate of titanium-zirconium implants in partially edentulous patients: results after 24 months of follow-up', Clin Oral Implants Res, 23: 873-81. Benic, G. I., G. O. Gallucci, M. Mokti, C. H. Hammerle, H. P. Weber, and R. E. Jung. 2013. 'Titanium-zirconium narrow-diameter versus titanium regular-diameter implants for anterior and premolar single crowns: 1-year results of a randomized controlled clinical study', J Clin Periodontol, 40: 1052-61. Berglundh, T., I. Abrahamsson, N. P. Lang, and J. Lindhe. 2003. 'De novo alveolar bone formation adjacent to endosseous implants', Clin Oral Implants Res, 14: 251-62. Bornstein, M. M., H. Harnisch, A. Lussi, and D. Buser. 2007. 'Clinical performance of wide-body implants with a sandblasted and acid-etched (SLA) surface: results of a 3-year follow-up study in a referral clinic', Int J Oral Maxillofac Implants, 22: 631-8. Bornstein, M. M., J. G. Wittneben, U. Bragger, and D. Buser. 2010. 'Early loading at 21 days of non-submerged titanium implants with a chemically modified sandblasted and acid-etched surface: 3-year results of a prospective study in the posterior mandible', J Periodontol, 81: 809-18. Bosshardt, D. D., V. Chappuis, and D. Buser. 2017. 'Osseointegration of titanium, titanium alloy and zirconia dental implants: current knowledge and open questions', Periodontol 2000, 73: 22-40. Boyan, B. D., R. Batzer, K. Kieswetter, Y. Liu, D. L. Cochran, S. Szmuckler-Moncler, D. D. Dean, and Z. Schwartz. 1998. 'Titanium surface roughness alters responsiveness of MG63 osteoblast-like cells to 1 alpha,25-(OH)2D3', J Biomed Mater Res, 39: 77-85. Boyan, B. D., A. Cheng, R. Olivares-Navarrete, and Z. Schwartz. 2016. 'Implant Surface Design Regulates Mesenchymal Stem Cell Differentiation and Maturation', Adv Dent Res, 28: 10-7. Branemark, P. I., B. O. Hansson, R. Adell, U. Breine, J. Lindstrom, O. Hallen, and A. Ohman. 1977. 'Osseointegrated implants in the treatment of the edentulous jaw. Experience from a 10-year period', Scand J Plast Reconstr Surg Suppl, 16: 1-132. Bruderer, M., R. G. Richards, M. Alini, and M. J. Stoddart. 2014. 'Role and regulation of RUNX2 in osteogenesis', Eur Cell Mater, 28: 269-86. Brunski, J. B. 1988. 'Biomaterials and biomechanics in dental implant design', Int J Oral Maxillofac Implants, 3: 85-97. Buser, D., N. Broggini, M. Wieland, R. K. Schenk, A. J. Denzer, D. L. Cochran, B. Hoffmann, A. Lussi, and S. G. Steinemann. 2004. 'Enhanced bone apposition to a chemically modified SLA titanium surface', J Dent Res, 83: 529-33. Buser, D., S. F. Janner, J. G. Wittneben, U. Bragger, C. A. Ramseier, and G. E. Salvi. 2012. '10-year survival and success rates of 511 titanium implants with a sandblasted and acid-etched surface: a retrospective study in 303 partially edentulous patients', Clin Implant Dent Relat Res, 14: 839-51. Buser, D., J. Ruskin, F. Higginbottom, R. Hardwick, C. Dahlin, and R. K. Schenk. 1995. 'Osseointegration of titanium implants in bone regenerated in membrane-protected defects: a histologic study in the canine mandible', Int J Oral Maxillofac Implants, 10: 666-81. Buser, D., R. K. Schenk, S. Steinemann, J. P. Fiorellini, C. H. Fox, and H. Stich. 1991. 'Influence of surface characteristics on bone integration of titanium implants. A histomorphometric study in miniature pigs', J Biomed Mater Res, 25: 889-902. Buser, D., L. Sennerby, and H. De Bruyn. 2017. 'Modern implant dentistry based on osseointegration: 50 years of progress, current trends and open questions', Periodontol 2000, 73: 7-21. Cameron, H. U., R. M. Pilliar, and I. MacNab. 1973. 'The effect of movement on the bonding of porous metal to bone', J Biomed Mater Res, 7: 301-11. Chrcanovic, B. R., T. Albrektsson, and A. Wennerberg. 2014. 'Immediate nonfunctional versus immediate functional loading and dental implant failure rates: a systematic review and meta-analysis', J Dent, 42: 1052-9. Cochran, D. L. 2006. 'The evidence for immediate loading of implants', J Evid Based Dent Pract, 6: 155-63. Cochran, D. L., D. Buser, C. M. ten Bruggenkate, D. Weingart, T. M. Taylor, J. P. Bernard, F. Peters, and J. P. Simpson. 2002. 'The use of reduced healing times on ITI implants with a sandblasted and acid-etched (SLA) surface: early results from clinical trials on ITI SLA implants', Clin Oral Implants Res, 13: 144-53. Dai, J., J. Gong, N. Kong, and Y. Yao. 2020. 'Cellular architecture response to aspect ratio tunable nanoarrays', Nanoscale, 12: 12395-404. Davies, J. E. 1998. 'Mechanisms of endosseous integration', Int J Prosthodont, 11: 391-401. ———. 2003. 'Understanding peri-implant endosseous healing', J Dent Educ, 67: 932-49. Delaine-Smith, R. M., and G. C. Reilly. 2012. 'Mesenchymal stem cell responses to mechanical stimuli', Muscles Ligaments Tendons J, 2: 169-80. Deporter, D. A., P. A. Watson, R. M. Pilliar, A. H. Melcher, J. Winslow, T. P. Howley, P. Hansel, C. Maniatopoulos, A. Rodriguez, D. Abdulla, and et al. 1986. 'A histological assessment of the initial healing response adjacent to porous-surfaced, titanium alloy dental implants in dogs', J Dent Res, 65: 1064-70. Dohan Ehrenfest, D. M., L. Vazquez, Y. J. Park, G. Sammartino, and J. P. Bernard. 2011. 'Identification card and codification of the chemical and morphological characteristics of 14 dental implant surfaces', J Oral Implantol, 37: 525-42. Fischer, K., and T. Stenberg. 2012. 'Prospective 10-year cohort study based on a randomized controlled trial (RCT) on implant-supported full-arch maxillary prostheses. Part 1: sandblasted and acid-etched implants and mucosal tissue', Clin Implant Dent Relat Res, 14: 808-15. Frost, H. M. 1987. 'Bone 'mass' and the 'mechanostat': a proposal', Anat Rec, 219: 1-9. Ganeles, J., A. Zollner, J. Jackowski, C. ten Bruggenkate, J. Beagle, and F. Guerra. 2008. 'Immediate and early loading of Straumann implants with a chemically modified surface (SLActive) in the posterior mandible and maxilla: 1-year results from a prospective multicenter study', Clin Oral Implants Res, 19: 1119-28. Grassi, S., A. Piattelli, L. C. de Figueiredo, M. Feres, L. de Melo, G. Iezzi, R. C. Alba, Jr., and J. A. Shibli. 2006. 'Histologic evaluation of early human bone response to different implant surfaces', J Periodontol, 77: 1736-43. Han, J., M. Lulic, and N. P. Lang. 2010. 'Factors influencing resonance frequency analysis assessed by Osstell mentor during implant tissue integration: II. Implant surface modifications and implant diameter', Clin Oral Implants Res, 21: 605-11. Hansson, H. A., T. Albrektsson, and P. I. Branemark. 1983. 'Structural aspects of the interface between tissue and titanium implants', J Prosthet Dent, 50: 108-13. Ho, W. F., W. K. Chen, S. C. Wu, and H. C. Hsu. 2008. 'Structure, mechanical properties, and grindability of dental Ti-Zr alloys', J Mater Sci Mater Med, 19: 3179-86. Hyvari, L., M. Ojansivu, M. Juntunen, K. Kartasalo, S. Miettinen, and S. Vanhatupa. 2018. 'Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages', Stem Cells Int, 2018: 2190657. Ioannidis, A., G. O. Gallucci, R. E. Jung, S. Borzangy, C. H. Hammerle, and G. I. Benic. 2015. 'Titanium-zirconium narrow-diameter versus titanium regular-diameter implants for anterior and premolar single crowns: 3-year results of a randomized controlled clinical study', J Clin Periodontol, 42: 1060-70. Karabuda, Z. C., J. Abdel-Haq, and V. Arisan. 2011. 'Stability, marginal bone loss and survival of standard and modified sand-blasted, acid-etched implants in bilateral edentulous spaces: a prospective 15-month evaluation', Clin Oral Implants Res, 22: 840-9. Khatiwala, C. B., P. D. Kim, S. R. Peyton, and A. J. Putnam. 2009. 'ECM compliance regulates osteogenesis by influencing MAPK signaling downstream of RhoA and ROCK', J Bone Miner Res, 24: 886-98. Kieswetter, K., Z. Schwartz, D. D. Dean, and B. D. Boyan. 1996. 'The role of implant surface characteristics in the healing of bone', Crit Rev Oral Biol Med, 7: 329-45. Koike, M., P. E. Lockwood, J. C. Wataha, and T. Okabe. 2007. 'Initial cytotoxicity of novel titanium alloys', J Biomed Mater Res B Appl Biomater, 83: 327-31. Kumper, S., F. K. Mardakheh, A. McCarthy, M. Yeo, G. W. Stamp, A. Paul, J. Worboys, A. Sadok, C. Jorgensen, S. Guichard, and C. J. Marshall. 2016. 'Rho-associated kinase (ROCK) function is essential for cell cycle progression, senescence and tumorigenesis', Elife, 5: e12994. Kuo, H. C., Y. H. Yang, S. K. Lai, S. F. Yap, and P. S. Ho. 2009. 'The Association between health-related quality of life and prosthetic status and prosthetic needs in Taiwanese adults', J Oral Rehabil, 36: 217-25. Lang, N. P., S. Jepsen, and Group Working. 2009. 'Implant surfaces and design (Working Group 4)', Clin Oral Implants Res, 20 Suppl 4: 228-31. Lang, N. P., G. E. Salvi, G. Huynh-Ba, S. Ivanovski, N. Donos, and D. D. Bosshardt. 2011. 'Early osseointegration to hydrophilic and hydrophobic implant surfaces in humans', Clin Oral Implants Res, 22: 349-56. Lee, K., E. H. Kim, N. Oh, N. A. Tuan, N. H. Bae, S. J. Lee, K. G. Lee, C. Y. Eom, E. K. Yim, and S. Park. 2016. 'Contribution of actin filaments and microtubules to cell elongation and alignment depends on the grating depth of microgratings', J Nanobiotechnology, 14: 35. Linder, L., and J. Lundskog. 1975. 'Incorporation of stainless steel, titanium and Vitallium in bone', Injury, 6: 277-85. Linez-Bataillon, P., F. Monchau, M. Bigerelle, and H. F. Hildebrand. 2002. 'In vitro MC3T3 osteoblast adhesion with respect to surface roughness of Ti6Al4V substrates', Biomol Eng, 19: 133-41. Listgarten, M. A., N. P. Lang, H. E. Schroeder, and A. Schroeder. 1991. 'Periodontal tissues and their counterparts around endosseous implants [corrected and republished with original paging, article orginally printed in Clin Oral Implants Res 1991 Jan-Mar;2(1):1-19]', Clin Oral Implants Res, 2: 1-19. Lotz, E. M., R. Olivares-Navarrete, S. Berner, B. D. Boyan, and Z. Schwartz. 2016. 'Osteogenic response of human MSCs and osteoblasts to hydrophilic and hydrophobic nanostructured titanium implant surfaces', J Biomed Mater Res A, 104: 3137-48. Martin, J. Y., Z. Schwartz, T. W. Hummert, D. M. Schraub, J. Simpson, J. Lankford, Jr., D. D. Dean, D. L. Cochran, and B. D. Boyan. 1995. 'Effect of titanium surface roughness on proliferation, differentiation, and protein synthesis of human osteoblast-like cells (MG63)', J Biomed Mater Res, 29: 389-401. Montero, J., R. Castillo-Oyague, C. D. Lynch, A. Albaladejo, and A. Castano. 2013. 'Self-perceived changes in oral health-related quality of life after receiving different types of conventional prosthetic treatments: a cohort follow-up study', J Dent, 41: 493-503. Muller, F., M. Naharro, and G. E. Carlsson. 2007. 'What are the prevalence and incidence of tooth loss in the adult and elderly population in Europe?', Clin Oral Implants Res, 18 Suppl 3: 2-14. Nevins, M., W. V. Giannobile, M. K. McGuire, R. T. Kao, J. T. Mellonig, J. E. Hinrichs, B. S. McAllister, K. S. Murphy, P. K. McClain, M. L. Nevins, D. W. Paquette, T. J. Han, M. S. Reddy, P. T. Lavin, R. J. Genco, and S. E. Lynch. 2005. 'Platelet-derived growth factor stimulates bone fill and rate of attachment level gain: results of a large multicenter randomized controlled trial', J Periodontol, 76: 2205-15. Ng, F., S. Boucher, S. Koh, K. S. Sastry, L. Chase, U. Lakshmipathy, C. Choong, Z. Yang, M. C. Vemuri, M. S. Rao, and V. Tanavde. 2008. 'PDGF, TGF-beta, and FGF signaling is important for differentiation and growth of mesenchymal stem cells (MSCs): transcriptional profiling can identify markers and signaling pathways important in differentiation of MSCs into adipogenic, chondrogenic, and osteogenic lineages', Blood, 112: 295-307. Nicolau, P., F. Guerra, R. Reis, T. Krafft, K. Benz, and J. Jackowski. 2019. '10-year outcomes with immediate and early loaded implants with a chemically modified SLA surface', Quintessence Int, 50: 114-24. Nicolau, P., J. Korostoff, J. Ganeles, J. Jackowski, T. Krafft, M. Neves, J. Divi, M. Rasse, F. Guerra, and K. Fischer. 2013. 'Immediate and early loading of chemically modified implants in posterior jaws: 3-year results from a prospective randomized multicenter study', Clin Implant Dent Relat Res, 15: 600-12. Oates, T. W., P. Valderrama, M. Bischof, R. Nedir, A. Jones, J. Simpson, H. Toutenburg, and D. L. Cochran. 2007. 'Enhanced implant stability with a chemically modified SLA surface: a randomized pilot study', Int J Oral Maxillofac Implants, 22: 755-60. Ogawa, T., and I. Nishimura. 2003. 'Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes', Int J Oral Maxillofac Implants, 18: 200-10. Osman, R. B., and M. V. Swain. 2015. 'A Critical Review of Dental Implant Materials with an Emphasis on Titanium versus Zirconia', Materials (Basel), 8: 932-58. Park, J. Y., and J. E. Davies. 2000. 'Red blood cell and platelet interactions with titanium implant surfaces', Clin Oral Implants Res, 11: 530-9. Piattelli, A., A. Ruggeri, M. Franchi, N. Romasco, and P. Trisi. 1993. 'An histologic and histomorphometric study of bone reactions to unloaded and loaded non-submerged single implants in monkeys: a pilot study', J Oral Implantol, 19: 314-20. Prowse, P. D., C. G. Elliott, J. Hutter, and D. W. Hamilton. 2013. 'Inhibition of Rac and ROCK signalling influence osteoblast adhesion, differentiation and mineralization on titanium topographies', PLoS One, 8: e58898. Rausch-fan, X., Z. Qu, M. Wieland, M. Matejka, and A. Schedle. 2008. 'Differentiation and cytokine synthesis of human alveolar osteoblasts compared to osteoblast-like cells (MG63) in response to titanium surfaces', Dent Mater, 24: 102-10. Saulacic, N., D. D. Bosshardt, M. M. Bornstein, S. Berner, and D. Buser. 2012. 'Bone apposition to a titanium-zirconium alloy implant, as compared to two other titanium-containing implants', Eur Cell Mater, 23: 273-86; discussion 86-8. Schenk, R. K., and D. Buser. 1998. 'Osseointegration: a reality', Periodontol 2000, 17: 22-35. Schwartz, Z., C. H. Lohmann, M. Sisk, D. L. Cochran, V. L. Sylvia, J. Simpson, D. D. Dean, and B. D. Boyan. 2001. 'Local factor production by MG63 osteoblast-like cells in response to surface roughness and 1,25-(OH)2D3 is mediated via protein kinase C- and protein kinase A-dependent pathways', Biomaterials, 22: 731-41. Siebers, D., P. Gehrke, and H. Schliephake. 2010. 'Delayed function of dental implants: a 1- to 7-year follow-up study of 222 implants', Int J Oral Maxillofac Implants, 25: 1195-202. Sista, S., C. Wen, P. D. Hodgson, and G. Pande. 2011. 'The influence of surface energy of titanium-zirconium alloy on osteoblast cell functions in vitro', J Biomed Mater Res A, 97: 27-36. Søballe, K., E. S. Hansen, B. Rasmussen H, P. H. Jørgensen, and C. Bünger. 1992. 'Tissue ingrowth into titanium and hydroxyapatite-coated implants during stable and unstable mechanical conditions', J Orthop Res, 10: 285-99. Stein, G. S., J. B. Lian, A. J. van Wijnen, J. L. Stein, M. Montecino, A. Javed, S. K. Zaidi, D. W. Young, J. Y. Choi, and S. M. Pockwinse. 2004. 'Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression', Oncogene, 23: 4315-29. Sumner, D. R., T. M. Turner, R. M. Urban, A. S. Virdi, and N. Inoue. 2006. 'Additive enhancement of implant fixation following combined treatment with rhTGF-beta2 and rhBMP-2 in a canine model', J Bone Joint Surg Am, 88: 806-17. Szmukler-Moncler, S., H. Salama, Y. Reingewirtz, and J. H. Dubruille. 1998. 'Timing of loading and effect of micromotion on bone-dental implant interface: review of experimental literature', J Biomed Mater Res, 43: 192-203. Taborelli, M., M. Jobin, P. Francois, P. Vaudaux, M. Tonetti, S. Szmukler-Moncler, J. P. Simpson, and P. Descouts. 1997. 'Influence of surface treatments developed for oral implants on the physical and biological properties of titanium. (I) Surface characterization', Clin Oral Implants Res, 8: 208-16. Takahashi, M., M. Kikuchi, and O. Okuno. 2004. 'Mechanical properties and grindability of experimental Ti-Au alloys', Dent Mater J, 23: 203-10. Teo, B. K., S. T. Wong, C. K. Lim, T. Y. Kung, C. H. Yap, Y. Ramagopal, L. H. Romer, and E. K. Yim. 2013. 'Nanotopography modulates mechanotransduction of stem cells and induces differentiation through focal adhesion kinase', ACS Nano, 7: 4785-98. Textor, Marcus, Caroline Sittig, Vinzenz Frauchiger, Samuele Tosatti, and Donald M. Brunette. 2001. 'Properties and Biological Significance of Natural Oxide Films on Titanium and Its Alloys.' in, Titanium in Medicine: Material Science, Surface Science, Engineering, Biological Responses and Medical Applications (Springer Berlin Heidelberg: Berlin, Heidelberg). Uhthoff, H. K., and J. P. Germain. 1977. 'The reversal of tissue differentiation around screws', Clin Orthop Relat Res: 248-52. W. Nicholson, John. 2020. 'Titanium Alloys for Dental Implants: A Review', Prosthesis, 2: 100-16. Wang, H. L., Z. Ormianer, A. Palti, M. L. Perel, P. Trisi, and G. Sammartino. 2006. 'Consensus conference on immediate loading: the single tooth and partial edentulous areas', Implant Dent, 15: 324-33. Wang, T. F., Y. Y. Chen, Y. M. Liou, and C. Chou. 2014. 'Investigating tooth loss and associated factors among older Taiwanese adults', Arch Gerontol Geriatr, 58: 446-53. Weber, H. P., D. Morton, G. O. Gallucci, M. Roccuzzo, L. Cordaro, and L. Grutter. 2009. 'Consensus statements and recommended clinical procedures regarding loading protocols', Int J Oral Maxillofac Implants, 24 Suppl: 180-3. Weinberg, L. A. 1993. 'The biomechanics of force distribution in implant-supported prostheses', Int J Oral Maxillofac Implants, 8: 19-31. Wennerberg, A., and T. Albrektsson. 2009. 'Effects of titanium surface topography on bone integration: a systematic review', Clin Oral Implants Res, 20 Suppl 4: 172-84. Wennerberg, A., L. M. Svanborg, S. Berner, and M. Andersson. 2013. 'Spontaneously formed nanostructures on titanium surfaces', Clin Oral Implants Res, 24: 203-9. Wennerberg, Ann. 2015. Implant surfaces and their biological and clinical impact. Yang, S. E., Y. G. Park, K. Han, J. A. Min, and S. Y. Kim. 2016. 'Dental pain related to quality of life and mental health in South Korean adults', Psychol Health Med, 21: 981-92. Yin, L., Y. Chang, Y. You, C. Liu, J. Li, and H. C. Lai. 2019. 'Biological responses of human bone mesenchymal stem cells to Ti and TiZr implant materials', Clin Implant Dent Relat Res, 21: 550-64. Yuan, L., N. Sakamoto, G. Song, and M. Sato. 2012. 'Migration of human mesenchymal stem cells under low shear stress mediated by mitogen-activated protein kinase signaling', Stem Cells Dev, 21: 2520-30. ———. 2013. 'Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1/CXCR4 axis via MAPK signaling pathways', Stem Cells Dev, 22: 2384-93. Zelig, R., V. M. Jones, R. Touger-Decker, E. R. Hoskin, S. R. Singer, L. Byham-Gray, D. R. Radler, and P. Rothpletz-Puglia. 2019. 'The Eating Experience: Adaptive and Maladaptive Strategies of Older Adults with Tooth Loss', JDR Clin Trans Res, 4: 217-28. Zhang, F., A. Weidmann, J. B. Nebe, U. Beck, and E. Burkel. 2010. 'Preparation, microstructures, mechanical properties, and cytocompatibility of TiMn alloys for biomedical applications', J Biomed Mater Res B Appl Biomater, 94: 406-13. Zhang, L., G. Jiang, X. Zhao, and Y. Gong. 2016. 'Dimethyloxalylglycine Promotes Bone Marrow Mesenchymal Stem Cell Osteogenesis via Rho/ROCK Signaling', Cell Physiol Biochem, 39: 1391-403. Zheng, L., L. Chen, Y. Chen, J. Gui, Q. Li, Y. Huang, M. Liu, X. Jia, W. Song, J. Ji, X. Gong, R. Shi, and Y. Fan. 2016. 'The effects of fluid shear stress on proliferation and osteogenesis of human periodontal ligament cells', J Biomech, 49: 572-9. Zinger, O., K. Anselme, A. Denzer, P. Habersetzer, M. Wieland, J. Jeanfils, P. Hardouin, and D. Landolt. 2004. 'Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography', Biomaterials, 25: 2695-711. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80726 | - |
| dc.description.abstract | "中文摘要 人工植牙為目前牙科重建的治療選擇之一，而骨整合（osseointegration）則是確保人工植體治療成功的要件。過去研究顯示噴砂後酸蝕處理（sandblasted and acid-etching; SLA）的植體複合表面對人體組織親和力良好，並可加速骨整合。進一步在SLA製程中使用氮氣、並保存於等張溶液的製程（modified SLA），亦是臨床選項之一。近年來植體材質在四級鈦中添加鋯（zirconia）以提升植體機械強度。但這些材料對骨整合的優缺點並未被詳細探討。本實驗目的為在體外實驗中探討植體金屬或表面性質對人體幹細胞成骨反應的影響。 本實驗檢測人體骨髓幹細胞在兩種植體材質（純鈦或鈦鋯合金）上施加三種表面處理（拋光、SLA處理、modified SLA處理）上之細胞活性與骨分化能力。將幹細胞培養於六種表面上，經過第一、三天後使用Alamar Blue assay量化細胞生長狀況，並以免疫螢光染色法觀察細胞F-actin 與vinculin分布情形；於第七、十天使用Alizarin red assay量化礦化產物；於第一、四天使用RT-PCR確認Rock2及Runx2基因表現量。 實驗結果顯示，modified SLA對水接觸角為零，親水性表現比另兩者皆有顯著改善。SLA純鈦、SLA鈦鋯、modified SLA純鈦、modified SLA鈦鋯表面粗糙度數值分別為2.26±0.12, 2.21±0.27, 1.67±0.12, 2.64±0.21微米，顯著比拋光表面粗糙。免疫螢光染色顯示拋光表面細胞之面積顯著較其餘組別大；modified SLA表面在第七天較其餘組別顯著較多礦化物沉積，且在第十天時，經表面處理後之金屬顯著高於拋光表面組別的礦化物沉積；同樣的，在RT-PCR中，modified SLA鈦鋯有最高的Runx2及Rock2基因表現量，亦顯著高於modified SLA純鈦的基因表現量。 總結以上，SLA及modified SLA處理的表面，提高表面粗糙度後加速成骨相關基因表現量和礦化基質沈澱。而modified SLA處理後的鈦鋯合金比起純鈦合金有更佳的初期促骨分化表現。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:14:16Z (GMT). No. of bitstreams: 1 U0001-1610202100043500.pdf: 2783347 bytes, checksum: ae630d90c3260841e51d10a4ed1804a5 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | Table of Contents 口試委員會審書 I 誌謝 II 中文摘要 III Abstract IV Table of Contents V List of Figures VI List of Tables VII Chapter I Introduction 1 1.1 The Need for Dental Implants 1 1.2 Osseointegration 2 1.3 The Materials of Dental Implants 4 1.4 Surface Modification on Osseonintegration 6 1.5 Timing of Implant Placement and Loading 9 1.6 Cell Behavior under Loading 12 Chapter II Objective 14 Chapter III Materials and Methods 15 3.1 Titanium Discs and Ti-Zr Discs with Different Surface Treatments 15 3.2 Characterization of Examined Discs 17 3.2.1 Surface Topography by Scanning Electron Microscopy 17 3.2.2 Surface Roughness (Ra) 18 3.2.3 Hydrophilicity by the Contact Angle (˚) 19 3.3 In vitro Investigations 20 3.3.1 Cell Culture 20 3.3.2 Cell Viability 21 3.3.3 Cell Morphology and Adhesion Behaviors 22 3.3.4 Cell Mineralization Assay 24 3.3.5 Gene Expression Assays 25 3.4 Statistical Analysis 27 Chapter IV Results 28 4.1 Surface Roughness 28 4.2 Contact Angle Goniometry 29 4.3 Surface Characterization 30 4.4 Cell Morphological Analysis 31 4.5 Alamar Blue® Assay 32 4.6 Alizarin Red Assay 33 4.7 Gene Expression Profile 34 Chapter V Discussion 36 Chapter VI Conclusion 42 Figures 43 Reference 60 | |
| dc.language.iso | en | |
| dc.subject | 牙科植體表面處理 | zh_TW |
| dc.subject | 骨整合 | zh_TW |
| dc.subject | 幹細胞 | zh_TW |
| dc.subject | 成骨分化能力 | zh_TW |
| dc.subject | osseointegration | en |
| dc.subject | zirconium | en |
| dc.subject | mesenchymal stem cells | en |
| dc.subject | cell adhesion | en |
| dc.subject | immediate dental implant loading | en |
| dc.title | 人工植體材料與表面性質對於骨髓幹細胞之活性與骨分化潛能評估 | zh_TW |
| dc.title | The Influence of the Material and Surface Properties of Dental Implants on the Behaviors of the Bone Marrow Stem Cells | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭彥彬(Hsin-Tsai Liu),王進瑋(Chih-Yang Tseng) | |
| dc.subject.keyword | 骨整合,幹細胞,成骨分化能力,牙科植體表面處理, | zh_TW |
| dc.subject.keyword | osseointegration,immediate dental implant loading,cell adhesion,mesenchymal stem cells,zirconium, | en |
| dc.relation.page | 71 | |
| dc.identifier.doi | 10.6342/NTU202103771 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-28 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 臨床牙醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床牙醫學研究所 | |
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