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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 林璧鳳(Bi-Fong Lin) | |
| dc.contributor.author | Chieh Lu | en |
| dc.contributor.author | 盧頡 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:09:28Z | - |
| dc.date.available | 2021-11-04 | |
| dc.date.available | 2022-11-24T03:09:28Z | - |
| dc.date.copyright | 2021-11-04 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-29 | |
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J Nutr, 149(5), 716-722. doi:10.1093/jn/nxy320 Reddel, S., Del Chierico, F., Quagliariello, A., Giancristoforo, S., Vernocchi, P., Russo, A., Fiocchi, A., Rossi, P., Putignani, L., El Hachem, M. (2019). Gut microbiota profile in children affected by atopic dermatitis and evaluation of intestinal persistence of a probiotic mixture. Sci Rep, 9(1), 4996. doi:10.1038/s41598-019-41149-6 Riviere, A., Selak, M., Lantin, D., Leroy, F., De Vuyst, L. (2016). Bifidobacteria and butyrate-producing colon bacteria: Importance and strategies for their stimulation in the human gut. Front Microbiol, 7, 979. doi:10.3389/fmicb.2016.00979 Rodenbeck, D. L., Silverberg, J. I., Silverberg, N. B. (2016). Phototherapy for atopic dermatitis. Clin Dermatol, 34(5), 607-613. doi:10.1016/j.clindermatol.2016.05.011 Rosser, E. C., Piper, C. J. M., Matei, D. E., Blair, P. A., Rendeiro, A. F., Orford, M., Alber, D. G., Krausgruber, T., Catalan, D., Klein, N., Manson, J. J., Drozdov, I., Bock, C., Wedderburn, L. 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Front Endocrinol (Lausanne), 11, 25. doi:10.3389/fendo.2020.00025 Silverberg, J. I., Hanifin, J., Simpson, E. L. (2013). Climatic factors are associated with childhood eczema prev……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80564 | - |
| dc.description.abstract | "異位性皮膚炎 (atopic dermatitis, eczema) 係常見的過敏炎症，嬰兒為好發族群之一。母乳為嬰兒主要營養來源，哺餵母乳有助嬰兒發育、免疫調節，因此以往建議親餵母乳。然而近年研究發現哺餵母乳的嬰兒也有過敏風險，推論可能為母乳的營養成分差異造成。母乳含微量游離的短鏈脂肪酸，已知短鏈脂肪酸具抗發炎作用，可改善過敏氣喘、腸道發炎等疾病，故本研究欲探討母乳的短鏈脂肪酸含量與嬰兒異位性皮膚炎的相關性。本研究建立以氣相層析-質譜法 (gas chromatography-mass spectrometry, GC-MS) 分析母乳游離短鏈脂肪酸之分析方法，並進行方法確效，評估乙醇 (ethanol)、三氯醋酸 (trichloroacetic acid, TCA)、乙腈 (acetonitrile, ACN) 共三種溶劑處理方式，再檢測來自臺大醫院小兒過敏門診，嬰兒小於6月齡的母乳樣品，分析病例組 (n=47) 與控制組 (n=47) 的母乳游離短鏈脂肪酸含量，並對母親進行為期1個月的飲食頻率問卷調查。結果顯示，乙醇處理可能令乙酸 (acetic acid)、丙酸 (propionic acid)、丁酸 (butyric acid) 與己酸 (caproic acid) 等分析物酯化；TCA干擾層析圖譜，不利於建立檢量線。ACN可有效去除母乳樣品的蛋白質，且各分析物於檢量線濃度範圍內的線性關係良好 (R2 ≥ 0.999)；定量極限均為0.5 μg/mL且無明顯基質效應。各分析物同日間 (intraday) 與異日間 (inter-day) 分析之回收率與CV如下，乙酸回收率85.4-113.6%，同日間不同濃度CV為5.9%、4.7%，異日間不同濃度CV為12.4%、8.6%；丙酸回收率85.4-113.6%，同日間不同濃度CV為1.7%、0.8%，異日間不同濃度CV為0.7%、0.4%；丁酸回收率96.3-114.6%，同日間不同濃度CV為6.0%、3.0%，異日間不同濃度CV為0.5%、1.5%；己酸回收率113.8%-116.9%，同日間不同濃度CV為1.1%、0.9%，異日間不同濃度CV為1.3%、1.2%；均符合食藥署公布之食品化學檢驗方法之確效規範。病例組嬰兒所攝取的母乳己酸含量較高，乙酸、丁酸無差異，且均未測得丙酸。飲食頻率問卷結果發現，母親飲食的n-6 PUFAs對母乳乙酸呈正相關趨勢，EPA對母乳乙酸含量呈負相關趨勢；母親飲食的膳食纖維與n-6 PUFAs攝取量和母乳丁酸呈負相關趨勢，脂肪、n-3 PUFAs、EPA與DHA攝取量對丁酸含量負相關；膳食纖維、EPA、DHA攝取量與母乳己酸含量呈負相關趨勢，脂肪、n-3 PUFAs、n-6 PUFAs對己酸含量呈負相關。綜上所述，哺乳期間母親攝取較多的膳食纖維、EPA、DHA與n-6 PUFA，可能有助降低母乳己酸含量，進而降低嬰兒患有異位性皮膚炎的風險。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:09:28Z (GMT). No. of bitstreams: 1 U0001-2510202113562600.pdf: 3489504 bytes, checksum: 6d2785a3bda9e3237aa11a148ce4eb6b (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | " 誌謝 I 摘要 III ABSTRACT V 圖目錄 IX 表目錄 IX 縮寫對照表 X 第一章 緒論 1 第一節 文獻回顧 1 一、 異位性皮膚炎 (atopic dermatitis, AD) 1 (一) 異位性皮膚炎簡介 1 (二) 異位性皮膚炎症狀 1 (三) 異位性皮膚炎成因 3 (四) 異位性皮膚炎的免疫反應 4 (五) 異位性皮膚炎的治療 5 二、 母乳 (breast milk) 6 (一) 母乳簡介 6 (二) 母乳成分 6 (三) 母乳對過敏疾病的影響 9 三、 短鏈脂肪酸 (short-chain fatty acids, SCFAs) 10 (一) 短鏈脂肪酸的吸收與代謝 10 (二) 短鏈脂肪酸的免疫調節功能 10 (三) 短鏈脂肪酸與異位性皮膚炎 13 第二節 研究動機 14 第二章 母乳的短鏈脂肪酸含量之檢測方法確效 15 第一節 前言 15 第二節 材料與方法 16 【儀器】 16 【藥品】 16 【方法】 16 1. 檢液配製 16 2. 檢量線配製 17 3. 氣相層析-質譜儀分析條件 17 4. 定量極限 18 5. 專一性 18 6. 準確度 19 7. 精密度 19 第三節 結果 21 一、 檢液配置 21 二、 短鏈脂肪酸之線性評估 25 三、 短鏈脂肪酸之氣相層析-質譜儀分析條件 26 四、定量極限 30 五、專一性 30 六、準確度 32 七、精密度 34 第三章 母乳的短鏈脂肪酸含量與嬰兒異位性皮膚炎的相關性探討 36 第一節 前言 36 第二節 材料與方法 36 一、 研究對象與實驗流程 36 二、 飲食頻率問卷調查 (food frequency questionnaire, FFQ) 37 三、 母乳短鏈脂肪酸分析 38 1. 檢體收集 38 2. 母乳前處理 38 3. 氣相層析-質譜儀分析條件 38 4. 統計分析 38 第三節 結果 39 一、 母乳短鏈脂肪酸含量對嬰兒異位性皮膚炎的影響 39 二、 母乳短鏈脂肪酸含量對嬰兒異位性皮膚炎病情的影響 42 三、 母親飲食與母乳短鏈脂肪酸相關性 43 第四章 綜合討論與結論 45 第一節 綜合討論 45 一、 母乳短鏈脂肪酸分析之前處理條件 45 二、 母乳短鏈脂肪酸含量對嬰兒異位性皮膚炎的影響 46 三、 母親飲食脂肪酸組成對母乳短鏈脂肪酸組成的影響 46 四、母親飲食對母乳短鏈脂肪酸組成的影響 48 五、實驗限制 48 第二節 結論 49 參考文獻50 附錄 66 " | |
| dc.language.iso | zh-TW | |
| dc.subject | 短鏈脂肪酸 | zh_TW |
| dc.subject | 母乳 | zh_TW |
| dc.subject | 方法確效 | zh_TW |
| dc.subject | 異位性皮膚炎 | zh_TW |
| dc.subject | 母親飲食 | zh_TW |
| dc.subject | atopic dermatitis | en |
| dc.subject | short-chain fatty acid | en |
| dc.subject | breast milk | en |
| dc.subject | method validation | en |
| dc.subject | maternal diet | en |
| dc.title | 母乳的短鏈脂肪酸組成與嬰兒異位性皮膚炎的相關性探討 | zh_TW |
| dc.title | Study on the correlation between composition of short-chain fatty acids in breast milk and atopic dermatitis in infants | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 江伯倫(Hsin-Tsai Liu),王麗潔(Chih-Yang Tseng),江孟燦,蘇南維 | |
| dc.subject.keyword | 異位性皮膚炎,方法確效,母乳,短鏈脂肪酸,母親飲食, | zh_TW |
| dc.subject.keyword | atopic dermatitis,method validation,breast milk,short-chain fatty acid,maternal diet, | en |
| dc.relation.page | 71 | |
| dc.identifier.doi | 10.6342/NTU202104136 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-29 | |
| dc.contributor.author-college | 生命科學院 | zh_TW |
| dc.contributor.author-dept | 生化科技學系 | zh_TW |
| 顯示於系所單位： | 生化科技學系 | |
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