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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 劉力瑜(Li-Yu Liu) | |
| dc.contributor.author | Yan-Pui Nixon So | en |
| dc.contributor.author | 蘇恩培 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:08:26Z | - |
| dc.date.available | 2021-11-04 | |
| dc.date.available | 2022-11-24T03:08:26Z | - |
| dc.date.copyright | 2021-11-04 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-29 | |
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Cytokinin induces genome-wide binding of the type-B response regulator ARR10 to regulate growth and development in Arabidopsis. Proc. Natl. Acad. Sci. USA 114, E5995-E6004. https://doi.org/10.1073/pnas.1620749114 23. Abbasi F, Onodera H, Toki S, Tanaka H, Komatsu S. OsCDPKI3, a calcium-dependent protein kinase gene from rice, is induced by cold and gibberellin in rice leaf sheath. Plant Mol Biol. 2004;55(4):541–52. 24. Wang Y, Hou Y, Qiu J, Wang H, Wang S, Tang L, et al. Abscisic acid promotes jasmonic acid biosynthesis via a 'SAPK10-bZIP72-AOC' pathway to synergistically inhibit seed germination in rice (Oryza sativa). New Phytol. 2020;228(4):1336–53. https://doi.org/10.1111/nph.16774. 25. Anwar, A., Liu, Y., Dong, R. et al. The physiological and molecular mechanism of brassinosteroid in response to stress: a review. Biol Res 51, 46 (2018). https://doi.org/10.1186/s40659-018-0195-2 26. Yudina, L.; Sukhova, E.; Sherstneva, O.; Grinberg, M.; Ladeynova, M.; Vodeneev, V.; Sukhov, V. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80520 | - |
| dc.description.abstract | "抵禦農業中的天氣不穩定性是農業的主要任務之一，為了最大程度地減少收成損失，了解計劃生長，新陳代謝和抵抗環境的機制非常重要。在環境壓力下，在不同濃度植物激素下植物細胞的代謝和生理調節中起著至關重要的作用。 為了全面了解基因的功能（特異性）和基因之間的關係（協同作用），在不同植物激素下進行基因網絡研究非常重要。在這項研究中，從網絡開源數據庫下載的不同植物激素下的微陣列基因表達數據，並構建了加權基因共表達網絡。此外，為了研究基因模塊和植物激素之間的非線性關係，在使用奇異值分解和雙標圖之前，使用子組本質相關係數（subCID）來代替了先前研究所使用取特徵基因模塊表現量的平均。為了清楚的觀察基因模塊在不同植物激素下在不同組織部位中表達水平的變化,計算在雙標圖中基因模塊和不同植物激素處理之間的角度，並進行統計檢驗。 研究結果發現，大多數基因模塊對根和芽組織中植物激素的反應均不同，而相同基因模塊對根和芽組織中植物激素的反應也不同，也在基因本體分析和文獻研究中得到證實。此外，利用subCID還發現了不同植物激素下基因模塊之間的基因協同作用。因此，依據本研究的分析結果，可提供跟先前研究不同的統計方法，用於研究微陣列數據中更準確的基因協同作用和特異性。 " | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:08:26Z (GMT). No. of bitstreams: 1 U0001-2610202122452600.pdf: 2436987 bytes, checksum: ef00643b68dcf7b8de0453d24b246b81 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審定書………………………………………….………….………....…# 誌謝………………………………………………….………….……..…………………i 摘要………………………………………………………………..…………………….ii Abstract...…………………………………………………………………………..…...iii Table of Contents…………...………………………………………………………......iv List of Figures……….…………………………….……................................................vi List of Tables……….…………………………….……................................................vii Chapter1 Introduction…………………………………………………….……………...1 1.1 Plant hormones and Oryza sativa……………………………..…………………..1 1.2 Relation between plant hormones and gene expressions……..…………......…….3 1.3 Microarray gene expression platform…….……………………….………..……..3 1.4 Applications of microarrays…..………………………..……………………...….4 1.5 Weighed gene co-expression network analysis and gene modules……………….5 1.6 Specificity and synergy of gene modules………………………………..……......5 1.7 Objective of this study………………………..…………………………………...6 Chapter 2 Methods of Analysis…………………………………………….....................7 2.1 Data processing before analysis……......................................................................7 2.2 Differential expression genes selection...................................................................7 2.3 WGCNA and subCID……………………………………………...……………...8 2.3.1 Weighted correlation network analysis (WGCNA)…………………..…....…....9 2.3.2 subCID (subgroup of coefficient of intrinsic dependence (CID))……………..11 2.3.3 Inner product of biplot…………………………………………………………12 2.4 Gene Ontology Analysis…………………………..……………………………..13 Chapter 3 Results……………..………………………………………..…….................15 3.1 Data processing and differential expression genes selection…….........................15 3.2 Identification of gene modules by WGCNA and subCID.....................................15 3.3.1 Non-subCID part: comparison of p-values of inner products between each gene modules and each plant hormone treatment between root and shoot……….……….16 3.3.2 subCID part: comparison of p-values of inner products between each gene modules and each plant hormone treatment between root and shoot……………......17 3.3.3 Comparison between gene modules response to plant hormones in different tissues in WGCNA versus subCID………………………………………………......18 3.4 Gene Ontology study on gene modules…………………………………….........19 3.4.1 Comparison between subCID and nonsubCID in root and shoot tissue in terms of gene ontology……………………………………………………………..………20 Chapter 4 Discussion…………………………………...................................................21 Chapter 5 Conclusion…………………………………………………………..............27 Reference…………….…………………………………………....................................29 Supplementary files……….…………………………….…….......................................43 | |
| dc.language.iso | en | |
| dc.subject | 基因協同作用和特異性 | zh_TW |
| dc.subject | 加權基因共表達網絡 | zh_TW |
| dc.subject | 子組本質相關係數 | zh_TW |
| dc.subject | 雙標圖 | zh_TW |
| dc.subject | 植物荷爾蒙 | zh_TW |
| dc.subject | subgroup of coefficient of intrinsic dependence | en |
| dc.subject | biplot | en |
| dc.subject | Plant hormone | en |
| dc.subject | weighted gene co-expression network analysis | en |
| dc.subject | gene specificity and synergy | en |
| dc.title | 微陣列數據中基因的協同作用和特異性綜合分析 | zh_TW |
| dc.title | Integrated analysis of microarray data to investigate gene synergy and specificity | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 蔡政安(Hsin-Tsai Liu),陳虹諺(Chih-Yang Tseng) | |
| dc.subject.keyword | 植物荷爾蒙,加權基因共表達網絡,子組本質相關係數,雙標圖,基因協同作用和特異性, | zh_TW |
| dc.subject.keyword | Plant hormone,weighted gene co-expression network analysis,subgroup of coefficient of intrinsic dependence,biplot,gene specificity and synergy, | en |
| dc.relation.page | 57 | |
| dc.identifier.doi | 10.6342/NTU202104281 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-29 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 農藝學研究所 | zh_TW |
| 顯示於系所單位： | 農藝學系 | |
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