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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 張惠雯(Hui-Wen Chang) | |
| dc.contributor.author | Ting-Wei Lee | en |
| dc.contributor.author | 李庭瑋 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:07:27Z | - |
| dc.date.available | 2021-11-03 | |
| dc.date.available | 2022-11-24T03:07:27Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-25 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80476 | - |
| dc.description.abstract | "地衣桿菌發酵產物（Bacillus licheniformis-fermented products, BLFP）作為益生菌，已被證實具抗細菌、抗病毒和抗發炎的能力。此研究目的在於使用次世代定序比較同一飼主飼養的慢性下痢貓隻（八隻）和正常貓隻（四隻）的腸道微生物群，及評估服用地衣桿菌發酵產物對於慢性下痢貓隻的臨床症狀及腸道微生物群改變之影響。在服用BLFP的八隻慢性下痢貓隻中，有六隻貓呈現臨床上的改善，其中有兩隻糞便狀況轉為正常。下痢貓隻的厚壁菌門/擬桿菌門（Firmicutes/Bacteroidetes）的比值高於健康貓隻，此比例在有臨床改善的下痢貓隻也高於無改善的下痢貓隻。下痢貓隻無論是否有無服用BLFP的擬桿菌門（Bacteroidetes）和擬桿菌綱（Bacteroidia）皆顯著低於正常貓隻。服用BLFP後的下痢貓隻相對於服用前有顯著較高的Blautia spp.、Ruminococcus torques和Ruminococcus gnavus，此三種菌屬於梭狀桿菌屬第十四群菌，且報告顯著具益於維持腸道健康功能。此外，在服用BLFP後的下痢貓隻腸道中產氣莢膜梭菌（Clostridium perfringens）有顯著減少之情形。整體來說，服用BLFP在下痢貓隻具有改善臨床症狀和腸道微生物叢的效益。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:07:27Z (GMT). No. of bitstreams: 1 U0001-2210202118135400.pdf: 1891374 bytes, checksum: 078500989f70d9469ae502620e46760a (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 摘要 I Abstract II Contents IV List of tables VII List of figures VIII Chapter 1 Literature review 1 1.1 General concepts of diarrhea 1 1.2 The prevalence of diarrhea in companion animals 1 1.3 The causes of feline diarrhea 2 1.3.1 Feline infectious diarrhea 2 1.3.2 Feline non-infectious diarrhea 4 1.4 Feline chronic enteropathy activity index (FCEAI) 5 1.5 Probiotic: Bacillus licheniformis – fermented products 6 1.6 Fecal microbiota 7 1.7 Next-generation sequencing (NGS) 9 1.8 Aims of the study 12 Chapter 2 Material and Methods 13 2.1 Animals and treatments 13 2.2 Stool scoring 13 2.3 Feline chronic enteropathy activity index (FCEAI) 14 2.4 Fecal collection 15 2.5 DNA extraction 15 2.6. Next generation sequencing 15 2.7 Library construction and sequencing 16 2.8 Statistical analyses 16 Chapter 3 Results 18 3.1 Animals and grouping 18 3.1.1 Stool scoring 18 3.1.2 FCEAI 19 3.2 Next generation sequencing (NGS) 20 3.2.1 Sequence analysis and rarefaction 20 3.2.2 OTU-based analysis 21 3.2.3 LEfSe results 24 Chapter 4 Discussion 25 4.1 Fecal microbiota in diarrheal and non-diarrheal cats 26 4.2 The correlation between fecal score and FCEAI 28 4.3 Effects of BLFP administration on relieving clinical signs 28 4.4 Alteration in fecal microbiota after BLFP administration 30 Tables 33 Figures 38 References 43 | |
| dc.language.iso | en | |
| dc.subject | 次世代定序 | zh_TW |
| dc.subject | 地衣桿菌發酵產物 | zh_TW |
| dc.subject | 益生菌 | zh_TW |
| dc.subject | 腸道微生物群 | zh_TW |
| dc.subject | 貓慢性下痢 | zh_TW |
| dc.subject | probiotics | en |
| dc.subject | Bacillus licheniformis-fermented products | en |
| dc.subject | next generation sequencing | en |
| dc.subject | feline chronic diarrhea | en |
| dc.subject | fecal microbiota | en |
| dc.title | 地衣桿菌發酵產物對貓慢性下痢與腸道微生物群之影響 | zh_TW |
| dc.title | The Effects of Bacillus licheniformis-fermented Products on Feline Chronic Diarrhea and Intestinal Microbiota | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 武敬和(Ching-Ho Wu) | |
| dc.contributor.oralexamcommittee | 鄭謙仁(Hsin-Tsai Liu),張晏禎(Chih-Yang Tseng),龐飛 | |
| dc.subject.keyword | 地衣桿菌發酵產物,益生菌,腸道微生物群,貓慢性下痢,次世代定序, | zh_TW |
| dc.subject.keyword | Bacillus licheniformis-fermented products,probiotics,fecal microbiota,feline chronic diarrhea,next generation sequencing, | en |
| dc.relation.page | 57 | |
| dc.identifier.doi | 10.6342/NTU202104050 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-26 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 分子暨比較病理生物學研究所 | zh_TW |
| 顯示於系所單位： | 分子暨比較病理生物學研究所 | |
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