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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80440完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 黃升龍(Sheng-Lung Huang) | |
| dc.contributor.author | Rajendran Soundararajan | en |
| dc.contributor.author | 桑德揚 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:06:43Z | - |
| dc.date.available | 2022-01-17 | |
| dc.date.available | 2022-11-24T03:06:43Z | - |
| dc.date.copyright | 2022-01-17 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-12-17 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80440 | - |
| dc.description.abstract | 從基於 Mirau 的高解析全域式光學同調斷層掃描 (FF-OCT) 中提取的背向散射光譜數據，在生物醫學中具有潛在的應用。高品質的自製摻鈦藍寶石單纖衣晶體光纖寬帶光源在 OCT 成像中以高速成像提供了對體內皮膚組織的更深穿透，具有細胞解析度。 驅動 Mirau 干涉儀的壓電轉換器 (PZT) 的磁滯非線性在 OCT 掃描期間表現出位移不準確。這種不準確性顯著影響了從 OCT 系統中提取的深度相關頻譜。由有效的前饋補償，實現了 PZT 磁滯的高階線性化。實驗結果表明，多項式算子參數少、建模精度高、輸入輸出關係平滑，優於 Prandtl-Ishlinskii (PI)模型。因此，在 FF-OCT 系統中實施多項式磁滯模型，以實現超高 PZT精準定位，從而可以準確獲得背向散射光譜。 FF-OCT 系統的性能通過對體外靛氰綠 (ICG) 著色顆粒和非著色微米球的成像進行了測試和驗證。光譜信號是通過短時傅立葉變換(STFT)從原始干涉信號中獲得的，在780 nm 的波長窗口，4-µm樣本長度之光譜解析度為 54.42 nm。來自 ICG 顆粒的背向散射光譜隨著濃度的增加表現出最大強度和藍移，而微米球導致強度低於 ICG。由ICG 和微米球光譜的比較結果，驗證了這種光譜分析方法。 為進一步驗證此光譜分析於活體前臂皮膚的三維斷層掃描應用，本研究提取了不同深度的皮膚組織的光譜特徵。由於複雜的皮膚解剖結構和色素吸收，本研究發現體內皮膚的反向散射光譜顯示出與深度相關的光譜偏移和帶寬變化。 具有高速、高對比度之細胞解析度三維斷層掃描成像和光譜提取能力的OCT 成像有助於識別組織成分的分子/化學成分和光學特性，由體內深層組織反向散射的這種高速光譜採集，未來可應用於臨床環境中的疾病診斷。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:06:43Z (GMT). No. of bitstreams: 1 U0001-1612202114224200.pdf: 7481605 bytes, checksum: 240477538427cad53dc3a475e5173b5c (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | Abstract III Table of Contents V List of Figures IX List of Tables XIII Chapter 1 Introduction 1 1.1 Motivation 4 1.2 Research objectives 5 1.3 Aim and dissertation organization 5 Chapter 2 Optical Coherence Tomography 7 2.1 Development of OCT 8 2.1.1 Time-domain OCT 10 2.1.2 Fourier-domain OCT 11 2.2 Principle and theory 13 2.3 Mirau interferometer 18 2.4 OCT light sources 21 2.4.1 Co-drawing laser-heated pedestal growth (LHPG) system 25 2.4.2 Titanium-doped sapphire single crystal fiber 28 2.5 OCT detectors 31 2.5.1 CCD vs. CMOS 31 2.5.2 CMOS camera 32 2.5.3 High-speed CMOS camera in FF-OCT imaging 37 2.6 Full-field optical coherence tomography 40 2.6.1 Experimental setup 41 2.6.2 OCT signal extraction and image processing 42 2.7 Performance factors in OCT 45 2.7.1 Axial and lateral resolution 45 2.7.2 Lateral resolution and depth of focus 47 2.7.3 Interference efficiency 48 2.7.4 Signal-to-noise ratio (SNR) 49 2.7.5 Noise considerations 50 Chapter 3 Nonlinear Hysteresis Compensation of Piezoelectric Transducer 52 3.1 Nonlinear hysteresis of piezoelectric transducer 53 3.2 Hysteresis compensation models: Overview 54 3.2.1 The classical PI model 56 3.2.2 Polynomial model 58 3.3 Piezoelectric transducer’s hysteresis calibration 59 3.4 Feedforward linearization of the initial loading curve 60 3.4.1 Direct inverse method of Prandtl-Ishlinskii’s model 62 3.4.2 Polynomial hysteresis compensation model 65 3.4.3 Comparison between PI model and polynomial model 66 3.5 Implementation of hysteresis compensation models in FF-OCT system 68 3.5.1 PI model implementation 68 3.5.2 Polynomial model implementation 69 Chapter 4 Spectroscopic Optical Coherence Tomography and Data Validation 71 4.1 Time-frequency analysis 72 4.1.1 Short-time Fourier transform (STFT) 72 4.1.2 Wavelet transform 73 4.1.3 Wigner-Ville distribution (WV) 73 4.1.4 Dual window method 74 4.2 Principle of SOCT 75 4.3. Applications of SOCT 78 4.4 Materials and methods 82 4.4.1 Fluorophores in NIR imaging (650 - 900 nm) 82 4.4.2 Indocyanine green (ICG) 84 4.4.3 Microspheres 86 4.5 Spectroscopic full-field OCT data extraction and processing 87 4.6 In vitro spectroscopic data validation 89 Chapter 5 Spectroscopic Full-field Optical Coherence Tomography in Dermatology 95 5.1 Skin structure and biology 96 5.2 Optical properties of skin 105 5.3 OCT applications in dermatology 109 5.4 Full-field OCT imaging of in vivo skin 113 5.5 Spectroscopic measurements of in vivo human skin 116 5.6 Depth-dependent backscattered signal analysis 120 Chapter 6 Conclusion and Future Work 122 Bibliography 125 Appendix 137 I. MATLAB codes for PZT hysteresis compensation 137 i. Polynomial hysteresis: Function and parameter’s identification 137 ii. PI model parameter’s identification 139 II. MATLAB codes for Spectroscopic FF-OCT signal analysis 140 i. A-scan to 4-point image conversion 140 ii. Spectroscopic analysis using STFT 142 | |
| dc.language.iso | en | |
| dc.subject | 光學同調斷層掃描 | zh_TW |
| dc.subject | 前饋磁滯補償 | zh_TW |
| dc.subject | 壓電轉換器 | zh_TW |
| dc.subject | 光譜學 | zh_TW |
| dc.subject | 磁滯 | zh_TW |
| dc.subject | 皮膚科 | zh_TW |
| dc.subject | 斷層影像處理 | zh_TW |
| dc.subject | 傅立葉變換 | zh_TW |
| dc.subject | feedforward hysteresis compensation | en |
| dc.subject | Optical coherence tomography | en |
| dc.subject | piezoelectric transducer | en |
| dc.subject | hysteresis | en |
| dc.subject | dermatology | en |
| dc.subject | tomographic image processing | en |
| dc.subject | Fourier transform | en |
| dc.subject | spectroscopy | en |
| dc.title | 光譜全場光學相干斷層掃描：深度相關的人體皮膚後向散射光譜 | zh_TW |
| dc.title | Spectroscopic Full-field Optical Coherence Tomography: Depth-dependent Human Skin Backscattering Spectra | en |
| dc.date.schoolyear | 110-1 | |
| dc.description.degree | 博士 | |
| dc.contributor.oralexamcommittee | 林晃巖(Hsin-Tsai Liu),李穎玟(Chih-Yang Tseng),徐世祥,李翔傑 | |
| dc.subject.keyword | 光學同調斷層掃描,光譜學,傅立葉變換,斷層影像處理,皮膚科,磁滯,壓電轉換器,前饋磁滯補償, | zh_TW |
| dc.subject.keyword | Optical coherence tomography,spectroscopy,Fourier transform,tomographic image processing,dermatology,hysteresis,piezoelectric transducer,feedforward hysteresis compensation, | en |
| dc.relation.page | 143 | |
| dc.identifier.doi | 10.6342/NTU202104538 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-12-21 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 光電工程學研究所 | zh_TW |
| 顯示於系所單位： | 光電工程學研究所 | |
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