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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 蘇璧伶(Bi-Ling Su) | |
| dc.contributor.author | Jou-Chien Fang | en |
| dc.contributor.author | 方柔茜 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:05:48Z | - |
| dc.date.available | 2021-11-08 | |
| dc.date.available | 2022-11-24T03:05:48Z | - |
| dc.date.copyright | 2021-11-08 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-15 | |
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C., Li, D., Su, M., Jian, R., Du, L. Y. (2020). Molecular detection and genetic characteristics of Babesia gibsoni in dogs in Shaanxi Province, China. Parasites vectors, 13(1), 1-14. Harrus, S., Bark, H., Waner, T. (1997). Canine monocytic ehrlichiosis: an update. The Compendium on continuing education for the practicing veterinarian, 19, 431-444. Harrus, S., Kass, P. H., Klement, E., Waner, T. (1997). Canine monocytic ehrlichiosis: a retrospective study of 100 cases, and an epidemiological investigation of prognostic indicators for the disease. Veterinary Record, 141(14), 360-363. Harrus, S., Kenny, M., Miara, L., Aizenberg, I., Waner, T., Shaw, S. (2004). Comparison of simultaneous splenic sample PCR with blood sample PCR for diagnosis and treatment of experimental Ehrlichia canis infection. Antimicrobial agents and chemotherapy, 48(11), 4488-4490. Harrus, S., Perlman-Avrahami, A., Mumcuoglu, K. Y., Morick, D., Eyal, O., Baneth, G. (2011). Molecular detection of Ehrlichia canis, Anaplasma bovis, Anaplasma platys, Candidatus Midichloria mitochondrii and Babesia canis vogeli in ticks from Israel. Clinical Microbiology and Infection, 17(3), 459-463. Harrus, S., Waner, T., Avidar, Y., Bogin, E., Peh, H. C., Bark, H. (1996). Serum protein alterations in canine ehrlichiosis. Veterinary parasitology, 66(3-4), 241-249. Harrus, S., Waner, T., Aizenberg, I., Foley, J. E., Poland, A. M., Bark, H. (1998). Amplification of ehrlichial DNA from dogs 34 months after infection with Ehrlichia canis. Journal of Clinical Microbiology, 36(1), 73-76. Harrus, S., Waner, T., Bark, H., Jongejan, F., Cornelissen, A. W. (1999). Recent advances in determining the pathogenesis of canine monocytic ehrlichiosis. Journal of clinical microbiology, 37(9), 2745-2749. Harvey, J. W., Simpson, C. F., Gaskin, J. M. (1978). Cyclic thrombocytopenia induced by a Rickettsia-like agent in dogs. Journal of Infectious Diseases, 137(2), 182-188. Hegarty, B. C., de Paiva Diniz, P. P. V., Bradley, J. M., Lorentzen, L., Breitschwerdt, E. (2009). Clinical relevance of annual screening using a commercial enzyme-linked immunosorbent assay (SNAP 3Dx) for canine ehrlichiosis. Journal of the American Animal Hospital Association, 45(3), 118-124. Hibler, S. C., Hoskins, J. D., Greene, C. E. (1986). Rickettsial infections in dogs. II. Ehrlichiosis and infectious cyclic thrombocytopenia. The Compendium on continuing education for the practicing veterinarian, USA. Higuchi, S., Fujimori, M., Hoshi, F., Kawamura, S., Yasuda, Y. (1995). Development of Babesia gibsoni in the salivary glands of the larval tick, Rhipicephalus sanguineus. Journal of Veterinary Medical Science, 57(1), 117-119. Hildebrandt, P. K., Conroy, J. D., McKee, A. E., Nyindo, M. B. A., Huxsoll, D. L. (1973). Ultrastructure of Ehrlichia canis. Infection and immunity, 7(2), 265-271. Hildebrandt, P. K., Huxsoll, D. L., Walker, J. S., Nims, R. M., Taylor, R., Andrews, M. (1973). Pathology of canine ehrlichiosis (tropical canine pancytopenia). American journal of veterinary research, 34(10), 1309-1320. Hongo, I., Bloch, K. C. (2006). Ehrlichia infection of the central nervous system. Current treatment options in neurology, 8(3), 179-184. Hoskins, J. D. (1991). Canine haemobartonellosis, canine hepatozoonosis, and feline cytauxzoonosis. Veterinary Clinics of North America: Small Animal Practice, 21(1), 129-140. Huber, D., Reil, I., Duvnjak, S., Jurković, D., Lukačević, D., Pilat, M., Beck, A., Mihaljević, Ž., Vojta, L., Polkinghorne, A. Beck, R. (2017). Molecular detection of Anaplasma platys, Anaplasma phagocytophilum and Wolbachia sp. but not Ehrlichia canis in Croatian dogs. Parasitology research, 116(11), 3019-3026. Hulme-Moir, K. L., Barker, E. N., Stonelake, A., Helps, C. R., Tasker, S. (2010). Use of real-time quantitative polymerase chain reaction to monitor antibiotic therapy in a dog with naturally acquired Mycoplasma haemocanis infection. Journal of veterinary diagnostic investigation, 22(4), 582-587. Hutcheon, D. (1893). Diseases amongst dogs. Malignant jaundice or bilious fever of the dog. Agricultural Journal of the Cape of Good Hope, 6, 476-477. Huxsoll, D., Hildebrandt, P., Nims, R., Ferguson, J., Walker, J. (1969). Ehrlichia canis-the causative agent of a haemorrhagic disease of dogs? Veterinary Record, 85(21), 587-587. Ikadai, H., Tanaka, H., Shibahara, N., Matsuu, A., Uechi, M., Itoh, N., Oshiro, S., Kudo, N., Igarashi, I., Oyamada, T. (2004). Molecular evidence of infections with Babesia gibsoni parasites in Japan and evaluation of the diagnostic potential of a loop-mediated isothermal amplification method. Journal of clinical microbiology, 42(6), 2465-2469. Inokuma, H., Yoshizaki, Y., Matsumoto, K., Okuda, M., Onishi, T., Nakagome, K., Kosugi, R. Hirakawa, M. (2004). Molecular survey of Babesia infection in dogs in Okinawa, Japan. Veterinary Parasitology, 121(3-4), 341-346. Inokuma, H., Yoshizaki, Y., Shimada, Y., Sakata, Y., Okuda, M., Onishi, T. (2003). Epidemiological survey of Babesia species in Japan performed with specimens from ticks collected from dogs and detection of new Babesia DNA closely related to Babesia odocoilei and Babesia divergens DNA. Journal of Clinical Microbiology, 41(8), 3494-3498. Ionita, M., Mitrea, I. L., Pfister, K., Hamel, D., Buzatu, C. M., Silaghi, C. (2012). Canine babesiosis in Romania due to Babesia canis and Babesia vogeli: a molecular approach. Parasitology research, 110(5), 1659-1664. Irwin, P. J. (2009). Canine babesiosis: from molecular taxonomy to control. Parasites vectors, 2(1), 1-9. Irwin, P. J. (2010). Canine babesiosis. Veterinary Clinics: Small Animal Practice, 40(6), 1141-1156. Irwin, P. J., Hutchinson, G. W. (1991). Clinical and pathological findings of Babesia infection in dogs. Australian Veterinary Journal, 68(6), 204-209. Iqbal, Z., Chaichanasiriwithaya, W., Rikihisa, Y. (1994). Comparison of PCR with other tests for early diagnosis of canine ehrlichiosis. Journal of Clinical Microbiology, 32(7), 1658-1662. Ishimine, T., Makimura, S., Kitazawa, S., Tamura, S., Suzuki, N. (1978). Pathophysiological findings on blood of Beagles experimentally infected with Babesia gibsoni. Japanese Journal of Tropical Medicine and Hygiene, 6(1), 15-26. Iwakami, S., Ichikawa, Y., Inokuma, H. (2014). Molecular survey of Babesia gibsoni using Haemaphysalis longicornis collected from dogs and cats in Japan. Journal of Veterinary Medical Science, 76(9): 1313–1316 Jacobs, P.A., Fourie, L.J., Kok, D.J. Horak……… | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80398 | - |
| dc.description.abstract | " 台灣位處東亞，氣候為熱帶到副熱帶季風，因此壁蝨為台灣犬隻常見的外寄生蟲。在台灣，犬隻常見的壁蝨媒介性疾病，包括焦蟲症 (babesiosis) 、艾利希體症 (ehrlichiosis) 及邊蟲症 (anaplasmosis)。然而，過去台灣研究多數聚焦在特定地區的犬隻，忽略壁蝨與病原分佈的關係。因此，本研究旨在探討台灣犬壁蝨媒介性疾病盛行率以及犬壁蝨分類與地域分布間之關聯性。 在本研究，我們收集389個自2015到2017年台灣各地區身上帶有壁蝨之犬隻血液樣本。分別於台灣北部收集258隻犬隻，中部86隻犬隻及南部45隻犬隻，並使用分子生物學檢測台灣犬常見種壁蝨媒介性病原—焦蟲 (Babesia vogeli, Babesia gibsoni)、艾利希體 (Ehrlichia canis)、邊蟲 (Anaplasma platys)、親血性黴漿菌 (Mycoplasma haemocanis, Candidatus Mycoplasma haematoparvum)。 本研究結果顯示，犬隻壁蝨媒介性疾病分子生物學檢測之盛行率為B. gibsoni 15.7%、B. vogeli 9.5%、A. platys 4.6%、Ca. M. haematoparvum 2.8%、E. canis 1.5%以及M. haemocanis 0.8%。將壁蝨的分佈及 B. gibsoni的陽性率作分析， B. gibsoni的盛行率與Haemaphysalis hystricis的分佈相符，大部分分布在台灣北部地區，少部分在中部地區。感染B. vogeli犬隻則與壁蝨Riphicephalus sanguineusi所在位置相符，分布全台。本研究結果可提供畜主參考高風險地區旅遊的危險性及犬隻壁蝨預防的重要性。另外，本研究也提供臨床獸醫在犬壁蝨媒介疾病區別診斷的重要參考。" | zh_TW |
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| dc.description.tableofcontents | 目錄 謝辭 i 摘要 ii Abstract iii 目錄 v 圖目錄 x 表目錄 xi 第一章 前言 1 第二章 文獻探討 2 第一節 台灣犬隻壁蝨媒介性疾病 2 2.1.1 焦蟲症 (Babesiosis) 2 2.1.1.1 疾病簡介 2 2.1.1.2 病原傳播與生活史 2 2.1.1.3 臨床症狀 4 2.1.1.4 診斷 4 2.1.1.4.1 臨床病理學 4 2.1.1.4.2 血液抹片 5 2.1.1.4.3 分子診斷 6 2.1.1.4.4 血清學診斷 6 2.1.1.4.5 病理學診斷 7 2.1.1.5 治療 7 2.1.2 艾利希體症 (Ehrlichiosis) 8 2.1.2.1 歷史背景及特性 8 2.1.2.2 病原傳播 9 2.1.2.3 臨床症狀 9 2.1.2.4 診斷 10 2.1.2.4.1 臨床病理學 10 2.1.2.4.2 血液抹片 10 2.1.2.4.3 影像學診斷 11 2.1.2.4.4 分子學診斷 11 2.1.2.4.5 血清學診斷 12 2.1.2.4.6 病理學診斷 12 2.1.2.5 治療 13 2.1.3 邊蟲症 (Anaplasmosis) 13 2.1.3.1 歷史背景與特性 13 2.1.3.2 病原傳播 14 2.1.3.3 臨床症狀 14 2.1.3.4 診斷 15 2.1.3.4.1 臨床病理學 15 2.1.3.4.2 血液抹片 15 2.1.3.4.3 分子學診斷 15 2.1.3.4.4 血清學診斷 16 2.1.3.5 治療 16 2.1.4 親血性黴漿菌症 (Hemoplasmosis) 16 2.1.4.1 歷史背景與特性 16 2.1.4.2 病原傳播 17 2.1.4.3 臨床症狀 18 2.1.4.4 診斷 19 2.1.4.4.1 臨床病理學 19 2.1.4.4.2 血液抹片 19 2.1.4.4.3 分子學診斷 19 2.1.4.4.4 血清學診斷 20 2.1.4.5 治療 20 2.1.5 台灣過往犬隻壁蝨媒介性疾病流行病學 21 第二節 壁蝨 21 2.2.1 背景介紹 21 2.2.2 特性及病原傳播 22 2.2.3 台灣犬隻壁蝨分類、分佈及特性 22 第三章 材料與方法 25 I. 犬壁蝨媒介性疾病盛行率 25 第一節 動物來源 25 第二節 血液分析及血液抹片檢查 25 第三節 聚合酶連鎖反應 25 3.1.1 核酸萃取 25 3.1.2 引子使用 26 3.1.3 聚合酶連鎖反應 26 3.1.4 電泳分析 27 3.1.5 Babesia gibsoni核酸定序與親緣分析 27 II. 犬壁蝨分類與地域分布間之關聯性 28 第一節 壁蝨樣本 28 第二節 依形態學特徵鑑定壁蝨 28 第四章 結果 29 I. 犬壁蝨媒介性疾病盛行率 29 第一節 動物來源 29 第二節 壁蝨媒介性病原之分子生物學病原檢測、血液抹片及血液檢查 29 第三節 Babesia gibsoni核酸定序與親緣分析 30 II. 壁蝨分類與地域分布間之關聯性 30 第一節 壁蝨品種及所在位置之分析 30 第五章 討論 32 參考文獻 38 圖 59 表 63 附件 73 | |
| dc.language.iso | zh-TW | |
| dc.subject | 壁蝨地域分布 | zh_TW |
| dc.subject | 壁蝨 | zh_TW |
| dc.subject | 犬隻壁蝨媒介性疾病 | zh_TW |
| dc.subject | 焦蟲症 | zh_TW |
| dc.subject | 艾利希體症 | zh_TW |
| dc.subject | 邊蟲症 | zh_TW |
| dc.subject | 親血性黴漿菌症 | zh_TW |
| dc.subject | 聚合酶鏈鎖反應 | zh_TW |
| dc.subject | ticks | en |
| dc.subject | tick geographic distribution | en |
| dc.subject | polymerase chain reaction (PCR) | en |
| dc.subject | hemoplasmosis | en |
| dc.subject | anaplasmosis | en |
| dc.subject | ehrlichiosis | en |
| dc.subject | babesiosis | en |
| dc.subject | tick-borne diseases | en |
| dc.title | 台灣地區犬壁蝨媒介性疾病的調查： Ⅰ. 犬壁蝨媒介性疾病盛行率 Ⅱ. 犬壁蝨分類與地域分布間之關聯性 | zh_TW |
| dc.title | The Research of Canine Tick-borne Diseases in Taiwan: Ⅰ. Prevalence of Tick-borne Diseases Ⅱ. Tick Identification and Geographic Distribution | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 周濟眾(Hsin-Tsai Liu),陳文英(Chih-Yang Tseng),劉品辰 | |
| dc.subject.keyword | 壁蝨,犬隻壁蝨媒介性疾病,焦蟲症,艾利希體症,邊蟲症,親血性黴漿菌症,聚合酶鏈鎖反應,壁蝨地域分布, | zh_TW |
| dc.subject.keyword | ticks,tick-borne diseases,babesiosis,ehrlichiosis,anaplasmosis,hemoplasmosis,polymerase chain reaction (PCR),tick geographic distribution, | en |
| dc.relation.page | 74 | |
| dc.identifier.doi | 10.6342/NTU202100186 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-16 | |
| dc.contributor.author-college | 獸醫專業學院 | zh_TW |
| dc.contributor.author-dept | 臨床動物醫學研究所 | zh_TW |
| 顯示於系所單位： | 臨床動物醫學研究所 | |
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