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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 孫家棟(Chia-Tung Shun) | |
| dc.contributor.author | Tzu-Cheng Su | en |
| dc.contributor.author | 蘇子誠 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:05:20Z | - |
| dc.date.available | 2021-07-07 | |
| dc.date.available | 2022-11-24T03:05:20Z | - |
| dc.date.copyright | 2021-07-07 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-06-29 | |
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Lesnikova I, Schreckenbach MN, Kristensen MP, Papanikolaou LL, Hamilton-Dutoit S. Usability of Immunohistochemistry in Forensic Samples With Varying Decomposition. Am J Forensic Med Pathol. 2018 Sep;39(3):185-191. 59. Wu CL, Su TC, Chang CC, Kor CT, Chang CH, Yang TH, Chiu PF, Tarng DC. Tubular Peroxiredoxin 3 as a Predictor of Renal Recovery from Acute Tubular Necrosis in Patients with Chronic Kidney Disease. Sci Rep. 2017 Feb 27;7:43589. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80372 | - |
| dc.description.abstract | 死亡後腎小管產生腐敗或自溶的死後組織變化和急性腎小管損傷十分類似，在顯微組織檢查鑑別兩者相當困難。目前文獻上許多的證據顯示氧化壓力和急性腎小管損傷的致病機轉有關，而其中過氧化物還原酶3 為一種抗氧化劑，維持人體內氧化和還原反應的平衡。本篇研究納入30個切片確診急性腎小管損傷案例，10個腎小管出現死後組織變化的猝死案例和10個正常腎臟組織案例，利用數位影像分析軟體比較過氧化物還原酶3 的免疫組織化學染色在腎小管染色強度。結果顯示急性腎小管損傷在過氧化物還原酶3 染色表現上比腎小管死後組織變化組和正常腎臟組織組來的強，且統計上有顯著差異 (p值<0.0001)。而死後腎小管組織變化組和正常腎臟組織組兩組之間，在過氧化物還原酶3 染色強度上無統計上差異 (P值=0.1306)。本篇研究結論顯示，相比於死後腎小管組織變化的過氧化物還原酶3 免疫組織化學染色表現，當過氧化物還原酶3 在腎小管表現升高時，應考慮急性腎小管損傷的發生。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:05:20Z (GMT). No. of bitstreams: 1 U0001-0906202119135200.pdf: 1894450 bytes, checksum: 669b42739302fa415692e10fcf64fc0a (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | "國立臺灣大學碩士學位論文口試委員會審定書 I 致謝 II 中文摘要 III Abstract IV Chapter one: Introduction 1 Chapter two: Material and Methods 2 Section one: Material 2 Section two: Methods 2 1. Histopathology 3 2. Immunohistochemistry 3 3. Immunohistochemical scoring system 4 4. Statistical analysis 4 Chapter three: Results 4 Section one: Histopathology 4 Section two: Immunohistochemistry 5 1. Peroxiredoxin 3 staining in normal control group 5 2. Peroxiredoxin 3 staining in postmortem group 5 3. Peroxiredoxin 3 staining in acute tubular injury group 5 4. Statistical analysis of quantitative immunohistochemical staining value between control, postmortem and acute tubular injury groups 6 Chapter four: Discussion 6 Section one: Challenge to diagnose acute tubular injury at postmortem examination 6 Section two: Oxidative stress, free radicals and related by-products 8 Section three: Relationship between oxidative stress and acute tubular injury 9 1. Ischemia/reperfusion induced acute tubular injury and oxidative stress 9 2. Nephrotoxic agent induced acute tubular injury and oxidative stress 10 3. Septic acute tubular injury and oxidative stress 11 Section four: Functional classes of antioxidant 12 Section five: Peroxiredoxin as an antioxidant 12 Section six: Peroxiredoxin 3 and acute tubular injury 13 Section seven: Study result discussion 13 1. Discussion of staining result in normal control group 14 2. Discussion of staining result in postmortem group 14 3. Discussion of staining result in acute tubular injury group 15 Section eight: Advantages of digital image analytic software 16 Section nine: Limitation of the study 16 Chapter five: Conclusion 17 Reference 18" | |
| dc.language.iso | en | |
| dc.subject | 過氧化物還原酶3 | zh_TW |
| dc.subject | 急性腎小管損傷 | zh_TW |
| dc.subject | 死後變化 | zh_TW |
| dc.subject | 氧化壓力 | zh_TW |
| dc.subject | postmortem change | en |
| dc.subject | peroxiredoxin 3 | en |
| dc.subject | oxidative stress | en |
| dc.subject | acute tubular injury | en |
| dc.title | 過氧化物還原酶3 鑑別生前急性腎小管損傷和腎小管死後變化之免疫組織化學染色的研究 | zh_TW |
| dc.title | Immunohistochemical study of peroxiredoxin 3 expression in differentiating antemortem acute tubular injury from postmortem change of renal tubules | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 許倬憲(Hsin-Tsai Liu),林維洲(Chih-Yang Tseng) | |
| dc.subject.keyword | 急性腎小管損傷,死後變化,過氧化物還原酶3,氧化壓力, | zh_TW |
| dc.subject.keyword | acute tubular injury,postmortem change,peroxiredoxin 3,oxidative stress, | en |
| dc.relation.page | 34 | |
| dc.identifier.doi | 10.6342/NTU202100983 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-06-29 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 法醫學研究所 | zh_TW |
| 顯示於系所單位： | 法醫學科所 | |
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