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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 盧子彬(Tzu-Pin Lu) | |
| dc.contributor.author | Kuan-Chen Lu | en |
| dc.contributor.author | 呂冠臻 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:03:40Z | - |
| dc.date.available | 2021-07-20 | |
| dc.date.available | 2022-11-24T03:03:40Z | - |
| dc.date.copyright | 2021-07-20 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-01 | |
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Burgess, MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data. Int J Epidemiol, 2017. 46(6): p. 1734-1739. 51. Tikkanen, E., S. Gustafsson, and E. Ingelsson, Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study. Circulation, 2018. 137(24): p. 2583-2591. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80274 | - |
| dc.description.abstract | "研究背景：流行病學研究表明，肥胖與心房顫動有所相關，並且已證實具有因果關係。從臨床觀察，體型的增加亦可能會增加心房顫動的風險，且與肥胖無關。而身體質量（body mass）及身體質量指數（body mass index, BMI）並非合適的人體測量指標，因其無法區分非脂肪質量和脂肪質量。本研究採用和軀幹非脂肪體重（trunk fat-free mass）與非脂肪體重指標（fat-free mass index）相關的單核苷酸多態性（SNP）為工具變項，執行孟德爾隨機化，藉此推論身形和心房顫動的因果關係。 材料與方法：使用英國生物資料庫（UK Biobank），共納入了7,350名受試者，包括1,225（16.67％）名心房顫動病例以及6,125名（83.33％）非心房顫動對照組。為了揭示軀幹非脂肪體重及非脂肪體重指標與心房顫動之間的因果關係，執行孟德爾隨機化。並使用逆方差加權法於英國生物資料庫(UK Biobank)進行因果估計。輔以加權中位數方法、MR-Egger迴歸和孟德爾隨機多效性殘差和離群值（MR-PRESSO）全局檢驗來檢測水平多效性效應。 結果：孟德爾隨機分配分析揭示非脂肪體重指標（β_IVW=0.202, p=8.42Ε-04）與軀幹非脂肪體重（β_IVW=0.169, p=1.53Ε-04）對心房顫動具有因果關係。顯示隨著非脂肪體重增加，對於罹患心房顫動之風險有正向且統計上顯著的因果關係。 結論：非脂肪體重指標及軀幹非脂肪體重與心房顫動之間存在強而一致的正相關，以孟德爾隨機分配分析表明非脂肪體重與心房顫動有因果關係。本研究亦使用多基因風險評分（polygenic risk score）作為工具變量，亦表明非脂肪體重指標和軀幹非脂肪體重對心房顫動的因果作用。與傳統的孟德爾隨機分配分析一致。 " | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:03:40Z (GMT). No. of bitstreams: 1 U0001-0107202111424300.pdf: 2664448 bytes, checksum: c27c4073aeeaf9849d54e9f48c802e02 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 論文口試委員審定書 i 謝辭 ii 摘要 iii Abstract v Chapter 1 Introduction 1 1.1 The epidemiology of arrhythmia 1 1.2 The diagnosis of atrial fibrillation 3 1.3 Observational study and Randomized controlled trial (RCT) 3 1.4 Mendelian randomization study (MR) 5 1.5 The aim of this study 6 Chapter 2 Material and Methods 7 2.1 Data source and study population 7 2.2 Propensity score matching (PSM) 8 2.3 Quality control 9 2.4 Genetic components selection 10 2.5 Definition of study exposure 11 2.6 Definition of study outcome 11 2.7 Mendelian randomization analyses 12 2.8 Polygenic risk score 14 2.9 Sensitivity analysis 16 Chapter 3 Results 19 3.1 Descriptive statistics 19 3.2 Association analysis 20 3.3 Mendelian randomization of causality inference 20 3.4 Sensitivity analyses 21 Chapter 4 Discussion 23 4.1 Principal findings 23 4.2 Possible interpretations 23 4.3 Strengths 24 4.4 Limitations 25 Chapter 5 References 27 Chapter 6 Appendix 31 | |
| dc.language.iso | en | |
| dc.subject | 多基因風險評分 | zh_TW |
| dc.subject | 孟德爾隨機化 | zh_TW |
| dc.subject | 心房顫動 | zh_TW |
| dc.subject | 英國生物庫 | zh_TW |
| dc.subject | 因果推論 | zh_TW |
| dc.subject | 非脂肪體重 | zh_TW |
| dc.subject | causal inference | en |
| dc.subject | Mendelian randomization | en |
| dc.subject | polygenic risk score | en |
| dc.subject | fat-free mass | en |
| dc.subject | atrial fibrillation | en |
| dc.subject | UK Biobank | en |
| dc.title | 孟德爾隨機化探非脂肪體重指標與心房顫動之因果關係 | zh_TW |
| dc.title | Association of Fat-Free Mass Indices and Atrial Fibrillation: Mendelian Randomization Analysis | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 郭柏秀(Hsin-Tsai Liu),蕭朱杏(Chih-Yang Tseng),蕭自宏 | |
| dc.subject.keyword | 孟德爾隨機化,多基因風險評分,非脂肪體重,心房顫動,英國生物庫,因果推論, | zh_TW |
| dc.subject.keyword | Mendelian randomization,polygenic risk score,fat-free mass,atrial fibrillation,UK Biobank,causal inference, | en |
| dc.relation.page | 51 | |
| dc.identifier.doi | 10.6342/NTU202101222 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-02 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 流行病學與預防醫學研究所 | zh_TW |
| 顯示於系所單位： | 流行病學與預防醫學研究所 | |
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