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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中(Pau-Chung Chen) | |
| dc.contributor.author | Che-Wei Liao | en |
| dc.contributor.author | 廖哲緯 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:03:07Z | - |
| dc.date.available | 2021-07-20 | |
| dc.date.available | 2022-11-24T03:03:07Z | - |
| dc.date.copyright | 2021-07-20 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-09 | |
| dc.identifier.citation | Alberti, K. G., Zimmet, P., Shaw, J. (2006). Metabolic syndrome--a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med, 23(5), 469-480. doi:10.1111/j.1464-5491.2006.01858.x Alterman, T., Luckhaupt, S. E., Dahlhamer, J. M., Ward, B. W., Calvert, G. M. (2013). Prevalence rates of work organization characteristics among workers in the U.S.: data from the 2010 National Health Interview Survey. Am J Ind Med, 56(6), 647-659. doi:10.1002/ajim.22108 Autier, P., Boniol, M., Pizot, C., Mullie, P. (2014). Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol, 2(1), 76-89. doi:10.1016/s2213-8587(13)70165-7 Bacha, F., Saad, R., Gungor, N., Arslanian, S. A. (2006). Are obesity-related metabolic risk factors modulated by the degree of insulin resistance in adolescents? Diabetes Care, 29(7), 1599-1604. doi:10.2337/dc06-0581 Barclay, K., Myrskylä, M. (2016). 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International Archives of Occupational and Environmental Health, 92(6), 763-793. doi:10.1007/s00420-019-01434-3 Zimmet, P., Alberti, G., Kaufman, F., Tajima, N., Silink, M., Arslanian, S., . . . Caprio, S. (2007). The metabolic syndrome in children and adolescents. The Lancet, 369(9579), 2059-2061. doi:https://doi.org/10.1016/S0140-6736(07)60958-1 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80241 | - |
| dc.description.abstract | "研究背景：過去已有許多文獻指出，母親在懷孕過程中從事輪班作業可能與一些生殖危害有關，包含胎兒低出生體重、早產、流產、神經行為發展遲緩等等，也有部分文獻指出會導致兒童在發育過程中較易出現肥胖情形，但跟肥胖相關聯的代謝症候群因子，例如胰島素抗性、血脂肪異常等，則鮮少有文獻提及。本研究著眼於探討母親在懷孕過程中從事輪班作業與兒童肥胖、代謝症候群的關聯，並放入飲食、運動、其他個人因素等干擾因子一併納入探討。 方法：本研究針對台灣出生世代長期追蹤研究 II (Taiwan Birth Panel Study II, TBPS II)，收集於2011至2012年出生之嬰兒，於2018年做後續追蹤，著重於探討產前及產後母親、嬰兒、及幼兒時期之健康情形與相關健康風險暴露之相關性；研究中透過追蹤檢查時測量之孩童身高、體重，以及抽血資料中測得之血糖、胰島素、血脂肪等資料，並透過結構化問卷評估母親及幼兒之家庭背景、飲食情況、及環境因子等；統計部分使用單變量及多變量之線性及羅吉斯迴歸，調整潛在干擾因子，以評估母親在懷孕過程中從事輪班作業與兒童肥胖、代謝症候群因子，例如胰島素阻抗(HOMA-IR)、血脂肪異常的關聯。 結果：本研究共納入407對母親及幼兒。透過流程圖做嚴謹的篩選分組，經調整干擾因子後之模型顯示，母親在懷孕過程中從事輪班作業，與兒童體重上升、過重與肥胖、胰島素阻抗(HOMA-IR)數值較高等風險皆有關連，此關聯性亦在排除體重過輕小孩的子族群中出現。而在比較母親在懷孕前從事輪班作業時，並沒有以上提及之發現。 結論：本研究顯示母親在懷孕過程中從事輪班作業，可能會與兒童體重上升、過重與肥胖、胰島素阻抗有關。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:03:07Z (GMT). No. of bitstreams: 1 U0001-0707202117593700.pdf: 955136 bytes, checksum: 6ded7f8cdf6c6d020d03e4ba3f612d6a (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 口試委員會審訂書.................................................................... 1 誌謝................................................................................2 中文摘要 ...........................................................................3 英文摘要 .......................................................................... 5 目錄.............................................................................. 7 Chapter 1. Introduction........................................................... 8 Chapter 2. Material and method................................................... 12 2.1. Study population and data collection........................................ 12 2.2. Measurement of neurocognitive function...................................... 13 2.3. Measurement of birth outcome and general health conditions.................. 14 2.4. Measurement of metabolic factors............................................ 15 2.5. Confounding variables ...................................................... 17 2.6. Statistical analysis ....................................................... 19 Chapter 3. Results............................................................... 21 3.1. Baseline characteristics of the population .................................. 21 3.2. Health outcome of the children at Birth and 7 years old ..................... 23 3.3. linear and logistic regression of child birth outcome........................ 24 3.4. Maternal shift work during pregnancy and child outcome at seven years old follow up – linear regression ….…………………………………….……………. 25 3.5. Maternal shift work during pregnancy and child outcome at seven years old follow up – logistic regression ……………………………………………………. 26 3.6. Sensitivity analysis: Maternal shift work before pregnancy and child health outcome........................................................................... 28 3.7. Sensitivity analysis for other covariates.................................... 29 3.8. Sensitivity analysis for regression models: Model fit and collinearity....... 31 Chapter 4. Discussion............................................................. 32 Chapter 5. Conclusions............................................................ 40 Chapter 6. Conflict of interests.................................................. 40 Figure 1 ......................................................................... 41 Table 1........................................................................... 42 Table 2........................................................................... 43 Table 3........................................................................... 44 Table 4........................................................................... 45 Table 5........................................................................... 46 Supplementary Table S1 ........................................................ 47 Supplementary Table S2 ........................................................ 48 Supplementary Table S3 ........................................................ 49 Supplementary Table S4 ........................................................ 50 Supplementary Table S5 ........................................................ 51 Supplementary Table S6 ....................................................... 52 Supplementary Table S7 ................................................... 53 References........................................................................ 54 | |
| dc.language.iso | en | |
| dc.subject | 懷孕期間 | zh_TW |
| dc.subject | 胰島素阻抗 | zh_TW |
| dc.subject | 肥胖 | zh_TW |
| dc.subject | 體重過重 | zh_TW |
| dc.subject | 輪班作業 | zh_TW |
| dc.subject | overweight | en |
| dc.subject | shift work | en |
| dc.subject | insulin resistance | en |
| dc.subject | HOMA-IR | en |
| dc.subject | during pregnancy | en |
| dc.title | 懷孕母親輪班作業與孩童早期肥胖、代謝疾病之關係探討 | zh_TW |
| dc.title | "Association between maternal shift work during pregnancy and child overweight, metabolic outcomes in early childhood" | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.advisor-orcid | 陳保中(0000-0002-6242-5974) | |
| dc.contributor.oralexamcommittee | 蘇大成(Hsin-Tsai Liu),陳美惠(Chih-Yang Tseng),林育正,楊孝友 | |
| dc.subject.keyword | 輪班作業,體重過重,肥胖,胰島素阻抗,懷孕期間, | zh_TW |
| dc.subject.keyword | shift work,overweight,insulin resistance,HOMA-IR,during pregnancy, | en |
| dc.relation.page | 60 | |
| dc.identifier.doi | 10.6342/NTU202101329 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-07-09 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| U0001-0707202117593700.pdf 授權僅限NTU校內IP使用（校園外請利用VPN校外連線服務） | 932.75 kB | Adobe PDF |
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