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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 魏安祺(An-Chi Wei) | |
| dc.contributor.author | Yu-Chih Chen | en |
| dc.contributor.author | 陳昱志 | zh_TW |
| dc.date.accessioned | 2022-11-23T09:17:25Z | - |
| dc.date.available | 2021-08-04 | |
| dc.date.available | 2022-11-23T09:17:25Z | - |
| dc.date.copyright | 2021-08-04 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-07-29 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/79935 | - |
| dc.description.abstract | 糖解作用(Glycolysis)是生物體的核心代謝途徑，在文獻中有不少可以提供參考的數學模型，因此是用電腦程式建模與模擬較好呈現的一個生化途徑。本論文透過Simulink®建模和其他電腦建模方法做比較，並且也對不同的糖解數學模型做比較，探討糖解模型之間的相似度與相異度，並探討是否可以用糖解模型之模擬取代生物實驗。 此篇論文重製了兩篇不同團隊提出來的糖解模型(簡化糖解模型及完整糖解模型)，加以修改、比較及討論。針對簡化過後的模型和還未簡化的模型，去比較這兩者糖解模型行為模式的差異，雖然不同的模型所探討的代謝問題不一樣，但因為探討的主要對象和生化機制相同，其存在相同的部分代謝途徑可以作為比較的重點。 本論文的架構為利用Simulink®去實現糖解作用的數學模型，針對不同的模型去做參數上面的調整，比較簡化前後的差異，另外比較及說明Simulink®這個套件的優缺點，及所適合使用的模型類型。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-23T09:17:25Z (GMT). No. of bitstreams: 1 U0001-2707202113525200.pdf: 3797120 bytes, checksum: 716e070255eaf5624f8b5a0efdc9c21a (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 第 1 章 Introduction 10 1-1研究動機及目的 11 1-2論文貢獻 11 1-3糖解作用(Glycolysis)介紹 12 1-4 Simulink®模擬工具 20 1-5 MWC model 21 1-6文獻回顧 22 第 2 章 Method 33 第 3 章 Result 42 3-1結果重現 42 3-2 Simulink®重現Turbo model和Simulink® 重現whole glycolysis model比較 44 第 4 章 Discussion 57 4-1模型比較 57 4-2 Simulink® 比較 60 Appendix 62 Reference 77 | |
| dc.language.iso | zh-TW | |
| dc.subject | 生物系統 | zh_TW |
| dc.subject | 糖解作用 | zh_TW |
| dc.subject | 數學模型 | zh_TW |
| dc.subject | Glycolysis | en |
| dc.subject | System biology | en |
| dc.subject | Simulink | en |
| dc.title | 利用Simulink®檢測糖解作用模型之動態行為 | zh_TW |
| dc.title | Analysis of dynamic behaviour in yeast glycolysis models using Simulink® | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 許少瑜(Hsin-Tsai Liu),何奕平(Chih-Yang Tseng) | |
| dc.subject.keyword | 生物系統,數學模型,糖解作用, | zh_TW |
| dc.subject.keyword | Glycolysis,Simulink,System biology, | en |
| dc.relation.page | 81 | |
| dc.identifier.doi | 10.6342/NTU202101796 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-07-29 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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| U0001-2707202113525200.pdf | 3.71 MB | Adobe PDF | 檢視/開啟 |
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